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  1. Article: Citrobacter keratitis: predisposing factors and clinical characteristics.

    Soleimani, Mohammad / Masoumi, Ahmad / Tabatabaei, Seyed Ali / Zamani, Mohammad Hossein

    Journal of ophthalmic inflammation and infection

    2023  Volume 13, Issue 1, Page(s) 3

    Abstract: Purpose: To report predisposing factors, clinical presentation, antibiotic sensitivity, and management of Citrobacter-caused infectious keratitis.: Methods: We retrospectively reviewed the medical records of culture-proven cases of Citrobacter ... ...

    Abstract Purpose: To report predisposing factors, clinical presentation, antibiotic sensitivity, and management of Citrobacter-caused infectious keratitis.
    Methods: We retrospectively reviewed the medical records of culture-proven cases of Citrobacter keratitis in a tertiary referral center for 8 years (from January 2012 to September 2020). Demographic data of the patients, predisposing factors, and presenting signs were extracted.
    Results: Eighteen cases of microbial keratitis due to Citrobacter spp. were identified. The median age of the patients was 66 years (range: 10-89, interquartile range : 59-81). Thirteen patients were male and 5 were female. Multiple predisposing factors were identified in all eyes, including ocular surface disease (n = 8), previous corneal surgery (n = 6), and history of ocular trauma (n = 6). Five patients were diabetic. Corrected distance visual acuity (CDVA) of patients was light perception (LP) in 8 patients, hand motion (HM) in 7, counting fingers (CF) at 1 m in 1, and CF at 2 m in 2 patients. Thirteen eyes exhibited hypopyon. An area of corneal thinning was observed in 7 eyes (38.9%). Endophthalmitis due to infectious keratitis developed in one patient. In vitro susceptibility testing confirmed high sensitivity to ceftazidime and aminoglycosides. Medical management consisted primarily of topical amikacin (20 mg/ml) combined with topical cefazoline (50 mg/ml) (72.2%). Surgical tectonic procedures were carried out in 7 eyes (38.9%).
    Conclusion: Citrobacter spp. is a rare cause of bacterial keratitis.Previous keratoplasty and ocular surface problems are important risk factors. The prognosis is not good and surgical tectonic intervention is required in many cases to resolve the corneal infection.
    Language English
    Publishing date 2023-01-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2592309-2
    ISSN 1869-5760
    ISSN 1869-5760
    DOI 10.1186/s12348-022-00322-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Superior Rectus Transposition and Medial Rectus Recession for Treatment of Duane Retraction Syndrome and Sixth Nerve Palsy.

    Akbari, Mohammad Reza / Masoumi, Ahmad / Mirmohammadsadeghi, Arash

    Journal of binocular vision and ocular motility

    2021  Volume 71, Issue 2, Page(s) 45–49

    Abstract: ... ...

    Abstract Purpose
    MeSH term(s) Abducens Nerve Diseases/surgery ; Duane Retraction Syndrome/surgery ; Eye Movements ; Humans ; Ophthalmologic Surgical Procedures ; Retrospective Studies
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Journal Article
    ISSN 2576-1218
    ISSN (online) 2576-1218
    DOI 10.1080/2576117X.2021.1879985
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  3. Article ; Online: Infectious keratitis caused by Klebsiella spp.: predisposing factors, presentation, and management.

    Masoumi, Ahmad / Zeidabadinejad, Haniyeh / Jafari, Behzad / Esfandiari, Amirreza / Soleimani, Mohammad

    International ophthalmology

    2022  Volume 43, Issue 4, Page(s) 1169–1173

    Abstract: Purpose: To study predisposing factors, clinical presentation and management strategies for Klebsiella keratitis.: Methods: A retrospective case review was performed on clinical records of culture-proven Klebsiella keratitis cases in a tertiary ... ...

