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  1. Article ; Online: Homelessness and COVID-19

    Massimo Ralli / Andrea Arcangeli / Lucia Ercoli

    Annals of Global Health, Vol 87, Iss

    Leaving No One Behind

    2021  Volume 1

    Abstract: The United Nations 2030 Agenda for Sustainable Development promotes the “Leaving no one behind” principle and sets goals in areas of critical importance. This principle has become extraordinarily important during the COVID-19 pandemic, and is especially ... ...

    Abstract The United Nations 2030 Agenda for Sustainable Development promotes the “Leaving no one behind” principle and sets goals in areas of critical importance. This principle has become extraordinarily important during the COVID-19 pandemic, and is especially relevant for fragile populations, such as people experiencing homelessness. Homeless persons live in congregate and poor hygiene settings that may favor virus transmission, often have underling physical and mental comorbidities that place them at high risk of severe forms of COVID-19, and have limited access to public healthcare and social services. In addition, the homeless are often overlooked by safety and health monitoring actions. All of these factors, taken together, place homeless persons at high risk of being left behind. It is therefore of utmost importance to put in place adequate public health measures to limit spread of infection among homeless persons, rapidly identify and isolate asymptomatic and minimally symptomatic subjects, promptly and appropriately treat positive cases, and correctly handle the entire socioeconomic environment of vulnerable people.
    Keywords Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Ubiquity Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Homeless Shelter Characteristics and Prevalence of SARS-CoV-2

    Massimo Ralli / Andrea Arcangeli / Aldo Morrone / Lucia Ercoli

    Western Journal of Emergency Medicine, Vol 22, Iss

    2020  Volume 2

    Keywords Medicine ; R ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher eScholarship Publishing, University of California
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Occupational Noise

    Adam Sheppard / Massimo Ralli / Antonio Gilardi / Richard Salvi

    International Journal of Environmental Research and Public Health, Vol 17, Iss 8963, p

    Auditory and Non-Auditory Consequences

    2020  Volume 8963

    Abstract: Occupational noise exposure accounts for approximately 16% of all disabling hearing losses, but the true value and societal costs may be grossly underestimated because current regulations only identify hearing impairments in the workplace if exposures ... ...

    Abstract Occupational noise exposure accounts for approximately 16% of all disabling hearing losses, but the true value and societal costs may be grossly underestimated because current regulations only identify hearing impairments in the workplace if exposures result in audiometric threshold shifts within a limited frequency region. Research over the past several decades indicates that occupational noise exposures can cause other serious auditory deficits such as tinnitus, hyperacusis, extended high-frequency hearing loss, and poor speech perception in noise. Beyond the audiogram, there is growing awareness that hearing loss is a significant risk factor for other debilitating and potentially life-threatening disorders such as cardiovascular disease and dementia. This review discusses some of the shortcomings and limitations of current noise regulations in the United States and Europe.
    Keywords occupational noise exposure ; ultra-high frequency ; otoacoustic emissions ; hidden hearing loss ; tinnitus ; hyperacusis ; Medicine ; R
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Beyond the labyrinth: Reevaluating contralateral hearing impacts in Ménière's disease.

    Alfonso, Scarpa / Mario, Carucci / Massimo, Ralli / Claudia, Cassandro / Pietro, De Luca / Giovanni, Salzano / Pasquale, Viola / Giuseppe, Chiarella / Antonio, Salzano Francesco

    American journal of otolaryngology

    2024  Volume 45, Issue 2, Page(s) 104224

    MeSH term(s) Humans ; Meniere Disease ; Ear, Inner ; Hearing
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Letter
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2024.104224
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  5. Article ; Online: Evaluation of General Health Status of Persons Living in Socio-Economically Disadvantaged Neighborhoods in a Large European Metropolitan City

    Claudia Iacoella / Fabio De-Giorgio / Gaspare Palaia / Mario Ferraioli / Andrea Arcangeli / Massimo Ralli

    Applied Sciences, Vol 12, Iss 7428, p

    2022  Volume 7428

    Abstract: Background: Living in socio-economically disadvantaged neighborhoods can predispose persons to numerous health conditions. The purpose of this study was to report the general health conditions of persons living in disadvantaged neighborhoods in Rome, ... ...

