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Article ; Online: Transcranial magnetic stimulation on the right dorsal attention network modulates the center-surround profile of the attentional focus.

Massironi, Andrea / Lazzari, Giorgio / La Rocca, Stefania / Ronconi, Luca / Daini, Roberta / Lega, Carlotta

Cerebral cortex (New York, N.Y. : 1991)

2024 Volume 34, Issue 2

Abstract: Psychophysical observations indicate that the spatial profile of visuospatial attention includes a central enhancement around the attentional focus, encircled by a narrow zone of reduced excitability in the immediate surround. This inhibitory ring ... ...

Abstract	Psychophysical observations indicate that the spatial profile of visuospatial attention includes a central enhancement around the attentional focus, encircled by a narrow zone of reduced excitability in the immediate surround. This inhibitory ring optimally amplifies relevant target information, likely stemming from top-down frontoparietal recurrent activity modulating early visual cortex activations. However, the mechanisms through which neural suppression gives rise to the surrounding attenuation and any potential hemispheric specialization remain unclear. We used transcranial magnetic stimulation to evaluate the role of two regions of the dorsal attention network in the center-surround profile: the frontal eye field and the intraparietal sulcus. Participants performed a psychophysical task that mapped the entire spatial attentional profile, while transcranial magnetic stimulation was delivered either to intraparietal sulcus or frontal eye field on the right (Experiment 1) and left (Experiment 2) hemisphere. Results showed that stimulation of right frontal eye field and right intraparietal sulcus significantly changed the center-surround profile, by widening the inhibitory ring around the attentional focus. The stimulation on the left frontal eye field, but not left intraparietal sulcus, induced a general decrease in performance but did not alter the center-surround profile. Results point to a pivotal role of the right dorsal attention network in orchestrating inhibitory spatial mechanisms required to limit interference by surrounding distractors.
MeSH term(s)	Humans ; Transcranial Magnetic Stimulation ; Functional Laterality/physiology ; Parietal Lobe/physiology ; Frontal Lobe/physiology ; Photic Stimulation/methods ; Magnetic Resonance Imaging ; Brain Mapping
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhae015
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Advancing Food Preservation: Sustainable Green-AgNPs Bionanocomposites in Paper-Starch Flexible Packaging for Prolonged Shelf Life.

Trotta, Federico / Da Silva, Sidonio / Massironi, Alessio / Mirpoor, Seyedeh Fatemeh / Lignou, Stella / Ghawi, Sameer Khalil / Charalampopoulos, Dimitris

Polymers

2024 Volume 16, Issue 7

Abstract: In the pursuit of enhancing food packaging, nanotechnology, particularly green silver nanoparticles (G-AgNPs), have gained prominence for its remarkable antimicrobial properties with high potential for food shelf-life extension. Our study aims to develop ...

Abstract	In the pursuit of enhancing food packaging, nanotechnology, particularly green silver nanoparticles (G-AgNPs), have gained prominence for its remarkable antimicrobial properties with high potential for food shelf-life extension. Our study aims to develop corn starch-based coating materials reinforced with G-AgNPs. The mechanical properties were examined using a uniaxial tensile tester, revealing that starch coated with the highest G-AgNPs concentration (12.75 ppm) exhibited UTS of 87.6 MPa compared to 48.48 MPa of control paper, a significant (
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym16070941
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Recent Advances in the Development of Biomimetic Materials.

Ciulla, Maria G / Massironi, Alessio / Sugni, Michela / Ensign, Matthew A / Marzorati, Stefania / Forouharshad, Mahdi

Gels (Basel, Switzerland)

2023 Volume 9, Issue 10

Abstract: In this review, we focused on recent efforts in the design and development of materials with biomimetic properties. Innovative methods promise to emulate cell microenvironments and tissue functions, but many aspects regarding cellular communication, ... ...

Abstract	In this review, we focused on recent efforts in the design and development of materials with biomimetic properties. Innovative methods promise to emulate cell microenvironments and tissue functions, but many aspects regarding cellular communication, motility, and responsiveness remain to be explained. We photographed the state-of-the-art advancements in biomimetics, and discussed the complexity of a "bottom-up" artificial construction of living systems, with particular highlights on hydrogels, collagen-based composites, surface modifications, and three-dimensional (3D) bioprinting applications. Fast-paced 3D printing and artificial intelligence, nevertheless, collide with reality: How difficult can it be to build reproducible biomimetic materials at a real scale in line with the complexity of living systems? Nowadays, science is in urgent need of bioengineering technologies for the practical use of bioinspired and biomimetics for medicine and clinics.
Language	English
Publishing date	2023-10-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels9100833
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Renewable Polysaccharides Micro/Nanostructures for Food and Cosmetic Applications.

