Article ; Online: MCI Conversion Prediction Using 3D Zernike Moments and the Improved Dynamic Particle Swarm Optimization Algorithm
Applied Sciences, Vol 13, Iss 4489, p
2023 Volume 4489
Abstract: Mild cognitive impairment (MCI) conversion prediction is a vital challenge in the area of Alzheimer’s disease (AD) as it could determine possible treatment pathways for AD patients. In this work, we presented a robust MCI conversion prediction framework ... ...
Abstract | Mild cognitive impairment (MCI) conversion prediction is a vital challenge in the area of Alzheimer’s disease (AD) as it could determine possible treatment pathways for AD patients. In this work, we presented a robust MCI conversion prediction framework based on the 3D-Zernike Moment (3D-ZM) method that generates statistical features (e.g., shape, texture, and symmetry information) from 3D-MRI scans and improved dynamic particle swarm optimization (IDPSO) that finds an informative sub-set of Zernike features for MCI conversion prediction. We quantified the efficiency of the proposed prediction framework on a large sample of MCI patients including 105 progressive-MCI (pMCI) and 121 stable-MCI (sMCI) at the baseline from the ADNI dataset. Using the proposed MCI conversion prediction framework, pMCI patients were distinguished from sMCI patients with an accuracy exceeding 75% (sensitivity, 83%, and specificity, 68%), which is well comparable with the state-of-the-art MCI conversion prediction approaches. Experimental results indicate that the 3D-ZM method can represent informative statistical patterns from 3D-MRI scans and IDPSO has a great capability to find meaningful statistical features for identifying MCI patients who are at risk of conversion to the AD stage. |
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Keywords | Alzheimer’s disease ; classification ; feature extraction ; improved dynamic PSO ; Zernike moment ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999 |
Subject code | 620 |
Language | English |
Publishing date | 2023-04-01T00:00:00Z |
Publisher | MDPI AG |
Document type | Article ; Online |
Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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