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  1. Article: Transparency and Affordability for Consumers Call for Commitments from Providers and Insurers.

    Massa, Lawrence

    Frontiers of health services management

    2019  Volume 35, Issue 3, Page(s) 35–40

    MeSH term(s) Costs and Cost Analysis/methods ; Costs and Cost Analysis/statistics & numerical data ; Delivery of Health Care/economics ; Delivery of Health Care/statistics & numerical data ; Health Personnel/economics ; Health Personnel/statistics & numerical data ; Humans ; Insurance Carriers/economics ; Insurance Carriers/statistics & numerical data ; United States
    Language English
    Publishing date 2019-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632858-1
    ISSN 0748-8157
    ISSN 0748-8157
    DOI 10.1097/HAP.0000000000000056
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  2. Article: Density function theory (DFT) calculated infrared absorption spectra for nitrosamines.

    Wallace, S / Lambrakos, S G / Massa, L

    Water science and technology : a journal of the International Association on Water Pollution Research

    2020  Volume 80, Issue 10, Page(s) 1967–1974

    Abstract: Absorption spectra within the infrared (IR) range of frequencies for nitrosamines in water are calculated using density function theory (DFT). Calculated in this study, are the IR spectra of ... ...

    Abstract Absorption spectra within the infrared (IR) range of frequencies for nitrosamines in water are calculated using density function theory (DFT). Calculated in this study, are the IR spectra of C
    MeSH term(s) Electrons ; Models, Molecular ; Molecular Conformation ; Nitrosamines ; Quantum Theory ; Spectroscopy, Fourier Transform Infrared ; Spectrum Analysis, Raman ; Vibration
    Chemical Substances Nitrosamines
    Language English
    Publishing date 2020-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 764273-8
    ISSN 1996-9732 ; 0273-1223
    ISSN (online) 1996-9732
    ISSN 0273-1223
    DOI 10.2166/wst.2020.018
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    Einzelsignatur: Show issues

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  3. Article ; Online: Reply to comment on: Morphovascular changes after Anti-VEGF intravitreal injection for a choroidal neovascularization secondary to COVID-19 infection in a pediatric patient.

    Cennamo, Gilda / Massa, Luigi / Montanaro, Lucia / Magli, Adriano / Costagliola, Ciro

    Photodiagnosis and photodynamic therapy

    2023  Volume 43, Page(s) 103675

    MeSH term(s) Humans ; Child ; Intravitreal Injections ; Photosensitizing Agents/therapeutic use ; Photochemotherapy/methods ; COVID-19 ; Ranibizumab/therapeutic use ; Choroidal Neovascularization/drug therapy
    Chemical Substances Photosensitizing Agents ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2023-06-25
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2023.103675
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  4. Article ; Online: Evaluation of changes in epivascular glia before and after intravitreal dexamethasone implant: An OCT pilot study.

    Cennamo, Gilda / Montanaro, Lucia / Massa, Luigi / Malvone, Emanuele / Costagliola, Ciro

    Photodiagnosis and photodynamic therapy

    2023  Volume 43, Page(s) 103688

    Abstract: Purpose: To detect changes in epivascular glia (EVG) in diabetic retinopathy after intravitreal dexamethasone implant using en face optical coherence tomography (enface OCT) and OCT angiography (OCTA) and to correlate improvements in functional and ... ...

    Abstract Purpose: To detect changes in epivascular glia (EVG) in diabetic retinopathy after intravitreal dexamethasone implant using en face optical coherence tomography (enface OCT) and OCT angiography (OCTA) and to correlate improvements in functional and structural features.
    Methods: A total of 38 eyes of 38 patients were enroled in this prospective study. They were divided into two different study groups: the first group including 20 eyes with diabetic retinopathy type 1 complicated by macular oedema and the control group including 18 eyes from 18 healthy age-matched patients. The main outcome measures were: (i) differences at baseline in the foveal avascuar zone (FAZ) area in the study group versus control; (ii) the presence of epivascular glia in the study group versus control, (iii) differences at baseline between foveal macular thickness versus control; (iv) changes in foveal macular thickness, FAZ and epivascular glia in the study group before and after intravitreal dexamethasone implant.
    Results: At baseline FAZ area detected at OCTA was larger in the study group than in the control group, and epivascular glia was only detected in the study group. Three months after intravitreal injection of dexamethasone implant in the study group the best corrected visual acuity (BCVA) improved and central macular tickness reduced (P<0.0001). No significant differences were found in FAZ area while epivascular glia disappeared in 80% of the patients after treatment.
    Conclusions: Glia activation due to retinal inflammation in diabetic retinopathy (DR) can be detected on en face-OCT as epivascular glia. Intravitreal dexamethasone (DEX) implant improves both the anatomical and functional condition in the presence of these signs.
    MeSH term(s) Humans ; Dexamethasone/therapeutic use ; Glucocorticoids ; Diabetic Retinopathy/drug therapy ; Pilot Projects ; Prospective Studies ; Photochemotherapy/methods ; Photosensitizing Agents/therapeutic use ; Macula Lutea ; Tomography, Optical Coherence/methods ; Intravitreal Injections ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Dexamethasone (7S5I7G3JQL) ; Glucocorticoids ; Photosensitizing Agents
    Language English
    Publishing date 2023-07-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2023.103688
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  5. Article ; Online: Morphovascular changes after anti-VEGF intravitreal injection for a choroidal neovascularization secondary to COVID-19 infection in a pediatric patient.

