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  1. Article ; Online: A review on Iranian Traditional Medicine about Leech Therapy in Polycystic Ovary Syndrome

    Maryam Bahman / Mojgan Tansaz

    Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, Vol 22, Iss 6, Pp 75-

    2019  Volume 84

    Abstract: Introduction: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. Complementary medicine with a comprehensive and holistic approach in treating the diseases has become more popular in many ... ...

    Abstract Introduction: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. Complementary medicine with a comprehensive and holistic approach in treating the diseases has become more popular in many countries. Since ancient times, leech therapy has been used to treat many diseases in Iranian traditional medicine. The present study was conducted with aim to review Iranian traditional medicine about leech therapy in polycystic ovary syndrome. Methods: In this review study, the issues related to polycystic ovary syndrome and leech therapy were studied in Iranian traditional medicine sources such as Qanun, kholasat al-hekmeh, Exir-e-aazam and Mofarrah al-gholub. Then, searching was performed in databases of PubMed, Google Scholar, Scopus, SID, and Magiran using the keywords such as “leech”, “leech therapy”, “Hirudo medicinalis”, “Hirudins” with “polycystic ovary syndrome”, “uterus”, and “oligoamenorrhea”. The review papers and clinical trial studies were searched in Persian and English languages without any time limitation, and the related materials were extracted and categorized. Results: The symptoms of PCOS such as the enlargement and stiffness of the ovaries and oligoamenorrhea were reported in ITM references entitled as “Ehtebas tams”. Leech therapy is useful in treatment of these patients by reducing the ovarian swelling, causing menstruation, eliminating waste material, as well as antioxidant and anti-inflammatory effects. Conclusion: Leech therapy can be used as a complementary treatment in patients with polycystic ovarian syndrome.
    Keywords ehtebas tams ; hirudins ; hirudo medicinalis ; iranian traditional medicine ; leech ; polycystic ovary syndrome ; Gynecology and obstetrics ; RG1-991
    Subject code 610
    Language Persian
    Publishing date 2019-08-01T00:00:00Z
    Publisher Mashhad University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats

    Mojgan Tansaz / Maryam Bahman / Mahmoud Khodadoost / Seyyed Shamsadin Athari / Saadat Ghafarzadeh / Hanieh Kashafroodi / Rasool Choopani

    Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, Vol 23, Iss 12, Pp 13-

    2021  Volume 24

    Abstract: Introduction: Polycystic ovary syndrome affects 5-10% of women of reproductive age and is characterized by irregular menstruation, hyperandrogenism, and ovarian cysts. Iranian traditional medicine products can be effective in treatment of this syndrome. ... ...

    Abstract Introduction: Polycystic ovary syndrome affects 5-10% of women of reproductive age and is characterized by irregular menstruation, hyperandrogenism, and ovarian cysts. Iranian traditional medicine products can be effective in treatment of this syndrome. This study was performed with aim to evaluate the effect of compound honey syrup on the polycystic ovary syndrome induced by estradiol valerate in female rats. Methods: In this experimental study conducted by traditional medicine and matria medica research center of Shahid Beheshti University of Medical Sciences in animal laboratory of Shahid Beheshti University of Medical Sciences on female rats in 2017, the compound honey syrup (Ma-ol-asal) (containing honey, cinnamon, ginger, saffron, cardamom, galangal, nutmeg, mace and mastic) was used. Thirty female rats were classified into five groups of cases: negative control, positive control, and three treatment groups (receiving two doses of compound honey syrup (1ml/kg and 2ml/kg) and metformin). Polycystic ovary syndrome was induced by injection of Estradiol valerate. At the end of intervention, the rats were euthanized, hormones were measured, and the ovarian histology was examined. Data were analyzed by SPSS software (version 24) and Kruskal-Wallis and Dunn-Bonferroni tests. p < 0.05 was considered statistically significant. Results: At the end of the study, weights of ovaries in the metformin and Ma-ol-asal 2 groups were higher than the untreated group. There was no change in body weight or abdominal fat. There was a significant increase in levels of progesterone in three treatment groups (P=0.002) and significant reduction of estrogen in the metformin group compared to the untreated group (P=0.021). There was significant reduction of number of ovary cysts in Ma-ol-asal 1 group (P=0.001), and significant increase in the number of Corpus luteum, and antral follicles in Ma-ol-asal 1 and 2 groups compared to the untreated group (P=0.010). The number of graph follicles did not differ significantly in the groups ...
    Keywords compound honey syrup ; metabolic syndrome ; polycystic ovary syndrome ; traditional persian medicine ; Gynecology and obstetrics ; RG1-991
    Subject code 630
    Language Persian
    Publishing date 2021-02-01T00:00:00Z
    Publisher Mashhad University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The importance of sleep hygiene in polycystic ovary syndrome from the view of Iranian traditional medicine and modern medicine

    Maryam Bahman / Homa Hajimehdipoor / Maryam Afrakhteh / Soodabeh Bioos / Fataneh Hashem-Dabaghian / Mojgan Tansaz

    International Journal of Preventive Medicine, Vol 9, Iss 1, Pp 87-

    2018  Volume 87

    Abstract: Polycystic ovary syndrome (PCOS) is known as the most common hormonal disorder in women at reproductive age. Recent studies have revealed a high prevalence of sleep disorders in PCOS, suggesting that it is an amendable factor for these patients; however, ...

