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Article: Dual Lumen Microcatheter in Percutaneous Biliary Drainage for Postoperative Bile Leakage: A Case Report.

Onishi, Yasuyuki / Shimizu, Hironori / Masano, Yuki / Ito, Takashi / Nakamoto, Yuji

2023 Volume 15, Issue 11, Page(s) e49274

Abstract: Percutaneous biliary intervention is widely accepted as an effective and safe treatment for various types of bile duct diseases. We present the case of a 44-year-old woman who developed bile leakage after a living-donor liver transplantation for locally ... ...

Abstract	Percutaneous biliary intervention is widely accepted as an effective and safe treatment for various types of bile duct diseases. We present the case of a 44-year-old woman who developed bile leakage after a living-donor liver transplantation for locally advanced cholangiocarcinoma. A percutaneous drainage tube was placed in the segment 8 bile duct via the blind end of the jejunum. However, the bile leakage was unchanged. Bile leakage from the right posterior hepatic duct was suspected. Using a dual lumen microcatheter, a percutaneous drainage tube was placed in the segment 7 bile duct via the blind end of the jejunum, which reduced the bile leakage. These results suggest that a dual lumen microcatheter is a valuable tool for navigating the biliary tree during difficult percutaneous biliary interventions.
Language	English
Publishing date	2023-11-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.49274
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Article ; Online: Venous outflow reconstruction in living-donor liver transplantation for Budd-Chiari syndrome involving vena cava.

Hata, Koichiro / Nishio, Takahiro / Kumagai, Motoyuki / Masano, Yuki / Kageyama, Shoichi / Okumura, Shinya / Ito, Takashi / Yamazaki, Kazuhiro / Minatoya, Kenji / Hatano, Etsuro

Journal of hepato-biliary-pancreatic sciences

2024

Language	English
Publishing date	2024-03-24
Publishing country	Japan
Document type	Case Reports
ZDB-ID	2536236-7
ISSN	1868-6982 ; 1868-6974
ISSN (online)	1868-6982
ISSN	1868-6974
DOI	10.1002/jhbp.1430
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Zs.A 4024: Show issues

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Article ; Online: Impact of very early introduction of everolimus on liver regeneration after partial liver transplantation in rats.

Hirata, Masaaki / Yagi, Shintaro / Ito, Takashi / Masano, Yuki / Miyachi, Yosuke / Yao, Siyuan / Sonoda, Mari / Masuda, Satohiro / Haga, Hironori / Hatano, Etsuro

Journal of hepato-biliary-pancreatic sciences

2023 Volume 30, Issue 7, Page(s) 882–892

Abstract: Background/purpose: This experimental study in rats aimed to investigate the impact of very early introduction (within 3 h) of everolimus (EVR) + reduced-tacrolimus (TAC) after partial liver transplantation (LT) on liver regeneration, rejection, and ... ...

Abstract	Background/purpose: This experimental study in rats aimed to investigate the impact of very early introduction (within 3 h) of everolimus (EVR) + reduced-tacrolimus (TAC) after partial liver transplantation (LT) on liver regeneration, rejection, and survival. Methods: Based on appropriate dose of EVR + reduced-TAC in 70% hepatectomy (Experiment 1), allogeneic 30% partial LT (Experiment 2) and whole LT (Experiment 3) were performed. Results: After partial LT in EVR + reduced-TAC therapy, restoration of liver graft weight (to that of the whole liver) was delayed compared with standard dose TAC monotherapy (standard-TAC) on day 3 (59.3% vs. 72.9%; p < .001) and 14 (88.1% vs. 95.5%; p = .01). Survival was 75%, which was not as high as the value of 100% observed for standard-TAC, because neither infection nor rejection could be prevented. By contrast, survival after whole LT was 100% as neither infection nor rejection occurred. Conclusions: The very early introduction of EVR + reduced-TAC after partial LT delayed liver regeneration, and made it difficult to manage the dose required to suppress both infection and rejection. On the other hand, EVR + reduced-TAC could be introduced safely very early after whole LT.
MeSH term(s)	Animals ; Rats ; Everolimus ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; Liver Transplantation ; Liver Regeneration ; Graft Rejection/prevention & control ; Tacrolimus/pharmacology ; Graft Survival
Chemical Substances	Everolimus (9HW64Q8G6G) ; Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2023-02-17
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2536236-7
ISSN	1868-6982 ; 1868-6974
ISSN (online)	1868-6982
ISSN	1868-6974
DOI	10.1002/jhbp.1310
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Article ; Online: Stepwise Approach for Acquisition of Microsurgical Skills through Rat Orthotopic Liver Transplantation Experiments.