    Cennamo, Gilda / Massa, Luigi / Montanaro, Lucia / Magli, Adriano / Costagliola, Ciro

    Photodiagnosis and photodynamic therapy

    2023  Volume 42, Page(s) 103577

    Abstract: Choroidal neovascularization (CNV) is a common pathologic lesion that occurs in various chorioretinopathy. Although the incidence of CNV is quite rare in children and adolescents, these lesions have a severe impact on visual acuity and quality of life ... ...

    Abstract Choroidal neovascularization (CNV) is a common pathologic lesion that occurs in various chorioretinopathy. Although the incidence of CNV is quite rare in children and adolescents, these lesions have a severe impact on visual acuity and quality of life over patients' lifetime. The management of CNV in pediatric patients is challenging, clear guidelines are limited due to a lack of randomized clinical trials. However, the more promising option is the use of vascular endothelial growth factor (VEGF) inhibitors. We reported a case of recurrent idiopathic choroidal neovascularization in a healthy pediatric patient after COVID 19 infection. Optical coherence tomography angiofraphy (OCTA) showed, in a non invasive way, a choroidal neovascularization at the posterior pole including macula and superior temporal arcade in the right eye, while the left eye was unaffected. In order to inactivate the neovascularization, intravitreal injections of anti-VEGF (Lucentis-Ranibizumab 0.3 mL) were performed in the right eye. Six months after the injections BCVA of the right eye was improved from 0.7 logMAR to 0.2 logMAR. OCT-A examination did not detect any signs of attivation of the preexistent neovascularization. It is reasonable to assert that Anti-VEGF could be the main treatment in case of choroidal neovascularization in young patients after COVID 19 infection due to the high chorioretinal level of VEGF-A described in these diseases.
    MeSH term(s) Adolescent ; Humans ; Child ; Vascular Endothelial Growth Factor A ; Angiogenesis Inhibitors/therapeutic use ; Intravitreal Injections ; Quality of Life ; Photosensitizing Agents/therapeutic use ; Photochemotherapy/methods ; COVID-19/complications ; COVID-19/pathology ; Ranibizumab/therapeutic use ; Choroidal Neovascularization/drug therapy ; Macula Lutea ; Tomography, Optical Coherence ; Fluorescein Angiography ; Retrospective Studies
    Chemical Substances Vascular Endothelial Growth Factor A ; Angiogenesis Inhibitors ; Photosensitizing Agents ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2023-04-19
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2023.103577
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  6. Book ; Online: Quantum Crystallography

    Matta, Cherif F. / Massa, Lou

    Projectors and kernel subspaces preserving N-representability

    2021  

    Abstract: Consider a projector matrix P, representing the first order reduced density matrix in a basis of orthonormal atom-centric basis functions. A mathematical question arises, and that is, how to break P into its natural component kernel projector matrices, ... ...

    Abstract Consider a projector matrix P, representing the first order reduced density matrix in a basis of orthonormal atom-centric basis functions. A mathematical question arises, and that is, how to break P into its natural component kernel projector matrices, while preserving N-representability of P. The answer relies upon 2- projector triple products, P'jPP'j. The triple product solutions, applicable within the quantum crystallography of large molecules, are determined by a new form of the Clinton equations, which - in their original form - have long been used to ensure N-representability of density matrices consistent with X-ray diffraction scattering factors.
    Keywords Quantum Physics ; Quantitative Biology - Biomolecules
    Publishing date 2021-09-07
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Quantum crystallography in medicinal chemistry.

    Matta, Chérif F / Massa, Lou

    Future medicinal chemistry

    2018  Volume 10, Issue 13, Page(s) 1525–1527

    MeSH term(s) Chemistry, Pharmaceutical ; Computer-Aided Design ; Crystallography/methods ; Drug Design ; Humans ; Quantum Theory ; Structure-Activity Relationship ; Thermodynamics
    Language English
    Publishing date 2018-07-11
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc-2018-0162
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  8. Article: Sleep disorders and peripartum

    Palagini, Laura / Massa, Lucia / Riemann, Dieter

    (In: Percudani, Mauro; Bramante, Alessandra; Brenna, Valeria; Pariante, Carmine (Ed.), Key topics in perinatal mental health (pp. 113-125). Cham: Springer)

    2022  

    Abstract: Sleep is commonly impaired during peripartum due to anatomical, endocrinological, physiological, psychological, behavioral, socioeconomic, and cultural factors. Cumulative evidence suggests that disrupted sleep in pregnancy is linked to negative ... ...

