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  1. Article ; Online: Characterizing after-hours hematology/oncology clinic calls.

    Phung, Quan H / Masel, Rebecca H / Bijlani, Sharan / Tanzer, Joshua Ray / Hsu, Andrew / Almhanna, Khaldoun

    Annals of palliative medicine

    2024  Volume 13, Issue 1, Page(s) 93–100

    Abstract: Background: After-hour calls can be resource intensive and remain a significant challenge to medical practices, though they have historically been poorly or non-reimbursable services. This study reviews after-hour calls from hematology/oncology patients ...

    Abstract Background: After-hour calls can be resource intensive and remain a significant challenge to medical practices, though they have historically been poorly or non-reimbursable services. This study reviews after-hour calls from hematology/oncology patients at a cancer center to characterize after-hour care needs, identify care gaps, and look for opportunities to improve outpatient healthcare delivery.
    Methods: This descriptive, retrospective Institutional Review Board-approved study analyzed patient calls between June 2015 to February 2021 in an academic hematology/oncology practice. Data from 500 calls were reviewed and cataloged into a database including patient demographics, clinical history, and information surrounding the call (e.g., primary reason for the call, outcome of the call). Calls were also categorized as being urgent or not from a patient or provider's perspective.
    Results: Among 500 calls, representing 398 unique patients, the average patient was 62 years old and 52% of calls were from females. Most calls were made to report symptoms (65%), followed by calls to follow-up on labs, tests, or imaging (13%), and clarifying treatment plans (10%). Oncology patients represented 67% of calls and hematology (malignant and benign) patients represented 33%. More specifically, patients with gastrointestinal cancer (25%), hematologic malignancies (24%), and thoracic cancer (13%) represented the diagnoses with the highest call volume.
    Conclusions: This study explores the complexity and variety of after-hour cancer patient calls. By systematically exploring patient calls, this data can provide insight into patients' needs outside of regular clinic times and help practices develop strategies to anticipate these needs, reduce after-hour call burden, and improve overall quality of care.
    MeSH term(s) Female ; Humans ; Middle Aged ; Hematology ; Medical Oncology ; Neoplasms ; Retrospective Studies ; Telephone ; Male
    Language English
    Publishing date 2024-01-10
    Publishing country China
    Document type Journal Article
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5839
    ISSN (online) 2224-5839
    ISSN 2224-5839
    DOI 10.21037/apm-23-80
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Seroconversion and outcomes after initial and booster COVID-19 vaccination in adults with hematologic malignancies.

    Ollila, Thomas A / Masel, Rebecca H / Reagan, John L / Lu, Shaolei / Rogers, Ralph D / Paiva, Kimberly J / Taher, Rashida / Burguera-Couce, Ella / Zayac, Adam S / Yakirevich, Inna / Niroula, Rabin / Barth, Peter / Olszewski, Adam J

    Cancer

    2022  Volume 128, Issue 18, Page(s) 3319–3329

    Abstract: Background: Patients with hematologic malignancies have impaired humoral immunity secondary to their malignancy and its treatment, placing them at risk of severe coronavirus disease-19 (COVID-19) infection and reduced response to vaccination.: Methods! ...

