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  1. Book ; Online: Approaching God

    Masterson, Patrick

    Between Phenomenology and Theology

    2013  

    Abstract: Approaching God explores the ways in which phenomenology, metaphysics and theological enquiry can throw light upon each other. This is a matter of great interest and importance to the future of philosophical theology and the philosophy of religion. What, ...

    Abstract Approaching God explores the ways in which phenomenology, metaphysics and theological enquiry can throw light upon each other. This is a matter of great interest and importance to the future of philosophical theology and the philosophy of religion. What, if anything, has philosophical reflection about God to contribute to Christian theology? And if indeed philosophy plays a positive role in theological reflection-what kind of philosophy? The first-person philosophical perspective of phenomenology or the objective philosophical perspective of metaphysics? Masterson devotes three chapters to, re
    Language English
    Size Online-Ressource (217 p)
    Publisher Bloomsbury Publishing
    Publishing place London
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781623563080 ; 1623563089
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Article ; Online: A chromosome-level genome for the nudibranch gastropod Berghia stephanieae helps parse clade-specific gene expression in novel and conserved phenotypes.

    Goodheart, Jessica A / Rio, Robin A / Taraporevala, Neville F / Fiorenza, Rose A / Barnes, Seth R / Morrill, Kevin / Jacob, Mark Allan C / Whitesel, Carl / Masterson, Park / Batzel, Grant O / Johnston, Hereroa T / Ramirez, M Desmond / Katz, Paul S / Lyons, Deirdre C

    BMC biology

    2024  Volume 22, Issue 1, Page(s) 9

    Abstract: Background: How novel phenotypes originate from conserved genes, processes, and tissues remains a major question in biology. Research that sets out to answer this question often focuses on the conserved genes and processes involved, an approach that ... ...

    Abstract Background: How novel phenotypes originate from conserved genes, processes, and tissues remains a major question in biology. Research that sets out to answer this question often focuses on the conserved genes and processes involved, an approach that explicitly excludes the impact of genetic elements that may be classified as clade-specific, even though many of these genes are known to be important for many novel, or clade-restricted, phenotypes. This is especially true for understudied phyla such as mollusks, where limited genomic and functional biology resources for members of this phylum have long hindered assessments of genetic homology and function. To address this gap, we constructed a chromosome-level genome for the gastropod Berghia stephanieae (Valdés, 2005) to investigate the expression of clade-specific genes across both novel and conserved tissue types in this species.
    Results: The final assembled and filtered Berghia genome is comparable to other high-quality mollusk genomes in terms of size (1.05 Gb) and number of predicted genes (24,960 genes) and is highly contiguous. The proportion of upregulated, clade-specific genes varied across tissues, but with no clear trend between the proportion of clade-specific genes and the novelty of the tissue. However, more complex tissue like the brain had the highest total number of upregulated, clade-specific genes, though the ratio of upregulated clade-specific genes to the total number of upregulated genes was low.
    Conclusions: Our results, when combined with previous research on the impact of novel genes on phenotypic evolution, highlight the fact that the complexity of the novel tissue or behavior, the type of novelty, and the developmental timing of evolutionary modifications will all influence how novel and conserved genes interact to generate diversity.
    MeSH term(s) Animals ; Gastropoda/genetics ; Phylogeny ; Evolution, Molecular ; Mollusca/genetics ; Chromosomes ; Phenotype ; Gene Expression
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2133020-7
    ISSN 1741-7007 ; 1741-7007
    ISSN (online) 1741-7007
    ISSN 1741-7007
    DOI 10.1186/s12915-024-01814-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: IBC - Proteomics, 1-2 March 2000, Basel Hilton, Switzerland.

