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  1. Article ; Online: Postoperative cavitating infarction following lobectomy: the importance of variant pulmonary anatomy.

    Brown, William John Hunter / Masani, Vidan / Batchelor, Tim / Rodrigues, Jonathan C L

    BMJ case reports

    2020  Volume 13, Issue 12

    Abstract: A 75-year-old woman was admitted to hospital with haemoptysis, fever and shortness of breath. She had undergone a right video-assisted thoracoscopic surgery upper lobectomy for an apical lung cancer 4 weeks earlier, and had been treated with antibiotics ... ...

    Abstract A 75-year-old woman was admitted to hospital with haemoptysis, fever and shortness of breath. She had undergone a right video-assisted thoracoscopic surgery upper lobectomy for an apical lung cancer 4 weeks earlier, and had been treated with antibiotics for 1 week prior to admission for a suspected postoperative lung abscess. Review of preoperative imaging found that she possessed a lobar pulmonary artery variant, with postoperative imaging confirming that the right lower lobe segmental pulmonary artery had been divided alongside the upper lobe vessels. The diagnosis of a lung abscess was thus revised to a cavitating pulmonary infarct. There are numerous variations of the pulmonary vasculature, all of which have the potential to cause a range of serious vascular complications if not appreciated preoperatively. Measures to mitigate the risk of complications resulting from vascular anomalies should be considered by both radiologists and surgeons, with effective lines of communication essential to safe working.
    MeSH term(s) Aged ; Female ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Positron Emission Tomography Computed Tomography ; Postoperative Complications/etiology ; Pulmonary Artery/abnormalities ; Pulmonary Artery/diagnostic imaging ; Pulmonary Artery/surgery ; Pulmonary Infarction/diagnostic imaging ; Pulmonary Infarction/etiology ; Radiography, Thoracic ; Thoracic Surgery, Video-Assisted/adverse effects ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2020-12-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-238138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Chest X-ray in suspected lung cancer is harmful.

    Foley, Robert W / Nassour, Vanessa / Oliver, Helen C / Hall, Toby / Masani, Vidan / Robinson, Graham / Rodrigues, Jonathan C L / Hudson, Benjamin J

    European radiology

    2021  Volume 31, Issue 8, Page(s) 6269–6274

    Abstract: Objectives: The aim of this study was to analyse the use of the chest radiograph (CXR) as the first-line investigation in primary care patients with suspected lung cancer.: Methods: Of 16,945 primary care referral CXRs (June 2018 to May 2019), 1,488 ... ...

    Abstract Objectives: The aim of this study was to analyse the use of the chest radiograph (CXR) as the first-line investigation in primary care patients with suspected lung cancer.
    Methods: Of 16,945 primary care referral CXRs (June 2018 to May 2019), 1,488 were referred for suspected lung cancer. CXRs were coded as follows: CX1, normal but a CT scan is recommended to exclude malignancy; CX2, alternative diagnosis; or CX3, suspicious for cancer. Kaplan-Meier survival analysis was undertaken by stratifying patients according to their CX code.
    Results: In the study period, there were 101 lung cancer diagnoses via a primary care CXR pathway. Only 10% of patients with a normal CXR (CX1) underwent subsequent CT and there was a significant delay in lung cancer diagnosis in these patients (p < 0.001). Lung cancer was diagnosed at an advanced stage in 50% of CX1 patients, 38% of CX2 patients and 57% of CX3 patients (p = 0.26). There was no survival difference between CX codes (p = 0.42).
    Conclusion: Chest radiography in the investigation of patients with suspected lung cancer may be harmful. This strategy may falsely reassure in the case of a normal CXR and prioritises resources to advanced disease.
    Key points: • Half of all lung cancer diagnoses in a 1-year period are first investigated with a chest X-ray. • A normal chest X-ray report leads to a significant delay in the diagnosis of lung cancer. • The majority of patients with a normal or abnormal chest X-ray have advanced disease at diagnosis and there is no difference in survival outcomes based on the chest X-ray findings.
    MeSH term(s) Humans ; Lung ; Lung Neoplasms/diagnostic imaging ; Radiography ; Radiography, Thoracic ; Tomography, X-Ray Computed ; X-Rays
    Language English
    Publishing date 2021-01-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-021-07708-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3300: Show issues Location:
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  3. Article ; Online: Pleural, pancreatic and prostatic involvement in IgG4-related disease mimicking pancreatic head malignancy.

    Foley, Robert W / Redman, Stewart L / Graham, Richard N / Phull, Jaspal S / Masani, Vidan / Colleypriest, Benjamin J / Little, David

    BJR case reports

    2020  Volume 6, Issue 2, Page(s) 20190110

    Abstract: We describe the case of a gentleman with pleural thickening. On follow-up imaging, dilatation of the main pancreatic and common biliary ducts was noted and an initial diagnosis of pancreatic malignancy was made. During his preoperative workup for ... ...

