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  1. Article: FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe.

    Jennings, Lucy / Walters, Heather Andrews / Mason, Jennifer M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: WEE1 kinase phosphorylates CDK1 and CDK2 to regulate origin firing and mitotic entry. Inhibition of WEE1 has become an attractive target for cancer therapy due to the simultaneous induction of replication stress and inhibition of the G2/M checkpoint. ... ...

    Abstract WEE1 kinase phosphorylates CDK1 and CDK2 to regulate origin firing and mitotic entry. Inhibition of WEE1 has become an attractive target for cancer therapy due to the simultaneous induction of replication stress and inhibition of the G2/M checkpoint. WEE1 inhibition in cancer cells with high levels of replication stress results in induction of replication catastrophe and mitotic catastrophe. To increase potential as a single agent chemotherapeutic, a better understanding of genetic alterations that impact cellular responses to WEE1 inhibition is warranted. Here, we investigate the impact of loss of the helicase, FBH1, on the cellular response to WEE1 inhibition. FBH1-deficient cells have a reduction in ssDNA and double strand break signaling indicating FBH1 is required for induction of replication stress response in cells treated with WEE1 inhibitors. Despite the defect in the replication stress response, FBH1-deficiency sensitizes cells to WEE1 inhibition by increasing mitotic catastrophe. We propose loss of FBH1 is resulting in replication-associated damage that requires the WEE1-dependent G2 checkpoint for repair.
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.15.540841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: UBC13-mediated template switching promotes replication stress resistance in FBH1-deficient cells.

    Hawks, Alexandra L / Bergmann, Amy / McCraw, Tyler J / Mason, Jennifer M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The proper resolution of DNA damage during replication is essential for genome stability. FBH1, a UvrD, helicase plays crucial roles in the DNA damage response. FBH1 promotes double strand break formation and signaling in response to prolonged ... ...

    Abstract The proper resolution of DNA damage during replication is essential for genome stability. FBH1, a UvrD, helicase plays crucial roles in the DNA damage response. FBH1 promotes double strand break formation and signaling in response to prolonged replication stress to initiate apoptosis. Human FBH1 regulates RAD51 to inhibit homologous recombination. A previous study suggested that mis-regulation of RAD51 may contribute to replication stress resistance in FBH1-deficient cells, but the underlying mechanism remains unknown. Here, we provide direct evidence that RAD51 promotes replication stress resistance in FBH1-deficient cells. We demonstrate inhibition of RAD51 using the small molecule, B02, partially rescues double strand break signaling in FBH1-deficient cells. We show that inhibition of only the strand exchange activity of RAD51 rescues double strand break signaling in FBH1 knockout cells. Finally, we show that depletion of UBC13, a E2 protein that promotes RAD51-dependent template switching, rescues double strand break formation and signaling sensitizing FBH1-deficient cells to replication stress. Our results suggest FBH1 regulates template switching to promote replication stress sensitivity.
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.04.556280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Turning the promise of multipurpose prevention technologies into a market reality: a commentary.

    Dam, Anita / Schueller, Jane / Peine, Kevin J / Mason, Jennifer / Dorward, Emily / Vij, Ashley

    Frontiers in reproductive health

    2023  Volume 5, Page(s) 1181043

    Abstract: The promise of multipurpose prevention technologies (MPTs) for the prevention of HIV and unintended pregnancy are on the horizon. While many are still in clinical development, others are closer to becoming a realistic, accessible option for users, like ... ...

    Abstract The promise of multipurpose prevention technologies (MPTs) for the prevention of HIV and unintended pregnancy are on the horizon. While many are still in clinical development, others are closer to becoming a realistic, accessible option for users, like the dual prevention pill (DPP). Researchers, governments, donors, and implementers will have to collaboratively address systemic challenges to successfully introduce and scale-up MPTs. To ensure the rollout of MPTs is successful, the global community should address user and country-specific needs, coordinate with advocates and policymakers, and set a realistic plan for product introduction and scale-up that considers the needs of both family planning (FP) and HIV programs, while laying the groundwork for future new product introduction. To achieve these aims, global and regional stakeholder coordination should emphasize country-led, person-centered decision-making while addressing: (1) procurement and supply chain barriers; (2) the potential burden on health systems; and (3) the impact on current programs.
    Language English
    Publishing date 2023-11-02
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3153
    ISSN (online) 2673-3153
    DOI 10.3389/frph.2023.1181043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe.

