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Article ; Online: The predictive value of modified soluble urokinase plasminogen activator receptor (suPAR) with National Early Warning Score (NEWS) for mortality in emergency elderly patients in Japan: a prospective pilot study.

Mitsunaga, Toshiya / Ohtaki, Yuhei / Seki, Yutaka / Mashiko, Kunihiro / Uzura, Masahiko / Okuno, Kenji / Takeda, Satoshi

Acute medicine & surgery

2023 Volume 10, Issue 1, Page(s) e840

Abstract: Aim: The aim of this study is to evaluate the ability of soluble urokinase plasminogen activator receptor (suPAR) and modified suPAR with National Early Warning Score (NEWS) for detecting mortality in elderly emergency patients who are older than 70 ... ...

Abstract	Aim: The aim of this study is to evaluate the ability of soluble urokinase plasminogen activator receptor (suPAR) and modified suPAR with National Early Warning Score (NEWS) for detecting mortality in elderly emergency patients who are older than 70 years. Methods: This is a secondary analysis of our previous study, which was a single-center prospective pilot study, carried out for 21 months in the emergency department of a secondary emergency institution in Japan. This study was carried out between September 16, 2020, and June 21, 2022. The study included all patients without trauma aged 70 years or older who presented to the emergency department. Discrimination was assessed by plotting the receiver-operating characteristic curve and calculating the area under the receiver-operating characteristic curve (AUC). Results: During the study period, 47 eligible older patients were included, among which 8 (17.0%) patients died. The median suPAR was significantly lower in the survivor's group than in the nonsurvivor's group ( Conclusion: Our single-center study has demonstrated the high utility of modified suPAR with NEWS as a predictive tool of mortality in elderly emergency patients. Evidence from multicenter studies is needed for introducing modified suPAR with NEWS in the emergency department setting.
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2751184-4
ISSN	2052-8817 ; 2052-8817
ISSN (online)	2052-8817
ISSN	2052-8817
DOI	10.1002/ams2.840
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Ability of combined soluble urokinase plasminogen activator receptor to predict preventable emergency attendance in older patients in Japan: a prospective pilot study.

Mitsunaga, Toshiya / Ohtaki, Yuhei / Yajima, Wataru / Sugiura, Kei / Seki, Yutaka / Mashiko, Kunihiro / Uzura, Masahiko / Takeda, Satoshi

PeerJ

2022 Volume 10, Page(s) e14322

Abstract: Soluble urokinase plasminogen activator receptor (suPAR) is a strong and nonspecific inflammatory biomarker that reflects various immunologic reactions, organ damage, and risk of mortality in the general population. Although prior research in acute ... ...

Abstract	Soluble urokinase plasminogen activator receptor (suPAR) is a strong and nonspecific inflammatory biomarker that reflects various immunologic reactions, organ damage, and risk of mortality in the general population. Although prior research in acute medical patients showed that an elevation in suPAR is related to intensive care unit admission and risk of readmission and mortality, no studies have focused on the predictive value of suPAR for preventable emergency attendance (PEA). This study aims to evaluate the predictive value of suPAR, which consists of a combination of white blood cell count (WBC), C-reactive protein (CRP), and the National Early Warning Score (NEWS), for PEA in older patients (>65 years) without trauma who presented to the emergency department (ED). This single-center prospective pilot study was conducted in the ED of the Association of EISEIKAI Medical and Healthcare Corporation Minamitama Hospital, in Hachiouji City, Tokyo, Japan, from September 16, 2020, to June 21, 2022. The study included all patients without trauma aged 65 years or older who were living in their home or a facility and presented to the ED when medical professionals decided an emergency consultation was required. Discrimination was assessed by plotting the receiver-operating characteristic (ROC) curve and calculating the area under the ROC curve (AUC). During the study period, 49 eligible older patients were included, and thirteen (26.5%) PEA cases were detected. The median suPAR was significantly lower in the PEA group than in the non-PEA group (
MeSH term(s)	Humans ; Aged ; Receptors, Urokinase Plasminogen Activator ; Pilot Projects ; Prospective Studies ; Prognosis ; Japan/epidemiology ; Pandemics ; COVID-19 ; C-Reactive Protein/analysis
Chemical Substances	Receptors, Urokinase Plasminogen Activator ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2022-11-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.14322
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Book: Ea resukyū dōkutākā

