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Article: Prehospital use of the intubating laryngeal mask airway in patients with severe polytrauma: a case series.

Mason, Andrew M

2009 Volume 2009, Page(s) 938531

Abstract: A case series of five patients is described demonstrating the utility of the intubating laryngeal mask airway in the prehospital setting, both as a primary airway rescue device and as a bridge to tracheal intubation. All patients were hypoxaemic, had ... ...

Abstract	A case series of five patients is described demonstrating the utility of the intubating laryngeal mask airway in the prehospital setting, both as a primary airway rescue device and as a bridge to tracheal intubation. All patients were hypoxaemic, had sustained severe polytrauma and were trapped in their vehicles following road traffic collisions. A probability of survival study showed better-than-predicted outcomes for the group as a whole.
Language	English
Publishing date	2009-06-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2502642-2
ISSN	1687-9635 ; 1687-9627
ISSN (online)	1687-9635
ISSN	1687-9627
DOI	10.1155/2009/938531
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A reappraisal of the Ni-[(Benzylprolyl)amino]benzophenone complex in the synthesis of α,α-disubstituted amino acid derivatives

Watson, Morag E / Jamieson, Craig / Kennedy, Alan R / Mason, Andrew M

Tetrahedron. 2019 July 26,

2019

Abstract: α,α-Disubstituted alkenyl amino acid derivatives (e.g. Fmoc-S5-OH) are valuable monomers in the construction of stapled peptide derivatives. Synthetic access to these is possible using the Ni-[(Benzylprolyl)amino]benzophenone (BPB) complex as a chiral ... ...

Abstract	α,α-Disubstituted alkenyl amino acid derivatives (e.g. Fmoc-S5-OH) are valuable monomers in the construction of stapled peptide derivatives. Synthetic access to these is possible using the Ni-[(Benzylprolyl)amino]benzophenone (BPB) complex as a chiral auxiliary. We discuss a reappraisal of the use of this, and demonstrate that epimerisation of the proline α-centre occurs during formation of the complex, leading to erosion in the enantiomeric excess of the final product. Modified conditions have been developed, providing the target compounds in high enantiomeric excess.
Keywords	amino acid derivatives ; benzophenones ; chemical reactions ; chemical structure ; nickel ; peptides ; proline
Language	English
Dates of publication	2019-0726
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	204285-x
ISSN	1464-5416 ; 0040-4020 ; 0563-2064
ISSN (online)	1464-5416
ISSN	0040-4020 ; 0563-2064
DOI	10.1016/j.tet.2019.130485
Database	NAL-Catalogue (AGRICOLA)

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Zs.B 1076: Show issues

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Article ; Online: Counting angels.

Mason, Andrew M

Emergency medicine journal : EMJ

2007 Volume 24, Issue 4, Page(s) 311

MeSH term(s)	Age Factors ; Airway Obstruction/therapy ; Child ; Child, Preschool ; Emergencies ; Emergency Medical Services/methods ; Equipment Design ; Guideline Adherence ; Humans ; Infant ; Infant, Newborn ; Intubation, Intratracheal/instrumentation ; Intubation, Intratracheal/methods ; Practice Guidelines as Topic
Language	English
Publishing date	2007-04
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emj.2007.046540
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Article ; Online: Kernel Methods for Predicting Yields of Chemical Reactions.

Haywood, Alexe L / Redshaw, Joseph / Hanson-Heine, Magnus W D / Taylor, Adam / Brown, Alex / Mason, Andrew M / Gärtner, Thomas / Hirst, Jonathan D

Journal of chemical information and modeling

2021 Volume 62, Issue 9, Page(s) 2077–2092

Abstract: The use of machine learning methods for the prediction of reaction yield is an emerging area. We demonstrate the applicability of support vector regression (SVR) for predicting reaction yields, using combinatorial data. Molecular descriptors used in ... ...