    Abstract We describe the case of a gentleman with pleural thickening. On follow-up imaging, dilatation of the main pancreatic and common biliary ducts was noted and an initial diagnosis of pancreatic malignancy was made. During his preoperative workup for pancreatic head malignancy, a PET-CT was performed, which demonstrated increased uptake in the pancreas, in the pleura and in the prostate gland. This raised the possibility of immunoglobulin G4-related disease (IgG4-RD), which was effectively treated with oral steroids. IgG4-RD is a well-described cause of autoimmune pancreatitis but can affect other regions, including the pleura and prostate. It is essential that radiologists are aware of the imaging findings in IgG4-RD and can direct clinicians towards this important multisystem diagnosis.
    Language English
    Publishing date 2020-09-29
    Publishing country England
    Document type Case Reports
    ISSN 2055-7159
    ISSN (online) 2055-7159
    DOI 10.1259/bjrcr.20190110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Resectable Clinical N2 Non-Small Cell Lung Cancer; What Is the Optimal Treatment Strategy? An Update by the British Thoracic Society Lung Cancer Specialist Advisory Group.

    Evison, Matthew / Clive, Amelia / Castle, Lianne / Powell, Helen / Thomas, Rachel / Buttery, Robert / Masani, Vidan / Harden, Susan / West, Doug / Woolhouse, Ian

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2017  Volume 12, Issue 9, Page(s) 1434–1441

    Abstract: Patients and clinicians are faced with uncertainty as to the optimal treatment strategy for potentially resectable NSCLC in which there is clinical evidence of involvement of the ipsilateral mediastinum. Randomized controlled trials and meta-analyses ... ...

    Abstract Patients and clinicians are faced with uncertainty as to the optimal treatment strategy for potentially resectable NSCLC in which there is clinical evidence of involvement of the ipsilateral mediastinum. Randomized controlled trials and meta-analyses have failed to demonstrate superiority of one bimodality strategy over another (chemotherapy plus surgery versus chemotherapy plus radiotherapy). One trial of trimodality treatment with chemotherapy, radiotherapy, and surgery demonstrated an improvement in progression-free, but not overall, survival versus chemotherapy and radiotherapy. There are a number of limitations to the data in this complex and heterogenous patient group. No randomized controlled trial has specifically studied patients with single-station N2 disease versus multistation N2 disease. When discussing treatment for fit patients with potentially resectable cN2 NSCLC, lung cancer teams should consider trimodality treatment with chemotherapy, radiotherapy, and surgery or bimodality treatment with chemotherapy and either surgery or radiotherapy. We advocate that all patients see both a thoracic surgeon and the oncology team to discuss these different approaches.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/surgery ; Carcinoma, Non-Small-Cell Lung/therapy ; England ; Female ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Lung Neoplasms/therapy ; Male ; Treatment Outcome
    Language English
    Publishing date 2017-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2017.05.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6664: Show issues Location:
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    Zs.MO 652: Show issues

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  5. Article ; Online: 18F-Fluorodeoxyglucose PET/CT and dynamic contrast-enhanced MRI as imaging biomarkers in malignant pleural mesothelioma.

    Hall, David O / Hooper, Clare E / Searle, Julie / Darby, Michael / White, Paul / Harvey, John E / Braybrooke, Jeremy P / Maskell, Nick A / Masani, Vidan / Lyburn, Iain D

    Nuclear medicine communications

    2017  Volume 39, Issue 2, Page(s) 161–170

    Abstract: Purpose: The purpose of this study was to compare the use of fluorine-18-fluorodeoxyglucose (F-FDG) PET with computed tomography (CT) and dynamic contrast-enhanced (DCE) MRI to predict prognosis and monitor treatment in malignant pleural mesothelioma.!## ...

    Abstract Purpose: The purpose of this study was to compare the use of fluorine-18-fluorodeoxyglucose (F-FDG) PET with computed tomography (CT) and dynamic contrast-enhanced (DCE) MRI to predict prognosis and monitor treatment in malignant pleural mesothelioma.
    Patients and methods: F-FDG PET/CT and DCE-MRI studies carried out as part of the South West Area Mesothelioma Pemetrexed trial were used. F-FDG PET/CT and DCE-MRI studies were carried out before treatment, and after two cycles of chemotherapy, on patients treated with pemetrexed and cisplatin. A total of 73 patients were recruited, of whom 65 had PET/CT and DCE-MRI scans. Baseline measurements from F-FDG PET/CT (maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis) and DCE-MRI (integrated area under the first 90s of the curve and washout slope) were compared with overall survival (OS) using Kaplan-Meier and Cox regression analyses, and changes in imaging measurements were compared with disease progression.
    Results: PET/CT and DCE-MRI measurements were not correlated with each other. Maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis were significantly related to OS with Cox regression analysis and Kaplan-Meir analysis, and DCE-MRI washout curve shape was significantly related to OS. DCE-MRI curve shape can be combined with F-FDG PET/CT to give additional prognostic information. Changes in measurements were not related to progression-free survival.
    Conclusions: F-FDG PET/CT and DCE-MRI give prognostic information in malignant pleural mesothelioma. Neither PET/CT nor DCE-MRI is useful for monitoring disease progression.
    MeSH term(s) Aged ; Aged, 80 and over ; Contrast Media ; Disease Progression ; Female ; Fluorodeoxyglucose F18 ; Humans ; Image Processing, Computer-Assisted ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Magnetic Resonance Imaging ; Male ; Mesothelioma/diagnostic imaging ; Mesothelioma/drug therapy ; Mesothelioma/pathology ; Mesothelioma, Malignant ; Positron Emission Tomography Computed Tomography ; Survival Analysis
    Chemical Substances Contrast Media ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2017-12-23
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000000789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1577: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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