Mashiko, Kunihiro

(Purehosupitaru Mook = : Prehospital ; 3)

2007

Author's details	kanshū Ishihara Shin, Mashiko Kunihiro ; henshū Mashiko Kunihiro
Series title	Purehosupitaru Mook = : Prehospital ; 3
MeSH term(s)	Ambulances ; Emergency Medical Services
Keywords	Japan
Language	Japanese
Size	xi, 213, iii p. :, ill.
Edition	Dai 1-han.
Publisher	Nagai Shoten
Publishing place	Ōsaka-shi
Document type	Book
ISBN	9784815917760 ; 4815917760
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: A System That Uses Advanced Automatic Collision Notification Technology to Dispatch Doctors to Traffic Accidents by Helicopter: The First 4 Cases.

Motomura, Tomokazu / Matsumoto, Hisashi / Mashiko, Kunihiro / Ishikawa, Hirotoshi / Nishimoto, Tetsuya / Takeyama, Yoshihiro

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

2020 Volume 87, Issue 4, Page(s) 220–226

Abstract: Introduction: To increase survival rates of patients with severe trauma from road traffic accidents, Japan launched the D-Call Net (DCN) system, which utilizes advanced automatic collision notification technology to dispatch doctors by helicopter. The ... ...

Abstract	Introduction: To increase survival rates of patients with severe trauma from road traffic accidents, Japan launched the D-Call Net (DCN) system, which utilizes advanced automatic collision notification technology to dispatch doctors by helicopter. The DCN system began in November 2015 and, as of October 2019, has dispatched doctors 4 times. Cases: Case 1-Canceled because trauma was mild. Case 2-Doctor made contact with 2 patients with moderate trauma 29 minutes earlier than would have occurred conventionally. This was the first case in the world to use automotive engineering data to dispatch a doctor to a patient. Case 3-An accident involving 3 severely injured patients activated DCN, enabling doctor-patient contact 20 minutes earlier than would have been possible conventionally. Case 4-DCN was ineffective. Discussion: According to 2008 data from Chiba Prefecture, in accidents where victims sustain severe trauma, the interval from accident occurrence to hospital arrival was 67 minutes, even when doctors were dispatched by air ambulance (Doctor-Heli [DH]). Use of accident information for faster doctor dispatch effectively improved survival rates. An algorithm was developed to use accident information to assess trauma severity (severity probability). DCN dispatches doctors by using data, including information on accident site and severity probability, which are sent to smartphones of doctors, thereby reducing the interval from accident to DH request by approximately 17 minutes. DCN is the first system in the world to use automotive engineering information for faster doctor dispatch to traffic accident sites. The system is crucial for improving survival rates and mitigating the aftereffects of traffic accidents.
MeSH term(s)	Accidents, Traffic/mortality ; Air Ambulances ; Aircraft ; Emergency Medical Dispatch/methods ; Emergency Medical Services/methods ; Humans ; Japan ; Survival Rate ; Time Factors ; Trauma Severity Indices
Language	English
Publishing date	2020-03-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2091563-9
ISSN	1347-3409 ; 1345-4676
ISSN (online)	1347-3409
ISSN	1345-4676
DOI	10.1272/jnms.JNMS.2020_87-406
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Article: Trauma systems in Japan: history, present status and future perspectives.