Hirata, Masaaki / Yagi, Shintaro / Ito, Takashi / Masano, Yuki / Okumura, Shinya / Yao, Siyuan / Miyachi, Yosuke / Aoki, Hikaru / Katano, Kaoru / Hatano, Etsuro

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes

2022 Volume 64, Issue 2, Page(s) 310–314

Abstract: Although rat liver transplantation (LT) is useful in training surgeons to perform microsurgery, mastering these surgical techniques remains difficult. Systematized training protocols that enable learning of the proper skills in a short period of time are ...

Abstract	Although rat liver transplantation (LT) is useful in training surgeons to perform microsurgery, mastering these surgical techniques remains difficult. Systematized training protocols that enable learning of the proper skills in a short period of time are needed. The present study describes an efficient five-step rat LT training protocol for surgeons designed to be mastered within 3 months through continuous training. The first step was to review all procedures by watching full videos of rat LT and to watch actual LT operations performed by a skilled surgeon, enabling recognition of the anatomy of rat abdominal organs. The second step was to perform ten donor operations, including ex vivo graft preparation, to learn the atraumatic and delicate techniques. The third step was to perform ten LTs, with the goal of achieving an anhepatic time <20 min and surviving until the next day. The fourth step was to perform ten additional LTs, with the goal of achieving 7 days of survival. The fifth step was to perform 5-10 more LTs, with the goal of achieving 7 days of survival in five consecutive LT operations. Systematizing the training was found to increase its efficiency. Furthermore, determining the specific number of operations in advance is useful to maintain motivation for training. Mastering efficient rat LT will not only enhance the success of preclinical research but will enable young surgeons to better perform vascular anastomoses under a microscope in humans.
MeSH term(s)	Humans ; Rats ; Animals ; Liver Transplantation/education ; Liver Transplantation/methods ; Anastomosis, Surgical/methods ; Surgeons/education ; Microsurgery/education
Language	English
Publishing date	2022-11-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	205700-1
ISSN	1421-9921 ; 0014-312X
ISSN (online)	1421-9921
ISSN	0014-312X
DOI	10.1159/000528092
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Article: [A Case of Advanced Gastric Cancer Treated Effectively with Combination Chemotherapy of Paclitaxel plus Ramucirumab].

Masano, Yuki / Moriyama, Hiroki / Murata, Toru / Sato, Bunpei / Usui, Yuji

Gan to kagaku ryoho. Cancer & chemotherapy

2019 Volume 46, Issue 8, Page(s) 1299–1302

Abstract: A 74-year-old man was referred to our hospital because of a gastric tumor. A Borrmann type 2 gastric tumor was found on upper gastrointestinal endoscopy, but tissue biopsy indicated only necrotic tissue and the preoperative diagnosis was difficult. ... ...

Abstract	A 74-year-old man was referred to our hospital because of a gastric tumor. A Borrmann type 2 gastric tumor was found on upper gastrointestinal endoscopy, but tissue biopsy indicated only necrotic tissue and the preoperative diagnosis was difficult. Contrast CT and FDG-PET revealed lymphadenopathy at multiple sites accompanied by high accumulation of FDG in the perigastric lymph nodes, left upper collarbicular fossa, bilateral hilar ganglia, and longitudinal cauda. Because the tumor was strongly suspected to be gastric cancer or malignant lymphoma, distal gastrectomy was performed. The tumor was finally diagnosed as a poorly differentiated adenocarcinoma with multiple lymph node metastasis. S-1 plus cisplatin therapy was administered as first-line chemotherapy, and paclitaxel(PTX)plus ramucirumab(RAM)therapy was administered as secondline chemotherapy. PTX plus RAM therapy was effective, and the patient achieved complete remission(CR), as observed on imaging. However, because adverse events such as numbness in the periphery of the limbs were noted, PTX plus RAM therapy was discontinued per the patient's request. Currently, 13 months since the interruption of treatment, the CR has been maintained, as determined on imaging.
MeSH term(s)	Aged ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Gastrectomy ; Humans ; Male ; Paclitaxel ; Stomach Neoplasms/drug therapy ; Ramucirumab
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Paclitaxel (P88XT4IS4D)
Language	Japanese
Publishing date	2019-09-09
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: Effects of Adding Congested Segment IV to the Left Lateral Graft on Short-term Outcomes in Pediatric Living-donor Liver-transplant Recipients.