    Abstract Background: Living in socio-economically disadvantaged neighborhoods can predispose persons to numerous health conditions. The purpose of this study was to report the general health conditions of persons living in disadvantaged neighborhoods in Rome, Italy, a large European metropolitan city. Participants were reached through the mobile facilities of the primary care services of the Dicastery for the Charity Services, Vatican City. Methods: People living in disadvantaged neighborhoods were reached with mobile medical units by doctors, nurses, and paramedics. Demographic characteristics, degree of social integration, housing conditions, and history of smoking and/or alcohol use were investigated. Unstructured interviews and general health assessments were performed to investigate common acute and/or chronic diseases, and history of positivity to COVID-19. Basic health parameters were measured; data were collected and analyzed. Results: Over a 10-month period, 436 individuals aged 18–95 years were enrolled in the study. Most lived in dormitories, whereas a few lived in unsheltered settings. Most participants (76%) were unemployed. Smoking and drinking habits were comparable to the general population. The most common pathological conditions were cardiovascular diseases in 103 subjects (23.39%), diabetes in 65 (14.9%), followed by musculoskeletal system disorders (11.7%), eye diseases (10.5%), psychiatric conditions such as anxiety and depression (9.2%), and chronic respiratory conditions (8.7%). Conclusions: Subjects in our sample showed several pathologic conditions that may be related to their living conditions, thus encouraging the development of more efficient and effective strategies for a population-tailored diagnosis and treatment.
    Keywords homelessness ; fragile populations ; disadvantaged conditions ; general health assessment ; prevention ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 300
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Diagnostic Predictors of Immunotherapy Response in Head and Neck Squamous Cell Carcinoma

    Piero Giuseppe Meliante / Federica Zoccali / Marco de Vincentiis / Massimo Ralli / Carla Petrella / Marco Fiore / Antonio Minni / Christian Barbato

    Diagnostics, Vol 13, Iss 862, p

    2023  Volume 862

    Abstract: Programmed cell death ligand-1 (PD-L1) binds PD-1 on CD 8+ lymphocytes, inhibiting their cytotoxic action. Its aberrant expression by head and neck squamous cell carcinoma (HNSCC) cells leads to immune escape. Pembrolizumab and nivolumab, two humanized ... ...

    Abstract Programmed cell death ligand-1 (PD-L1) binds PD-1 on CD 8+ lymphocytes, inhibiting their cytotoxic action. Its aberrant expression by head and neck squamous cell carcinoma (HNSCC) cells leads to immune escape. Pembrolizumab and nivolumab, two humanized monoclonal antibodies against PD-1, have been approved in HNSCC treatment, but ~60% of patients with recurrent or metastatic HNSCC fail to respond to immunotherapy and only 20 to 30% of treated patients have long-term benefits. The purpose of this review is to analyze all the fragmentary evidence present in the literature to identify what future diagnostic markers could be useful for predicting, together with PD-L1 CPS, the response to immunotherapy and its durability. We searched PubMed, Embase, and the Cochrane Register of Controlled Trials and we summarize the evidence collected in this review. We confirmed that PD-L1 CPS is a predictor of response to immunotherapy, but it should be measured across multiple biopsies and repeatedly over time. PD-L2, IFN-γ, EGFR, VEGF, TGF–β, TMB, blood TMB, CD73, TILs, alternative splicing, tumor microenvironment, and some macroscopic and radiological features are promising predictors worthy of further studies. Studies comparing predictors appear to give greater potency to TMB and CXCR9.
    Keywords head and neck squamous cell carcinoma ; immunotherapy ; PD-1/PD-L1 ; immunotherapy molecular marker ; immunotherapy resistance ; pembrolizumab ; Medicine (General) ; R5-920
    Subject code 610 ; 616
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Mass vaccination campaign for residents and workers and assistance to vulnerable populations during COVID-19 pandemic

    Massimo Ralli / Fabio De-Giorgio / Paolo Maurizio Soave / Lucia Ercoli / Andrea Arcangeli

    The Lancet Regional Health. Europe, Vol 2, Iss , Pp 100053- (2021)

    The experience of the healthcare services of the Vatican City

    2021  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Role of Clinical–Demographic Data in Survival Rates of Advanced Laryngeal Cancer

    Eugenia Allegra / Maria Rita Bianco / Massimo Ralli / Antonio Greco / Diletta Angeletti / Marco de Vincentiis

    Medicina, Vol 57, Iss 267, p

    2021  Volume 267

    Abstract: Background and Objectives : Laryngeal cancer is one of the most common cancers in the upper aerodigestive tract, and tobacco and alcohol habits are the most relevant risk factors. The role of these risk factors in the incidence of laryngeal carcinomas is ...