Abstract	The use of machine learning methods for the prediction of reaction yield is an emerging area. We demonstrate the applicability of support vector regression (SVR) for predicting reaction yields, using combinatorial data. Molecular descriptors used in regression tasks related to chemical reactivity have often been based on time-consuming, computationally demanding quantum chemical calculations, usually density functional theory. Structure-based descriptors (molecular fingerprints and molecular graphs) are quicker and easier to calculate and are applicable to any molecule. In this study, SVR models built on structure-based descriptors were compared to models built on quantum chemical descriptors. The models were evaluated along the dimension of each reaction component in a set of Buchwald-Hartwig amination reactions. The structure-based SVR models outperformed the quantum chemical SVR models, along the dimension of each reaction component. The applicability of the models was assessed with respect to similarity to training. Prospective predictions of unseen Buchwald-Hartwig reactions are presented for synthetic assessment, to validate the generalizability of the models, with particular interest along the aryl halide dimension.
MeSH term(s)	Machine Learning ; Prospective Studies
Language	English
Publishing date	2021-10-26
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	190019-5
ISSN	1549-960X ; 0095-2338
ISSN (online)	1549-960X
ISSN	0095-2338
DOI	10.1021/acs.jcim.1c00699
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Article ; Online: Synthesis of 6-substituted-4-hydroxy-2-pyridinones via intramolecular ketene trapping of functionalized enamine-dioxinones.

Patel, Bhavesh H / Mason, Andrew M / Barrett, Anthony G M

Organic letters

2011 Volume 13, Issue 19, Page(s) 5156–5159

Abstract: The synthesis of various 6-substituted-4-hydroxy-2-pyridinones is reported. The functionalized keto-dioxinones were constructed via a diethylzinc mediated crossed Claisen condensation reaction and subsequent enamine formation, thermolysis, and ... ...

Abstract	The synthesis of various 6-substituted-4-hydroxy-2-pyridinones is reported. The functionalized keto-dioxinones were constructed via a diethylzinc mediated crossed Claisen condensation reaction and subsequent enamine formation, thermolysis, and cyclization-aromatization providing the pyridinone unit.
MeSH term(s)	Cyclization ; Ethylenes/chemistry ; Hydroxylation ; Ketones/chemistry ; Molecular Structure ; Oxyquinoline/chemistry ; Pyridones/chemical synthesis ; Stereoisomerism
Chemical Substances	Ethylenes ; Ketones ; Pyridones ; Oxyquinoline (5UTX5635HP) ; ketene (LEP3SM032A)
Language	English
Publishing date	2011-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/ol202028t
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Article: Efficient two directional syntheses of a homophthalate ester and novel resorcylate oligomers

Patel, Bhavesh H / Heath, Scott F.A / Mason, Andrew M / Barrett, Anthony G.M

Tetrahedron letters. 2011 Apr. 27, v. 52, no. 17

2011

Abstract: Thermolysis of 6,6′-(2-oxopropane-1,3-diyl)bis(2,2-dimethyl-4H-1,3-dioxin-4-one) in the presence of methanol gave a triketo-ester which subsequently aromatized to provide a synthetically useful homophthalate ester. Enolate C-acylation in the presence of ... ...

Abstract	Thermolysis of 6,6′-(2-oxopropane-1,3-diyl)bis(2,2-dimethyl-4H-1,3-dioxin-4-one) in the presence of methanol gave a triketo-ester which subsequently aromatized to provide a synthetically useful homophthalate ester. Enolate C-acylation in the presence of diethylzinc was used to synthesize other double diketo-dioxinones, which on cyclization, aromatization and dioxinone ring opening gave novel double resorcylate derivatives.
Keywords	chemical structure ; methanol ; thermal degradation
Language	English
Dates of publication	2011-0427
Size	p. 2258-2261.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	204287-3
ISSN	1873-3581 ; 0040-4039
ISSN (online)	1873-3581
ISSN	0040-4039
DOI	10.1016/j.tetlet.2011.01.100
Database	NAL-Catalogue (AGRICOLA)

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Article: Rescue ventilation: resolving a "cannot mask ventilate, cannot intubate" situation during exchange of a Combitube for a definitive airway.

Rich, James M / Mason, Andrew M / Tillmann, H A / Foreman, Michael

AANA journal

2009 Volume 77, Issue 5, Page(s) 339–342

Abstract: Our anesthesia care team was called to care for a patient who was admitted to the emergency department with the esophageal-tracheal double-lumen airway device (Combitube, Tyco Healthcare, Nellcor, Pleasanton, California) in place, which needed to be ... ...