Massironi, Alessio / Morelli, Andrea / Puppi, Dario / Chiellini, Federica

Molecules (Basel, Switzerland)

2020 Volume 25, Issue 21

Abstract: The worldwide diffusion of nanotechnologies into products nowadays has completely revolutionized human life, providing novel comfort and benefits. Their inclusion in food and cosmetic has a heavy impact over the market, allowing the development of higher ...

Abstract	The worldwide diffusion of nanotechnologies into products nowadays has completely revolutionized human life, providing novel comfort and benefits. Their inclusion in food and cosmetic has a heavy impact over the market, allowing the development of higher value products with enhanced properties. Natural origin polymers and in particular polysaccharides represent a versatile platform of materials for the development of micro/nanostructured additives for food and cosmetic products due to their chemical versatility, biocompatibility, and abundance. Here, we review the current applications of polysaccharides-based micro/nanostructures, taking into consideration the precursors' production, isolation, and extraction methods and highlighting the advantages, possible drawbacks, and market diffusion.
MeSH term(s)	Agaricales/chemistry ; Biocompatible Materials/chemistry ; Biological Products/chemistry ; Cellulose/chemistry ; Complex Mixtures/chemistry ; Cosmetics/chemistry ; Edible Grain/chemistry ; Food Additives/chemistry ; Humans ; Nanostructures/chemistry ; Phaeophyceae/chemistry ; Polysaccharides/chemistry
Chemical Substances	Biocompatible Materials ; Biological Products ; Complex Mixtures ; Cosmetics ; Food Additives ; Polysaccharides ; Cellulose (9004-34-6)
Language	English
Publishing date	2020-10-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25214886
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.MO 81: Show issues

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Article ; Online: Silver Bionanocomposites as Active Food Packaging: Recent Advances & Future Trends Tackling the Food Waste Crisis.

Trotta, Federico / Da Silva, Sidonio / Massironi, Alessio / Mirpoor, Seyedeh Fatemeh / Lignou, Stella / Ghawi, Sameer Khalil / Charalampopoulos, Dimitris

Polymers

2023 Volume 15, Issue 21

Abstract: Food waste is a pressing global challenge leading to over $1 trillion lost annually and contributing up to 10% of global greenhouse gas emissions. Extensive study has been directed toward the use of active biodegradable packaging materials to improve ... ...

Abstract	Food waste is a pressing global challenge leading to over $1 trillion lost annually and contributing up to 10% of global greenhouse gas emissions. Extensive study has been directed toward the use of active biodegradable packaging materials to improve food quality, minimize plastic use, and encourage sustainable packaging technology development. However, this has been achieved with limited success, which can mainly be attributed to poor material properties and high production costs. In the recent literature, the integration of silver nanoparticles (AgNPs) has shown to improve the properties of biopolymer, prompting the development of bionanocomposites. Furthermore, the antibacterial properties of AgNPs against foodborne pathogens leads towards food shelf-life improvement and provides a route towards reducing food waste. However, few reviews have analyzed AgNPs holistically throughout a portfolio of biopolymers from an industrial perspective. Hence, this review critically analyses the antibacterial, barrier, mechanical, thermal, and water resistance properties of AgNP-based bionanocomposites. These advanced materials are also discussed in terms of food packaging applications and assessed in terms of their performance in enhancing food shelf-life. Finally, the current barriers towards the commercialization of AgNP bionanocomposites are critically discussed to provide an industrial action plan towards the development of sustainable packaging materials to reduce food waste.
Language	English
Publishing date	2023-10-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15214243
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Synthesis and Characterization of Curcumin-Loaded Nanoparticles of Poly(Glycerol Sebacate): A Novel Highly Stable Anticancer System.

Massironi, Alessio / Marzorati, Stefania / Marinelli, Alessandra / Toccaceli, Marta / Gazzotti, Stefano / Ortenzi, Marco Aldo / Maggioni, Daniela / Petroni, Katia / Verotta, Luisella

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 20

Abstract: The research for alternative administration methods for anticancer drugs, towards enhanced effectiveness and selectivity, represents a major challenge for the scientific community. In the last decade, polymeric nanostructured delivery systems represented ...