    Abstract Background: Patients with hematologic malignancies have impaired humoral immunity secondary to their malignancy and its treatment, placing them at risk of severe coronavirus disease-19 (COVID-19) infection and reduced response to vaccination.
    Methods: The authors retrospectively analyzed serologic responses to initial and booster COVID-19 vaccination in 378 patients with hematologic malignancy and subsequently tracked COVID-19-related outcomes.
    Results: Seroconversion occurred in 181 patients (48%) after initial vaccination; patients who had active malignancy or those who were recently treated with a B-cell-depleting monoclonal antibody had the lowest rates of seroconversion. For initial nonresponders to vaccination, seroconversion after a booster dose occurred in 48 of 85 patients (56%). The seroconversion rate after the booster was similar for patients on (53%) and off (58%) active therapy (p = .82). Thirty-three patients (8.8%) developed a COVID-19 infection, and there were three COVID-19-related deaths (0.8%). Although no significant association was observed between postvaccination seroconversion and the incidence of COVID-19 infection, no patient with seroconversion died from COVID-19, and no patient who received tixagevimab/cilgavimab (N = 25) was diagnosed with a COVID-19 infection.
    Conclusions: Booster vaccinations can promote seroconversion in a significant proportion of patients who are seronegative after the initial vaccination course regardless of the specific vaccine or on/off treatment status at the time of revaccination. Although postvaccination seroconversion may not be associated with a decrease in any (including asymptomatic) COVID-19 infection, the authors' experience suggested that effective vaccination (including a booster), supplemented by passive immunization using tixagevimab/cilgavimab in case of lack of seroconversion, effectively eliminated the risk of COVID-19 death in the otherwise high-risk population.
    Lay summary: Patients with hematologic malignancy, especially lymphoma, have an impaired response to coronavirus disease 2019 (COVID-19) vaccination. In this single-institution review, less than one half of the patients studied made detectable antibodies. For those who did not make detectable antibodies after initial vaccination, over one half (65%) were able to produce antibodies after booster vaccination. By the end of February 2022, 33 of the original 378 patients had a documented COVID-19 infection. The only deaths from COVID-19 were in those who had undetectable antibodies, and no patient who received prophylactic antibody therapy developed a COVID-19 infection.
    MeSH term(s) Adult ; Antibodies, Monoclonal ; Antibodies, Viral ; COVID-19 ; COVID-19 Vaccines ; Hematologic Neoplasms ; Hepatitis B Vaccines ; Humans ; Retrospective Studies ; Seroconversion ; Vaccination
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Viral ; COVID-19 Vaccines ; Hepatitis B Vaccines ; tixagevimab ; cilgavimab (1KUR4BN70F)
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.34354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Use of Two Distillation Columns in Systems with Maximum Temperature Limitations

    Masel, Rebecca H / Luyben William L / Smith Dalton W

    Industrial & Engineering Chemistry Research. 2013 Apr. 10, v. 52, no. 14

    2013  

    Abstract: Maximum temperature limitations are encountered in distillation columns in which thermally sensitive materials are being separated. Fixing the temperature and composition of the bottoms product fixes the column base pressure and, hence, the condenser ... ...

    Abstract Maximum temperature limitations are encountered in distillation columns in which thermally sensitive materials are being separated. Fixing the temperature and composition of the bottoms product fixes the column base pressure and, hence, the condenser pressure. The distillate composition at this pressure sets the condenser temperature. In many systems, this temperature is lower than that attainable with cooling water, so expensive refrigeration must be used. Instead of using a single column with a refrigerated condenser, it is sometimes more economical to use two columns. In the first column, pressure is established to permit the use of cooling water (322 K reflux-drum temperature), and a portion of the light component is produced as the distillate stream. The maximum base temperature limitation is achieved by taking a bottoms stream that is a mixture of the light and heavy components. Then this stream is separated in a second column that uses a refrigerated condenser. The rest of the light component is produced as the distillate and the heavy component is produced as the bottoms. This paper presents a quantitative comparison of the two alternative flowsheets. Results show that the two-column process is more economical when two conditions exist: (1) there is a large difference in the normal boiling points between the light and heavy components, and (2) the composition of the feed stream has a significant amount of the light component.
    Keywords boiling point ; chemistry ; distillation ; engineering ; refrigeration ; temperature
    Language English
    Dates of publication 2013-0410
    Size p. 5172-5176.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 1484436-9
    ISSN 1520-5045 ; 0888-5885
    ISSN (online) 1520-5045
    ISSN 0888-5885
    DOI 10.1021%2Fie3033735
    Database NAL-Catalogue (AGRICOLA)

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