    Abstract Background and Objectives : Laryngeal cancer is one of the most common cancers in the upper aerodigestive tract, and tobacco and alcohol habits are the most relevant risk factors. The role of these risk factors in the incidence of laryngeal carcinomas is well known, yet only a few studies have been conducted on their role as risk factors of prognosis. The aim of the study was to assess the impact of clinical–demographic data on overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) in patients with advanced-stage laryngeal cancer (Stage III–IV) who underwent total laryngectomy. Materials and Methods : This retrospective study was carried out on patients with Stage III–IV laryngeal squamous cell carcinoma treated with total laryngectomy between 2004 and 2014. For each patient, clinical and anamnestic data were collected and collated in a database, including alcohol and smoking habits. Results : Considering the variable age, family history, alcohol, grading, subsite, stage, pT stage, pN stage, and adjuvant therapy, no statistical significance was found for five-year OS. Smoking was the only variable that was statistically significant ( p = 0.0043). A relevant difference was noted in the five-year DFS between pN-negative and pN-positive tumors (74.3% vs. 55.26%, respectively; p = 0.056), and a statistically significant difference was found between non- and ≤20 cigarettes/day smokers and heavy smokers (77.78% vs. 53.66%, respectively; p = 0.021). The five-year disease-specific survival rate was 68.83%, and a significant difference was detected for the smoking and pN stage variables. Heavy smokers (43.90% died vs. 16.67% of the non- and ≤20 cigarettes/day smokers; p = 0.0057) and pN-positive (42.1% died vs. 20.51% of the pN-negative patients; p = 0.042) patients had a worse prognosis. Conclusion : Smoking in our study was found to be an important independent risk factor for worse OS and DSS in patients with advanced laryngeal cancer.
    Keywords total laryngectomy ; tobacco-related cancers ; laryngeal cancer ; advanced laryngeal cancer ; Medicine (General) ; R5-920
    Subject code 616 ; 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Rare localization of tongue vascular lesion detected by multi‐parametric magnetic resonance imaging

    Antonio Gilardi / Massimo Ralli / Andrea Colizza / Arianna Di Stadio / Daniela Messineo / Mara Riminucci / Alessandro Corsi / Antonio Greco / Marco de Vincentiis

    Clinical Case Reports, Vol 10, Iss 1, Pp n/a-n/a (2022)

    2022  

    Abstract: Abstract Hemangiomas are developmental vascular abnormalities that are common in the head and neck (60%), rare in the oral cavity, and uncommon in the tongue. A patient performed a multi‐parametric MRI, which characterized the lesion of his tongue, ... ...

    Abstract Abstract Hemangiomas are developmental vascular abnormalities that are common in the head and neck (60%), rare in the oral cavity, and uncommon in the tongue. A patient performed a multi‐parametric MRI, which characterized the lesion of his tongue, providing relevant information for diagnostic, therapeutic orientation, and realization of slight aggressive surgery with consequent excellent recovery.
    Keywords differential diagnosis ; hemangioma ; MRI ; surgical planning ; tongue cancer ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Obstructive Sleep Apnea Syndrome

    Giannicola Iannella / Giuseppe Magliulo / Antonio Greco / Marco de Vincentiis / Massimo Ralli / Antonino Maniaci / Annalisa Pace / Claudio Vicini

    International Journal of Environmental Research and Public Health, Vol 19, Iss 2459, p

    From Symptoms to Treatment

    2022  Volume 2459

    Abstract: Obstructive sleep apnea (OSA) syndrome is a respiratory sleep disorder characterized by partial or complete recurrent episodes of upper airway collapse that occur during the night. The OSA manifests with a reduction (hypopnea) or complete cessation ( ... ...

    Abstract Obstructive sleep apnea (OSA) syndrome is a respiratory sleep disorder characterized by partial or complete recurrent episodes of upper airway collapse that occur during the night. The OSA manifests with a reduction (hypopnea) or complete cessation (apnea) of airflow in the upper airways, associated with breathing effort. OSA is a frequent and often underestimated pathology affecting between 2 and 5% of the middle-aged population. Typical nocturnal symptoms are the persistent snoring and awakenings with dyspnea sensation. On the other hand, diurnal symptoms could be sleepiness, headaches, asthenia, neurological disorders, and impaired personal relationships. Surgery of the velo-pharyngeal region had a huge evolution going from ablative techniques (UP3 and LAUP) to remodeling techniques of the pharyngeal lateral walls.
    Keywords obstructive sleep apnea ; sleep ; sleep apnea treatment ; sleep apnea surgery ; Medicine ; R
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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