    Masterson, P J

    Comparative and functional genomics

    2008  Volume 2, Issue 3, Page(s) 180–185

    Language English
    Publishing date 2008-07-16
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2043139-9
    ISSN 1532-6268 ; 1531-6912
    ISSN (online) 1532-6268
    ISSN 1531-6912
    DOI 10.1002/cfg.80
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5880: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online: The sense of creation

    Masterson, Patrick

    experience and the god beyond

    (Ashgate philosophy of religion series)

    2008  

    Abstract: What kind of experience might help to confirm and make sense of the puzzling belief in divine creation, so central to the main monotheistic religions? Anselm and Aquinas developed a philosophical understanding of 'Creation' as an asymmetrical ... ...

    Institution ebrary, Inc
    Author's details Patrick Masterson
    Series title Ashgate philosophy of religion series
    Abstract What kind of experience might help to confirm and make sense of the puzzling belief in divine creation, so central to the main monotheistic religions? Anselm and Aquinas developed a philosophical understanding of 'Creation' as an asymmetrical relationship between the world and God i.e. that the world is really related to God in a relationship of total dependence but God is in no way really related to or modified by this created world. This idea of an asymmetrical relationship is the key concept unifying all aspects of this book which discusses the three main inter-related questions in a philos
    Keywords Creation ; God ; Religion/Philosophy ; Transcendence of God
    Language English
    Size Online-Ressource (x, 153 p)
    Publisher Ashgate Pub
    Publishing place Aldershot, England ;Burlington, VT
    Document type Book ; Online
    Note Includes bibliographical references (p. [145]-149) and index
    ISBN 0754664260 ; 9780754664260 ; 9780754692393 ; 0754692396
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article: A chromosome-level genome for the nudibranch gastropod

    Goodheart, Jessica A / Rio, Robin A / Taraporevala, Neville F / Fiorenza, Rose A / Barnes, Seth R / Morrill, Kevin / Jacob, Mark Allan C / Whitesel, Carl / Masterson, Park / Batzel, Grant O / Johnston, Hereroa T / Ramirez, M Desmond / Katz, Paul S / Lyons, Deirdre C

    bioRxiv : the preprint server for biology

    2023  

    Abstract: How novel phenotypes originate from conserved genes, processes, and tissues remains a major question in biology. Research that sets out to answer this question often focuses on the conserved genes and processes involved, an approach that explicitly ... ...

    Abstract How novel phenotypes originate from conserved genes, processes, and tissues remains a major question in biology. Research that sets out to answer this question often focuses on the conserved genes and processes involved, an approach that explicitly excludes the impact of genetic elements that may be classified as clade-specific, even though many of these genes are known to be important for many novel, or clade-restricted, phenotypes. This is especially true for understudied phyla such as mollusks, where limited genomic and functional biology resources for members of this phylum has long hindered assessments of genetic homology and function. To address this gap, we constructed a chromosome-level genome for the gastropod
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.04.552006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dog10K_Boxer_Tasha_1.0: A Long-Read Assembly of the Dog Reference Genome.

    Jagannathan, Vidhya / Hitte, Christophe / Kidd, Jeffrey M / Masterson, Patrick / Murphy, Terence D / Emery, Sarah / Davis, Brian / Buckley, Reuben M / Liu, Yan-Hu / Zhang, Xiang-Quan / Leeb, Tosso / Zhang, Ya-Ping / Ostrander, Elaine A / Wang, Guo-Dong

    Genes

    2021  Volume 12, Issue 6

    Abstract: The domestic dog has evolved to be an important biomedical model for studies regarding the genetic basis of disease, morphology and behavior. Genetic studies in the dog have relied on a draft reference genome of a purebred female boxer dog named "Tasha" ... ...

