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  1. Article ; Online: Radiomics and theranostics with molecular and metabolic probes in prostate cancer: toward a personalized approach.

    Filippi, Luca / Urso, Luca / Bianconi, Francesco / Palumbo, Barbara / Marzola, Maria Cristina / Evangelista, Laura / Schillaci, Orazio

    Expert review of molecular diagnostics

    2023  Volume 23, Issue 3, Page(s) 243–255

    Abstract: Introduction: In the last decade, two new radionuclide-based therapies, : Areas covered: The basic principles of PCa molecular imaging are illustrated, with a particular attention to the combined use of diagnosis and therapy in a unique approach (the ...

    Abstract Introduction: In the last decade, two new radionuclide-based therapies,
    Areas covered: The basic principles of PCa molecular imaging are illustrated, with a particular attention to the combined use of diagnosis and therapy in a unique approach (the so-called theranostics) for response prediction and assessment in patients submitted to
    Expert opinion: Theranostic metabolic and molecular probes have been successfully applied to predict and monitor response to radionuclide-based therapies. In particular, both
    MeSH term(s) Male ; Humans ; Precision Medicine ; Positron Emission Tomography Computed Tomography/methods ; Radiopharmaceuticals/therapeutic use ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/therapy ; Radioisotopes
    Chemical Substances Radiopharmaceuticals ; Radioisotopes
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2112530-2
    ISSN 1744-8352 ; 1473-7159
    ISSN (online) 1744-8352
    ISSN 1473-7159
    DOI 10.1080/14737159.2023.2192351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6073: Show issues Location:
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  2. Article ; Online: Molecular imaging of PARP in cancer: state-of-the-art.

    Filippi, Luca / Urso, Luca / Frantellizzi, Viviana / Marzo, Katia / Marzola, Maria Cristina / Schillaci, Orazio / Evangelista, Laura

    Expert review of molecular diagnostics

    2023  Volume 23, Issue 12, Page(s) 1167–1174

    Abstract: Introduction: Poly-ADP-ribose-polymerase inhibitors (PARPi), which exploit the processes of so-called 'synthetic lethality,' have been successfully implemented in oncological practice. However, not all patients respond to PARPi, and there is an unmet ... ...

    Abstract Introduction: Poly-ADP-ribose-polymerase inhibitors (PARPi), which exploit the processes of so-called 'synthetic lethality,' have been successfully implemented in oncological practice. However, not all patients respond to PARPi, and there is an unmet need for noninvasive biomarkers suitable for patient selection and monitoring during PARPi therapy.
    Areas covered: The first clinical applications of molecular imaging with positron emission tomography/computed tomography (PET/CT) with [18F]-FluorThanatrace ([18F]-FTT) and [18F]-PARPi, highly effective PARP-ligands, in patients with several malignancies (head and neck, ovarian, prostate, and breast cancer) are covered, with a particular focus on its potential for pre-treatment selection and follow-up.
    Expert opinion: By a search made on the most common database, such as PubMed and Google Scholar in a period from January 2010 and 2023, first clinical evidence suggests that PET/CT with [18F]-FTT and [18F]-PARPi might represent a reliable tool for in vivo imaging and quantification of PARP-1 expression in ovarian, prostate, breast, head, and neck cancer, supporting their potential usefulness for patient selection before PARPi-therapies. In addition, a reduction in [18F]-FTT uptake has been registered after therapy initiation and seems to be correlated with patient outcome after PARPi-based regimens. Further studies are needed to better address the value of PARPI-radiolabeled PET imaging in these clinical settings, especially as it concerns technical features such as optimal scan modality (dynamic vs. static) and timing.
    MeSH term(s) Male ; Humans ; Female ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography/methods ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Molecular Imaging ; Ovarian Neoplasms/drug therapy
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2112530-2
    ISSN 1744-8352 ; 1473-7159
    ISSN (online) 1744-8352
    ISSN 1473-7159
    DOI 10.1080/14737159.2023.2287503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cavernous Hepatic Hemangioma at 18F-Choline Positron Emission Tomography-Computed Tomography: Be Aware of the Pitfall.

    Maffione, Anna Margherita / Urso, Luca / Caterina, Modonesi / Chondrogiannis, Sotirios / Grassetto, Gaia / Bartoletti, Paola / Marzola, Maria Cristina

    Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India

    2023  Volume 38, Issue 4, Page(s) 402–403

    Abstract: We report a case of a patient performing a positron emission tomography-computed tomography (PET-CT) scan with [18F]F-Choline for biochemical relapse (Prostate specific antigen (PSA) 1.2 ng/ml) of prostate cancer. Two large areas of focal uptake with a ... ...