Abstract	Our anesthesia care team was called to care for a patient who was admitted to the emergency department with the esophageal-tracheal double-lumen airway device (Combitube, Tyco Healthcare, Nellcor, Pleasanton, California) in place, which needed to be exchanged for a definitive airway because the patient required an extended period of mechanical ventilation. Several techniques were attempted to exchange the esophageal-tracheal Combitube (ETC) without success. First, we attempted direct laryngoscopy with the ETC in place after deflation of the No. 1 proximal cuff and sweeping the ETC to the left. We were prepared to use bougie-assisted intubation but could not identify any airway anatomy. After removal of the ETC, we unsuccessfully attempted ventilation/intubation with a laryngeal mask airway (LMA Fastrach, LMA North America, San Diego, California). Our third attempt was insertion of another laryngeal mask airway (LMA Unique, LMA North America) with marginal ventilation, but we again experienced unsuccessful intubation using a fiberscope. The ETC was reinserted after each intubation attempt because mask ventilation was impossible. Before proceeding with cricothyrotomy, we repeated direct laryngoscopy but without the ETC in place. We identified the tip of the epiglottis, which allowed for bougie-assisted intubation. This obviated the need for emergency cricothyrotomy.
MeSH term(s)	Emergencies/nursing ; Emergency Treatment/methods ; Emergency Treatment/nursing ; Epiglottis/anatomy & histology ; Equipment Design ; Equipment Failure ; Hematoma, Subdural/complications ; Hematoma, Subdural/therapy ; Humans ; Intubation, Intratracheal/instrumentation ; Intubation, Intratracheal/methods ; Intubation, Intratracheal/nursing ; Laryngeal Masks ; Laryngeal Muscles/surgery ; Laryngoscopy/methods ; Laryngoscopy/nursing ; Male ; Middle Aged ; Nurse Anesthetists ; Nursing Assessment/methods ; Obesity, Morbid/complications ; Respiration, Artificial/instrumentation ; Syringes ; Unconsciousness/complications ; Unconsciousness/therapy
Language	English
Publishing date	2009-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	603605-3
ISSN	0094-6354
ISSN	0094-6354
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Zs.A 1286: Show issues

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Article ; Online: MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo-allergic and anaphylactoid reactions.

Grimes, Jak / Desai, Sapna / Charter, Neil W / Lodge, James / Moita Santos, Rita / Isidro-Llobet, Albert / Mason, Andrew M / Wu, Zining / Wolfe, Lawrence A / Anantharaman, Lakshmi / Green, Andrew / Bridges, Angela M / Dalmas Wilk, Deidre A / Brown, Andrew J

Pharmacology research & perspectives

2019 Volume 7, Issue 6, Page(s) e00547

Abstract: Activation of MrgX2, an orphan G protein-coupled receptor expressed on mast cells, leads to degranulation and histamine release. Human MrgX2 binds promiscuously to structurally diverse peptides and small molecules that tend to have basic properties ( ... ...

Abstract	Activation of MrgX2, an orphan G protein-coupled receptor expressed on mast cells, leads to degranulation and histamine release. Human MrgX2 binds promiscuously to structurally diverse peptides and small molecules that tend to have basic properties (basic secretagogues), resulting in acute histamine-like adverse drug reactions of injected therapeutic agents. We set out to identify MrgX2 orthologues from other mammalian species used in nonclinical stages of drug development. Previously, the only known orthologue of human MrgX2 was from mouse, encoded by
MeSH term(s)	Anaphylaxis/chemically induced ; Anaphylaxis/immunology ; Animals ; Cell Degranulation/drug effects ; Cell Degranulation/immunology ; Cell Line, Tumor ; Cell-Penetrating Peptides/administration & dosage ; Cell-Penetrating Peptides/adverse effects ; Disease Models, Animal ; Drug Evaluation, Preclinical/adverse effects ; HEK293 Cells ; Histone-Lysine N-Methyltransferase/antagonists & inhibitors ; Humans ; Mast Cells/drug effects ; Mast Cells/immunology ; Mast Cells/metabolism ; Nerve Tissue Proteins/agonists ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/immunology ; Nerve Tissue Proteins/metabolism ; Peptide Fragments/administration & dosage ; Peptide Fragments/adverse effects ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/immunology ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Neuropeptide/agonists ; Receptors, Neuropeptide/genetics ; Receptors, Neuropeptide/immunology ; Receptors, Neuropeptide/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Recombinant Proteins/metabolism ; Syndrome ; Vancomycin/administration & dosage ; Vancomycin/adverse effects ; p-Methoxy-N-methylphenethylamine/pharmacology
Chemical Substances	Cell-Penetrating Peptides ; MRGPRX2 protein, human ; Nerve Tissue Proteins ; Peptide Fragments ; Receptors, G-Protein-Coupled ; Receptors, Neuropeptide ; Recombinant Proteins ; p-Methoxy-N-methylphenethylamine (4091-50-3) ; Vancomycin (6Q205EH1VU) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43)
Language	English
Publishing date	2019-12-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2740389-0
ISSN	2052-1707 ; 2052-1707
ISSN (online)	2052-1707
ISSN	2052-1707
DOI	10.1002/prp2.547
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Article: AANA journal course: update for nurse anesthetists. The SLAM Emergency Airway Flowchart: a new guide for advanced airway practitioners.

