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  1. Article ; Online: Lessons Learnt from Case Series of Out-of-hospital Cardiac Arrest and Unexpected Death after COVID-19 Vaccination.

    Maruyama, Toru / Uesako, Hayata

    Internal medicine (Tokyo, Japan)

    2023  Volume 62, Issue 22, Page(s) 3267–3275

    Abstract: Vaccination against COVID-19 has raised concerns about myocarditis in young men, as out-of-hospital cardiac arrest (OHCA) or sudden death after vaccination has been reported sporadically. Common features of these cases are occurrence in young men, within ...

    Abstract Vaccination against COVID-19 has raised concerns about myocarditis in young men, as out-of-hospital cardiac arrest (OHCA) or sudden death after vaccination has been reported sporadically. Common features of these cases are occurrence in young men, within a few weeks after vaccination, in patients with no structural heart diseases. Cases of unexplained nocturnal death showed fibrotic or hypertrophied myocardium, and one case of OHCA presented ventricular fibrillation (VF) triggered by a prominent J wave on an automated external defibrillator and histopathologic findings compatible with myocarditis. Both myocarditis and J waves are prevalent in young men, and these cases imply that myocarditis augments J waves, which trigger VFs, and primary electrical disorders are a leading cause of death. To prevent such issues, artificial intelligence (AI)-assisted interpretation of historical electrocardiogram findings may help predict future J wave formation leading to VF, as digital electrocardiogram (ECG) findings are well suited for AI interpretation.
    MeSH term(s) Humans ; Male ; Arrhythmias, Cardiac ; Artificial Intelligence ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Myocarditis/etiology ; Out-of-Hospital Cardiac Arrest/therapy ; Vaccination ; Ventricular Fibrillation
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-08-23
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.2298-23
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  2. Article ; Online: Carbon Monoxide Alleviates Post-ischemia-reperfusion Skeletal Muscle Injury and Systemic Inflammation.

    Taguchi, Kazuaki / Ogaki, Shigeru / Maeda, Hitoshi / Ishima, Yu / Watanabe, Hiroshi / Otagiri, Masaki / Maruyama, Toru

    Biological & pharmaceutical bulletin

    2024  Volume 47, Issue 4, Page(s) 868–871

    Abstract: Restoration of blood flow in skeletal muscle after a prolonged period of ischemia induces muscular ischemia-reperfusion injury, leading to local injury/dysfunction in muscles followed by systemic inflammatory responses. However, preventive/curative ... ...

    Abstract Restoration of blood flow in skeletal muscle after a prolonged period of ischemia induces muscular ischemia-reperfusion injury, leading to local injury/dysfunction in muscles followed by systemic inflammatory responses. However, preventive/curative agents for skeletal muscle ischemia injury are unavailable in clinics to date. Increasing evidence has validated that carbon monoxide (CO) prevents the progression of ischemia-reperfusion injury in various organs owing to its versatile bioactivity. Previously, we developed a bioinspired CO donor, CO-bound red blood cells (CO-RBC), which mimics the dynamics of RBC-associated CO in the body. In the present study, we have tested the therapeutic potential of CO-RBC in muscular injury/dysfunction and secondary systemic inflammation induced by skeletal muscle ischemia-reperfusion. The results indicate that CO-RBC rather than RBC alone suppressed elevation of plasma creatine phosphokinase, a marker of muscular injury, in rats subjected to both hind limbs ischemia-reperfusion. In addition, the results of the treadmill walking test revealed a significantly decreased muscular motor function in RBC-treated rats subjected to both hind limbs ischemia-reperfusion than that in healthy rats, however, CO-RBC treatment facilitated sustained muscular motor functions after hind limbs ischemia-reperfusion. Furthermore, CO-RBC rather than RBC suppressed the production of tumour necrosis factor (TNF)-α and interleukin (IL)-6, which were upregulated by muscular ischemia-reperfusion. Interestingly, CO-RBC treatment induced higher levels of IL-10 compared to saline or RBC treatments. Based on these findings, we suggest that CO-RBC exhibits a suppressive effect against skeletal muscle injury/dysfunction and systemic inflammatory responses after skeletal muscle ischemia-reperfusion.
    MeSH term(s) Animals ; Reperfusion Injury/drug therapy ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Carbon Monoxide ; Male ; Inflammation/drug therapy ; Rats, Sprague-Dawley ; Erythrocytes/drug effects ; Erythrocytes/metabolism ; Rats ; Creatine Kinase/blood ; Hindlimb/blood supply ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/blood ; Interleukin-6/metabolism ; Interleukin-6/blood
    Chemical Substances Carbon Monoxide (7U1EE4V452) ; Creatine Kinase (EC 2.7.3.2) ; Tumor Necrosis Factor-alpha ; Interleukin-6
    Language English
    Publishing date 2024-03-31
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b23-00917
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  3. Article ; Online: Constipation and heart failure: An overlooked but important linkage.