Aoki, Hikaru / Ito, Takashi / Hirata, Masaaki / Kadohisa, Masashi / Yamamoto, Miki / Uebayashi, Elena Yukie / Shirai, Hisaya / Okumura, Shinya / Masano, Yuki / Ogawa, Eri / Okamoto, Tatsuya / Okajima, Hideaki / Hatano, Etsuro

Transplantation direct

2023 Volume 9, Issue 11, Page(s) e1551

Abstract: Background: In some pediatric patients undergoing living-donor liver transplantation, segment IV without the middle hepatic vein can be added to a left lateral segment graft to obtain larger graft volume. Because no clear consensus on this technique ... ...

Abstract	Background: In some pediatric patients undergoing living-donor liver transplantation, segment IV without the middle hepatic vein can be added to a left lateral segment graft to obtain larger graft volume. Because no clear consensus on this technique exists, this study investigated the effects of congested areas on postoperative outcomes in pediatric patients with biliary atresia undergoing living-donor liver transplantation. Methods: We retrospectively reviewed data of recipients with biliary atresia aged ≤15 y who had undergone living-donor liver transplantation at Kyoto University Hospital between 2006 and 2021 and with graft-to-recipient weight ratios (GRWR) of ≤2%. Based on the percentage of congested area in the graft, patients were classified into the noncongestion (n = 40; ≤10%) and congestion (n = 13; >10%) groups. To compare the differences between groups with similar nooncongestive GRWRs and investigate the effect of adding congested areas, patients in the noncongestion group with GRWRs of ≤1.5% were categorized into the small noncongestion group (n = 24). Results: GRWRs and backgrounds were similar between the noncongestion and congestion groups; however, patients in the congestion group demonstrated significantly longer prothrombin times, higher ascites volumes, and longer hospitalization. Further, compared with the small noncongestion group, the congestion group had significantly greater GRWR and similar noncongestive GRWR; however, the congestion group had significantly longer prothrombin time recovery ( Conclusions: In pediatric liver-transplant recipients, adding a congested segment IV to the left lateral segment to obtain larger graft volume may negatively impact short-term postoperative outcomes.
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ISSN	2373-8731
ISSN	2373-8731
DOI	10.1097/TXD.0000000000001551
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Article ; Online: Impact of thoracic shape on the surgical outcomes of laparoscopic-assisted living donor hepatectomy.

Tanaka, Kosuke / Ogiso, Satoshi / Yoh, Tomoaki / Abdelhafez, Ahmed Hussein / Masano, Yuki / Okumura, Shinya / Kageyama, Shoichi / Ito, Takashi / Hata, Koichiro / Hatano, Etsuro

Annals of gastroenterological surgery

2023 Volume 8, Issue 3, Page(s) 490–497

Abstract: Background: Although laparoscopic-assisted donor hepatectomy (LADH) has become the definitive procedure for harvesting living donor livers, its surgical outcomes in association with donor body shape have not been elucidated.: Methods: The impact of ... ...