    Jennings, Lucy / Walters, Heather Andrews / McCraw, Tyler J / Turner, Joshua L / Mason, Jennifer M

    DNA repair

    2023  Volume 133, Page(s) 103611

    Abstract: WEE1 kinase phosphorylates CDK1 and CDK2 to regulate origin firing and mitotic entry. Inhibition of WEE1 has become an attractive target for cancer therapy due to the simultaneous induction of replication stress and inhibition of the G2/M checkpoint. ... ...

    Abstract WEE1 kinase phosphorylates CDK1 and CDK2 to regulate origin firing and mitotic entry. Inhibition of WEE1 has become an attractive target for cancer therapy due to the simultaneous induction of replication stress and inhibition of the G2/M checkpoint. WEE1 inhibition in cancer cells with high levels of replication stress results in induction of replication catastrophe and mitotic catastrophe. To increase potential as a single agent chemotherapeutic, a better understanding of genetic alterations that impact cellular responses to WEE1 inhibition is warranted. Here, we investigate the impact of loss of the helicase, FBH1, on the cellular response to WEE1 inhibition. FBH1-deficient cells have a reduction in ssDNA and double strand break signaling indicating FBH1 is required for induction of replication stress response in cells treated with WEE1 inhibitors. Despite the defect in the replication stress response, FBH1-deficiency sensitizes cells to WEE1 inhibition by increasing mitotic catastrophe. We propose loss of FBH1 is resulting in replication-associated damage that requires the WEE1-dependent G2 checkpoint for repair.
    MeSH term(s) Cell Cycle Proteins/metabolism ; DNA Helicases/metabolism ; Cell Death ; Signal Transduction ; Mitosis ; Cell Line, Tumor
    Chemical Substances Cell Cycle Proteins ; DNA Helicases (EC 3.6.4.-)
    Language English
    Publishing date 2023-12-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2023.103611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is group and save still a necessary test in the preoperative workup for breast cancer surgery?

    Batt, Jeremy / Chambers, Alice / Mason, Jennifer / Mullan, Michelle

    Journal of perioperative practice

    2020  Volume 31, Issue 5, Page(s) 187–190

    Abstract: Introduction: Trust guidelines state that patients undergoing mastectomy have one group and save (G&S) sample preoperatively, or two for bilateral or complex mastectomy. Breast surgical patients rarely require blood transfusion, and G&S testing is ... ...

    Abstract Introduction: Trust guidelines state that patients undergoing mastectomy have one group and save (G&S) sample preoperatively, or two for bilateral or complex mastectomy. Breast surgical patients rarely require blood transfusion, and G&S testing is costly and labour intensive. Our study assessed whether preoperative G&S testing is warranted for breast surgery patients.
    Methods: Retrospective review of consecutive patients undergoing mastectomies from one centre, from June 2018 to June 2019 identified 190 women. Review of electronic records for G&S tests was performed and transfusions prescribed. Discussion with laboratory personnel regarding costs of processing G&S tests.
    Results: Forty-six (32%) patients who underwent simple mastectomies had one G&S, eight (6%) patients had two. Twenty (45%) patients who underwent bilateral/complex mastectomy/reconstruction had one G&S and four (9%) had two. No patients required peri or postoperative blood transfusions. Seventy-eight G&S tests performed cost the trust £1,082.
    Conclusion: Simple mastectomies rarely require blood transfusions. G&S tests cost £13.83 and are time consuming for the patient and laboratory. We propose that G&S tests are unnecessary for patients undergoing simple mastectomies and preoperative protocols require adjustment. Trust policy is to have 'routine G&S'; however, 124 patients did not have any G&S testing. Had the guideline been followed, this would have cost the Trust a further £1,715.
    MeSH term(s) Blood Transfusion ; Breast Neoplasms/diagnosis ; Breast Neoplasms/surgery ; Female ; Humans ; Mastectomy ; Preoperative Care ; Retrospective Studies
    Language English
    Publishing date 2020-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2226186-2
    ISSN 2515-7949 ; 1750-4589
    ISSN (online) 2515-7949
    ISSN 1750-4589
    DOI 10.1177/1750458920925354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Looking ahead to a trauma service with COVID-19.