Mashiko, Kunihiro

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

2005 Volume 72, Issue 4, Page(s) 194–202

Abstract: As trauma is the leading cause of death for persons 1 to 24 years in Japan, the trauma system must be established to save lives and to reduce serious sequelae. However, the trauma system has not been evaluated since 2000. In May 2002, it revealed that ... ...

Abstract	As trauma is the leading cause of death for persons 1 to 24 years in Japan, the trauma system must be established to save lives and to reduce serious sequelae. However, the trauma system has not been evaluated since 2000. In May 2002, it revealed that the deaths of about 40% of expired trauma patients who arrived at emergency centers with some vital signs were probably preventable. This result increased the awareness of the need for establishing the trauma system. Then, the Japan Prehospital Trauma Evaluation and Care program for emergency medical technicians was developed, the doctor helicopter system was promoted, the Japan Advanced Trauma Evaluation and Care program for physicians was developed, and the trauma registry program was started. The extension of the procedures that can be performed by Japanese paramedics should be extended with the establishment of a medical control system. However, the key to securing quality regional trauma care is to designate a trauma care hospital as a trauma center and to transport severely injured patients there as rapidly as possible.
MeSH term(s)	Forecasting ; History, 20th Century ; Japan ; Patient Transfer/organization & administration ; Trauma Centers/history ; Trauma Centers/organization & administration ; Trauma Centers/trends ; United States
Language	English
Publishing date	2005-07-28
Publishing country	Japan
Document type	Historical Article ; Journal Article
ZDB-ID	2091563-9
ISSN	1347-3409 ; 1345-4676
ISSN (online)	1347-3409
ISSN	1345-4676
DOI	10.1272/jnms.72.194
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Article ; Online: Comparison of the Diagnostic Value of Immunochromatography Kits in Corona Virus Disease 2019 Patients: A Prospective Pilot Study.

Mitsunaga, Toshiya / Seki, Yutaka / Yoshioka, Masakata / Suzuki, Ippei / Akita, Kumi / Mashiko, Syunsuke / Uzura, Masahiko / Takeda, Satoshi / Sekine, Akihiro / Mashiko, Kunihiro

JMA journal

2021 Volume 4, Issue 1, Page(s) 32–40

Abstract: Introduction: The spread of coronavirus 2019 (COVID-19) is a serious problem all over the world. Several immunochromatography kits of the antibody for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed, but it is still ... ...

Abstract	Introduction: The spread of coronavirus 2019 (COVID-19) is a serious problem all over the world. Several immunochromatography kits of the antibody for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed, but it is still unclear which kits have high diagnostic value. This study aims to evaluate the accuracy rate for antibody detection of each immunochromatography kit and reveal which kit has a high diagnostic value for antibody detection. Methods: This study was carried out between 1 August 2020 and 14 October 2020 at the Association of EISEIKAI Medical and Healthcare Corporation Minamitama Hospital. Patients diagnosed with COVID-19 and approximately 30 days after symptom onset were included as the positive group. The serum SARS-CoV-2 antibodies were analysed using seven immunochromatography kits. Results: Twenty samples (Positive group: 10 patients, Negative group: 10 healthy medical workers) were included in this study. The median age of the patients was 44 years, and the median duration from symptom onset was 30.5 days in the positive group. The accuracy rates for IgM/IgG detection were: 90.0%/100% in Kit A; 50.0%/95.0% in Kit B; 55.0%/65.0% in Kit C; 60.0%/55.0% in Kit D; 50.0%/80.0% in Kit E; 80.0%/90.0% in Kit F; and 90.0%/100% in Kit G. Conclusions: Our study showed that there is a variation of accuracy rates between immunochromatography kits for antibodies of SARS-CoV-2. COVID-19 IgG/IgM RAPID TEST CASSETTE (Hangzhou Biotest Biotech Co., Ltd., China) and Nadal COVID-19 IgG/IgM Rapid Test (BioServUK Ltd., UK: United Kingdom) have high accuracy rates for both IgM and IgG detection. Evidence from large population studies of immunochromatography kits is needed to clarify the details of diagnostic value for SARS-CoV-2.
Language	English
Publishing date	2021-01-14
Publishing country	Japan
Document type	Journal Article
ZDB-ID	3053329-6
ISSN	2433-3298 ; 2433-328X
ISSN (online)	2433-3298
ISSN	2433-328X
DOI	10.31662/jmaj.2020-0084
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Article: The evaluation of factors affecting antibody response after administration of the BNT162b2 vaccine: a prospective study in Japan.