Abstract	The research for alternative administration methods for anticancer drugs, towards enhanced effectiveness and selectivity, represents a major challenge for the scientific community. In the last decade, polymeric nanostructured delivery systems represented a promising alternative to conventional drug administration since they ensure secure transport to the selected target, providing active compounds protection against elimination, while minimizing drug toxicity to non-target cells. In the present research, poly(glycerol sebacate), a biocompatible polymer, was synthesized and then nanostructured to allow curcumin encapsulation, a naturally occurring polyphenolic phytochemical isolated from the powdered rhizome of
MeSH term(s)	Humans ; Curcumin/chemistry ; Cell Line, Tumor ; Nanoparticles/chemistry ; Polymers/chemistry ; Antineoplastic Agents/chemistry ; Water ; Particle Size ; Drug Carriers/chemistry
Chemical Substances	Curcumin (IT942ZTH98) ; poly(glycerol-sebacate) ; Polymers ; Antineoplastic Agents ; Water (059QF0KO0R) ; Drug Carriers
Language	English
Publishing date	2022-10-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27206997
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Zs.MO 81: Show issues

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Article ; Online: Selective Supercritical CO

Massironi, Alessio / Di Fonzo, Alessandro / Bassanini, Ivan / Ferrandi, Erica Elisa / Marzorati, Stefania / Monti, Daniela / Verotta, Luisella

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 15

Abstract: The valorization of biomass residuals constitutes a key aspect of circular economy and thus a major challenge for the scientific community. Among industrial wastes, plant residuals could represent an attractive source of bioactive compounds. In this ... ...

Abstract	The valorization of biomass residuals constitutes a key aspect of circular economy and thus a major challenge for the scientific community. Among industrial wastes, plant residuals could represent an attractive source of bioactive compounds. In this context, a residue from the industrial extraction of
MeSH term(s)	Carbon Dioxide/chemistry ; Chromatography, Supercritical Fluid/methods ; Cucurbita ; Plant Oils/chemistry ; Seeds/chemistry
Chemical Substances	Plant Oils ; Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2022-07-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27154783
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Article ; Online: Development and Characterization of Highly Stable Silver NanoParticles as Novel Potential Antimicrobial Agents for Wound Healing Hydrogels.

Massironi, Alessio / Franco, Albina Ribeiro / Babo, Pedro Sousa / Puppi, Dario / Chiellini, Federica / Reis, Rui L / Gomes, Manuela Estima

International journal of molecular sciences

2022 Volume 23, Issue 4

Abstract: Recurrent microbial infections are a major cause of surgical failure and morbidity. Wound healing strategies based on hydrogels have been proposed to provide at once a barrier against pathogen microbial colonization, as well as a favorable environment ... ...

Abstract	Recurrent microbial infections are a major cause of surgical failure and morbidity. Wound healing strategies based on hydrogels have been proposed to provide at once a barrier against pathogen microbial colonization, as well as a favorable environment for tissue repair. Nevertheless, most biocompatible hydrogel materials are more bacteriostatic than antimicrobial materials, and lack specific action against pathogens. Silver-loaded polymeric nanocomposites have efficient and selective activity against pathogenic organisms exploitable for wound healing. However, the loading of metallic nanostructures into hydrogels represents a major challenge due to the low stability of metal colloids in aqueous environments. In this context, the aim of the present study was the development of highly stable silver nanoparticles (AgNPs) as novel potential antimicrobial agents for hyaluronic acids hydrogels. Two candidate stabilizing agents obtained from natural and renewable sources, namely cellulose nanocrystals and ulvan polysaccharide, were exploited to ensure high stability of the silver colloid. Both stabilizing agents possess inherent bioactivity and biocompatibility, as well as the ability to stabilize metal nanostructures thanks to their supramolecular structures. Silver nitrate reduction through sodium borohydride in presence of the selected stabilizing agents was adopted as a model strategy to achieve AgNPs with narrow size distribution. Optimized AgNPs stabilized with the two investigated polysaccharides demonstrated high stability in phosphate buffer saline solution and strong antimicrobial activity. Loading of the developed AgNPs into photocrosslinked methacrylated hyaluronic acid hydrogels was also investigated for the first time as an effective strategy to develop novel antimicrobial wound dressing materials.
MeSH term(s)	Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Bandages ; Cellulose/chemistry ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Metal Nanoparticles/chemistry ; Nanocomposites/chemistry ; Polysaccharides/chemistry ; Silver/chemistry ; Wound Healing/drug effects
Chemical Substances	Anti-Infective Agents ; Hydrogels ; Polysaccharides ; ulvan ; Silver (3M4G523W1G) ; Cellulose (9004-34-6)
Language	English
Publishing date	2022-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23042161
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Ulvan as novel reducing and stabilizing agent from renewable algal biomass: Application to green synthesis of silver nanoparticles