    Maruyama, Toru / Hieda, Michinari / Eiraku, Kunimitsu / Uozumi, Yuki / Nomura, Hideyuki

    Geriatrics & gerontology international

    2023  Volume 23, Issue 3, Page(s) 255–256

    MeSH term(s) Humans ; Constipation ; Heart Failure
    Language English
    Publishing date 2023-01-25
    Publishing country Japan
    Document type Letter ; Comment
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14545
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  4. Article ; Online: Impact of mental and developmental disorders on disability in Japanese university students: A cross-sectional study.

    Omodaka, Yusaku / Sato, Takeshi / Maruyama, Toru

    Journal of American college health : J of ACH

    2022  , Page(s) 1–6

    Abstract: Objective: This study utilized the World Health Organization Disability Assessment Schedule version 2 (WHODAS 2.0) to identify vulnerable students and explore the impact of mental and developmental disorders on disability.: Participants: A total of ... ...

    Abstract Objective: This study utilized the World Health Organization Disability Assessment Schedule version 2 (WHODAS 2.0) to identify vulnerable students and explore the impact of mental and developmental disorders on disability.
    Participants: A total of 156 undergraduates who visited support service offices at large-scale universities in Japan between April 2018 and March 2020 were included.
    Methods: The 36-item WHODAS 2.0 was administered, and data were gathered regarding mental and developmental disabilities. Mann-Whitney and Kruskal-Wallis tests were conducted.
    Results: Parents/guardians typically initiated consultation with student support services. Students whose parents had initiated consultation did not have higher scores in any WHODAS domain except "Life Activities." In every WHODAS domain except "Cognition," the "Mental Disorder" group scored significantly higher than the "No Disorder" group. The addition of "Developmental Disorders" significantly increased WHODAS scores, except in "Mobility."
    Conclusions: The WHODAS is a useful tool for identifying vulnerable students.
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604907-2
    ISSN 1940-3208 ; 0744-8481
    ISSN (online) 1940-3208
    ISSN 0744-8481
    DOI 10.1080/07448481.2022.2068961
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 427: Show issues Location:
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  5. Article: Rheological Abnormalities in Human Erythrocytes Subjected to Oxidative Inflammation.

    Maruyama, Toru / Hieda, Michinari / Mawatari, Shiro / Fujino, Takehiko

    Frontiers in physiology

    2022  Volume 13, Page(s) 837926

    Abstract: Erythrocytes are oxygen carriers and exposed to redox cycle in oxygenation and deoxygenation of hemoglobin. This indicates that circulating erythrocytes are vulnerable to the oxidative injury occurring under the imbalance of redox homeostasis. In this ... ...

    Abstract Erythrocytes are oxygen carriers and exposed to redox cycle in oxygenation and deoxygenation of hemoglobin. This indicates that circulating erythrocytes are vulnerable to the oxidative injury occurring under the imbalance of redox homeostasis. In this review article, two topics are presented concerning the human erythrocytes exposed to the oxidative inflammation including septic and sterile conditions. First, we demonstrate rheological derangement of erythrocytes subjected to acute oxidative injury caused by exogenous generators of reactive oxygen species (ROS). Erythrocyte filterability as whole-cell deformability has been estimated by the gravity-based nickel mesh filtration technique in our laboratory and was dramatically impaired in a time-dependent manner after starting exposure to the ROS generators, that is associated with concurrent progression of membrane protein degradation, phospholipid peroxidation, erythrocyte swelling, methemoglobin formation, and oxidative hemolysis. Second, we introduce an impairment of erythrocyte filterability confirmed quantitatively in diabetes mellitus and hypertension of animal models and patients under treatment. Among the cell geometry, internal viscosity, and membrane property as the three major determinants of erythrocyte deformability, erythrocyte membrane alteration is supposed to be the primary cause of this impairment in these lifestyle-related diseases associated with persistent oxidative inflammation. Excessive ROS trigger the inflammatory responses and reduce the erythrocyte membrane fluidity. Oxidative inflammation increasing erythrocyte membrane rigidity underlies the impaired systemic microcirculation, which is observed in diabetic and/or hypertensive patients. On the other hand, elevated internal viscosity caused by sickle hemoglobin polymerization is a primary cause of impaired erythrocyte filterability in sickle cell disease (SCD). However, oxidative inflammation is also involved in the pathophysiology of SCD. The physiologic level of ROS acts as signaling molecules for adaptation to oxidative environment, but the pathological level of ROS induces suicidal erythrocyte death (eryptosis). These findings provide further insight into the ROS-related pathophysiology of many clinical conditions.
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.837926
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  6. Article: Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways.