Mitsunaga, Toshiya / Ohtaki, Yuhei / Seki, Yutaka / Yoshioka, Masakata / Mori, Hiroshi / Suzuka, Midori / Mashiko, Syunsuke / Takeda, Satoshi / Mashiko, Kunihiro

PeerJ

2021 Volume 9, Page(s) e12316

Abstract: The aim of this study was to evaluate the antibody reaction after administration of the BNT162b2 vaccine, and to reveal the factors that affect antibody production. This prospective study was carried out in the Association of EISEIKAI Medical and ... ...

Abstract	The aim of this study was to evaluate the antibody reaction after administration of the BNT162b2 vaccine, and to reveal the factors that affect antibody production. This prospective study was carried out in the Association of EISEIKAI Medical and Healthcare Corporation Minamitama Hospital, in Tokyo, Japan, from April 15, 2021 to June 09, 2021. All our hospital's workers who were administered the BNT162b2 vaccine as part of a routine program were included in this study. We calculated the anti-SARS-CoV-2 spike-specific antibody titter (1) before vaccination, (2) 7 to 20 days after the first vaccination, and (3) A total of 7 to 20 days after the second vaccination. The low-antibody titer group (LABG) was defined as the group having less than 25 percentiles of antibody titer. Univariate and Multivariate logistic regression analysis were performed to ascertain the effects of factors on the likelihood of LABG. A total of 374 participants were eventually included in our study, and they were divided into 94 LABG and 280 non-LABG. All samples showed significant antibody elevation in the second antibody test, with a mean value of 3,476 U/mL. When comparing the LABG and non-LABG groups, the median age, blood sugar, and HbA1c were significantly higher in the LABG group. The rates of participants with low BMI (<18.5) and high BMI (>30) were significantly higher in the LABG group. The proportion of chronic lung disease, hypertension, diabetes, dyslipidemia, autoimmune disease, and cancer were significantly higher in the LABG group. Although there was no significant difference confirmed with respect to the exercise hours per day, the proportion of participants that did not perform outdoor exercises was significantly higher in the LABG group. The time interval between the second vaccination and the second antibody test, and between the first and the second vaccination was significantly longer in the non-LABG group. In the multivariate logistic regression analysis, older than 60 years, the past history of hypertension, HbA1c higher than 6.5%, and lack of outdoor exercises were significant suppressors of antibody responses, whereas the length of days from the first to the second vaccination longer than 25 days promoted a significant antibody response. Again, our single-center study demonstrates that older than 60 years, hypertension, HbA1c higher than 6.5%, and lack of outdoor exercises were significant suppressors of antibody responses, whereas the length of days from the first to the second vaccination longer than 25 days promoted a significant antibody response. Evidence from multi-center studies is needed to develop further vaccination strategies.
Language	English
Publishing date	2021-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.12316
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Article ; Online: The evaluation of factors affecting antibody response after administration of the BNT162b2 vaccine: A prospective study in Japan

