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Article ; Online: Trends of thrombo-inflammation biomarkers after Tocilizumab predict treatment failure better than scores in patients with severe SARS-CoV2 related respiratory failure.

Masotti, Luca / Cioni, Elisa / Grifoni, Elisa / Cei, Francesco / Tarquini, Roberto

2022 Volume 103, Page(s) 111–112

MeSH term(s)	Antibodies, Monoclonal, Humanized ; Biomarkers ; Humans ; Inflammation ; RNA, Viral ; Respiratory Insufficiency ; SARS-CoV-2 ; Treatment Failure ; COVID-19 Drug Treatment
Chemical Substances	Antibodies, Monoclonal, Humanized ; Biomarkers ; RNA, Viral ; tocilizumab (I031V2H011)
Language	English
Publishing date	2022-06-06
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2022.06.004
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Zs.A 2608: Show issues

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Article ; Online: Diagnosis and treatment of acute pulmonary thromboembolism in the elderly: clinical practice and implications for nurses.

Masotti, Luca

Journal of emergency nursing

2008 Volume 34, Issue 4, Page(s) 330–339

MeSH term(s)	Acute Disease ; Age Distribution ; Aged ; Aging/pathology ; Aging/physiology ; Algorithms ; Blood Coagulation ; Contraindications ; Decision Trees ; Diagnosis, Differential ; Drug Monitoring/methods ; Drug Monitoring/nursing ; Echocardiography ; Emergency Nursing/methods ; Emergency Treatment/methods ; Emergency Treatment/nursing ; Geriatric Assessment ; Humans ; Incidence ; Nurse's Role ; Nursing Assessment/methods ; Partial Thromboplastin Time ; Prevalence ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/therapy ; Risk Assessment ; Risk Factors ; Thrombolytic Therapy/methods ; Thrombolytic Therapy/nursing
Language	English
Publishing date	2008-06-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604632-0
ISSN	1527-2966 ; 0099-1767
ISSN (online)	1527-2966
ISSN	0099-1767
DOI	10.1016/j.jen.2007.04.023
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Zs.B 2509: Show issues

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Article ; Online: Efficacy and Safety of Edoxaban in Cancer-Associated Venous Thromboembolism: A Real World Retrospective Study.

Grifoni, Elisa / Baroncelli, Andrea / Pinto, Gabriele / Cosentino, Eleonora / Micheletti, Irene / Signorini, Ira / Panigada, Grazia / Landini, Giancarlo / Masotti, Luca

TH open : companion journal to thrombosis and haemostasis

2022 Volume 6, Issue 2, Page(s) e99–e106

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2022-03-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2901738-5
ISSN	2512-9465 ; 2567-3459
ISSN (online)	2512-9465
ISSN	2567-3459
DOI	10.1055/a-1783-9744
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Zs.A 7138: Show issues

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Article ; Online: A rapid and cost-effective diagnostic algorithm for the detection of SARS-CoV-2 infection in the emergency area by combining highly sensitive antigenic test and RT-PCR.

Salvetti, Sara / Lavinia, Federica / Rosi, Nico / Vanni, Simone / Masotti, Luca / Tarquini, Roberto / Guarducci, Silvia / Rossolini, Gian Maria / Montenora, Iolanda

Diagnostic microbiology and infectious disease

2022 Volume 103, Issue 4, Page(s) 115727

Abstract: A diagnostic algorithm for SARS-CoV-2 infection in patients admitted to the emergency area, based on a combination of rapid antigen and molecular testing, has been evaluated with 3070 nasopharyngeal swabs. Compared to molecular test alone, the proposed ... ...