    Ikeda-Imafuku, Mayumi / Fukuta, Tatsuya / Tuan Giam Chuang, Victor / Sawa, Tomohiro / Maruyama, Toru / Otagiri, Masaki / Ishida, Tatsuhiro / Ishima, Yu

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 1

    Abstract: Oxidative stress is responsible for the onset and progression of various kinds of diseases including rhabdomyolysis-induced acute kidney injury (AKI). Antioxidants are, therefore, thought to aid in the recovery of illnesses linked to oxidative stress. ... ...

    Abstract Oxidative stress is responsible for the onset and progression of various kinds of diseases including rhabdomyolysis-induced acute kidney injury (AKI). Antioxidants are, therefore, thought to aid in the recovery of illnesses linked to oxidative stress. Supersulfide species have been shown to have substantial antioxidative activity; however, due to their limited bioavailability, few supersulfide donors have had their actions evaluated in vivo. In this study, human serum albumin (HSA) and N-acetyl-L-cysteine polysulfides (NACSn), which have polysulfides in an oxidized form, were conjugated to create a supersulfide donor. HSA is chosen to be a carrier of NACSn because of its extended blood circulation and high level of biocompatibility. In contrast to a supersulfide donor containing reduced polysulfide in HSA, the NACSn-conjugated HSAs exhibited stronger antioxidant activity than HSA and free NACSn without being uptaken by the cells in vitro. The supersulfide donor reduced the levels of blood urea nitrogen and serum creatinine significantly in a mouse model of rhabdomyolysis-induced AKI. Supersulfide donors significantly reduced the expression of oxidative stress markers in the kidney. These results indicate that the developed supersulfide donor has the therapeutic effect on rhabdomyolysis-induced AKI.
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17010128
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  7. Article ; Online: A senile case of heart failure associated with hypermagnesemia induced by magnesium-containing laxative agent.

    Eiraku, Kunimitsu / Uozumi, Yuki / Hieda, Michinari / Maruyama, Toru / Nomura, Hideyuki

    Geriatrics & gerontology international

    2022  Volume 22, Issue 10, Page(s) 897–899

    MeSH term(s) Heart Failure/diagnosis ; Heart Failure/etiology ; Humans ; Laxatives/adverse effects ; Laxatives/chemistry ; Magnesium/adverse effects ; Magnesium/analysis ; Metabolic Diseases/complications ; Metabolic Diseases/etiology
    Chemical Substances Laxatives ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2022-09-07
    Publishing country Japan
    Document type Case Reports ; Letter ; Comment
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14478
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  8. Article ; Online: [Characterization of Supersulfide in Serum Albumin and Its Therapeutic Application].

    Ikeda, Mayumi / Fukuta, Tatsuya / Iwao, Yasunori / Otagiri, Masaki / Maruyama, Toru / Ishida, Tatsuhiro / Ishima, Yu

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2023  Volume 144, Issue 1, Page(s) 51–56

    Abstract: Recent studies have shown that proteins already possess supersulfides during the translation. However, the distribution and the role of supersulfides are not fully understood. In this review, we focus on supersulfides in biological fluids, especially in ... ...

    Abstract Recent studies have shown that proteins already possess supersulfides during the translation. However, the distribution and the role of supersulfides are not fully understood. In this review, we focus on supersulfides in biological fluids, especially in serum. Various methods for measuring supersulfides have been developed, and these methods have elucidated the presence of supersulfides in serum proteins including serum albumin. Since the levels of supersulfides in serum and serum albumin of patients with chronic kidney disease were lower than those in healthy subjects and recovered by hemodialysis, the levels of supersulfides in serum would be an indicator reflecting oxidative stress. In addition, it has long been known that serum albumin is responsible for sulfur transference. We have applied this phenomenon to the synthesis of sulfur-added albumin (S
    MeSH term(s) Humans ; Serum Albumin/metabolism ; Oxidative Stress ; Oxidation-Reduction ; Renal Insufficiency, Chronic ; Sulfur
    Chemical Substances Serum Albumin ; Sulfur (70FD1KFU70)
    Language Japanese
    Publishing date 2023-12-14
    Publishing country Japan
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.23-00162-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Fourier analysis of periodic weakly stationary processes

    Maruyama, Toru

    Advances in mathematical economics Vol. 20 , p. 151-180

    a note on Slutsky's observation

    2016  Volume 20, Page(s) 151–180

    Author's details Toru Maruyama
    Language English
    Publisher Springer
    Publishing place Tokyo ; Berlin ; Heidelberg ; New York
    Document type Article
    ZDB-ID 1500427-2
    ISSN 1866-2226
    Database ECONomics Information System

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  10. Article ; Online: Remodeling induced by atrial fibrillation--how far does it extend?

    Maruyama, Toru

    Circulation journal : official journal of the Japanese Circulation Society

    2012  Volume 76, Issue 4, Page(s) 812–813

    MeSH term(s) Atrial Fibrillation/surgery ; Catheter Ablation ; Female ; Humans ; Male
    Language English
    Publishing date 2012-02-18
    Publishing country Japan
    Document type Editorial ; Comment
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.cj-12-0155
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