Mitsunaga, Toshiya / Ohtaki, Yuhei / Seki, Yutaka / Yoshioka, Masakata / Mori, Hiroshi / Suzuka, Midori / Mashiko, Syunsuke / Takeda, Satoshi / Mashiko, Kunihiro

medRxiv

Abstract	The aim of this study was to evaluate the antibody reaction after administration of the BNT162b2 vaccine, and to reveal the factors that affect antibody production. This prospective study was carried out in the Association of EISEIKAI Medical and Healthcare Corporation Minamitama Hospital, in Tokyo, Japan, from April 15, 2021 to June 09, 2021. All our hospital9s workers who were administered the BNT162b2 vaccine as part of a routine program were included in this study. We calculated the anti-SARS-CoV-2 spike-specific antibody titter 1) before vaccination, 2) seven to twenty days after the first vaccination, and 3) seven to twenty days after the second vaccination. The low-antibody titer group (LABG) was defined as the group having less than 25 percentiles of antibody titer. Univariate and Multivariate logistic regression analysis were performed to ascertain the effects of factors on the likelihood of LABG. 374 participants were eventually included in our study, and they were divided into 94 LABG and 280 non-LABG. All samples showed significant antibody elevation in the second antibody test, with a mean value of 3476 U/mL. When comparing the LABG and non-LABG groups, the median age, blood sugar, and HbA1c were significantly higher in the LABG group. The rates of participants with low BMI (<18.5) and high BMI (>30) were significantly higher in the LABG group. The proportion of chronic lung disease, hypertension, diabetes, dyslipidemia, autoimmune disease, and cancer were significantly higher in the LABG group. Although there was no significant difference confirmed with respect to the exercise hours per day, the proportion of participants that did not perform outdoor activities was significantly higher in the LABG group. The time interval between the second vaccination and the second antibody test, and between the first and the second vaccination was significantly longer in the non-LABG group. Our logistic regression analysis revealed that the age, obesity, hypertension, diabetes, dyslipidemia, antihypertensive drug, antilipid drug, γ-GT, BS, HbA1c, and lack of outdoor activity were significant suppressors of antibody reaction, whereas maintaining the appropriate time interval between the first and the second vaccination could promote a significant antibody response. In the multivariate logistic regression analysis, age, obesity, and lack of outdoor activities were significant suppressors of antibody reaction, whereas the length of days from the first to the second vaccination promoted a significant antibody response. Our single-center study demonstrates that age, obesity, and lack of outdoor activities were significant suppressors of antibody response, whereas maintaining the appropriate time interval between the first and the second vaccination could promote a significant antibody response. Evidence from multi-center studies is needed to develop further vaccination strategies.
Keywords	covid19
Language	English
Publishing date	2021-06-27
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.06.20.21259177
Database	COVID19

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Article ; Online: Evaluation of the antibody response and adverse reactions of the BNT162b2 vaccine of participants with prior COVID-19 infection in Japan

Mitsunaga, Toshiya / Ohtaki, Yuhei / Seki, Yutaka / Yoshioka, Masakata / Mori, Hiroshi / Suzuka, Midori / Mashiko, Syunsuke / Takeda, Satoshi / Mashiko, Kunihiro

medRxiv

Abstract: Objective Vaccination programs are important to preventing COVID-19 infection. BNT162b2 is new type of vaccine, and previous studies have shown that the antibody response was significantly elevated in patients with prior COVID-19 infection after the ... ...

Abstract	Objective Vaccination programs are important to preventing COVID-19 infection. BNT162b2 is new type of vaccine, and previous studies have shown that the antibody response was significantly elevated in patients with prior COVID-19 infection after the first dose of BNT162b2 vaccination. However, no study has evaluated the efficacy of the vaccination or the adverse reactions of people with prior COVID-19 infection in Japan. The aim of this study is to evaluate the antibody titer and adverse reactions of BNT162b2 vaccine among participants with prior COVID-19 infection in Japan. Methods The data for this prospective study was collected between April 15, 2021, and June 9, 2021. All of the hospital staff who received the BNT162b2 vaccine were included in this study and were sorted into either the prior infection group or the control group. We collected the data of adverse reactions through self-reporting and calculated the anti-SARS-CoV-2 spike-specific antibody titer for all participants. Results The antibody titer of the prior-infection group in first antibody test was significantly higher than that of the control group in the second antibody test. There was no significant difference in adverse reactions between the prior infection group receiving its first vaccination and the control group receiving its second vaccination. Furthermore, the history of prior infection was not related to local and systemic adverse reactions in the multivariate logistic regression analysis. Conclusion Our study shows that the antibody response following the first vaccination in the prior COVID-19 infection group was found to be comparable to that of the second vaccination in the control group; however, the evaluation of adverse reactions was inadequate and further, large-scale studies are needed.
Keywords	covid19
Language	English
Publishing date	2021-07-22
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.07.18.21260579
Database	COVID19

