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Article: Acute perforation in a gastrojejunocolic fistula after a laparascopic Roux-en-Y gastric bypass: case report.

Velleman, Jos / Masereel, Benoit / Geyskens, Paul

2023 Volume 9, Issue 1, Page(s) 41

Abstract: Background: Gastrojejunocolic fistulas are a rare type of fistulas after a laparascopic Roux-en-Y gastric bypass (LRYGB). They are known as a chronic complication. This case report is the first to describe an acute perforation in a gastrojejunocolic ... ...

Abstract	Background: Gastrojejunocolic fistulas are a rare type of fistulas after a laparascopic Roux-en-Y gastric bypass (LRYGB). They are known as a chronic complication. This case report is the first to describe an acute perforation in a gastrojejunocolic fistula after LRYGB. Case presentation: A 61-year-old woman with a history of a laparascopic gastric bypass was diagnosed with an acute perforation in a gastrojejunocolic fistula. A laparascopic repair was performed by closing the defect in the gastrojejunal anastomosis as well as the defect in the transverse colon. However, 6 weeks later, a dehiscence of the gastrojejunal anastomosis occured. This was reconstructed by an open revision of the gastric pouch and gastrojejunal anastomosis. Long-term follow up showed no recurrence. Conclusions: Combining the findings of our case with other literature, a laparoscopic repair with wide resection of the fistula, a revision of the gastric pouch and gastrojejunal anastomosis as well as closing the defect in the colon seems to be the best approach in case of an acute perforation in a gastrojejunocolic fistula after LRYGB.
Language	English
Publishing date	2023-03-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2809613-7
ISSN	2198-7793
ISSN	2198-7793
DOI	10.1186/s40792-023-01620-z
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Article ; Online: Comparison of several strategies for the deployment of a multivariate regression model on several handheld NIR instruments. Application to the quality control of medicines.

Ciza, P H / Sacre, P-Y / Waffo, C / Kimbeni, T M / Masereel, B / Hubert, Ph / Ziemons, E / Marini, R D

Journal of pharmaceutical and biomedical analysis

2022 Volume 215, Page(s) 114755

Abstract: Chemometrics applied to spectroscopic measurements such as near-infrared are gaining more and more importance for quality control of pharmaceutical products. Handheld near-infrared devices show great promise as a medicines quality screening technique for ...

Abstract	Chemometrics applied to spectroscopic measurements such as near-infrared are gaining more and more importance for quality control of pharmaceutical products. Handheld near-infrared devices show great promise as a medicines quality screening technique for post-marketing surveillance. These devices are able to detect substandard and falsified medicines in pharmaceutical supply chains and enable rapid action before these medicines reach patients. The instrumental and environmental changes, expected or not, can adversely affect the analytical performances of prediction models developed for routine applications. Based on a previous study, PLS prediction models were developed and validated on three similar handheld NIR transmission spectrophotometers of the same model and from same company. These models have shown to be effective in analyzing metformin tablet samples, but significant spectral differences between handheld systems complicated their deployment for routine analysis. In this study, different strategies have been applied and compared to correct the instrumental variations, including global modelling (GM) and calibration transfer methods (Direct Standardization, DS; Spectral Space Transformation, SST and Slope/Bias correction, SBC), considering the RMSEP and the accuracy profile as assessment criteria. The transfer methods showed good capabilities to maintain the predictive performances comparable to that of the global modelling approach, except for a remaining slight bias. This approach is interesting since very few standardization samples are required to develop an adequate transfer model. GM, SST and SBC were able to correct/handle drifts in the spectral responses of different handheld instruments and thus may help to avoid the need for a long, laborious, and costly full recalibration process due to inter-instrument variations.
MeSH term(s)	Calibration ; Counterfeit Drugs/analysis ; Humans ; Quality Control ; Spectroscopy, Near-Infrared/methods ; Tablets/chemistry
Chemical Substances	Counterfeit Drugs ; Tablets
Language	English
Publishing date	2022-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2022.114755
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Article: Revue critique des nouveaux principes actifs à usage humain commercialisés en Belgique au cours de la période 2001-2005.

Masereel, B

Journal de pharmacie de Belgique

2006 Volume 61, Issue 2, Page(s) 45–57

Title translation	Critical review of new chemical and biological molecules launched in Belgium during the period 2001-2005.
MeSH term(s)	Belgium ; Drug Approval ; Drug Industry ; Humans
Language	French
Publishing date	2006
Publishing country	Belgium
Document type	Journal Article ; Review
ZDB-ID	840991-2
ISSN	0047-2166
ISSN	0047-2166
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Article: Nouveaux principes actifs.

Masereel, B

Journal de pharmacie de Belgique

2005 Volume 60, Issue 1, Page(s) 1–16

Title translation	A survey of some new drugs.
MeSH term(s)	Belgium ; Data Collection ; Drug Approval ; Pharmaceutical Preparations
Chemical Substances	Pharmaceutical Preparations
Language	French
Publishing date	2005
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	840991-2
ISSN	0047-2166
ISSN	0047-2166
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Article: Nouvelles entités chimiques entrant dans la composition de spécialités pharmaceutiques commercialisées en Belgique en 2003.

