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  1. Article ; Online: Curative intent therapy for DLBCL in the elderly.

    Tucci, Alessandra / Masina, Lorenzo / Luminari, Stefano

    Leukemia & lymphoma

    2024  Volume 65, Issue 5, Page(s) 560–569

    Abstract: Older patients with aggressive lymphoma are extremely heterogeneous due to the high frequency of functional limitations and comorbidities and to the different biological profiles and clinical behavior of the disease. The stratification in three geriatric ...

    Abstract Older patients with aggressive lymphoma are extremely heterogeneous due to the high frequency of functional limitations and comorbidities and to the different biological profiles and clinical behavior of the disease. The stratification in three geriatric categories (fit-unfit-frail) based on multidimensional geriatric assessment (GA) helps physicians tailor a potentially curative treatment.While an intensive approach with the standard R-CHOP regimen is feasible in fit patients, leading to similar long-term response and survival rates compared to younger ones, in unfit patients a balance between treatment toxicity and curative intent can be obtained through the reduction of dose intensity. Frail patients, treated with best supportive care so far, could benefit from a chemo-free approach with new target drugs. These novel agents, either alone or in combination with chemo-immunotherapy, are changing the therapeutic landscape of older patients with aggressive lymphoma, both in first-line therapy and in the setting of the relapsed/refractory disease.
    MeSH term(s) Humans ; Age Factors ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Combined Modality Therapy/adverse effects ; Combined Modality Therapy/methods ; Disease Management ; Geriatric Assessment ; Lymphoma, Large B-Cell, Diffuse/therapy ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/mortality ; Prognosis ; Treatment Outcome
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2024.2302323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: High mortality in fully vaccinated hematologic patients treated with anti-CD20 antibodies during the "Omicron wave" of COVID-19 pandemic.

    Cattaneo, Chiara / Masina, Lorenzo / Pagani, Chiara / Cancelli, Valeria / Daffini, Rosa / Tucci, Alessandra / Rossi, Giuseppe

    Hematological oncology

    2022  Volume 41, Issue 1, Page(s) 205–207

    MeSH term(s) Humans ; COVID-19 ; Pandemics
    Language English
    Publishing date 2022-08-19
    Publishing country England
    Document type Letter
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.3064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1816: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Myeloid neoplasm occurrence during stable molecular remission of NPM1-mutated AML: are we facing secondary disease or AML relapse?

    Giupponi, Carlotta / Bertoli, Diego / Borlenghi, Erika / Cattaneo, Chiara / Zollner, Tatiana / Masina, Lorenzo / Bagnasco, Samuele / Cerqui, Elisa / Federico, Francesca / Pagani, Chiara / Archetti, Silvana / Brugnoni, Duilio / Rossi, Giuseppe / Tucci, Alessandra

    Blood cancer journal

    2023  Volume 13, Issue 1, Page(s) 194

    MeSH term(s) Humans ; Neoplasm Recurrence, Local/genetics ; Nuclear Proteins/genetics ; Nucleophosmin ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/genetics ; Mutation ; Prognosis
    Chemical Substances Nuclear Proteins ; Nucleophosmin (117896-08-9)
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Letter
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-023-00959-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19 does not impact on outcome of myeloma patients infected while undergoing autologous stem cell transplantation.

    Masina, Lorenzo / Bianchetti, Nicola / Passi, Angela / Bottelli, Chiara / Bagnasco, Samuele / Spolzino, Angelica / Oberti, Margherita / Chiarini, Marco / Belotti, Angelo / Voltolini, Simone / Faglioni, Laura / Rossi, Giuseppe / Tucci, Alessandra / Cattaneo, Chiara

    Hematological oncology

    2023  Volume 41, Issue 3, Page(s) 555–558

    Abstract: Here we report two cases of myeloma patients who became positive for SARS-CoV-2 infection during the acute phase of autologous stem cell transplant. Both patients were promptly treated with monoclonal antibodies and remdesivir, and, despite the profound ... ...

    Abstract Here we report two cases of myeloma patients who became positive for SARS-CoV-2 infection during the acute phase of autologous stem cell transplant. Both patients were promptly treated with monoclonal antibodies and remdesivir, and, despite the profound neutropenia and lymphopenia, they did not develop respiratory failure and they remained paucisymptomatic during the entire period of aplasia. Neutrophil engraftment took place as expected and the patients were discharged quickly and did not experience adverse effects after discharge.
    MeSH term(s) Humans ; Multiple Myeloma/complications ; Multiple Myeloma/therapy ; Hematopoietic Stem Cell Transplantation ; COVID-19/complications ; SARS-CoV-2 ; Transplantation, Autologous
    Language English
    Publishing date 2023-02-17
    Publishing country England
    Document type Case Reports
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.3127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1816: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Results of an Innovative Program for Surveillance, Prophylaxis, and Treatment of Infectious Complications Following Allogeneic Stem Cell Transplantation in Hematological Malignancies (BATMO Protocol).

    Malagola, Michele / Turra, Alessandro / Signorini, Liana / Corbellini, Silvia / Polverelli, Nicola / Masina, Lorenzo / Del Fabro, Giovanni / Lorenzotti, Silvia / Fumarola, Benedetta / Farina, Mirko / Morello, Enrico / Radici, Vera / Buttini, Eugenia Accorsi / Colnaghi, Federica / Bernardi, Simona / Re, Federica / Caruso, Arnaldo / Castelli, Francesco / Russo, Domenico

    Frontiers in oncology

    2022  Volume 12, Page(s) 874117

    Abstract: Background: Infectious complications are a significant cause of morbidity and mortality in patients undergoing allogeneic haematopoietic stem cell transplantation (Allo-SCT). The BATMO (Best-Antimicrobial-Therapy-TMO) is an innovative program for ... ...

    Abstract Background: Infectious complications are a significant cause of morbidity and mortality in patients undergoing allogeneic haematopoietic stem cell transplantation (Allo-SCT). The BATMO (Best-Antimicrobial-Therapy-TMO) is an innovative program for infection prevention and management and has been used in our centre since 2019. The specific features of the BATMO protocol regard both prophylaxis during neutropenia (abandonment of fluoroquinolone, posaconazole use in high-risk patients, aerosolized liposomal amphotericin B use until engraftment or a need for antifungal treatment, and letermovir use in CMV-positive recipients from day 0 to day +100) and therapy (empirical antibiotics based on patient clinical history and colonization, new antibiotics used in second-line according to antibiogram with the exception of carbapenemase-producing
    Methods: Data on the infectious complications of 116 transplant patients before BATMO protocol (Cohort A; 2016 - 2018) were compared to those of 84 transplant patients following the introduction of the BATMO protocol (Cohort B; 2019 - 2021). The clinical and transplant characteristics of the 2 Cohorts were comparable, even though patients in Cohort B were at a higher risk of developing bacterial, fungal, and CMV infections, due to a significantly higher proportion of myeloablative regimens and haploidentical donors.
    Results: No change in the incidence of infections with organ localization was observed between the two Cohorts. A significant reduction in
    Discussion: The results of this study suggest that the BATMO program is safe. In particular, the choice to avoid prophylaxis with fluoroquinolone was associated with an increase in Gram-negative BSIs by day +30, but this did not translate into higher levels of mortality. Moreover, this strategy was associated with a significant reduction of
    Language English
    Publishing date 2022-06-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.874117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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