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Article ; Online: Morphological evaluation of areas of damage in blunt cardiac injury and investigation of traffic accident research.

Kutsukata, Noriyoshi / Sakamoto, Yuichiro / Mashiko, Kunihiro / Ochi, Masami

General thoracic and cardiovascular surgery

2012 Volume 60, Issue 1, Page(s) 31–35

Abstract: Purpose: This study investigated the relation between the cause of blunt cardiac injury and areas of damage. For the purpose of injury prevention, we also examined traffic accident cases in a micro study using engineering-based medicine.: Methods: ... ...

Abstract	Purpose: This study investigated the relation between the cause of blunt cardiac injury and areas of damage. For the purpose of injury prevention, we also examined traffic accident cases in a micro study using engineering-based medicine. Methods: Among the 2673 patients transported to our facility within the 15-month period from February 2009 to April 2010, there were 12 cases of cardiac perforation. We studied these cases anatomically to evaluate the morphology of the damaged cardiac areas. We conducted a detailed micro-study in two cases regarding the circumstances surrounding the traffic accident and the vehicular damage. Results: Subjects were nine men (mean age 64 years). The mean Injury Severity Score was 54.0 ± 19.6, and the probability of survival was 0.147. The actual survival rate was 16.7% (2 survivors, 10 deaths). Lesion sites in the 12 cases (21 sites in total) were the right atrium in 8 cases, superior and inferior vena cava in 5 cases, right ventricle in 4 cases, pulmonary artery and left atrium in 1 case each, and pulmonary vein in 2 cases, excluding the left ventricle and ascending aorta. In three cases, the aortic isthmus was also injured. Conclusion: Blunt cardiac injury was more common on the right side chamber. The survival rate was extremely close to the calculated survival probability. Proper seatbelt usage is important for the prevention of blunt cardiac injury due to traffic accidents. Increased severity of injury may be associated with accidents involving light motor vehicles.
MeSH term(s)	Accidents, Traffic/mortality ; Accidents, Traffic/prevention & control ; Aged ; Aged, 80 and over ; Female ; Heart Atria/injuries ; Heart Atria/pathology ; Heart Injuries/diagnosis ; Heart Injuries/etiology ; Heart Injuries/mortality ; Heart Injuries/pathology ; Heart Injuries/prevention & control ; Heart Ventricles/injuries ; Heart Ventricles/pathology ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Pulmonary Artery/injuries ; Pulmonary Artery/pathology ; Pulmonary Veins/injuries ; Pulmonary Veins/pathology ; Seat Belts ; Severity of Illness Index ; Survival Rate ; Vena Cava, Inferior/injuries ; Vena Cava, Inferior/pathology ; Vena Cava, Superior/injuries ; Vena Cava, Superior/pathology ; Wounds, Nonpenetrating/diagnosis ; Wounds, Nonpenetrating/etiology ; Wounds, Nonpenetrating/mortality ; Wounds, Nonpenetrating/pathology ; Wounds, Nonpenetrating/prevention & control
Language	English
Publishing date	2012-01-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2376888-5
ISSN	1863-6713 ; 1863-6705
ISSN (online)	1863-6713
ISSN	1863-6705
DOI	10.1007/s11748-011-0853-6
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