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Article ; Online: Dietary Fiber Inulin Improves Murine Imiquimod-Induced Psoriasis-like Dermatitis

Mai Yoshida / Yoko Funasaka / Hidehisa Saeki / Masami Yamamoto / Naoko Kanda

International Journal of Molecular Sciences, Vol 24, Iss 14197, p

2023 Volume 14197

Abstract: Psoriasis is a chronic skin disease with interleukin (IL)-17-dominated inflammation and hyperproliferation of epidermis. Dietary fiber is fermented by the gut microbiome into short-chain fatty acids (SCFAs) that manifest anti-inflammatory effects. We ... ...

Abstract	Psoriasis is a chronic skin disease with interleukin (IL)-17-dominated inflammation and hyperproliferation of epidermis. Dietary fiber is fermented by the gut microbiome into short-chain fatty acids (SCFAs) that manifest anti-inflammatory effects. We examined if feeding with an inulin-enriched high-fiber diet (HFD) might improve topical imiquimod-induced psoriasis-like dermatitis in mice. HFD reduced thickening and total severity scores of imiquimod-induced dermatitis and reduced epidermal thickness, inflammatory infiltrates, including Ly6G+ neutrophils, and epidermal Ki67+ proliferating cells. HFD reduced mRNA levels of IL-17A, IL-17F, IL-22, IL-1β, tumor necrosis factor (TNF)-α, CXCL1, CXCL2, and keratin 16 and increased those of transforming growth factor (TGF)-β1 and cyclin-dependent kinase inhibitor 1A in imiquimod-induced dermatitis. In 16S rRNA sequencing of the gut microbiome, imiquimod increased relative abundance of phylum Firmicutes, while HFD increased that of phylum Bacteroidota and genus Bacteroides . HFD increased serum and fecal concentrations of SCFA propionate. Oral propionate reduced inflammatory infiltrates and epidermal Ki67+ cells and reduced mRNA levels of IL-17A, IL-17F, IL-17C, IL-22, IL-1β, IL-6, TNF-α, CXCL1, CCL20 and increased those of TGF-β1and IL-10 in imiquimod-indued dermatitis. Dietary inulin supplementation improves imiquimod-induced psoriasis-like dermatitis partially via propionate, and may be a promising adjunctive therapy for psoriasis.
Keywords	psoriasis ; high-fiber diet ; inulin ; imiquimod ; propionate ; interleukin-17 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Three new species of Eimeria (Apicomplexa

Toshihiro Tokiwa / Shyun Chou / Hina Kitazoe / Keiko Ito / Ryouta Torimoto / Yuki Shoshi / Chizu Sanjoba / Masami Yamamoto / Hisashi Yoshimura

International Journal for Parasitology: Parasites and Wildlife, Vol 18, Iss , Pp 194-

Eimeriidae) from the Amami rabbit, Pentalagus furnessi (Mammalia: Leporidae)

2022 Volume 200

Abstract: The Amami rabbit, Pentalagus furnessi (Mammalia: Lagomorpha: Leporidae), is a relict and endangered species endemic to the Amami-Oshima and Tokunoshima Islands, located in southwestern Japan. Here, we described three new species of Eimeria (Apicomplexa: ... ...