    Title translation Schlafstörungen und Peripartum (DeepL)
    Series title In: Percudani, Mauro; Bramante, Alessandra; Brenna, Valeria; Pariante, Carmine (Ed.), Key topics in perinatal mental health (pp. 113-125). Cham: Springer
    Abstract Sleep is commonly impaired during peripartum due to anatomical, endocrinological, physiological, psychological, behavioral, socioeconomic, and cultural factors. Cumulative evidence suggests that disrupted sleep in pregnancy is linked to negative gestational and birth outcomes, including an increased risk of peripartum psychopathology. Disturbed sleep has been associated with the emergence of new depressive symptoms in pregnancy and postpartum and may be the final common pathway in the development of postpartum psychotic episodes. Most importantly, sleep disturbances during peripartum have linked to an increased suicidal risk. Maternal sleep patterns in pregnancy may also entrain infant sleep patterns, which can in turn lead to disrupted maternal postpartum sleep. Sleep in the perinatal period has been considered a family issue with potential short-term and the long-term consequences on the mental health of the whole family, in particular modifying a child's vulnerability to mental health across the lifespan. In this framework, assessing and treating sleep disturbances during peripartum should be a priority in clinical practice. It might reduce the risk for postpartum psychopathology and prevent short-term/long-term consequences on the whole family's mental health. Alternatively, modulation of sleep-wake patterns could offer relief to women in whom symptoms of these disorders have already developed. In this chapter, pregnancy-related changes in sleep physiology and the most frequent sleep disturbances in peripartum are discussed. (c) The Author(s), under exclusive license to Springer Nature Switzerland AG
    Keywords Alpträume ; Gesundheitliche Folgen ; Health Outcomes ; Insomnia ; Mental Health ; Nightmares ; Physiologie ; Physiology ; Postnatal Period ; Postnatale Phase ; Pregnancy ; Psychische Gesundheit ; Psychopathologie ; Psychopathology ; Restless Leg Syndrom ; Restless Leg Syndrome ; Schlaf-Wach-Störungen ; Schlaflosigkeit ; Schlafqualität ; Schwangerschaft ; Sleep Quality ; Sleep Wake Disorders
    Language English
    Document type Article
    DOI 10.1007/978-3-030-91832-3_7
    Database PSYNDEX

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  9. Article: The futurist: a conversation with Minnesota's Chief Hospital Executive. Interview by Carmen Peota.

    Massa, Lawrence

    Minnesota medicine

    2011  Volume 94, Issue 9, Page(s) 22–23

    MeSH term(s) Cost Control/trends ; Financing, Government/economics ; Financing, Government/organization & administration ; Forecasting ; Hospital-Physician Relations ; Hospitals, State/economics ; Hospitals, State/organization & administration ; Humans ; Minnesota ; Physician Executives
    Language English
    Publishing date 2011-09
    Publishing country United States
    Document type Interview
    ZDB-ID 391068-4
    ISSN 1945-3051 ; 0026-556X
    ISSN (online) 1945-3051
    ISSN 0026-556X
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  10. Article ; Online: Lipid-Lowering Drug Therapy: Critical Approach for Implementation in Clinical Practice.

    Rossi, Maddalena / Fabris, Enrico / Barbisan, Davide / Massa, Laura / Sinagra, Gianfranco

    American journal of cardiovascular drugs : drugs, devices, and other interventions

    2021  Volume 22, Issue 2, Page(s) 141–155

    Abstract: Increased levels of low-density lipoprotein cholesterol (LDL-C) are recognized as a primary risk factor for atherosclerotic cardiovascular disease, which remains the leading cause of death worldwide. Lowering LDL-C levels clearly reduces the risk of ... ...

    Abstract Increased levels of low-density lipoprotein cholesterol (LDL-C) are recognized as a primary risk factor for atherosclerotic cardiovascular disease, which remains the leading cause of death worldwide. Lowering LDL-C levels clearly reduces the risk of cardiovascular events, with benefits related to both absolute reduction and duration of treatment; however, a threshold below which low LDL-C levels can be dangerous has never been established. Since the discovery of statins, cardiovascular research has focused on developing new lipid-lowering agents. Ezetimibe and proprotein convertase subtilisin-kexin type 9 inhibitors have been found to further reduce LDL-C values and subsequent cardiovascular risk. Novel recently approved inclisiran and bempedoic acid, currently being tested in cardiovascular outcomes studies, are further expanding our pharmacological armamentarium, enabling the clinician to diminish residual risk related to LDL-C. Moreover, new agents are paving the way to successful treatment of homozygous familial hypercholesterolemia. This review summarizes the main characteristics of current and emerging lipid-lowering therapies to assist with comprehensive evidence-based decision making.
    MeSH term(s) Anticholesteremic Agents/adverse effects ; Cholesterol, LDL ; Ezetimibe ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hypolipidemic Agents/adverse effects ; Proprotein Convertase 9
    Chemical Substances Anticholesteremic Agents ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Hypolipidemic Agents ; Proprotein Convertase 9 (EC 3.4.21.-) ; Ezetimibe (EOR26LQQ24)
    Language English
    Publishing date 2021-09-13
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2052547-3
    ISSN 1179-187X ; 1175-3277
    ISSN (online) 1179-187X
    ISSN 1175-3277
    DOI 10.1007/s40256-021-00497-3
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