    Mason, Jennifer / West, Emily / Jackson, Phillipa

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2020  Volume 74, Issue 1, Page(s) 223–243

    MeSH term(s) Ambulatory Care Facilities ; COVID-19 ; Emergency Service, Hospital ; Humans ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-28
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2020.08.129
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  7. Book ; Online: Understanding social research

    Mason, Jennifer

    thinking creatively about method

    2011  

    Abstract: Focussing on three key areas in the social sciences, this book draws together contributors from a variety of areas who use a range of methodological approaches to present the reader with an inspirational guide to understanding and using methods and ... ...

    Author's details ed. by Jennifer Mason
    Abstract Focussing on three key areas in the social sciences, this book draws together contributors from a variety of areas who use a range of methodological approaches to present the reader with an inspirational guide to understanding and using methods and approaches in their research
    Language English
    Size Online-Ressource (265 p)
    Publisher SAGE Publications
    Publishing place London
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780857021366 ; 9780857021373 ; 9781283859004 ; 9781446209868 ; 9781848601444 ; 9781848601451 ; 0857021362 ; 0857021370 ; 1283859009 ; 1446209865 ; 1848601441 ; 184860145X
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Article ; Online: Shifting dynamics: Changes in the relationship between total fertility rate and contraceptive prevalence rate in Jordan between 2012 and 2017.

    Bietsch, Kristin / Arbaji, Ali / Mason, Jennifer / Rosenberg, Rebecca / Al Ouri, Malak

    Gates open research

    2021  Volume 4, Page(s) 160

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Journal Article
    ISSN 2572-4754
    ISSN (online) 2572-4754
    DOI 10.12688/gatesopenres.13188.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Chromosome ends as adaptive beginnings: the potential role of dysfunctional telomeres in subtelomeric evolvability.

    Mason, Jennifer M O / McEachern, Michael J

    Current genetics

    2018  Volume 64, Issue 5, Page(s) 997–1000

    Abstract: Telomeres serve as protective caps that help the cell differentiate between the naturally occurring ends of chromosomes and double-stranded breaks. When telomere capping function becomes compromised, chromosome ends are subjected to elevated rates of ... ...

    Abstract Telomeres serve as protective caps that help the cell differentiate between the naturally occurring ends of chromosomes and double-stranded breaks. When telomere capping function becomes compromised, chromosome ends are subjected to elevated rates of chromosome alterations. These effects can be particularly dramatic in the telomere-adjacent subtelomeric region. While the catastrophic impact of severe telomere dysfunction on genome stability has been well documented, the adaptive telomere failure hypothesis considers an alternative role telomere dysfunction may play in adaptive evolution. This hypothesis suggests that low levels of telomere failure, induced by certain environmental stresses, can lead to elevated subtelomeric recombination. Mutational loss, duplication, or modification of subtelomeric contingency genes could ultimately facilitate adaptation by generating novel mutants better able to survive environmental stress. In this perspective, we discuss recent work that examined mild telomere dysfunction and its role in altering the adaptive potential of subtelomeric genes.
    MeSH term(s) Chromosomes, Fungal ; DNA Breaks, Double-Stranded ; DNA Replication ; Evolution, Molecular ; Genomic Instability ; Mutation ; Saccharomyces cerevisiae/genetics ; Telomere/physiology
    Language English
    Publishing date 2018-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 282876-5
    ISSN 1432-0983 ; 0172-8083
    ISSN (online) 1432-0983
    ISSN 0172-8083
    DOI 10.1007/s00294-018-0822-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 2586: Show issues Location:
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  10. Article ; Online: Opportunities to strengthen integration of family planning into HIV platforms to achieve the UNAIDS 2030 fast-track targets.

    Okegbe, Tishina / Mason, Jennifer / Schueller, Jane / Muraleetharan, Ohvia / Vrazo, Alexandra / Traub, Ariana / Jansuk, Kandyang / Mathias, Selina

    AIDS (London, England)

    2022  Volume 36, Issue 15, Page(s) 2221–2224

    MeSH term(s) Humans ; Family Planning Services ; HIV Infections/prevention & control ; Acquired Immunodeficiency Syndrome/prevention & control
    Language English
    Publishing date 2022-08-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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