Masereel, B

Journal de pharmacie de Belgique

2004 Volume 59, Issue 1, Page(s) 1–12

Title translation	A survey of some new pharmaceutical specialties introduced in Belgium in 2003.
MeSH term(s)	Belgium ; Drug Approval ; Drug Therapy ; Humans ; Pharmaceutical Preparations
Chemical Substances	Pharmaceutical Preparations
Language	French
Publishing date	2004
Publishing country	Belgium
Document type	Journal Article ; Review
ZDB-ID	840991-2
ISSN	0047-2166
ISSN	0047-2166
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Article: Rectal duplication: a case report.

Didden, K / Masereel, B / Geyskens, P

Acta chirurgica Belgica

2013 Volume 113, Issue 4, Page(s) 301–303

Abstract: Gastrointestinal tract duplications are uncommon congenital abnormalities, that may occur anywhere along the alimentary tract. Most frequently they occur at the level of the small bowel tract and are symptomatic before the age of two. In our case we ... ...

Abstract	Gastrointestinal tract duplications are uncommon congenital abnormalities, that may occur anywhere along the alimentary tract. Most frequently they occur at the level of the small bowel tract and are symptomatic before the age of two. In our case we report the history of a 68-years old women with a colon duplication, especially a rectal duplication. This is very exceptional.
MeSH term(s)	Aged ; Colectomy/methods ; Colonoscopy ; Diagnosis, Differential ; Female ; Humans ; Rectal Diseases/congenital ; Rectal Diseases/diagnosis ; Rectal Diseases/surgery ; Rectum/abnormalities ; Tomography, X-Ray Computed
Language	English
Publishing date	2013-11-09
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	210274-2
ISSN	0001-5458
ISSN	0001-5458
DOI	10.1080/00015458.2013.11680933
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Article ; Online: Monte Carlo Calculation of Radioimmunotherapy with (90)Y-, (177)Lu-, (131)I-, (124)I-, and (188)Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts.

Lucas, S / Feron, O / Gallez, B / Masereel, B / Michiels, C / Vander Borght, T

Computational and mathematical methods in medicine

2015 Volume 2015, Page(s) 284360

Abstract: Radioimmunotherapy has shown that the use of monoclonal antibodies combined with a radioisotope like (131)I or (90)Y still remains ineffective for solid and radioresistant tumour treatment. Previous simulations have revealed that an increase in the ... ...

Abstract	Radioimmunotherapy has shown that the use of monoclonal antibodies combined with a radioisotope like (131)I or (90)Y still remains ineffective for solid and radioresistant tumour treatment. Previous simulations have revealed that an increase in the number of (90)Y labelled to each antibody or nanoobject could be a solution to improve treatment output. It now seems important to assess the treatment output and toxicity when radionuclides such as (90)Y, (177)Lu, (131)I, (124)I, and (188)Re are used. Tumour control probability (TCP) and normal tissue complication probability (NTCP) curves versus the number of radionuclides per nanoobject were computed with MCNPX to evaluate treatment efficacy for solid tumours and to predict the incidence of surrounding side effects. Analyses were carried out for two solid tumour sizes of 0.5 and 1.0 cm radius and for nanoobject (i.e., a radiolabelled antibody) distributed uniformly or nonuniformly throughout a solid tumour (e.g., Non-small-cell-lung cancer (NSCLC)). (90)Y and (188)Re are the best candidates for solid tumour treatment when only one radionuclide is coupled to one carrier. Furthermore, regardless of the radionuclide properties, high values of TCP can be reached without toxicity if the number of radionuclides per nanoobject increases.
MeSH term(s)	Algorithms ; Antibodies, Monoclonal/therapeutic use ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Computer Simulation ; Humans ; Iodine Radioisotopes/therapeutic use ; Lung/radiation effects ; Lung Neoplasms/radiotherapy ; Lutetium/therapeutic use ; Models, Statistical ; Monte Carlo Method ; Nanomedicine/methods ; Neoplasms/immunology ; Neoplasms/radiotherapy ; Radiation Pneumonitis/diagnosis ; Radioimmunotherapy/instrumentation ; Radioimmunotherapy/methods ; Radioisotopes/therapeutic use ; Radiotherapy Planning, Computer-Assisted/methods ; Rhenium/therapeutic use ; Yttrium Radioisotopes/therapeutic use
Chemical Substances	Antibodies, Monoclonal ; Iodine Radioisotopes ; Radioisotopes ; Yttrium Radioisotopes ; Lutetium (5H0DOZ21UJ) ; Rhenium (7440-15-5)
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2252430-7
ISSN	1748-6718 ; 1748-670X ; 1027-3662
ISSN (online)	1748-6718
ISSN	1748-670X ; 1027-3662
DOI	10.1155/2015/284360
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Article ; Online: Preparation and characterization of a new harmine-based antiproliferative compound in complex with cyclodextrin: Increasing solubility while maintaining biological activity.