Massironi, Alessio / Andrea Morelli / Cristina Della Pina / Dario Puppi / Federica Chiellini / Giovanna Batoni / Giuseppantonio Maisetta / Lucia Grassi / Semih Esin / Simona Braccini

Carbohydrate polymers. 2019 Jan. 01, v. 203

2019

Abstract: Silver nanoparticles (AgNPs) have been intensively investigated in virtue of their optical and antimicrobial properties, although their applications have been limited due to inherent toxicity and to the need of employing harsh chemical reagents for the ... ...

Abstract	Silver nanoparticles (AgNPs) have been intensively investigated in virtue of their optical and antimicrobial properties, although their applications have been limited due to inherent toxicity and to the need of employing harsh chemical reagents for the synthesis. In this work, ulvan, a sulfated polysaccharide extracted from green algae belonging to Ulva armoricana sp., was for the first time investigated and identified as reducing and stabilizing agent for AgNPs synthesis by using milder conditions than those conventionally adopted by chemical methods. The synthesized AgNPs were thoroughly characterized to highlight the structure and the role exerted by ulvan in their synthesis and stabilization. The formation of AgNPs stabilized by a thick ulvan shell was assessed by UV–vis, XRD, TEM, DLS and zeta potential analyses. The developed Ulvan based AgNps showed an IC50 in the range of 10 μg/ml in Balb/3T3 mouse embryo fibroblasts and antimicrobial activity toward both Gram + and Gram − bacteria.
Keywords	algae ; antimicrobial properties ; bacteria ; biomass ; embryo (animal) ; fibroblasts ; inhibitory concentration 50 ; mice ; nanosilver ; polysaccharides ; stabilizers ; toxicity ; transmission electron microscopy ; ultraviolet-visible spectroscopy ; Ulva rigida ; X-ray diffraction ; zeta potential
Language	English
Dates of publication	2019-0101
Size	p. 310-321.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2018.09.066
Database	NAL-Catalogue (AGRICOLA)

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Article: Extra-Small Gold Nanospheres Decorated With a Thiol Functionalized Biodegradable and Biocompatible Linear Polyamidoamine as Nanovectors of Anticancer Molecules.

Bloise, Nora / Massironi, Alessio / Della Pina, Cristina / Alongi, Jenny / Siciliani, Stella / Manfredi, Amedea / Biggiogera, Marco / Rossi, Michele / Ferruti, Paolo / Ranucci, Elisabetta / Visai, Livia

Frontiers in bioengineering and biotechnology

2020 Volume 8, Page(s) 132

Abstract: Gold nanoparticles are elective candidate for cancer therapy. Current efforts are devoted to developing innovative methods for their synthesis. Besides, understanding their interaction with cells have become increasingly important for their clinical ... ...

Abstract	Gold nanoparticles are elective candidate for cancer therapy. Current efforts are devoted to developing innovative methods for their synthesis. Besides, understanding their interaction with cells have become increasingly important for their clinical application. This work aims to describe a simple approach for the synthesis of extra-small gold nanoparticles for breast cancer therapy. In brief, a biocompatible and biodegradable polyamidoamine (named AGMA1-SH), bearing 20%, on a molar basis, thiol-functionalized repeat units, is employed to stabilize and coat extra-small gold nanospheres of different sizes (2.5, 3.5, and 5 nm in gold core), and to generate a nanoplatform for the link with Trastuzumab monoclonal antibody for HER2-positive breast cancer targeting. Dynamic light scattering, transmission electron microscopy, ultraviolet visible spectroscopy, X-ray powder diffraction, circular dichroism, protein quantification assays are used for the characterization. The targeting properties of the nanosystems are explored to achieve enhanced and selective uptake of AGMA1-SH-gold nanoparticles by
Language	English
Publishing date	2020-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2020.00132
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