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  1. Article ; Online: Effect of Rivaroxaban in Stroke Prevention in Patient with Atrial Fibrillation due to Valvular Heart Disease

    Waqar shamim / Muhammad Rizwan / Rizwan Rasul Khan / Masood Javed / Nasir Mahmood / Kashif Nawaz

    Journal of Aziz Fatimah Medical and Dental College, Vol 4, Iss

    2022  Volume 1

    Abstract: Objective: To observe the effect of rivaroxaban in patients with atrial fibrillation due to valvular heart diseases for proper anticoagulation to avoid stroke. Methodology: An observational follow up study was carried out in Cardiology Department of Aziz ...

    Abstract Objective: To observe the effect of rivaroxaban in patients with atrial fibrillation due to valvular heart diseases for proper anticoagulation to avoid stroke. Methodology: An observational follow up study was carried out in Cardiology Department of Aziz Fatimah Hospital, Faisalabad from February to August 2021. The study included 36 patients of valvular heart disease with atrial fibrillation on warfarin, whose INR was not tested during the last 4 months due to lack of facility nearby. All patients with non valvular atrial fibrillation were excluded .All patients were given rivaroxaban to replace warfarin. These patients were followed up for 6 months in the OPD of the same hospital to observe the end points including stroke and bleeding episodes and ischemic changes on ECG. Results: Total of 36 patients of mean age and SD of 56±7.00 years were followed up. Out of which 20 were male and 16 were female subjects.Not a single incident of stroke or bleeding episode or bruises was observed during the 6 month follow up. On echocardiographic examination, none of the patients showed clot in the left atrium. Left atrium size and LV ejection fraction remained the same, during next visit. LA size 44±5 and 44±6 on 1st and second visit respectively (p value =0.059) No other ischemic changes found in the ECG of any patient. International normalization ratio (INR) mean and SD was 2.1± 0.9, 2.2± 0.8, on 1st and 2nd visit of follow up respectively and no significant difference was noted between INR values. Conclusion: Rivaroxaban can be given safely to the patients with valvular heart disease with atrial fibrillation, particularly in patients who cannot get the INR checked on regular basis.
    Keywords Atrial fibrillation ; Rivaroxaban ; Valvular Heart Disease ; Dentistry ; RK1-715 ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Aziz Fatimah Medical and Dental College
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Frequency of Eosinophilia among Patients of Chronic Obstructive Pulmonary Disease with Acute Exacerbation

    Masood Javed / Ghulam Abbas Sheikh / Muhammad Rizwan / Rizwan Rasul Khan / Nasir Mehmood / Mubarak Ali Anjum

    Journal of Aziz Fatimah Medical and Dental College, Vol 2, Iss

    2021  Volume 2

    Abstract: Objective: To determine the frequency of eosinophilia among patients of chronic obstructive pulmonary disease with acute exacerbation Methodology: This cross-sectional study was carried out at Aziz Fatimah Hospital (AFH), Faisalabad from February 2020- ... ...

    Abstract Objective: To determine the frequency of eosinophilia among patients of chronic obstructive pulmonary disease with acute exacerbation Methodology: This cross-sectional study was carried out at Aziz Fatimah Hospital (AFH), Faisalabad from February 2020-May 2020. Ethical approval was taken from Institutional Ethical Committee of Aziz Fatimah Medical and Dental College. After obtaining informed consent, 135 patients of chronic obstructive pulmonary disease were enrolled by non-probability consecutive sampling technique according to inclusion and exclusion criteria. All the information was collected on predesigned proforma. Blood samples were drawn and sent to the AFH pathology laboratory for determination of eosinophilia. Statistical analysis was performed by SPSS 21. Mean and percentages were determined for continuous and categorical variables respectively. Chi square test was applied for differences in proportions. Results: This study comprised of 135 patients of chronic obstructive pulmonary disease. Out of total participants 48.89% (n=66) were male and 51.11% (n=69) were females. Mean±SD of the age of the study subjects was 56.30±7.01 years. Eosinophilia was found in 39.26% (n=53) patients of chronic obstructive pulmonary disease with acute exacerbation. Conclusion: Eosinophilia is frequently found in patients of chronic obstructive pulmonary disease with acute exacerbation.
    Keywords Acute Exacerbation Chronic Obstructive Pulmonary Disease ; Eosinophilia ; Dentistry ; RK1-715 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Aziz Fatimah Medical and Dental College
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: THE HEMATOLOGICAL SIDE EFFECTS ASSOCIATED WITH COMBINATION ANTIVIRAL THERAPY (CONVENTIONAL INTERFERON AND RIBAVARIN) IN PATIENTS WITH HEPATITIS “C” INFECTION

    Khalid Amin / Dilshad Muhammad / Masood Javed

    Journal of University Medical & Dental College, Vol 6, Iss

    2015  Volume 4

    Abstract: ABSTRACT INTRODUCTION: Hepatitis C virus infection is a major cause of chronic hepatic diseases. According to WHO statistics, the global prevalence of HCV is 3.1%. In East Mediterranean Region (including Pakistan), the prevalence is 4.6%. The most ... ...

    Abstract ABSTRACT INTRODUCTION: Hepatitis C virus infection is a major cause of chronic hepatic diseases. According to WHO statistics, the global prevalence of HCV is 3.1%. In East Mediterranean Region (including Pakistan), the prevalence is 4.6%. The most effective therapeutic regimen for infection with hepatitis C virus (HCV) is the combination of interferon alfa and ribavirin (combination therapy) and is effective in approximately 80% of patients infected with hepatitis C virus. The side effects of combination therapy predominantly include hematological abnormalities along with fatigue, influenza-like symptoms, gastrointestinal disturbances and neuropsychiatric symptoms. OBJECTIVE: To evaluate the frequency of Haematological side effects with combination antiviral therapy (interferon and ribavarin) in patients with hepatitis 'C' Infection. STUDY DESIGN: Descriptive case series SETTING: Department of Medicine, DHQ Hospital, Faisalabad STUDY DURATION: th th Six months from 29 November 2013 to 29 May 2014 MATERIALS AND METHODS: Total 150 patients with the diagnosis of Hepatitis C were included. Hemoglobin, Leukocyte count and Platelet count was sent before after 2 weeks and then after every four weeks of starting antiviral therapy in DHQ, hospital Laboratory. Informed consent was taken .The primary outcome measure was the frequency of hematological side effects associated with Interferon and Ribavirin in these patients. RESULTS: A total of 150 patients in Medicine Department DHQ were included in the study. Out of these 150 patients, 66(44%) were male and 84(56%) were female. Mean age of the patients was 36.58+ 3.975 (range 20-45 years). Mean hemoglobin level before starting Antiviral therapy was 13.0g/dl (range 11.0-16.0g/dl). Clinically significant anemia (Hb< 9g/dl) occurred in 73% of the patients after starting the therapy. The mean drop in the hemoglobin concentration in the first two 9weeks of the treatment was 3 g/dl. Leucopenia (<3 x10 /L) occurred in 56 % of the patients and all 9patients recovered after ...
    Keywords Hepatitis C ; Interferon ; Hematological side effects ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2015-12-01T00:00:00Z
    Publisher University of Faisalabad
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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