    Abstract We report a case of a patient performing a positron emission tomography-computed tomography (PET-CT) scan with [18F]F-Choline for biochemical relapse (Prostate specific antigen (PSA) 1.2 ng/ml) of prostate cancer. Two large areas of focal uptake with a cold core within the liver were observed. A contrast-enhanced ultrasound scan performed after the PET scan characterized these lesions as cavernous hepatic hemangiomas, and therefore, a biopsy was not performed; 3 years of follow-up and PET and MRI finding stability confirmed the benignity of their nature.
    Language English
    Publishing date 2023-12-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 2181722-4
    ISSN 0974-0244 ; 0972-3919
    ISSN (online) 0974-0244
    ISSN 0972-3919
    DOI 10.4103/ijnm.ijnm_65_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Prognostic Value of 18F-FDG PET/CT in Monitoring Chemotherapy in Ovarian Cancer Both at Initial Diagnosis and at Recurrent Disease.

    Rubello, Domenico / Marzola, Maria Cristina / Colletti, Patrick M

    Clinical nuclear medicine

    2018  Volume 43, Issue 10, Page(s) 735–738

    Abstract: Published experiences related to the prognostic relevance of negative or positive FDG PET/CT in patients treated for ovarian cancer for progression-free survival and overall survival are typically heterogeneous retrospective analyses. Several points have ...

    Abstract Published experiences related to the prognostic relevance of negative or positive FDG PET/CT in patients treated for ovarian cancer for progression-free survival and overall survival are typically heterogeneous retrospective analyses. Several points have been well defined, these are as follows: (a) there is a correlation between FDG tumor uptake and prognosis; (b) ovarian cancer patients treated by neoadjuvant or adjuvant chemotherapy can be divided into responders with reduction in tumor FDG uptake during and after treatment and nonresponders where tumor FDG uptake remains stable or increases after treatment;
    MeSH term(s) Female ; Fluorodeoxyglucose F18 ; Humans ; Ovarian Neoplasms/diagnostic imaging ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/pathology ; Positron Emission Tomography Computed Tomography ; Prognosis ; Recurrence ; Treatment Outcome
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2018-07-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000002227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1276: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Re: The Prognostic Value of 18F-FDG PET/CT in Monitoring Chemotherapy in Ovarian Cancer Both at Initial Diagnosis and at Recurrent Disease.

    Rubello, Domenico / Marzola, Maria Cristina / Colletti, Patrick M

    Clinical nuclear medicine

    2018  Volume 44, Issue 4, Page(s) 342–344

    MeSH term(s) Female ; Fluorodeoxyglucose F18 ; Humans ; Ovarian Neoplasms ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Prognosis
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2018-10-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000002318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1276: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Fludeoxyglucose F 18 PET/CT Assessment of Ovarian Cancer.

    Marzola, Maria Cristina / Chondrogiannis, Sotirios / Rubello, Domenico

    PET clinics

    2018  Volume 13, Issue 2, Page(s) 179–202

    Abstract: Ovarian cancer is one of the most common gynecologic cancers and one of the leading causes of cancer death in women. It is often asymptomatic in early stages, and thus most patients are diagnosed when it is of advanced stage. For these reasons, the role ... ...

    Abstract Ovarian cancer is one of the most common gynecologic cancers and one of the leading causes of cancer death in women. It is often asymptomatic in early stages, and thus most patients are diagnosed when it is of advanced stage. For these reasons, the role of biomarkers and tomographic imaging is crucial. Fludeoxyglucose F 18 PET/CT is a useful imaging modality in different clinical settings of the disease, overcoming some limits of conventional imaging and influencing prognosis and therapeutic approaches. PET/MR imaging is an emerging modality, and its potential role remains to be explored.
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Fluorodeoxyglucose F18 ; Humans ; Middle Aged ; Neoplasm Invasiveness/pathology ; Neoplasm Staging ; Ovarian Neoplasms/diagnostic imaging ; Ovarian Neoplasms/pathology ; Positron Emission Tomography Computed Tomography/methods ; Practice Guidelines as Topic ; Radiographic Image Enhancement ; Sensitivity and Specificity
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2018-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2764575-7
    ISSN 1879-9809 ; 1556-8598
    ISSN (online) 1879-9809
    ISSN 1556-8598
    DOI 10.1016/j.cpet.2017.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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  7. Article ; Online: Molecular imaging in hereditary succinate dehydrogenase mutation-related paragangliomas.

    Marzola, Maria Cristina / Rubello, Domenico

    Clinical nuclear medicine

    2015  Volume 40, Issue 6, Page(s) e313–8

    Abstract: Multiple paraganglioma (PGL) syndromes related to succinate dehydrogenase (SDH) gene mutations are rare hereditary conditions. These present with heterogeneous clinical signs and symptoms and in many cases are difficult to classify. We summarize the ... ...

