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  1. Article ; Online: A sobering addition to the literature on COVID-19 and the brain.

    Mahajan, Amit / Mason, Graeme F

    The Journal of clinical investigation

    2021  Volume 131, Issue 8

    Abstract: Several coronavirus disease 2019 (COVID-19) studies have focused on neuropathology. In this issue of the JCI, Qin, Wu, and Chen et al. focused specifically on people whose acute infection lacked obvious neurological involvement. Severely infected ... ...

    Abstract Several coronavirus disease 2019 (COVID-19) studies have focused on neuropathology. In this issue of the JCI, Qin, Wu, and Chen et al. focused specifically on people whose acute infection lacked obvious neurological involvement. Severely infected patients showed abnormal gray matter volumes, white matter diffusion, and cerebral blood flow compared with healthy controls and those with mild infection. The data remain associative rather than mechanistic, but correlations with systemic immune markers suggest effects of inflammation, hypercoagulation, or other aspects of disease severity. Mechanistic research is warranted. Given the lack of obvious neurological symptoms, neurocognitive assessments were not performed, but the findings suggest that such assessments may be warranted in severely affected patients, even without obvious symptoms. Further, studying CNS involvement of other disorders with overlapping pathophysiologies such as inflammation, coagulation, hypoxia, or direct viral infection may reveal the causes for COVID-19-related neuropathology.
    MeSH term(s) Brain/diagnostic imaging ; COVID-19 ; Cerebrovascular Circulation ; Humans ; Nervous System Diseases ; SARS-CoV-2
    Language English
    Publishing date 2021-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI148376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Novel approaches to estimate prefrontal synaptic strength in vivo in humans: of relevance to depression, schizophrenia, and ketamine.

    Abdallah, Chadi G / Mason, Graeme F

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2021  Volume 47, Issue 1, Page(s) 399–400

    MeSH term(s) Depression/drug therapy ; Humans ; Ketamine/pharmacology ; Prefrontal Cortex/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Schizophrenia/drug therapy
    Chemical Substances Receptors, N-Methyl-D-Aspartate ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2021-08-02
    Publishing country England
    Document type News ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-021-01122-2
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    Zs.A 2379: Show issues Location:
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  3. Article ; Online: Mapping Lithium in the Brain: New 3-Dimensional Methodology Reveals Regional Distribution in Euthymic Patients With Bipolar Disorder.

    Mason, Graeme F / Krystal, John H

    Biological psychiatry

    2020  Volume 88, Issue 5, Page(s) 367–368

    MeSH term(s) Bipolar Disorder/drug therapy ; Brain/diagnostic imaging ; Hippocampus ; Humans ; Lithium ; Magnetic Resonance Imaging
    Chemical Substances Lithium (9FN79X2M3F)
    Language English
    Publishing date 2020-08-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2020.05.023
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    Zs.A 720: Show issues Location:
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  4. Article ; Online: Measurement of neuro-energetics and neurotransmission in the rat olfactory bulb using

    Chowdhury, Golam M I / Behar, Kevin L / Mason, Graeme F / Rothman, Douglas L / de Graaf, Robin A

    NMR in biomedicine

    2023  , Page(s) e4957

    Abstract: The olfactory bulb (OB) plays a fundamental role in the sense of smell and has been implicated in several pathologies, including Alzheimer's disease. Despite its importance, high metabolic activity and unique laminar architecture, the OB is not ... ...

    Abstract The olfactory bulb (OB) plays a fundamental role in the sense of smell and has been implicated in several pathologies, including Alzheimer's disease. Despite its importance, high metabolic activity and unique laminar architecture, the OB is not frequently studied using MRS methods, likely due to the small size and challenging location. Here we present a detailed metabolic characterization of OB metabolism, in terms of both static metabolite concentrations using
    Language English
    Publishing date 2023-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.4957
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    Zs.A 2869: Show issues Location:
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  5. Article ; Online: Cortical GABA levels are reduced in young adult binge drinkers: Association with recent alcohol consumption and sex.