    Abstract The domestic dog has evolved to be an important biomedical model for studies regarding the genetic basis of disease, morphology and behavior. Genetic studies in the dog have relied on a draft reference genome of a purebred female boxer dog named "Tasha" initially published in 2005. Derived from a Sanger whole genome shotgun sequencing approach coupled with limited clone-based sequencing, the initial assembly and subsequent updates have served as the predominant resource for canine genetics for 15 years. While the initial assembly produced a good-quality draft, as with all assemblies produced at the time, it contained gaps, assembly errors and missing sequences, particularly in GC-rich regions, which are found at many promoters and in the first exons of protein-coding genes. Here, we present Dog10K_Boxer_Tasha_1.0, an improved chromosome-level highly contiguous genome assembly of Tasha created with long-read technologies that increases sequence contiguity >100-fold, closes >23,000 gaps of the CanFam3.1 reference assembly and improves gene annotation by identifying >1200 new protein-coding transcripts. The assembly and annotation are available at NCBI under the accession GCF_000002285.5.
    MeSH term(s) Animals ; Contig Mapping ; Dogs/genetics ; Genome ; Molecular Sequence Annotation
    Language English
    Publishing date 2021-05-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes12060847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Sizing up the current ETF landscape

    Masterson, Phil / Wilchusky, Sue

    The journal of investing Vol. 18 , p. 33-38

    2009  Volume 18, Page(s) 33–38

    Author's details Phil Masterson and Sue Wilchusky
    Keywords Indexderivat ; Welt
    Language English
    Size graph. Darst.
    Publisher Institutional Investor
    Publishing place New York, NY
    Document type Article
    ZDB-ID 1359366-3
    ISSN 1068-0896
    Database ECONomics Information System

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  8. Article ; Online: Did the prion protein become vulnerable to misfolding after an evolutionary divide and conquer event?

    Richmond, Kacy / Masterson, Patrick / Ortiz, Juan Felipe / Siltberg-Liberles, Jessica

    Journal of biomolecular structure & dynamics

    2013  Volume 32, Issue 7, Page(s) 1074–1084

    Abstract: Despite high sequence identity among mammalian prion proteins (PrPs), mammals have varying rates of susceptibility to prion disease resulting in a so-called species barrier. The species barrier follows no clear pattern, with closely related species or ... ...

    Abstract Despite high sequence identity among mammalian prion proteins (PrPs), mammals have varying rates of susceptibility to prion disease resulting in a so-called species barrier. The species barrier follows no clear pattern, with closely related species or similar sequences being no more likely to infect each other, and remains an unresolved enigma. Variation of the conformationally flexible regions may alter the thermodynamics of the conformational change, commonly referred to as the conformational conversion, which occurs in the pathogenic process of the mammalian prion protein. A conformational ensemble scenario is supported by the species barrier in prion disease and evidence that there are strains of pathogenic prion with different conformations within species. To study how conformational flexibility has evolved in the prion protein, an investigation was undertaken on the evolutionary dynamics of structurally disordered regions in the mammalian prion protein, non-mammalian prion protein that is not vulnerable to prion disease, and remote homologs Doppel and Shadoo. Structural disorder prediction analyzed in an evolutionary context revealed that the occurrence of increased or altered conformational flexibility in mammalian PrPs coincides with key events among PrP, Doppel, and Shadoo. Comparatively rapid evolutionary dynamics of conformational flexibility in the prion protein suggest that the species barrier is not a static phenomenon. A small number of amino acid substitutions can repopulate the conformational ensemble and have a disproportionately large effect on pathogenesis.
    MeSH term(s) Animals ; Evolution, Molecular ; GPI-Linked Proteins/chemistry ; Nerve Tissue Proteins/chemistry ; Phylogeny ; Prions/chemistry ; Protein Conformation ; Protein Folding ; Species Specificity
    Chemical Substances GPI-Linked Proteins ; Nerve Tissue Proteins ; PRND protein, human ; Prions ; SPRN protein, human
    Language English
    Publishing date 2013-07-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2013.809022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Rapid evolutionary dynamics of structural disorder as a potential driving force for biological divergence in flaviviruses.

    Ortiz, Juan F / MacDonald, Madolyn L / Masterson, Patrick / Uversky, Vladimir N / Siltberg-Liberles, Jessica

    Genome biology and evolution

    2013  Volume 5, Issue 3, Page(s) 504–513

    Abstract: Protein structure is commonly regarded to be conserved and to dictate function. Most proteins rely on conformational flexibility to some degree. Are regions that convey conformational flexibility conserved over evolutionary time? Can changes in ... ...