    Abstract Purpose: To study predisposing factors, clinical presentation and management strategies for Klebsiella keratitis.
    Methods: A retrospective case review was performed on clinical records of culture-proven Klebsiella keratitis cases in a tertiary referral center over an 8-year period (from 2012 to 2020).
    Results: Thirty eight episodes of culture-proven Klebsiella keratitis were identified in 37 patients. The mean age of the patients was 62.9 years (range, 24-101). Multiple predisposing factors were identified in 33 eyes including history of previous keratoplasty (n = 11) history of ocular trauma (n = 7), preexisting ocular surface disease (n = 7) and diabetes (n = 6). Corrected distance visual acuity (CDVA) at presentation was light perception (LP) in 16 patients, hand motion (HM) in 12, counting fingers (CF) at 50 cm in 5, CF at 1 m in 1, CF at 2 m in 2. One patient had a CDVA of 3/10. On initial examination Hypopyon was detected in 21 eyes. Descemet's membrane folds were present in 1 eye. Corneal thinning was identified in 20 eyes and perforation occurred in 4 patients. Corneal ulcer progressed to endophthalmitis in one patient. Microbiologic sensitivity testing showed that 89.5% isolates were sensitive to amikacin (34/38),88.9%sensitive to ceftazidime (32/36),94.4% were sensitive to gentamicin (34/36),97.2% sensitive to ciprofloxacin (35/36), and 100% to levofloxacin (26/26).Ultimately, one or more surgical procedures was needed in 21 patients.
    Conclusion: Previous keratoplasty, history of ocular trauma, ocular surface disease and systemic disease such as diabetes are major risk factors for Klebsiella keratitis. In most of the patients, surgical and tectonic procedures were necessary to control the infection.
    MeSH term(s) Humans ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Retrospective Studies ; Eye Infections, Bacterial/diagnosis ; Eye Infections, Bacterial/epidemiology ; Eye Infections, Bacterial/therapy ; Keratitis/drug therapy ; Cornea/microbiology ; Risk Factors ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-09-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-022-02515-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Increased Rate of Infectious Keratitis After PRK in the COVID-19 Era: The Possible Role of Face Masks.

    Soleimani, Mohammad / Masoumi, Ahmad / Farrokhpour, Hossein / Keykhaei, Mohammad / Zeidabadinejad, Haniyeh / Tabatabaei, Seyed Ali

    Journal of refractive surgery (Thorofare, N.J. : 1995)

    2022  Volume 38, Issue 2, Page(s) 78–81

    Abstract: Purpose: To evaluate the rate of infectious keratitis after photorefractive keratectomy (PRK) before and during the coronavirus disease 2019 (COVID-19) pandemic.: Methods: A retrospective chart review was performed on patients who were diagnosed as ... ...

    Abstract Purpose: To evaluate the rate of infectious keratitis after photorefractive keratectomy (PRK) before and during the coronavirus disease 2019 (COVID-19) pandemic.
    Methods: A retrospective chart review was performed on patients who were diagnosed as having infectious keratitis after PRK between January 2015 and January 2021.
    Results: The study period was divided into the pre-COVID-19 era (between January 2015 and February 2020) and the COVID-19 era (between February 2020 and January 2021). A total of 47 patients were diagnosed as having infectious keratitis after PRK: 22 were diagnosed in the pre-COVID-19 era and 25 were diagnosed in the COVID-19 era. The rate ratio for infectious keratitis after PRK was 5.68 during the COVID-19 pandemic (CI: 3.20 to 10.07,
    Conclusions: The rate of infectious keratitis after PRK increased during the COVID-19 pandemic. This may be due to the increased use of face masks in this era.
    MeSH term(s) COVID-19 ; Humans ; Keratitis/diagnosis ; Keratitis/epidemiology ; Keratitis/etiology ; Lasers, Excimer/therapeutic use ; Masks ; Pandemics ; Photorefractive Keratectomy ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article
    ISSN 1081-597X
    ISSN 1081-597X
    DOI 10.3928/1081597X-20211201-01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Applications of mesenchymal stem cells in ocular surface diseases: sources and routes of delivery.

    Soleimani, Mohammad / Masoumi, Ahmad / Momenaei, Bita / Cheraqpour, Kasra / Koganti, Raghuram / Chang, Arthur Y / Ghassemi, Mahmoud / Djalilian, Ali R

    Expert opinion on biological therapy

    2023  Volume 23, Issue 6, Page(s) 509–525

    Abstract: Introduction: Mesenchymal stem cells (MSCs) are novel, promising agents for treating ocular surface disorders. MSCs can be isolated from several tissues and delivered by local or systemic routes. They produce several trophic factors and cytokines, which ...

    Abstract Introduction: Mesenchymal stem cells (MSCs) are novel, promising agents for treating ocular surface disorders. MSCs can be isolated from several tissues and delivered by local or systemic routes. They produce several trophic factors and cytokines, which affect immunomodulatory, transdifferentiating, angiogenic, and pro-survival pathways in their local microenvironment via paracrine secretion. Moreover, they exert their therapeutic effect through a contact-dependent manner.
    Areas covered: In this review, we discuss the characteristics, sources, delivery methods, and applications of MSCs in ocular surface disorders. We also explore the potential application of MSCs to inhibit senescence at the ocular surface.
    Expert opinion: Therapeutic application of MSCs in ocular surface disorders are currently under investigation. One major research area is corneal epitheliopathies, including chemical or thermal burns, limbal stem cell deficiency, neurotrophic keratopathy, and infectious keratitis. MSCs can promote corneal epithelial repair and prevent visually devastating sequelae of non-healing wounds. However, the optimal dosages and delivery routes have yet to be determined and further clinical trials are needed to address these fundamental questions.
    MeSH term(s) Humans ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells
    Language English
    Publishing date 2023-02-09
    Publishing country England
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2023.2175605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Clinical Features, Risk Factors, and Management of Candida Keratitis.

