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  1. Article ; Online: Low incidence of BRAF and NRAS mutations in a population with a high incidence of melanoma.

    Neville, Grace / Marzario, Barbara / Shilling, David / Hand, Collette K / Heffron, Cynthia

    Virchows Archiv : an international journal of pathology

    2024  Volume 484, Issue 3, Page(s) 475–479

    Abstract: Reported rates of BRAF mutation in Irish cutaneous melanoma cohorts are lower than the reported international data. We aimed to assess the mutational status of a cohort of primary cutaneous melanomas and to correlate it with clinical follow-up data.A ... ...

    Abstract Reported rates of BRAF mutation in Irish cutaneous melanoma cohorts are lower than the reported international data. We aimed to assess the mutational status of a cohort of primary cutaneous melanomas and to correlate it with clinical follow-up data.A total of 92 cases of primary cutaneous melanoma diagnosed at a single institution in 2012 were analyzed. Regions containing common mutations in the BRAF, NRAS, KIT, and KRAS genes were investigated by PCR amplification followed by Sanger sequencing. Demographic details, tumor characteristics, and 10-year outcome data were also obtained.Ten cases with BRAF V600E mutations (11.6%) and five (5.49%) NRAS mutations (4 at Q61R, 1 at Q61K) were detected. No statistically significant differences were noted between groups for age, gender, depth of invasion, nodal status, or recurrence status (p ≥ 0.05).These findings suggest that the Irish population has a markedly lower incidence of BRAF and NRAS mutations in melanoma than those reported in other cohorts.
    MeSH term(s) Humans ; Melanoma/pathology ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Proto-Oncogene Proteins B-raf/genetics ; Incidence ; GTP Phosphohydrolases/genetics ; Mutation ; Membrane Proteins/genetics
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; GTP Phosphohydrolases (EC 3.6.1.-) ; BRAF protein, human (EC 2.7.11.1) ; NRAS protein, human (EC 3.6.1.-) ; Membrane Proteins
    Language English
    Publishing date 2024-01-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-023-03732-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud III Zs.10: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Palmoplantar Pustulosis: Clinical Characteristics and Variability in Therapeutic Approaches.

    Seale, Emily / Li, Heidi Oi-Yee / Waugh, Miranda / Cino, Daniela / Marzario, Barbara / Kirchhof, Mark G

    Journal of cutaneous medicine and surgery

    2023  Volume 28, Issue 1, Page(s) 88–89

    MeSH term(s) Humans ; Psoriasis/drug therapy ; Acute Disease ; Chronic Disease ; Exanthema
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Letter
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/12034754231211343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4987: Show issues Location:
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  3. Article ; Online: An evidence-based guide to SARS-CoV-2 vaccination of patients on immunotherapies in dermatology.

    Gresham, Louise M / Marzario, Barbara / Dutz, Jan / Kirchhof, Mark G

    Journal of the American Academy of Dermatology

    2021  Volume 84, Issue 6, Page(s) 1652–1666

    Abstract: Immune-mediated diseases and immunotherapeutics can negatively affect normal immune functioning and, consequently, vaccine safety and response. The COVID-19 pandemic has incited research aimed at developing a novel severe acute respiratory syndrome ... ...

    Abstract Immune-mediated diseases and immunotherapeutics can negatively affect normal immune functioning and, consequently, vaccine safety and response. The COVID-19 pandemic has incited research aimed at developing a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. As SARS-CoV-2 vaccines are developed and made available, the assessment of anticipated safety and efficacy in patients with immune-mediated dermatologic diseases and requiring immunosuppressive and/or immunomodulatory therapy is particularly important. A review of the literature was conducted by a multidisciplinary committee to provide guidance on the safety and efficacy of SARS-CoV-2 vaccination for dermatologists and other clinicians when prescribing immunotherapeutics. The vaccine platforms being used to develop SARS-CoV-2 vaccines are expected to be safe and potentially effective for dermatology patients on immunotherapeutics. Current guidelines for the vaccination of an immunocompromised host remain appropriate when considering future administration of SARS-CoV-2 vaccines.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Evidence-Based Medicine ; Humans ; Immunocompromised Host ; Immunologic Factors/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Risk Assessment ; SARS-CoV-2 ; Skin Diseases/immunology ; Skin Diseases/therapy
    Chemical Substances COVID-19 Vaccines ; Immunologic Factors ; Immunosuppressive Agents
    Language English
    Publishing date 2021-01-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2021.01.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1540: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Response to comment on "An evidence-based guide to SARS-Cov-2 vaccination of patients on immunotherapies in dermatology."

    Gresham, Louise M / Marzario, Barbara / Dutz, Jan / Kirchhof, Mark G

    Journal of the American Academy of Dermatology

    2021  Volume 85, Issue 2, Page(s) e91

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Dermatology ; Humans ; Immunotherapy ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-04-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2021.04.026
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    Zs.A 1540: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Methods for Identifying Culprit Drugs in Cutaneous Drug Eruptions: A Scoping Review.

    Bose, Reetesh / Ogbalidet, Selam / Boshra, Mina / Finstad, Alexandra / Marzario, Barbara / Huang, Christina / Fahim, Simone

    Journal of cutaneous medicine and surgery

    2021  Volume 26, Issue 2, Page(s) 162–168

    Abstract: Background: Cutaneous drug eruptions are a significant source of morbidity, mortality, and cost to the healthcare system. Identifying the culprit drug is essential; however, despite numerous methods being published, there are no consensus guidelines.: ...

