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  1. Article ; Online: Ebola virus disease sequelae and viral persistence in animal models: Implications for the future.

    Durant, Olivia / Marzi, Andrea

    PLoS pathogens

    2024  Volume 20, Issue 3, Page(s) e1012065

    Abstract: Ebola virus disease (EVD), caused by infection with Ebola virus, results in severe, acute illness with a high mortality rate. As the incidence of outbreaks of EVD increases and with the development and approval of medical countermeasures (MCMs) against ... ...

    Abstract Ebola virus disease (EVD), caused by infection with Ebola virus, results in severe, acute illness with a high mortality rate. As the incidence of outbreaks of EVD increases and with the development and approval of medical countermeasures (MCMs) against the acute disease, late phases of EVD, including sequelae, recrudescence, and viral persistence, are occuring more frequently and are now a focus of ongoing research. Existing animal disease models recapitulate acute EVD but are not suitable to investigate the mechanisms of these late disease phenomena. Although there are challenges in establishing such a late disease model, the filovirus research community has begun to call for the development of an EBOV persistence model to address late disease concerns. Ultimately, this will aid the development of MCMs against late disease and benefit survivors of future EVD and filovirus outbreaks.
    MeSH term(s) Animals ; Hemorrhagic Fever, Ebola ; Ebolavirus ; Disease Outbreaks ; Disease Progression ; Disease Models, Animal
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1012065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Marburg Virus Disease: Global Threat or Isolated Events?

    Marzi, Andrea / Feldmann, Heinz

    The Journal of infectious diseases

    2023  Volume 228, Issue 2, Page(s) 103–105

    MeSH term(s) Animals ; Humans ; Marburg Virus Disease/epidemiology ; Hemorrhagic Fever, Ebola ; Ebolavirus ; Marburgvirus/genetics ; Viral Vaccines
    Chemical Substances Viral Vaccines
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Hemorrhagic Fever Viruses: Pathogenesis and Countermeasures.

    Mire, Chad E / Marzi, Andrea

    Microorganisms

    2022  Volume 10, Issue 3

    Abstract: Before December 2019 and the COVID-19 pandemic, the general public was to some extent aware that zoonotic viruses can spill over into the human population and cause a disease outbreak [ ... ]. ...

    Abstract Before December 2019 and the COVID-19 pandemic, the general public was to some extent aware that zoonotic viruses can spill over into the human population and cause a disease outbreak [...].
    Language English
    Publishing date 2022-03-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10030591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hemorrhagic Fever Viruses: Pathogenesis and Countermeasures

    Mire, Chad E. / Marzi, Andrea

    Microorganisms. 2022 Mar. 09, v. 10, no. 3

    2022  

    Abstract: Before December 2019 and the COVID-19 pandemic, the general public was to some extent aware that zoonotic viruses can spill over into the human population and cause a disease outbreak [ ... ] ...

    Abstract Before December 2019 and the COVID-19 pandemic, the general public was to some extent aware that zoonotic viruses can spill over into the human population and cause a disease outbreak [...]
    Keywords COVID-19 infection ; fever ; human population ; pathogenesis
    Language English
    Dates of publication 2022-0309
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10030591
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Evaluation of Ebola Virus Countermeasures in Guinea Pigs.

    Marzi, Andrea

    Methods in molecular biology (Clifton, N.J.)

    2017  Volume 1628, Page(s) 283–291

    Abstract: Ebola virus (EBOV) pathology in humans remains incompletely understood; therefore, a number of rodent and nonhuman primate (NHP) models have been established to study the disease caused by this virus. While the macaque model most accurately recapitulates ...

    Abstract Ebola virus (EBOV) pathology in humans remains incompletely understood; therefore, a number of rodent and nonhuman primate (NHP) models have been established to study the disease caused by this virus. While the macaque model most accurately recapitulates human disease, rodent models, which display only certain aspects of human disease but are more cost-effective, are widely used for initial screens during EBOV countermeasure development. In particular, mice and guinea pigs were among the first species used for the efficacy testing of EBOV vaccines and therapeutics. While mice have low predictive value, guinea pigs have proven to be a more reliable predictor for the evaluation of countermeasures in NHPs. In addition, guinea pigs are larger in size compared to mice, allowing for more frequent collection of blood samples at larger volumes. However, guinea pigs have the disadvantage that there is only a limited pool of immunological tools available to characterize host responses to vaccination, treatment and infection. In this chapter, the efficacy testing of an EBOV vaccine and a therapeutic in the guinea pig model are described.
    MeSH term(s) Animals ; Disease Models, Animal ; Ebola Vaccines/pharmacology ; Ebolavirus/immunology ; Ebolavirus/pathogenicity ; Guinea Pigs ; Hemorrhagic Fever, Ebola/drug therapy ; Hemorrhagic Fever, Ebola/virology ; Humans ; Mice ; Vaccination/methods
    Chemical Substances Ebola Vaccines
    Language English
    Publishing date 2017-06-02
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-7116-9_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  6. Article ; Online: Multidimensional sample analysis to determine pandemic viral evolution.

    O'Donnell, Kyle L / Marzi, Andrea

    EBioMedicine

    2023  Volume 92, Page(s) 104606

    MeSH term(s) Humans ; Pandemics ; Evolution, Molecular ; Phylogeny
    Language English
    Publishing date 2023-05-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2023.104606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Biodefence research two decades on: worth the investment?