Meinguet, Céline / Masereel, Bernard / Wouters, Johan

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2015 Volume 77, Page(s) 135–140

Abstract: The trisubstituted harmine derivative, 2, present a submicromolar antiproliferative activity on 5 cancer cell lines but a moderate kinetic solubility in pH 7.4 buffer. The aim of this work was to develop a 2-cyclodextrin complex in order to increase the ... ...

Abstract	The trisubstituted harmine derivative, 2, present a submicromolar antiproliferative activity on 5 cancer cell lines but a moderate kinetic solubility in pH 7.4 buffer. The aim of this work was to develop a 2-cyclodextrin complex in order to increase the drug solubility while maintaining the biological activity. Firstly, the 2 increasing solubility in presence of several cyclodextrins (CDs) has been shown, with a maximum for 7 glucose subunit CD (βCD and 2 HP-βCD). Phase solubility experiment in presence of 2 HP-βCD has underline an AL-type profile until 80 mM which suggest a 1:1 stoichiometry and a K1:1 of 116 M(-1) and a CE of 0.28 have been calculated. This 1:1 stoichiometry was confirmed by Job Plot experiment, following the CD H-3 proton by (1)H NMR. Secondly, (1)H NMR study of compound 2 in presence of βCD and geometry optimization of the complex has underline an inclusion of 2 into the CD, via the indole part of the drug. Finally, the efficiency of the 2 antiproliferative effect is not affected by the complexation, as shown by viability test.
MeSH term(s)	Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclodextrins/chemistry ; Drug Evaluation, Preclinical ; Harmine/chemistry ; Harmine/pharmacology ; Humans ; Proton Magnetic Resonance Spectroscopy ; Solubility
Chemical Substances	Cyclodextrins ; Harmine (4FHH5G48T7)
Language	English
Publishing date	2015-09-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2015.06.010
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Article: Nouveaux médicaments 2000.

Oslet, J / Masereel, B

Journal de pharmacie de Belgique

2001 Volume 56, Issue 1, Page(s) 1–32

Title translation	A survey of some new drugs, 2000.
MeSH term(s)	Pharmaceutical Preparations
Chemical Substances	Pharmaceutical Preparations
Language	French
Publishing date	2001-01
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	840991-2
ISSN	0047-2166
ISSN	0047-2166
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Article ; Online: Validation and standardization of the ETP-based activated protein C resistance test for the clinical investigation of steroid contraceptives in women: an unmet clinical and regulatory need.

Douxfils, Jonathan / Morimont, Laure / Delvigne, Anne-Sophie / Devel, Philippe / Masereel, Bernard / Haguet, Hélène / Bouvy, Céline / Dogné, Jean-Michel

Clinical chemistry and laboratory medicine

2019 Volume 58, Issue 2, Page(s) 294–305

Abstract: Background Regulatory bodies recommend the use of an assay based on the assessment of the endogenous thrombin potential (ETP) for the investigation of the activated protein C resistance (APCr) in the development of steroid contraceptives in women. ... ...

Abstract	Background Regulatory bodies recommend the use of an assay based on the assessment of the endogenous thrombin potential (ETP) for the investigation of the activated protein C resistance (APCr) in the development of steroid contraceptives in women. However, the assays described in the literature are home-made and not standardized regarding the method, the reagents, the reference plasma and the quality controls. In the absence of any commercially available method, we aimed at validating the ETP-based APCr assay. Methods The validation was performed according to regulatory standards. The method targets a 90% inhibition of the ETP in healthy donors in the presence of APC compared to the same condition in the absence of APC. As a large-scale production of a pool of plasma from well-selected healthy donors is impossible, algorithms were applied to a commercial reference plasma to correlate with the selected pool. Results Repeatability and intermediate precision passed the acceptance criteria. The assay demonstrated a curvilinear dose response to protein S and APC concentrations (R2 > 0.99). Analysis of plasma samples from 47 healthy individuals (22 women not taking combined hormonal contraceptives [CHC], and 25 men not Factor V Leiden carriers) confirmed the validity of the test, with a mean inhibition percentage of 90%. Investigations in 15 women taking different contraceptives and in two subjects with Factor V Leiden confirmed the good sensitivity and performance of the assay. Conclusions This validation provides the pharmaceutical industry, the regulatory bodies and physicians with a reproducible, sensitive and validated gold-standard ETP-based APCr assay.
MeSH term(s)	Activated Protein C Resistance/diagnosis ; Adult ; Algorithms ; Blood Coagulation Tests/methods ; Blood Coagulation Tests/standards ; Contraceptive Agents/administration & dosage ; Factor V/analysis ; Female ; Humans ; Male ; Protein C/analysis ; Protein C/standards ; Reference Standards ; Reproducibility of Results
Chemical Substances	Contraceptive Agents ; Protein C ; factor V Leiden ; Factor V (9001-24-5)
Language	English
Publishing date	2019-08-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2019-0471
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