    Marinkovic, Ksenija / Alderson Myers, Austin B / Arienzo, Donatello / Sereno, Martin I / Mason, Graeme F

    NeuroImage. Clinical

    2022  Volume 35, Page(s) 103091

    Abstract: Binge drinking refers to a pattern of alcohol intake that raises blood alcohol concentration to or above legal intoxication levels. It is common among young adults and is associated with health risks that scale up with alcohol intake. Acute intoxication ... ...

    Abstract Binge drinking refers to a pattern of alcohol intake that raises blood alcohol concentration to or above legal intoxication levels. It is common among young adults and is associated with health risks that scale up with alcohol intake. Acute intoxication depresses neural activity via complex signaling mechanisms by enhancing inhibition mediated by gamma-amino butyric acid (GABA), and by decreasing excitatory glutamatergic effects. Evidence primarily rooted in animal research indicates that the brain compensates for the acute depressant effects under the conditions of habitual heavy use. These neuroadaptive changes are reflected in neural hyperexcitability via downregulated inhibitory signaling, which becomes apparent as withdrawal symptoms. However, human evidence on the compensatory reduction in GABA signaling is scant. The neurochemical aspect of this mechanistic model was evaluated in the present study with proton magnetic resonance spectroscopy (
    MeSH term(s) Alcohol Drinking ; Binge Drinking ; Blood Alcohol Content ; Brain ; Child, Preschool ; Ethanol ; Female ; Humans ; Male ; Young Adult ; gamma-Aminobutyric Acid
    Chemical Substances Blood Alcohol Content ; Ethanol (3K9958V90M) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2022-06-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2022.103091
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  6. Article ; Online: Biological embedding of early trauma: the role of higher prefrontal synaptic strength.

    Tamman, Amanda J F / Jiang, Lihong / Averill, Christopher L / Mason, Graeme F / Averill, Lynnette A / Abdallah, Chadi G

    European journal of psychotraumatology

    2023  Volume 14, Issue 2, Page(s) 2246338

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Female ; Male ; Pilot Projects ; Brain ; Emotions ; Glutamates ; Ketamine
    Chemical Substances Glutamates ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2586642-4
    ISSN 2000-8066 ; 2000-8066
    ISSN (online) 2000-8066
    ISSN 2000-8066
    DOI 10.1080/20008066.2023.2246338
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  7. Article: Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome.

    Marinkovic, Ksenija / White, David R / Alderson Myers, Austin / Parker, Katie S / Arienzo, Donatello / Mason, Graeme F

    Brain sciences

    2023  Volume 13, Issue 12

    Abstract: After recovering from the acute COVID-19 illness, a substantial proportion of people continue experiencing post-acute sequelae of COVID-19 (PASC), also termed "long COVID". Their quality of life is adversely impacted by persistent cognitive dysfunction ... ...

    Abstract After recovering from the acute COVID-19 illness, a substantial proportion of people continue experiencing post-acute sequelae of COVID-19 (PASC), also termed "long COVID". Their quality of life is adversely impacted by persistent cognitive dysfunction and affective distress, but the underlying neural mechanisms are poorly understood. The present study recruited a group of mostly young, previously healthy adults (24.4 ± 5.2 years of age) who experienced PASC for almost 6 months following a mild acute COVID-19 illness. Confirming prior evidence, they reported noticeable memory and attention deficits, brain fog, depression/anxiety, fatigue, and other symptoms potentially suggestive of excitation/inhibition imbalance. Proton magnetic resonance spectroscopy (
    Language English
    Publishing date 2023-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13121666
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  8. Article ; Online: Rates of pyruvate carboxylase, glutamate and GABA neurotransmitter cycling, and glucose oxidation in multiple brain regions of the awake rat using a combination of [2-

    McNair, Laura M / Mason, Graeme F / Chowdhury, Golam Mi / Jiang, Lihong / Ma, Xiaoxian / Rothman, Douglas L / Waagepetersen, Helle S / Behar, Kevin L

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2022  Volume 42, Issue 8, Page(s) 1507–1523

    Abstract: Anaplerosis occurs predominately in astroglia through the action of pyruvate carboxylase (PC). The rate of PC (Vpc) has been reported for cerebral cortex (or whole brain) of awake humans and anesthetized rodents, but regional brain rates remain largely ... ...