Abstract	The Amami rabbit, Pentalagus furnessi (Mammalia: Lagomorpha: Leporidae), is a relict and endangered species endemic to the Amami-Oshima and Tokunoshima Islands, located in southwestern Japan. Here, we described three new species of Eimeria (Apicomplexa: Eimeriidae) parasites detected from fecal samples of wild Amami rabbits. Eimeria furnessi n. sp., recorded in 21 (58.3%) samples, has ellipsoidal oocysts with two walls and micropyle, 26.0 × 16.6 μm, and elongate-ovoidal sporocysts, 13.1 × 6.3 μm, with Stieda body. Eimeria hilleri n. sp., recorded in 9 (25.0%) samples, has ellipsoidal oocysts with two walls and micropyle, 34.7 × 21.4 μm, and elongate-fusiform to elongate-ovoidal sporocysts, 15.7 × 8.3 μm, with Stieda and substieda bodies. Eimeria sagentae n. sp., recorded in 13 (36.1%) samples, has ellipsoidal oocysts with two walls and micropyle, 20.9 × 14.5 μm, and elongate-ovoidal sporocysts, 10.4 × 5.0 μm, with Stieda body. The three new species can be distinguished by the size and color of their oocysts. Further studies related to the pathogenicity of these parasites can improve the breeding and propagation procedures of the Amami rabbit.
Keywords	Amami rabbit ; Eimeria ; Eimeriidae ; Endangered species ; Pentalagus furnessi ; Leporidae ; Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mouse Gastric Epithelial Cells Resist CagA Delivery by the Helicobacter pylori Type IV Secretion System

Rejina Shrestha / Naoko Murata-Kamiya / Satoshi Imai / Masami Yamamoto / Tetsuya Tsukamoto / Sachiyo Nomura / Masanori Hatakeyama

International Journal of Molecular Sciences, Vol 23, Iss 2492, p

2022 Volume 2492

Abstract: The initial step in bacterial infection is adherence of the bacterium to the target cell surface. Helicobacter pylori exploits the interaction of bacterial adhesin protein HopQ with human epithelial CEACAMs (CEACAM1, 5, and 6) to stably adhere to gastric ...

Abstract	The initial step in bacterial infection is adherence of the bacterium to the target cell surface. Helicobacter pylori exploits the interaction of bacterial adhesin protein HopQ with human epithelial CEACAMs (CEACAM1, 5, and 6) to stably adhere to gastric epithelial cells, which is necessary for delivery of the H. pylori CagA oncoprotein into the epithelial cells via a type IV secretion system. In contrast to human CEACAMs, however, HopQ does not interact with Ceacam1 (mouse CEACAM1) in vitro or in CHO cells ectopically expressing Ceacam1. Since the mouse genome lacks Ceacam5 and Ceacam6 , no significant HopQ–Ceacam interaction may occur in mouse gastric epithelial cells. Here, we found that the mouse stomach has a much lower expression level of Ceacam1 than the expression level of CEACAM1 in the human stomach. Consistently, mouse gastric epithelial cells resist CagA delivery by cagA -positive H. pylori , and the delivery is restored by ectopic expression of human CEACAM1 or CEACAM5 in mouse gastric epithelial cells. Thus, despite the fact that mice are routinely used for H. pylori infection studies, a low expression level of Ceacam1 in the mouse stomach together with the loss or greatly reduced interaction of HopQ with Ceacams make the mouse an inappropriate model for studying the role of H. pylori -delivered CagA in gastric pathogenesis, including the development of gastric cancer.
Keywords	Helicobacter pylori ; mouse gastric epithelial cells ; CEACAM ; CagA ; HopQ ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570 ; 616
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multiple cystic sphere formation from PK-8 cells in three-dimensional culture

Yuuki Shichi / Fujiya Gomi / Yoshibumi Ueda / Keisuke Nonaka / Fumio Hasegawa / Yasuko Hasegawa / Nae Hinata / Hisashi Yoshimura / Masami Yamamoto / Kimimasa Takahashi / Tomio Arai / Toshiyuki Ishiwata

Biochemistry and Biophysics Reports, Vol 32, Iss , Pp 101339- (2022)

2022

Abstract: Three-dimensional (3D) culture of cancer cells mimics the in vivo environment. Recently, we reported that pancreatic ductal adenocarcinoma (PDAC) cell lines with epithelial and mesenchymal features formed differently shaped spheres in 3D culture. However, ...