Abstract	A diagnostic algorithm for SARS-CoV-2 infection in patients admitted to the emergency area, based on a combination of rapid antigen and molecular testing, has been evaluated with 3070 nasopharyngeal swabs. Compared to molecular test alone, the proposed algorithm allowed to significantly reduce costs and average time to results.
MeSH term(s)	Algorithms ; COVID-19/diagnosis ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Cost-Benefit Analysis ; Humans ; Nasopharynx ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/genetics ; Sensitivity and Specificity
Language	English
Publishing date	2022-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2022.115727
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Article ; Online: Trends in length of hospital stay in acute pulmonary embolism over the years. What is changing in the era of direct oral anticoagulants?

Masotti, Luca / Vannucchi, Vieri / Poggi, Marzia / Landini, Giancarlo

Journal of cardiovascular medicine (Hagerstown, Md.)

2017 Volume 18, Issue 7, Page(s) 556–559

MeSH term(s)	Administration, Oral ; Aged ; Aged, 80 and over ; Antithrombins/administration & dosage ; Antithrombins/adverse effects ; Drug Utilization Review ; Factor Xa Inhibitors/administration & dosage ; Factor Xa Inhibitors/adverse effects ; Female ; Humans ; Italy ; Length of Stay/trends ; Male ; Middle Aged ; Patient Admission ; Practice Patterns, Physicians'/trends ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/drug therapy ; Retrospective Studies ; Time Factors ; Treatment Outcome
Chemical Substances	Antithrombins ; Factor Xa Inhibitors
Language	English
Publishing date	2017
Publishing country	United States
Document type	Letter
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000000356
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Zs.A 5210: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Management of oral anticoagulation in very old patients with non valvular atrial fibrillation related acute ischemic stroke.

Vannucchi, Vieri / Moroni, Federico / Grifoni, Elisa / Marcucci, Rossella / Landini, Giancarlo / Prisco, Domenico / Masotti, Luca

Journal of thrombosis and thrombolysis

2019 Volume 49, Issue 1, Page(s) 86–93

Abstract: The optimal management of oral anticoagulation (OAC) in the acute phase of non valvular atrial fibrillation (NVAF)-related acute ischemic stroke (AIS) remains controversial, especially in very old patients. Therefore, the aim of our study was to evaluate ...

Abstract	The optimal management of oral anticoagulation (OAC) in the acute phase of non valvular atrial fibrillation (NVAF)-related acute ischemic stroke (AIS) remains controversial, especially in very old patients. Therefore, the aim of our study was to evaluate the practical management of OAC in this context. We conducted an observational retrospective study on patients 85-years old and older admitted to two Italian hospitals for NVAF-related AIS. For each patient, clinical and brain computed tomography data were recorded. Type of OAC (vitamin K antagonists, VKAs or Direct Oral Anticoagulants, DOACs), dosage and starting day after AIS were registered. For each patient 90-day all cause mortality, stroke recurrence, any bleeding and modified Rankin scale (mRS) were reported. One-hundred-seventeen patients, with mean age 89.2 ± 3.4 years, were enrolled. In-hospital and 90-day mortality (out of 109 patients) were 6% and 19.7%, respectively. OAC was started in 93 patients (80.5%), on average after 6 ± 3 days from the acute event. Of them, 88 patients (94.6%) received DOACs, while 5 (5.4%) received VKAs. Patients receiving OAC were significantly younger and suffering from less severe stroke compared with patients who did not receive OAC. Patients receiving OAC presented a reduced in-hospital (2.2% vs. 20.8%, p < 0.004) and 90-day all-cause mortality (9.4% vs. 62.5%, p < 0.001). In patients receiving DOACs, low dosages were used in 87.5% of patients. The use of OAC was not associated with an increased rate of hemorrhagic transformation (HT) during hospitalization (13.2% vs. 9.5%, p = 0.54) or any bleeding at 90-day follow-up. Severe dysphagia and mRS ≥ 4 were found to be independent risk factors for not prescribing OAC. The optimal management of OAC in very old patients suffering from NVAF-related AIS remains a dilemma. In our real world study the majority of patients received OAC as secondary prevention treatment without increase in bleeding risk. Dysphagia and severe disability were independent factors for not prescribing OAC. Further investigations aimed at identifying the optimal approach to OAC during the acute phase of NVAF-related ischemic stroke in this subgroup of patients are warranted.
MeSH term(s)	Administration, Oral ; Aged, 80 and over ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Brain Ischemia/epidemiology ; Brain Ischemia/prevention & control ; Female ; Humans ; Male ; Retrospective Studies ; Stroke/epidemiology ; Stroke/prevention & control
Chemical Substances	Anticoagulants
Language	English
Publishing date	2019-10-17
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-019-01972-0
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Zs.A 4352: Show issues