    Long, Carrie M / Marzi, Andrea

    The Lancet. Infectious diseases

    2021  Volume 21, Issue 8, Page(s) e222–e233

    Abstract: For the past 20 years, the notion of bioterror has been a source of considerable fear and panic worldwide. In response to the terror attacks of 2001 in the USA, extensive research funding was awarded to investigate bioterror-related pathogens. The global ...

    Abstract For the past 20 years, the notion of bioterror has been a source of considerable fear and panic worldwide. In response to the terror attacks of 2001 in the USA, extensive research funding was awarded to investigate bioterror-related pathogens. The global scientific legacy of this funding has extended into the present day, highlighted by the ongoing COVID-19 pandemic. Unsurprisingly, the surge in biodefence-related research and preparedness has been met with considerable apprehension and opposition. Here, we briefly outline the history of modern bioterror threats and biodefence research, describe the scientific legacy of biodefence research by highlighting advances pertaining to specific bacterial and viral pathogens, and summarise the future of biodefence research and its relevance today. We sought to address the sizeable question: have the past 20 years of investment into biodefence research and preparedness been worth it? The legacy of modern biodefence funding includes advancements in biosecurity, biosurveillence, diagnostics, medical countermeasures, and vaccines. In summary, we feel that these advances justify the substantial biodefence funding trend of the past two decades and set a precedent for future funding.
    MeSH term(s) Biomedical Research/economics ; Bioterrorism/prevention & control ; Financial Support ; Humans ; Investments ; Risk Assessment ; Vaccines/immunology
    Chemical Substances Vaccines
    Language English
    Publishing date 2021-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(21)00382-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5743: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book: Psychoanalysis, identity, and the Internet

    Marzi, Andrea

    explorations into cyberspace

    (Library of technology and mental health)

    2016  

    Author's details edited by Andrea Marzi
    Series title Library of technology and mental health
    MeSH term(s) Psychoanalysis/trends ; Internet ; Social Identification ; Behavior, Addictive ; Social Media
    Language English
    Size l, 217 pages ;, 23 cm.
    Document type Book
    Note "First published in Italy by Franco Angeli Editore, Milan, 2013"--Title page verso.
    ISBN 9781782204312 ; 1782204318
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article ; Online: Bivalent VSV Vectors Mediate Rapid and Potent Protection from Andes Virus Challenge in Hamsters.

    Marceau, Joshua / Safronetz, David / Martellaro, Cynthia / Marzi, Andrea / Rosenke, Kyle / Feldmann, Heinz

    Viruses

    2024  Volume 16, Issue 2

    Abstract: Orthohantaviruses may cause hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome. Andes virus (ANDV) is the only orthohantavirus associated with human-human transmission. Therefore, emergency vaccination would be a valuable public ...

    Abstract Orthohantaviruses may cause hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome. Andes virus (ANDV) is the only orthohantavirus associated with human-human transmission. Therefore, emergency vaccination would be a valuable public health measure to combat ANDV-derived infection clusters. Here, we utilized a promising vesicular stomatitis virus (VSV)-based vaccine to advance the approach for emergency applications. We compared monovalent and bivalent VSV vectors containing the Ebola virus (EBOV), glycoprotein (GP), and ANDV glycoprotein precursor (GPC) for protective efficacy in pre-, peri- and post-exposure immunization by the intraperitoneal and intranasal routes. Inclusion of the EBOV GP was based on its favorable immune cell targeting and the strong innate responses elicited by the VSV-EBOV vaccine. Our data indicates no difference of ANDV GPC expressing VSV vectors in pre-exposure immunization independent of route, but a potential benefit of the bivalent VSVs following peri- and post-exposure intraperitoneal vaccination.
    MeSH term(s) Cricetinae ; Animals ; Humans ; Orthohantavirus ; Vesiculovirus/genetics ; Vesicular stomatitis Indiana virus/genetics ; Ebolavirus/genetics ; Ebola Vaccines ; Glycoproteins ; Antibodies, Viral
    Chemical Substances Ebola Vaccines ; Glycoproteins ; Antibodies, Viral
    Language English
    Publishing date 2024-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16020279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Single Case Observation: Is the Ebola Virus Soluble Glycoprotein an Indicator of Viral Recrudescence?

    Furuyama, Wakako / Davey, Richard T / Chertow, Daniel S / Marzi, Andrea

    The Journal of infectious diseases

    2023  Volume 228, Issue Suppl 7, Page(s) S631–S634

    Abstract: This case study investigated the long-term expression dynamics of Ebola virus (EBOV) soluble glycoprotein (sGP) in the serum of a patient who was infected with EBOV in West Africa and recovered from acute Ebola virus disease (EVD) at the National ... ...

    Abstract This case study investigated the long-term expression dynamics of Ebola virus (EBOV) soluble glycoprotein (sGP) in the serum of a patient who was infected with EBOV in West Africa and recovered from acute Ebola virus disease (EVD) at the National Institutes of Health Clinical Center in Bethesda, Maryland. Samples from this patient were collected during acute EVD and during convalescence up to day 361 following illness onset. Although blood samples were negative by reverse transcription-quantitative polymerase chain reaction after recovery from acute EVD, we detected small amounts of EBOV sGP in the serum of the patient long after recovery, potentially indicating viral recrudescence. As this was only observed in a single patient, additional longitudinal patient samples are needed to confirm our hypothesis that EBOV sGP may be an indicator of viral recrudescence long after recovery from acute EVD.
    MeSH term(s) Humans ; Ebolavirus/genetics ; Hemorrhagic Fever, Ebola ; Glycoproteins ; Africa, Western ; Maryland
    Chemical Substances Glycoproteins
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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