    Abstract Multiple paraganglioma (PGL) syndromes related to succinate dehydrogenase (SDH) gene mutations are rare hereditary conditions. These present with heterogeneous clinical signs and symptoms and in many cases are difficult to classify. We summarize the pathophysiological, clinical, laboratory, and morphological and functional imaging characteristics of SDH gene mutation PGLs, emphasizing F-FDG and F-DOPA PET/CT. We correlate clinical and genetic features of SDH-related PGLs with specific PET radiopharmaceuticals, with the aim to obtain an "individualized" diagnostic approach.
    MeSH term(s) Humans ; Molecular Imaging ; Mutation ; Paraganglioma/diagnostic imaging ; Paraganglioma/genetics ; Positron-Emission Tomography ; Radiopharmaceuticals ; Succinate Dehydrogenase/genetics
    Chemical Substances Radiopharmaceuticals ; Succinate Dehydrogenase (EC 1.3.99.1)
    Language English
    Publishing date 2015-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000000572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1276: Show issues Location:
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  8. Article: The Role of Molecular Imaging in Patients with Brain Metastases: A Literature Review.

    Urso, Luca / Bonatto, Elena / Nieri, Alberto / Castello, Angelo / Maffione, Anna Margherita / Marzola, Maria Cristina / Cittanti, Corrado / Bartolomei, Mirco / Panareo, Stefano / Mansi, Luigi / Lopci, Egesta / Florimonte, Luigia / Castellani, Massimo

    Cancers

    2023  Volume 15, Issue 7

    Abstract: Over the last several years, molecular imaging has gained a primary role in the evaluation of patients with brain metastases (BM). Therefore, the "Response Assessment in Neuro-Oncology" (RANO) group recommends amino acid radiotracers for the assessment ... ...

    Abstract Over the last several years, molecular imaging has gained a primary role in the evaluation of patients with brain metastases (BM). Therefore, the "Response Assessment in Neuro-Oncology" (RANO) group recommends amino acid radiotracers for the assessment of BM. Our review summarizes the current use of positron emission tomography (PET) radiotracers in patients with BM, ranging from present to future perspectives with new PET radiotracers, including the role of radiomics and potential theranostics approaches. A comprehensive search of PubMed results was conducted. All studies published in English up to and including December 2022 were reviewed. Current evidence confirms the important role of amino acid PET radiotracers for the delineation of BM extension, for the assessment of response to therapy, and particularly for the differentiation between tumor progression and radionecrosis. The newer radiotracers explore non-invasively different biological tumor processes, although more consistent findings in larger clinical trials are necessary to confirm preliminary results. Our review illustrates the role of molecular imaging in patients with BM. Along with magnetic resonance imaging (MRI), the gold standard for diagnosis of BM, PET is a useful complementary technique for processes that otherwise cannot be obtained from anatomical MRI alone.
    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15072184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Lutathera

    Urso, Luca / Nieri, Alberto / Uccelli, Licia / Castello, Angelo / Artioli, Paolo / Cittanti, Corrado / Marzola, Maria Cristina / Florimonte, Luigia / Castellani, Massimo / Bissoli, Sergio / Porto, Francesca / Boschi, Alessandra / Evangelista, Laura / Bartolomei, Mirco

    Pharmaceutics

    2023  Volume 15, Issue 4

    Abstract: ... ...

    Abstract Lutathera
    Language English
    Publishing date 2023-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15041110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: PSMA PET/CT in Castration-Resistant Prostate Cancer: Myth or Reality?

    Urso, Luca / Filippi, Luca / Castello, Angelo / Marzola, Maria Cristina / Bartolomei, Mirco / Cittanti, Corrado / Florimonte, Luigia / Castellani, Massimo / Zucali, Paolo / Bruni, Alessio / Sabbatini, Roberto / Dominici, Massimo / Panareo, Stefano / Evangelista, Laura

    Journal of clinical medicine

    2023  Volume 12, Issue 22

    Abstract: Background: prostate-specific membrane antigen (PSMA) ligand PET has been recently incorporated into international guidelines for several different indications in prostate cancer (PCa) patients. However, there are still some open questions regarding the ...

    Abstract Background: prostate-specific membrane antigen (PSMA) ligand PET has been recently incorporated into international guidelines for several different indications in prostate cancer (PCa) patients. However, there are still some open questions regarding the role of PSMA ligand PET in castration-resistant prostate cancer (CRPC). The aim of this work is to assess the clinical value of PSMA ligand PET/CT in patients with CRPC.
    Results: PSMA ligand PET has demonstrated higher detection rates in comparison to conventional imaging and allows for a significant reduction in the number of M0 CRPC patients. However, its real impact on patients' prognosis is still an open question. Moreover, in CRPC patients, PSMA ligand PET presents some sensitivity and specificity limitations. Due to its heterogeneity, CRPC may present a mosaic of neoplastic clones, some of which could be PSMA-/FDG+, or vice versa. Likewise, unspecific bone uptake (UBU) and second primary neoplasms (SNPs) overexpressing PSMA in the neoangiogenic vessels represent potential specificity issues. Integrated multi-tracer imaging (PSMA ligand and [
    Language English
    Publishing date 2023-11-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12227130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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