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Article ; Online: Post-Stroke Detection of Subclinical Paroxysmal Atrial Fibrillation in Patients With Embolic Stroke of Undetermined Source in the Real World Practice: The Empoli ESUS Atrial Fibrillation (E 2 AF) Study.

Grifoni, Elisa / Baldini, Giulia / Baldini, Mariella / Pinto, Gabriele / Micheletti, Irene / Madonia, Elisa M / Cosentino, Eleonora / Bartolozzi, Maria L / Bertini, Elisabetta / Dei, Alessandro / Signorini, Ira / Giannoni, Sara / Del Rosso, Attilio / Prisco, Domenico / Guidi, Leonello / Masotti, Luca

The neurologist

2023 Volume 28, Issue 1, Page(s) 25–31

Abstract: Background: Subclinical paroxysmal atrial fibrillation (AF) is one of the main occult causative mechanisms of embolic stroke of undetermined source (ESUS). Aim of this study was to identify AF predictors, and to develop a score to predict the ... ...

Abstract	Background: Subclinical paroxysmal atrial fibrillation (AF) is one of the main occult causative mechanisms of embolic stroke of undetermined source (ESUS). Aim of this study was to identify AF predictors, and to develop a score to predict the probability of AF detection in ESUS. Methods: We retrospectively analyzed ESUS patients undergoing 2-week external electrocardiographic monitoring. Patients with and without AF detection were compared. On the basis of multivariate analysis, predictors of AF were identified and used to develop a predictive score, which was then compared with other existing literature scores. Results: Eighty-two patients, 48 females, mean age±SD 72±10 years, were included. In 36 patients (43.9%) AF was detected. The frequency of age 75 years or above and arterial hypertension, and the median CHA 2 DS 2 -VASc score were significantly higher in patients with AF compared with those without. National Institutes of Health Stroke Scale (NIHSS) score ≥8 was the only independent variable associated with AF detection. We derived the Empoli ESUS-AF (E 2 AF) score (NIHSS ≥8 5 points, arterial hypertension 3 points, age 75 years or above 2 points, age 65 to 74 years 1 point, history of coronary/peripheral artery disease 1 point, left atrial enlargement 1 point, posterior lesion 1 point, cortical or cortical-subcortical lesion 1 point), whose predictive power in detecting AF was good (area under the curve: 0.746, 95% confidence interval: 0.638-0.836) and higher than that of CHA 2 DS 2 -VASc and other scores. Conclusions: In our study NIHSS score ≥8 was the only independent predictor of post-ESUS-AF detection. The E 2 AF score appears to have a good predictive power for detecting AF. External validations are required.
MeSH term(s)	Aged ; Female ; Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Embolic Stroke/complications ; Hypertension/complications ; Hypertension/diagnosis ; Retrospective Studies ; Risk Factors ; Stroke/complications ; Stroke/diagnosis ; Male
Language	English
Publishing date	2023-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1361380-7
ISSN	2331-2637 ; 1074-7931
ISSN (online)	2331-2637
ISSN	1074-7931
DOI	10.1097/NRL.0000000000000440
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Zs.A 4641: Show issues

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Article ; Online: Validation of Empoli Embolic Stroke of Undetermined Source Atrial Fibrillation (E 2 AF) Score for Detecting Atrial Fibrillation in Patients With Embolic Stroke of Undetermined Source.