    Abstract Protein structure is commonly regarded to be conserved and to dictate function. Most proteins rely on conformational flexibility to some degree. Are regions that convey conformational flexibility conserved over evolutionary time? Can changes in conformational flexibility alter protein function? Here, the evolutionary dynamics of structurally ordered and disordered (flexible) regions are investigated genome-wide in flaviviruses, revealing that the amount and location of structural disorder fluctuates highly among related proteins. Some regions are prone to shift between structured and flexible states. Increased evolutionary dynamics of structural disorder is observed for some lineages but not in others. Lineage-specific transitions of this kind could alter the conformational ensemble accessible to the same protein in different species, causing a functional change, even if the predominant function remains conserved. Thus, rapid evolutionary dynamics of structural disorder is a potential driving force for phenotypic divergence among flaviviruses.
    MeSH term(s) Amino Acid Sequence ; Biological Evolution ; Evolution, Molecular ; Flavivirus/classification ; Flavivirus/genetics ; Molecular Sequence Data ; Mutation Rate ; Phylogeny ; Sequence Alignment ; Viral Proteins/chemistry ; Viral Proteins/genetics
    Chemical Substances Viral Proteins
    Language English
    Publishing date 2013-02-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2495328-3
    ISSN 1759-6653 ; 1759-6653
    ISSN (online) 1759-6653
    ISSN 1759-6653
    DOI 10.1093/gbe/evt026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A chromosome-level reference genome and pangenome for barn swallow population genomics.

    Secomandi, Simona / Gallo, Guido R / Sozzoni, Marcella / Iannucci, Alessio / Galati, Elena / Abueg, Linelle / Balacco, Jennifer / Caprioli, Manuela / Chow, William / Ciofi, Claudio / Collins, Joanna / Fedrigo, Olivier / Ferretti, Luca / Fungtammasan, Arkarachai / Haase, Bettina / Howe, Kerstin / Kwak, Woori / Lombardo, Gianluca / Masterson, Patrick /
    Messina, Graziella / Møller, Anders P / Mountcastle, Jacquelyn / Mousseau, Timothy A / Ferrer Obiol, Joan / Olivieri, Anna / Rhie, Arang / Rubolini, Diego / Saclier, Marielle / Stanyon, Roscoe / Stucki, David / Thibaud-Nissen, Françoise / Torrance, James / Torroni, Antonio / Weber, Kristina / Ambrosini, Roberto / Bonisoli-Alquati, Andrea / Jarvis, Erich D / Gianfranceschi, Luca / Formenti, Giulio

    Cell reports

    2023  Volume 42, Issue 1, Page(s) 111992

    Abstract: Insights into the evolution of non-model organisms are limited by the lack of reference genomes of high accuracy, completeness, and contiguity. Here, we present a chromosome-level, karyotype-validated reference genome and pangenome for the barn swallow ( ... ...

    Abstract Insights into the evolution of non-model organisms are limited by the lack of reference genomes of high accuracy, completeness, and contiguity. Here, we present a chromosome-level, karyotype-validated reference genome and pangenome for the barn swallow (Hirundo rustica). We complement these resources with a reference-free multialignment of the reference genome with other bird genomes and with the most comprehensive catalog of genetic markers for the barn swallow. We identify potentially conserved and accelerated genes using the multialignment and estimate genome-wide linkage disequilibrium using the catalog. We use the pangenome to infer core and accessory genes and to detect variants using it as a reference. Overall, these resources will foster population genomics studies in the barn swallow, enable detection of candidate genes in comparative genomics studies, and help reduce bias toward a single reference genome.
    MeSH term(s) Animals ; Swallows/genetics ; Metagenomics ; Genome/genetics ; Genomics ; Chromosomes
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.111992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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