Abstract	Three-dimensional (3D) culture of cancer cells mimics the in vivo environment. Recently, we reported that pancreatic ductal adenocarcinoma (PDAC) cell lines with epithelial and mesenchymal features formed differently shaped spheres in 3D culture. However, only PK-8 cells, the epithelial PDAC cell line with the highest E-cadherin expression among the eight PDAC cell lines, formed multiple cystic spheres in 3D culture. Optical coherence tomography revealed interconnected cysts inside the spheres. A weak inter-cellular adhesion, individual cell degeneration, necrosis, and secretory granules in the cytoplasm were observed in the PK-8 spheres using electron microscopy. The expression of MUC1, MUC5AC, and amylase was increased in PK-8 cells in the 3D culture compared with that in 2D culture. These findings suggest that highly E-cadherin-expressing epithelial PK-8 cells form multiple cystic spheres, which may be promoted by enhanced mucin and amylase synthesis in 3D culture.
Keywords	Pancreatic ductal adenocarcinoma/PDAC ; E-cadherin ; PK-8 ; Sphere ; Cyst ; Three-dimensional culture ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
Subject code	570
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Toxoplasma gondii infection in Amami spiny rat on Amami-Oshima Island, Japan

Toshihiro Tokiwa / Hisashi Yoshimura / Sayoko Hiruma / Yukie Akahori / Ayami Suzuki / Keiko Ito / Masami Yamamoto / Kazunori Ike

International Journal for Parasitology: Parasites and Wildlife, Vol 9, Iss , Pp 244-

2019 Volume 247

Abstract: The Amami spiny rat (Tokudaia osimensis) is an endangered rodent species that is endemic to the forests of Amami-Oshima Island, Kagoshima, Japan. In July 2018, a deceased adult male Amami spiny rat was found on the Yuwandake Mountain Trail on the south- ... ...

Abstract	The Amami spiny rat (Tokudaia osimensis) is an endangered rodent species that is endemic to the forests of Amami-Oshima Island, Kagoshima, Japan. In July 2018, a deceased adult male Amami spiny rat was found on the Yuwandake Mountain Trail on the south-central coast of Amami-Oshima Island. Histopathological observations revealed protozoan infections in the liver, lungs, and heart. Nested or semi-nested PCRs targeting the B1, SAG3, GRA6, and ROP18 genes successfully detected the genomic DNA of Toxoplasma gondii in the formalin-fixed and paraffin-embedded specimen. Sequence analyses of the SAG3, GRA6, and ROP18 genes suggested that the strain detected in the study specimen was related to the type II strain of T. gondii. This is the first confirmed case of T. gondii infection in an Amami spiny rat. Keywords: Amami-Oshima island, Disseminated toxoplasmosis, Tokudaia osimensis, Histopathology
Keywords	Zoology ; QL1-991
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Contribution of oral triamcinolone to treating proliferative and necrotising otitis externa in a 14-year-old Persian cat

Yutaka Momota / Junya Yasuda / Nobuaki Arai / Masami Yamamoto / Hisashi Yoshimura / Mitsutaka Ikezawa / Shuji Suzuki / Kimimasa Takahashi / Toshinori Sako

Journal of Feline Medicine and Surgery Open Reports, Vol

2017 Volume 3

Abstract: Case summary A 14-year-old female spayed cat was referred for recurrent otitis externa and unusual proliferative lesions in both ear canals. The affected pinnae and external ear canals were covered with large reddish-to-dark-brown verrucous and necrotic ... ...

Abstract	Case summary A 14-year-old female spayed cat was referred for recurrent otitis externa and unusual proliferative lesions in both ear canals. The affected pinnae and external ear canals were covered with large reddish-to-dark-brown verrucous and necrotic tissue. Friable material and exudates occluded both ear canals. Proliferative lesions developed in both ears 2–3 weeks before referral. The histopathological diagnosis from two biopsies obtained from the friable materials with endoscopic biopsy forceps was proliferative and necrotising otitis externa (PNOE). Treatment was initiated with once-daily application of a potent topical glucocorticoid (mometasone furoate) to both ears. Although the auricle and vertical ear canals responded well, no improvement was seen in the horizontal part of the ear canal after 9 weeks. Therefore, oral triamcinolone (0.9 mg/kg q24h) was added for 1 week, and was then tapered (q48h) for 3 weeks. Most lesions resolved, and after a further 2 weeks of prednisolone (2 mg/kg q48h) there was complete resolution. No recurrence was observed during a 2 year follow-up period. Relevance and novel information PNOE commonly occurs in kittens, but it can develop in older cats. To our knowledge, the PNOE in this case is the oldest age of onset reported. This condition is rare and was only described recently, and therapeutic options appear limited. According to previously published reports, steroid therapy is ineffective, and tacrolimus is the only treatment known to achieve resolution. However, oral and topical glucocorticoids were beneficial in this case.
Keywords	Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2017-02-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Molecular Mechanism of Gastric Carcinogenesis in Helicobacter pylori-Infected Rodent Models