Abstract	Background: Although laparoscopic-assisted donor hepatectomy (LADH) has become the definitive procedure for harvesting living donor livers, its surgical outcomes in association with donor body shape have not been elucidated. Methods: The impact of donor factors, including thoracic shape, on LADH outcomes was retrospectively investigated. Thoracic anthropometric data were examined in all LADHs with a left/right graft between 2013 and 2022. Results: The study included 210 LADHs, consisting of 106 left- and 104 right-lobe donors with similar blood loss and similar operation time. Males have greater thoracic depth and greater thoracic width compared with females, respectively. Thoracic depth was associated with graft weight ( Conclusion: The greater thoracic depth is associated with massive blood loss in right-lobe donors. Anthropometric parameters might be helpful for estimating LADH outcomes.
Language	English
Publishing date	2023-11-17
Publishing country	Japan
Document type	Journal Article
ISSN	2475-0328
ISSN (online)	2475-0328
DOI	10.1002/ags3.12755
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Article ; Online: Micro- and macro-borderless surgery using a newly developed high-resolution (4K) three-dimensional video system.

Yagi, Shintaro / Ito, Takashi / Shirai, Hisaya / Yao, Siyuan / Masano, Yuki / Ogawa, Eri / Gabata, Ryosuke / Uemoto, Shinji / Kobayashi, Eiji

PloS one

2021 Volume 16, Issue 5, Page(s) e0250559

Abstract: Objective: Microsurgery using conventional optical microscopes or surgical loupes features a limited field of view and imposes a serious strain on surgeons especially during long surgeries. Here we advocate the micro- and macro-borderless surgery (MMBS) ...

Abstract	Objective: Microsurgery using conventional optical microscopes or surgical loupes features a limited field of view and imposes a serious strain on surgeons especially during long surgeries. Here we advocate the micro- and macro-borderless surgery (MMBS) using a novel high-resolution (4K) three-dimensional (3D) video system. This study aimed to confirm the applicability of this concept in several surgical procedures. Methods: We evaluated the possible use and efficacy of MMBS in the following experiments in porcine subjects. Experiment 1 (non-inferiority test) consisted of dissection and anastomosis of carotid artery, portal vein, proper hepatic artery, and pancreatoduodenectomy with surgical loupe versus MMBS. Experiment 2 (feasibility test) consisted of intra-abdominal and intra-thoracic smaller arteries anastomosed by MMBS as a pre-clinical setting. Experiment 3 (challenge on new surgery) consisted of orthotopic liver transplantation of the graft from a donor after circulatory death maintained by machine perfusion. Circulation of the cardiac sheet with a vascular bed in experiment 2 and liver graft during preservation in experiment 3 was evaluated with indocyanine green fluorescence imaging equipped with this system. Results: Every procedure was completed by MMBS. The operator and assistants could share the same field of view in heads-up status. The focal depth was deep enough not to be disturbed by pulsing blood vessels or respiratory movement. The tissue circulation could be evaluated using fluorescence imaging of this system. Conclusions: MMBS using the novel system is applicable to various surgeries and valuable for both fine surgical procedures and high-level surgical education.
MeSH term(s)	Anastomosis, Surgical/methods ; Animals ; Depth Perception/physiology ; Hepatic Artery/surgery ; Imaging, Three-Dimensional/instrumentation ; Liver Transplantation/methods ; Surgery, Computer-Assisted/methods ; Swine ; Video Recording/instrumentation
Language	English
Publishing date	2021-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0250559
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Article ; Online: Dissecting aneurysm of the proper hepatic artery after laparoscopic hepatectomy possibly related to the Pringle maneuver: A case report.

Kurimoto, Makoto / Seo, Satoru / Yoh, Tomoaki / Shimizu, Hironori / Masano, Yuki / Ogiso, Satoshi / Anazawa, Takayuki / Ishii, Takamichi / Hata, Koichiro / Masui, Toshihiko / Taura, Kojiro / Hatano, Etsuro

Asian journal of endoscopic surgery

2022 Volume 15, Issue 3, Page(s) 633–637

Abstract: In hepatectomy, the Pringle maneuver is commonly used, but its association with iatrogenic injury is not yet well understood. This report presents a case of dissecting aneurysm of the proper hepatic artery (PHA) possibly associated with the Pringle ... ...