    Masoumi, Ahmad / Soleimani, Mohammad / Azizkhani, Momeneh / Izadi, Alireza / Cheraqpour, Kasra / Tabatabaei, Seyed Ali / Khodavaisy, Sadegh / Aminzadeh, Mehdi

    Ocular immunology and inflammation

    2023  , Page(s) 1–6

    Abstract: Background/aims: To determine the clinical features, predisposing factors, and management of infectious keratitis caused by : Methods: Retrospective chart review.: Results: The medical records of 52 patients (54 eyes) with : Conclusion: Local ... ...

    Abstract Background/aims: To determine the clinical features, predisposing factors, and management of infectious keratitis caused by
    Methods: Retrospective chart review.
    Results: The medical records of 52 patients (54 eyes) with
    Conclusion: Local immunosuppression and ocular surface disease play an important role in
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2023.2203752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ocular graft-versus-host disease (oGVHD): From A to Z.

    Soleimani, Mohammad / Mahdavi Sharif, Pouya / Cheraqpour, Kasra / Koganti, Raghuram / Masoumi, Ahmad / Baharnoori, Seyed Mahbod / Salabati, Mirataollah / Djalilian, Ali R

    Survey of ophthalmology

    2023  Volume 68, Issue 4, Page(s) 697–712

    Abstract: Allogeneic hematopoietic stem cell transplantation is a definitive therapy for a variety of disorders. One of the complications is acute graft-versus-host disease (aGVHD), which has a high mortality rate. Patients can also develop chronic graft-versus- ... ...

    Abstract Allogeneic hematopoietic stem cell transplantation is a definitive therapy for a variety of disorders. One of the complications is acute graft-versus-host disease (aGVHD), which has a high mortality rate. Patients can also develop chronic graft-versus-host disease (cGVHD), a more indolent yet afflicting condition that affects up to 70% of patients. Ocular involvement (oGVHD) is one of the most prevalent presentations of cGVHD and can manifest as dry eye disease, meibomian gland dysfunction, keratitis, and conjunctivitis. Early recognition of ocular involvement using regular clinical assessments as well as robust biomarkers can aid in better management and prevention. Currently, the therapeutic strategies for the management of cGVHD, and oGVHD in particular, have mainly focused on the control of symptoms. There is an unmet need for translating the preclinical and molecular understandings of oGVHD into clinical practice. Herein, we have comprehensively reviewed the pathophysiology, pathologic features, and clinical characteristics of oGVHD and summarized the therapeutic landscape available to combat it. We also discuss the direction of future research regarding a more directed delineation of pathophysiologic underpinnings of oGVHD and the development of preventive interventions.
    MeSH term(s) Humans ; Dry Eye Syndromes/diagnosis ; Dry Eye Syndromes/etiology ; Dry Eye Syndromes/therapy ; Graft vs Host Disease/diagnosis ; Graft vs Host Disease/etiology ; Graft vs Host Disease/drug therapy ; Eye ; Bronchiolitis Obliterans Syndrome ; Meibomian Gland Dysfunction ; Hematopoietic Stem Cell Transplantation/adverse effects ; Chronic Disease
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 391346-6
    ISSN 1879-3304 ; 0039-6257
    ISSN (online) 1879-3304
    ISSN 0039-6257
    DOI 10.1016/j.survophthal.2023.02.006
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  8. Article: Optical coherence tomography angiography in best vitelliform macular dystrophy.

    Mirshahi, Ahmad / Lashay, Alireza / Masoumi, Ahmad / Abrishami, Mojtaba

    Journal of current ophthalmology

    2019  Volume 31, Issue 4, Page(s) 442–445

    Abstract: Purpose: To report best vitelliform macular dystrophy (BVMD) with an intriguing pattern of vascular flow on optical coherence tomography angiography (OCTA).: Methods: Four eyes of two patients with BVMD were evaluated. Complete ophthalmic examination ...