Takeshi Toyoda / Masami Yamamoto / Shinji Takasu / Kumiko Ogawa / Masae Tatematsu / Tetsuya Tsukamoto

Diseases, Vol 2, Iss 2, Pp 168-

2014 Volume 186

Abstract: Since the discovery of Helicobacter pylori (H. pylori), many efforts have been made to establish animal models for the investigation of the pathological features and molecular mechanisms of gastric carcinogenesis. Among the animal models, Mongolian ... ...

Abstract	Since the discovery of Helicobacter pylori (H. pylori), many efforts have been made to establish animal models for the investigation of the pathological features and molecular mechanisms of gastric carcinogenesis. Among the animal models, Mongolian gerbils and mice are particularly useful for the analysis of H. pylori-associated inflammatory reactions and gastric cancer development. Inhibitors of oxidative stress, cyclooxygenase-2 (COX-2) and nuclear factor-κB, exert preventive effects on chronic gastritis and the development of adenocarcinomas in H. pylori-infected gerbils. Genetically-modified mouse models, including transgenic and knockout mice, have also revealed the importance of p53, COX-2/prostaglandin, Wnt/β-catenin, proinflammatory cytokines, gastrin and type III mucin in the molecular mechanisms of gastric carcinogenesis. Microarray technology is available for comprehensive gene analysis in the gastric mucosa of mouse models, and epigenetics, such as DNA methylation, could be an alternative approach to correlate the observations in animal models with the etiology in humans.
Keywords	gastric cancer ; Helicobacter pylori ; molecular mechanism ; carcinogenesis ; mouse ; Mongolian gerbil ; Medicine ; R
Subject code	616
Language	English
Publishing date	2014-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chile

Álvaro Insunza / Jorge Carrillo / Masami Yamamoto

Revista Chilena de Obstetricia y Ginecología, Vol 73, Iss 4, Pp 286-

¿Amniocentesis seriada ó Vmax de la arteria cerebral media (ACM), en el manejo de la embarazada en riesgo de enfermedad hemolítica perinatal por isoinmunizacion Rh?

2008 Volume 289

Keywords	Gynecology and obstetrics ; RG1-991 ; Medicine ; R ; DOAJ:Gynecology and Obstetrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	Spanish
Publishing date	2008-01-01T00:00:00Z
Publisher	Sociedad Chilena de Obstetricia y Ginecología
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Teratoma of the ovary in a free-ranging japanese raccoon dog (nyctereutes procyonoides viverrinus)

Yoshimura, Hisashi / Hiroshi Kajigaya / Maiko Moriya / Masami Yamamoto / Natsuko Sugiura / Shinji Kamiya / Takuya Kato / Tomohiko Endo / Toshiyuki Ishiwata / Yoko Matsuda

Journal of zoo and wildlife medicine. 2017 Mar., v. 48, no. 1

2017

Abstract: A young adult, female, free-ranging Japanese raccoon dog (Nyctereutes procyonoides viverrinus) with scabies infection was found dead as a result of traumatic injuries presumed to reflect vehicular trauma. Necropsy showed a large solid mass located on the ...