Abstract	In hepatectomy, the Pringle maneuver is commonly used, but its association with iatrogenic injury is not yet well understood. This report presents a case of dissecting aneurysm of the proper hepatic artery (PHA) possibly associated with the Pringle maneuver during laparoscopic hepatectomy, that was successfully treated by transcatheter arterial embolization (TAE). The patient was a woman in her 70s, and repeat hepatectomy for liver metastasis of rectal neuroendocrine neoplasm was planned. She underwent hand-assisted laparoscopic hepatectomy with the Pringle maneuver. On postoperative day (POD) 7, enhanced computed tomography showed a dissecting aneurysm of the PHA. TAE of the PHA to prevent hemorrhage was performed on POD 9 with no complications. Even after TAE, intrahepatic arterial flow was provided by the peribiliary arteries. This case suggests the possibility that the Pringle maneuver can cause a dissecting aneurysm of the hepatic artery.
MeSH term(s)	Aneurysm, Dissecting/surgery ; Female ; Hepatectomy/adverse effects ; Hepatectomy/methods ; Hepatic Artery/surgery ; Humans ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Liver Neoplasms/surgery
Language	English
Publishing date	2022-01-24
Publishing country	Japan
Document type	Case Reports
ZDB-ID	2503256-2
ISSN	1758-5910 ; 1758-5902
ISSN (online)	1758-5910
ISSN	1758-5902
DOI	10.1111/ases.13030
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Zs.A 6788: Show issues

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Article ; Online: Novel mouse model for cholestasis-induced liver fibrosis resolution by cholecystojejunostomy.

Yoshino, Kenji / Taura, Kojiro / Iwaisako, Keiko / Masano, Yuki / Uemoto, Yusuke / Kimura, Yusuke / Nam, Nguyen Hai / Nishino, Hiroto / Ikeno, Yoshinobu / Okuda, Yukihiro / Nishio, Takahiro / Yamamoto, Gen / Seo, Satoru / Uemoto, Shinji

Journal of gastroenterology and hepatology

2021 Volume 36, Issue 9, Page(s) 2493–2500

Abstract: Background and aim: Studies on the resolution of liver fibrosis are becoming more important in this era of etiologic eradication. In contrast to the extensive research on the recovery of liver fibrosis induced by hepatotoxic injuries, regression of ... ...

Abstract	Background and aim: Studies on the resolution of liver fibrosis are becoming more important in this era of etiologic eradication. In contrast to the extensive research on the recovery of liver fibrosis induced by hepatotoxic injuries, regression of cholestatic liver fibrosis has been insufficiently examined owing to the limited availability of animal models. Methods: We examined our novel recanalization mice model of biliary obstruction, involving anastomosis between the gallbladder and jejunum (G-J anastomosis) by invagination. Transgenic mice expressing green fluorescent protein (GFP) under the collagen 1(α)1 promoter underwent G-J anastomosis 14 days after bile duct ligation (BDL) and were sacrificed 14 days later. Results: Transaminase and total bilirubin levels decreased to almost normal values on day 14 after G-J anastomosis. G-J anastomosis resulted in dramatic reversal of liver fibrosis induced by BDL. Activated portal fibroblasts (PFs) double-positive for GFP and Thy-1 on immunofluorescence in the liver of BDL-injured mice became less noticeable following G-J anastomosis. Messenger RNA expression of markers for activated PFs in the liver was downregulated after anastomosis. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) were induced by BDL. After anastomosis, expressions of MMP-3, 8 as well as hepatocyte growth factor were further upregulated, whereas those of TIMP-1 and TIMP-3 were markedly downregulated. Conclusions: Our established G-J anastomosis model is associated with fibrosis resolution and reduced PF activation through reopening of bile duct obstruction and will be valuable for studying the recovery process of cholestatic liver fibrosis.
MeSH term(s)	Anastomosis, Surgical ; Animals ; Bile Ducts/surgery ; Cholestasis/etiology ; Cholestasis/pathology ; Disease Models, Animal ; Gallbladder ; Ligation ; Liver/pathology ; Liver Cirrhosis/etiology ; Liver Cirrhosis/pathology ; Mice ; Mice, Transgenic
Language	English
Publishing date	2021-01-22
Publishing country	Australia
Document type	Journal Article
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.15406
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