    Abstract Polycystic ovary syndrome (PCOS) is known as the most common hormonal disorder in women at reproductive age. Recent studies have revealed a high prevalence of sleep disorders in PCOS, suggesting that it is an amendable factor for these patients; however, the sleep was not considered in their treatment plan. According to the Iranian traditional medicine (ITM), sleep is an important item in the lifestyle modification of all diseases. The aim of this study is to determine the importance of sleep hygiene in PCOS from the view of ITM and Modern Medicine. In this study, some keywords about “sleep and PCOS” were searched in medical databases and some ITM books. Lifestyle modification is one of the first steps in treatment of patients with PCOS in which the emphasis will be mainly on exercise and diet. Despite proof of the high prevalence of sleep disorders in these patients, modification of sleep is not considered in their lifestyle. ITM as a holistic medicine emphasizes on lifestyle modification under the title of “Settah-e-Zaruria” (In Persian), the six essential schemes for the prevention and treatment of all diseases. Management of sleep is one of these schemes. There are many advices about sleep hygiene in both ITM and modern medicine. It seems that lifestyle modification should be expanded in PCOS patients to include more options, and sleep hygiene should be considered in their lifestyle alongside food and exercise.
    Keywords Iranian traditional medicine ; modern medicine ; polycystic ovary syndrome ; sleep ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Nutritional recommendations for patients with uterine discharge in Iranian Traditional Medicine

    Azam Meyari / Mojgan Tansaz / Maryam Yavari / Maryam Bahman / Hajar Memarzadeh Zavareh / Razieh Nabi Meybodi / Mehdi Biglerkhani / Seyedeh Atieh Naeimi

    Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, Vol 20, Iss ویژه نامه, Pp 68-

    2017  Volume 77

    Abstract: Introduction: Leucorrhea that was mentioned as Sayalan-e Rahem in Iranian traditional medicine is of the most common complains of women referring to gynecologic clinics. In Persian medicine, different treatment steps are proposed for these patients that ... ...

    Abstract Introduction: Leucorrhea that was mentioned as Sayalan-e Rahem in Iranian traditional medicine is of the most common complains of women referring to gynecologic clinics. In Persian medicine, different treatment steps are proposed for these patients that nutritional recommendation is the first step in this regard. This study was performed with aim to summarize and present the nutritional guidelines in Sayalan-e Rahem from various sources so that it can be used to reduce recurrence and the incidence of drug complications. Methods: In this review study, during several meetings of authors and reviewing the most popular sources of traditional Iranian medicine, the topics related to nutritional guidelines in uterine discharge were collected and classified. Also, nutritional recommendations for uterine discharges in different conventional medicine books and the studies in different journals were extracted and then compared. Results: Based on Iranian Physician's point of view, some types of food have been generally recommended for patients with Sayalan-e Rahem that among them, we can mention astringent (Barberry, Lentils, Sumac and Mung bean( and tonic foods (apple and quince(. Sourness, garlic, onion, turnip, cow meat and flatulent foods have been generally avoided in patients with Sayalan-e Rahem. If Sayalan-e Rahem be due to imbalance of four different humors in the body, appropriate diet will be advised for each distemperament. Conclusion: Considering lack of enough nutritional recommendation in conventional medicine for patients with leucorrhea, so attention to the mentioned above and performing scientifically evaluations on the effect of recommended food in Sayalan-e Rahem can be effective on enhancing health and life quality of women.
    Keywords iranian traditional medicine ; nutritional recommendations ; uterine discharge ; vaginitis ; Gynecology and obstetrics ; RG1-991
    Subject code 610
    Language Persian
    Publishing date 2017-11-01T00:00:00Z
    Publisher Mashhad University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: QSAR study of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2 using LS-SVM and GRNN based on principal components.

    Shahlaei, Mohsen / Sabet, Razieh / Ziari, Maryam Bahman / Moeinifard, Behzad / Fassihi, Afshin / Karbakhsh, Reza

    European journal of medicinal chemistry

    2010  Volume 45, Issue 10, Page(s) 4499–4508

    Abstract: Quantitative relationships between molecular structure and methionine aminopeptidase-2 inhibitory activity of a series of cytotoxic anthranilic acid sulfonamide derivatives were discovered. We have demonstrated the detailed application of two efficient ... ...

    Abstract Quantitative relationships between molecular structure and methionine aminopeptidase-2 inhibitory activity of a series of cytotoxic anthranilic acid sulfonamide derivatives were discovered. We have demonstrated the detailed application of two efficient nonlinear methods for evaluation of quantitative structure-activity relationships of the studied compounds. Components produced by principal component analysis as input of developed nonlinear models were used. The performance of the developed models namely PC-GRNN and PC-LS-SVM were tested by several validation methods. The resulted PC-LS-SVM model had a high statistical quality (R(2)=0.91 and R(CV)(2)=0.81) for predicting the cytotoxic activity of the compounds. Comparison between predictability of PC-GRNN and PC-LS-SVM indicates that later method has higher ability to predict the activity of the studied molecules.
    MeSH term(s) Aminopeptidases/antagonists & inhibitors ; Aminopeptidases/metabolism ; Least-Squares Analysis ; Metalloendopeptidases/antagonists & inhibitors ; Metalloendopeptidases/metabolism ; Neural Networks (Computer) ; Nonlinear Dynamics ; Principal Component Analysis ; Quantitative Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry ; Sulfonamides/pharmacology ; ortho-Aminobenzoates/chemical synthesis ; ortho-Aminobenzoates/chemistry ; ortho-Aminobenzoates/pharmacology
    Chemical Substances Sulfonamides ; ortho-Aminobenzoates ; anthranilic acid (0YS975XI6W) ; Aminopeptidases (EC 3.4.11.-) ; methionine aminopeptidase 2 (EC 3.4.11.18) ; Metalloendopeptidases (EC 3.4.24.-)
    Language English
    Publishing date 2010-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2010.07.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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