Abstract	A young adult, female, free-ranging Japanese raccoon dog (Nyctereutes procyonoides viverrinus) with scabies infection was found dead as a result of traumatic injuries presumed to reflect vehicular trauma. Necropsy showed a large solid mass located on the left ovarian region, occupying a third of the abdominal cavity. Histologically, the mass contained complex tissues derived from three germinal layers, with areas of cuboidal or columnar epithelium, keratinized squamous epithelium, bone, cartilage, and adipose tissue. This paper presents the first morphologic description of ovarian teratoma in a raccoon dog.
Keywords	abdominal cavity ; adipose tissue ; cartilage ; epithelium ; females ; keratinization ; necropsy ; Nyctereutes procyonoides ; scabies ; young adults
Language	English
Dates of publication	2017-03
Size	p. 265-268.
Publishing place	American Association of Zoo Veterinarians
Document type	Article
ZDB-ID	2174930-9
ISSN	1937-2825 ; 1042-7260
ISSN (online)	1937-2825
ISSN	1042-7260
DOI	10.1638/2016-0026.1
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Embolización selectiva de arterias uterinas en la resolución de patologías ginecológicas y emergencias obstétricas

Rodrigo Guzmán R / Patricio Vargas H / Julio Astudillo D / Rodrigo Riveros K / Masami Yamamoto C

Revista Chilena de Obstetricia y Ginecología, Vol 76, Iss 2, Pp 76-

2011 Volume 85

Abstract: Antecedentes: La embolización de arterias uterinas es un procedimiento que permite manejar patologías hemorrágicas ginecológicas y obstétricas de manera conservadora y mínimamente invasiva. Métodos: Revisión retrospectiva de casos tratados con ... ...

Abstract	Antecedentes: La embolización de arterias uterinas es un procedimiento que permite manejar patologías hemorrágicas ginecológicas y obstétricas de manera conservadora y mínimamente invasiva. Métodos: Revisión retrospectiva de casos tratados con embolización selectiva en nuestro Servicio desde su inicio en octubre de 2007. Objetivo: Conocer las indicaciones y resultados de esta técnica. Resultados: Seis casos por patología ginecológica y 7 de causa obstétrica fueron tratados con este procedimiento. El procedimiento fue factible y libre de complicaciones en todos los casos, siendo terapéutico en primera instancia en 12 de los 13 casos. En ningún caso se requirió un tratamiento complementario quirúrgico para cumplir el objetivo terapéutico planificado. Conclusiones: La embolización de arterias uterinas representa una excelente herramienta para tratar cuadros hemorrágicos graves del puerperio, deteniendo hemorragias activas con manejo conservador del útero. En casos de patología ginecológica, el resultado inmediato resulta adecuado, consiguiendo buen control de la hemorragia. Este procedimiento debe ser considerado como alternativa posible en el manejo de la patología hemorrágica obstétrica y ginecológica. Background: The uterine artery embolization is a procedure that can manage haemorrhagic obstretrics and gynecologic pathologies, in a conservative fashion and minimally invasive. Method: Retrospective review of cases that had been treated in our institution since October 2007. Objectives: To know the indication and results of this technique. Results: Six cases were done for gynecologic indications and seven for obstetrics cases. The procedure was feasible and without complications in all cases, being therapeutic in 12 of 13 patients. There was no need of a surgical procedure in order to achieve the therapeutic objective. Conclusions: The uterine artery embolization can be used as an excellent tool in the management of postpartum haemorrhage, reducing the necessity to perform an hysterectomy. In gynecology cases, the results in bleeding response are good as well. This procedure should be considerate as an acceptable alternative in the management of obstetric and gynecologic haemorragic pathology.
Keywords	Embolización de arteria uterina ; hemorragia posparto ; mioma uterino ; Uterine artery embolization ; postpartum hemorrhage ; myoma ; Gynecology and obstetrics ; RG1-991 ; Medicine ; R ; DOAJ:Gynecology and Obstetrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	Spanish
Publishing date	2011-01-01T00:00:00Z
Publisher	Sociedad Chilena de Obstetricia y Ginecología
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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