    Abstract Background: Cutaneous drug eruptions are a significant source of morbidity, mortality, and cost to the healthcare system. Identifying the culprit drug is essential; however, despite numerous methods being published, there are no consensus guidelines.
    Objectives: Conduct a scoping review to identify all published methods of culprit drug identification for cutaneous drug eruptions, compare the methods, and generate hypotheses for future causality assessment studies.
    Eligibility criteria: Peer-reviewed publications involving culprit drug identification methods.
    Sources of evidence: Medline, Embase, and Cochrane Central Register of Controlled Trials.
    Charting methods: Registered PRISMA-ScR format protocol on Open Science Forum.
    Results: In total, 109 studies and 26 reviews were included comprising 656,635 adverse drug events, most of which were cutaneous. There were 54 methods of culprit drug identification published, categorized as algorithms, probabilistic approaches, and expert judgment. Algorithms had higher sensitivity and positive predictive value, but lower specificity and negative predictive value. Probabilistic approaches had lower sensitivity and positive predictive value, but higher specificity and negative predictive value. Expert judgment was subjective, less reproducible, but the most frequently used to validate other methods. Studies suggest that greater accuracy may be achieved by specifically assessing cutaneous drug eruptions and using combinations of causality assessment categories.
    Conclusions: Culprit drug identification for adverse drug reactions remains a challenge. Many methods have been published, but there are no consensus guidelines. Using causality assessment methods specifically for cutaneous drug eruptions and combining aspects of the different causality assessment categories may improve efficacy. Further studies are needed to validate this hypothesis.
    MeSH term(s) Algorithms ; Consensus ; Drug Eruptions/diagnosis ; Drug Eruptions/etiology ; Drug-Related Side Effects and Adverse Reactions ; Exanthema ; Humans
    Language English
    Publishing date 2021-11-19
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/12034754211027509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4987: Show issues Location:
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  6. Article ; Online: Contact Dermatitis to Personal Sporting Equipment in Youth.

    Marzario, Barbara / Burrows, Dianne / Skotnicki, Sandy

    Journal of cutaneous medicine and surgery

    2016  Volume 20, Issue 4, Page(s) 323–326

    Abstract: Background: Contact dermatitis to personal sporting equipment in youth is poorly studied.: Objective: To review the results of patch testing 6 youth to their sporting equipment in a dermatology general private practice from 2006 to 2011.: Methods: ...

    Abstract Background: Contact dermatitis to personal sporting equipment in youth is poorly studied.
    Objective: To review the results of patch testing 6 youth to their sporting equipment in a dermatology general private practice from 2006 to 2011.
    Methods: A retrospective analysis of 6 youth aged 11 to 14 who were evaluated for chronic and persistent dermatitis occurring in relation to sports equipment was conducted. All patients were subjected to epicutaneous (patch) testing, which included some or all of the following: North American Contact Dermatitis Group (NACGD) series, textile series, rubber series, corticosteroid series, and raw material from the patients' own personal equipment.
    Results: All cases had 1 or more positive patch test reactions to an allergen within the aforementioned series, and 3 subjects tested positive to their personal equipment in raw form.
    Conclusions: Allergic contact dermatitis, not irritant, was deemed the relevant cause of chronic dermatitis in 4 of the 6 patients due to positive reactions to epicutaneous tests and/or personal equipment. The utility of testing to patients' own sporting equipment was shown to be of additional value and should be considered when patch testing for contact allergy to sporting equipment.
    MeSH term(s) Adolescent ; Child ; Dermatitis, Allergic Contact/diagnosis ; Dermatitis, Allergic Contact/etiology ; Dermatitis, Allergic Contact/therapy ; Female ; Hockey ; Humans ; Male ; Patch Tests ; Retrospective Studies ; Soccer ; Sports Equipment/adverse effects
    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/1203475415611377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4987: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Psychosocial needs assessment post kidney transplant: Feasibility of a post-transplant specific support group.

    Brijmohan, Angela / Famure, Olusegun / Sihota, Kiren / Shea, Mary / Marzario, Barbara / Mitchell, Margot

    CANNT journal = Journal ACITN

    2015  Volume 25, Issue 3, Page(s) 14–21

    Abstract: This project assessed unmet psychosocial needs of kidney transplant recipients and the feasibility of a support group located at an urban Canadian hospital to meet those needs. A survey assessed transplant recipient concerns about psychosocial issues ... ...

    Abstract This project assessed unmet psychosocial needs of kidney transplant recipients and the feasibility of a support group located at an urban Canadian hospital to meet those needs. A survey assessed transplant recipient concerns about psychosocial issues related to transplantation, interest in a support group, desired group composition, facilitation, leadership, barriers and alternative forms of support. Most respondents were more than two years since transplant and were more concerned about medical complications, returning to normalcy, and had a greater desire to talk to other transplant recipients. Forty per cent of respondents indicated they would be interested in a support group. However, 60% indicated that a support group hosted in the hospital setting would be a deterrent to attending, citing time and transportation as the greatest barriers. More research is needed to assess the feasibility of post-kidney transplant support groups closer to recipients' homes and the feasibility of alternative forms of support.
    MeSH term(s) Aged ; Canada ; Female ; Humans ; Kidney Transplantation/psychology ; Male ; Middle Aged ; Needs Assessment/organization & administration ; Quality of Life/psychology ; Self-Help Groups/organization & administration ; Social Support ; Socioeconomic Factors ; Surveys and Questionnaires ; Transplant Recipients/psychology ; Urban Population
    Language English
    Publishing date 2015-07
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2050507-3
    ISSN 1498-5136
    ISSN 1498-5136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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