Masotti, Luca / Grifoni, Elisa / Baglini, Alessia / Sivieri, Irene / Mannini, Marianna / Iandoli, Gina / Madonia, Elisa Maria / Cosentino, Eleonora / Micheletti, Irene / Signorini, Ira / Cioni, Elisa / Sansone, Teresa / Pelagalli, Giulia / Baldini, Mariella / Giannoni, Sara / Bertini, Elisabetta / Di Donato, Ilaria

The neurologist

2023 Volume 28, Issue 6, Page(s) 426–428

MeSH term(s)	Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Embolic Stroke ; Heart Atria ; Stroke/complications ; Stroke/diagnosis ; Risk Factors
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1361380-7
ISSN	2331-2637 ; 1074-7931
ISSN (online)	2331-2637
ISSN	1074-7931
DOI	10.1097/NRL.0000000000000497
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Article ; Online: Prognostic ability of four clinical grading scores in spontaneous intracerebral hemorrhage.

Masotti, Luca / Lorenzini, Gianni / Di Napoli, Mario / Godoy, Daniel Agustin

Acta neurologica Belgica

2017 Volume 117, Issue 1, Page(s) 325–327

Language	English
Publishing date	2017
Publishing country	Italy
Document type	Letter
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-016-0609-2
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Article: Efficacy and Safety of Edoxaban in Cancer-Associated Venous Thromboembolism: A Real World Retrospective Study

Grifoni, Elisa / Baroncelli, Andrea / Pinto, Gabriele / Cosentino, Eleonora / Micheletti, Irene / Signorini, Ira / Panigada, Grazia / Landini, Giancarlo / Masotti, Luca

TH Open

2022 Volume 06, Issue 02, Page(s) e99–e106

Abstract: Introduction: Few data exist on the use of edoxaban in cancer-associated venous thromboembolism (VTE) outside of clinical trials. Aim of this study was to evaluate the characteristics and outcomes of these patients in a real world clinical setting.: ... ...

Abstract	Introduction: Few data exist on the use of edoxaban in cancer-associated venous thromboembolism (VTE) outside of clinical trials. Aim of this study was to evaluate the characteristics and outcomes of these patients in a real world clinical setting. Methods: We retrospectively analyzed the characteristics of patients with cancer-associated VTE who were prescribed edoxaban. Follow-up at 3, 6, and 12 months was performed: VTE recurrences, bleedings, mortality, cancer progression and treatment, edoxaban interruption and its reason were assessed. Results: Fifty-four patients, 38 females (70.4%), mean age 71 ± 14 years, were enrolled. In 38 patients (70.4%), the episode of VTE was the first one, in 28 (51.8%) it was an isolated deep vein thrombosis (DVT), in 13 (24.1%) a pulmonary embolism (PE) associated with DVT, in 13 (24.1%) an isolated PE. Median time between cancer and VTE diagnosis was 6 (interquartile range [IQR] 2–47) months. Median time between VTE diagnosis and edoxaban prescription was 36 (IQR 7–117) days. At 3, 6, and 12 months the incidence of all-cause mortality was 16.6, 22.2, and 38.8%, that of VTE recurrence 1.8, 1.8, and 3.7%, and that of major bleeding 7.4, 9.2, and 12.9%, respectively. No bleeding was fatal. Of the 33 patients alive at 12 months, 32 (96.9%) were still on edoxaban therapy, in seven (21.2%) cancer was in progression. Conclusion: Our study, conducted on a real world population of patients with cancer-associated VTE, confirms the results of randomized controlled clinical trials, and supports the use of edoxaban as effective and safe treatment in this context.
Keywords	cancer ; venous thromboembolism ; bleeding ; edoxaban ; low molecular weight heparin
Language	English
Publishing date	2022-03-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2901738-5
ISSN	2512-9465 ; 2567-3459
ISSN (online)	2512-9465
ISSN	2567-3459
DOI	10.1055/a-1783-9744
Database	Thieme publisher's database

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