    Abstract Anaplerosis occurs predominately in astroglia through the action of pyruvate carboxylase (PC). The rate of PC (Vpc) has been reported for cerebral cortex (or whole brain) of awake humans and anesthetized rodents, but regional brain rates remain largely unknown and, hence, were subjected to investigation in the current study. Awake male rats were infused with either [2-
    MeSH term(s) Animals ; Brain/metabolism ; Carbon Isotopes/metabolism ; Glucose/metabolism ; Glutamic Acid/metabolism ; Glutamine/metabolism ; Male ; Neurons/metabolism ; Neurotransmitter Agents/metabolism ; Pyruvate Carboxylase/metabolism ; Rats ; Wakefulness ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Carbon Isotopes ; Neurotransmitter Agents ; Glutamine (0RH81L854J) ; Glutamic Acid (3KX376GY7L) ; gamma-Aminobutyric Acid (56-12-2) ; Pyruvate Carboxylase (EC 6.4.1.1) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X221074211
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    Zs.A 1663: Show issues Location:
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  9. Article ; Online: Q-Flux: A method to assess hepatic mitochondrial succinate dehydrogenase, methylmalonyl-CoA mutase, and glutaminase fluxes in vivo.

    Hubbard, Brandon T / LaMoia, Traci E / Goedeke, Leigh / Gaspar, Rafael C / Galsgaard, Katrine D / Kahn, Mario / Mason, Graeme F / Shulman, Gerald I

    Cell metabolism

    2022  Volume 35, Issue 1, Page(s) 212–226.e4

    Abstract: The mammalian succinate dehydrogenase (SDH) complex has recently been shown as capable of operating bidirectionally. Here, we develop a method (Q-Flux) capable of measuring absolute rates of both forward ( ... ...

    Abstract The mammalian succinate dehydrogenase (SDH) complex has recently been shown as capable of operating bidirectionally. Here, we develop a method (Q-Flux) capable of measuring absolute rates of both forward (V
    MeSH term(s) Animals ; Glucose/metabolism ; Glutaminase/metabolism ; Liver/metabolism ; Methylmalonyl-CoA Mutase/metabolism ; Proteins/metabolism ; Pyruvic Acid/metabolism ; Succinate Dehydrogenase/metabolism ; Rodentia
    Chemical Substances Glucose (IY9XDZ35W2) ; Glutaminase (EC 3.5.1.2) ; Methylmalonyl-CoA Mutase (EC 5.4.99.2) ; Proteins ; Pyruvic Acid (8558G7RUTR) ; Succinate Dehydrogenase (EC 1.3.99.1)
    Language English
    Publishing date 2022-12-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2022.11.011
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  10. Article: Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review.

    Woodcock, Eric A / Hillmer, Ansel T / Mason, Graeme F / Cosgrove, Kelly P

    Molecular neuropsychiatry

    2019  Volume 5, Issue 3, Page(s) 125–146

    Abstract: There is tremendous interest in the role of the neuroimmune system and inflammatory processes in substance use disorders (SUDs). Imaging biomarkers of the neuroimmune system in vivo provide a vital translational bridge between preclinical and clinical ... ...

    Abstract There is tremendous interest in the role of the neuroimmune system and inflammatory processes in substance use disorders (SUDs). Imaging biomarkers of the neuroimmune system in vivo provide a vital translational bridge between preclinical and clinical research. Herein, we examine two imaging techniques that measure putative indices of the neuroimmune system and review their application among SUDs. Positron emission tomography (PET) imaging of 18 kDa translocator protein availability is a marker associated with microglia. Proton magnetic resonance spectroscopy quantification of
    Language English
    Publishing date 2019-05-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2806946-8
    ISSN 2296-9179 ; 2296-9209
    ISSN (online) 2296-9179
    ISSN 2296-9209
    DOI 10.1159/000499621
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