Rich, James M / Mason, Andrew M / Ramsay, Michael A E

AANA journal

2004 Volume 72, Issue 6, Page(s) 431–439

Abstract: Advanced airway practitioners in anesthesiology, emergency medicine, and prehospital care can suddenly and unexpectedly face difficult airway situations that can surface without warning during mask ventilation or tracheal intubation. Although tracheal ... ...

Abstract	Advanced airway practitioners in anesthesiology, emergency medicine, and prehospital care can suddenly and unexpectedly face difficult airway situations that can surface without warning during mask ventilation or tracheal intubation. Although tracheal intubation remains the "gold standard" in airway management, it is not always achievable, and, when it proves impossible, appropriate alternative interventions must be used rapidly to avoid serious morbidity or mortality. The SLAM Emergency Airway Flowchart (SEAF) is intended to prevent the 3 reported primary causes of adverse respiratory events (ie, inadequate ventilation, undetected esophageal intubation, and difficult intubation). The 5 pathways of the SEAF include primary ventilation, rapid-sequence intubation, difficult intubation, rescue ventilation, and cricothyrotomy. It is intended for use with adult patients by advanced airway practitioners competent in direct laryngoscopy, tracheal intubation, administration of airway drugs, rescue ventilation, and cricothyrotomy. The SEAF has limitations (eg, suitable only for use with adult patients, cannot be used by certain categories of rescue personnel, and depends heavily on assessment of Spo2). A unique benefit is provision of simple alternative techniques that can be used when another technique fails.
MeSH term(s)	Algorithms ; Blood Gas Analysis ; Decision Trees ; Emergencies ; Equipment Failure ; Evidence-Based Medicine ; Glasgow Coma Scale ; Humans ; Intubation, Intratracheal/adverse effects ; Intubation, Intratracheal/methods ; Intubation, Intratracheal/nursing ; Laryngeal Masks ; Laryngoscopy ; Nurse Anesthetists/education ; Nurse Anesthetists/organization & administration ; Nursing Assessment/methods ; Patient Selection ; Respiration, Artificial/adverse effects ; Respiration, Artificial/methods ; Respiration, Artificial/nursing ; Resuscitation/adverse effects ; Resuscitation/methods ; Resuscitation/nursing
Language	English
Publishing date	2004-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603605-3
ISSN	0094-6354
ISSN	0094-6354
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Article ; Online: Design and Application of a DNA-Encoded Macrocyclic Peptide Library.

Zhu, Zhengrong / Shaginian, Alex / Grady, LaShadric C / O'Keeffe, Thomas / Shi, Xiangguo E / Davie, Christopher P / Simpson, Graham L / Messer, Jeffrey A / Evindar, Ghotas / Bream, Robert N / Thansandote, Praew P / Prentice, Naomi R / Mason, Andrew M / Pal, Sandeep

ACS chemical biology

2018 Volume 13, Issue 1, Page(s) 53–59

Abstract: A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × ... ...

Abstract	A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 10
MeSH term(s)	Amino Acids/chemistry ; DNA/chemistry ; Drug Evaluation, Preclinical/methods ; Molecular Targeted Therapy ; Peptide Library ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/genetics ; Peptides, Cyclic/pharmacology ; Polymerase Chain Reaction ; Respiratory Syncytial Viruses ; Viral Proteins/antagonists & inhibitors ; Viral Proteins/chemistry ; Viral Proteins/metabolism ; Von Hippel-Lindau Tumor Suppressor Protein/chemistry ; Von Hippel-Lindau Tumor Suppressor Protein/metabolism
Chemical Substances	Amino Acids ; Peptide Library ; Peptides, Cyclic ; Viral Proteins ; DNA (9007-49-2) ; Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27) ; VHL protein, human (EC 6.3.2.-)
Language	English
Publishing date	2018--19
Publishing country	United States
Document type	Journal Article
ISSN	1554-8937
ISSN (online)	1554-8937
DOI	10.1021/acschembio.7b00852
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