    Abstract Purpose: To report best vitelliform macular dystrophy (BVMD) with an intriguing pattern of vascular flow on optical coherence tomography angiography (OCTA).
    Methods: Four eyes of two patients with BVMD were evaluated. Complete ophthalmic examination including best corrected visual acuity (BCVA), spectral domain optical coherence tomography (SD-OCT), and OCTA were performed. Diagnosis was confirmed by electroretinography (ERG) and electrooculography (EOG) testing.
    Results: All eyes had the electrophysiologic confirmation of the BVMD. The first patient was 35 years old with BCVA of 20/20 and pseudohypopyon stage macular lesion in right eye (RE) and BCVA of 20/32 and vitelliruptive stage macular lesion in the left eye (LE). The second patient was 18 years old with BCVA of 20/25 and macular lesion in vitelliform stage in the RE and BCVA of 20/60 and choroidal neovascularization (CNV) in the LE. In all eyes, a distinct foveal avascular zone (FAZ) was not detectable in OCTA, with a bridging vessel in the FAZ. A dense subretinal capillary network compatible with CNV in the LE of second patient was observed.
    Conclusion: In our cases, we found bridging vessel in the FAZ, and it may be due to the effects of bestrophin on the calcium content and vascular endothelial growth factor (VEGF) secretion of the retinal pigment epithelium (RPE) cells.
    Language English
    Publishing date 2019-07-16
    Publishing country India
    Document type Journal Article
    ISSN 2452-2325
    ISSN 2452-2325
    DOI 10.1016/j.joco.2019.06.005
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  9. Article ; Online: Simultaneous photorefractive keratectomy and accelerated collagen cross-linking in high-risk refractive surgery (Tehran protocol): 3-year outcomes.

    Mohammadpour, Mehrdad / Farhadi, Behnaz / Mirshahi, Reza / Masoumi, Ahmad / Mirghorbani, Masoud

    International ophthalmology

    2020  Volume 40, Issue 10, Page(s) 2659–2666

    Abstract: Purpose: To evaluate safety and efficacy of performing simultaneous photorefractive keratectomy (PRK) and collagen cross-linking (CXL) in myopic patients with preoperative risk factors for developing keratectasia.: Methods: Seventeen eyes of 15 ... ...

    Abstract Purpose: To evaluate safety and efficacy of performing simultaneous photorefractive keratectomy (PRK) and collagen cross-linking (CXL) in myopic patients with preoperative risk factors for developing keratectasia.
    Methods: Seventeen eyes of 15 patients with at least one of the following risk factors were recruited: central keratometry (K
    Results: Mean follow-up time was 32.08 ± 7.79 months (range 25-49 months). Mean age of patients was 28.78 ± 3.80 years. Mean postoperative spherical equivalent was + 0.19 ± 0.42 (- 0.5 to + 1.0 [D]). Mean UDVA and CDVA improved from 0.9062 ± 0.485 log MAR and 0.0148 ± 0.043 log MAR to 0.0173 ± 0.040 log MAR and 0.0057 ± 0.023 log MAR, respectively (P = 0.011, P = 0.735). Mild degree of early postoperative stromal haze was seen which did not persist more than 6 months. There was no late stromal haze, corneal ectasia or other major postoperative complication in the follow-up period.
    Conclusion: Combined PRK and accelerated CXL is an efficient and safe procedure for high-risk refractive surgery candidates, with no increased risk of persistent corneal haze.
    MeSH term(s) Adult ; Collagen ; Corneal Stroma/surgery ; Corneal Topography ; Cross-Linking Reagents/therapeutic use ; Humans ; Iran ; Keratoconus/drug therapy ; Keratoconus/surgery ; Photorefractive Keratectomy ; Photosensitizing Agents/therapeutic use ; Riboflavin/therapeutic use ; Ultraviolet Rays ; Young Adult
    Chemical Substances Cross-Linking Reagents ; Photosensitizing Agents ; Collagen (9007-34-5) ; Riboflavin (TLM2976OFR)
    Language English
    Publishing date 2020-06-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-020-01447-9
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  10. Article: Effect of night work on image quality of optical coherence tomography angiography.

    Abrishami, Mojtaba / Fadakar, Pouran / Mirghorbani, Masoud / Masoumi, Ahmad / Hassanzadeh, Samira

    Journal of current ophthalmology

    2019  Volume 31, Issue 4, Page(s) 438–441

    Abstract: Purpose: To assess the effect of night shift work on image quality and artifacts when performing optical coherence tomography angiography (OCT-A).: Methods: In a prospective case series study, twenty nurses underwent OCT-A in two separate sessions: ... ...

    Abstract Purpose: To assess the effect of night shift work on image quality and artifacts when performing optical coherence tomography angiography (OCT-A).
    Methods: In a prospective case series study, twenty nurses underwent OCT-A in two separate sessions: early in the morning before duty shift and at the end of a night shift. Quantitative measurements of horizontal and vertical saccadic, blink, and stretch artifacts and also signal strength of the images were recorded. Moreover, using visual analogue scale of pain (VAS), the perceived pain and discomfort by blue focus light and red scanning laser were recorded.
    Results: Vertical and horizontal saccades, blink, and stretch artifacts were significantly higher after the night shift (
    Conclusion: Our study suggests that night shift may affect image quality of OCT-A by imposing more artifacts.
    Language English
    Publishing date 2019-09-17
    Publishing country India
    Document type Journal Article
    ISSN 2452-2325
    ISSN 2452-2325
    DOI 10.1016/j.joco.2019.08.003
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