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Article: Application of Immunohistochemistry in Clinical Practices as a Standardized Assay for Breast Cancer.

Masuda, Shinobu / Nakanishi, Yoko

2023 Volume 56, Issue 1, Page(s) 1–8

Abstract: Immunohistochemistry (IHC) has become an indispensable tool in the clinical practices for breast cancer; however, to achieve its standardization, numerous issues need to be overcome. In this review, we describe the development of IHC as an important ... ...

Abstract	Immunohistochemistry (IHC) has become an indispensable tool in the clinical practices for breast cancer; however, to achieve its standardization, numerous issues need to be overcome. In this review, we describe the development of IHC as an important clinical tool, and the challenges in standardizing IHC results for patients. We also present ideas for resolving the remaining issues and unmet needs, along with future directions.
Language	English
Publishing date	2023-02-14
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	280005-6
ISSN	1347-5800 ; 0044-5991
ISSN (online)	1347-5800
ISSN	0044-5991
DOI	10.1267/ahc.22-00050
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Article ; Online: Pathological examination of breast cancer biomarkers: current status in Japan.

Masuda, Shinobu

Breast cancer (Tokyo, Japan)

2016 Volume 23, Issue 4, Page(s) 546–551

Abstract: This article reviews the current status of pathological evaluation for biomarkers in Japan. The introduced issues are the international trends for estimation of biomarkers considering diagnosis and treatment decision, and pathological issues under ... ...

Abstract	This article reviews the current status of pathological evaluation for biomarkers in Japan. The introduced issues are the international trends for estimation of biomarkers considering diagnosis and treatment decision, and pathological issues under discussion, and how Japanese Breast Cancer Society (JBCS) members have addressed issues related to pathology and biomarkers evaluation. As topics of immunohistochemical study, (1) ASCO/CAP guidelines, (2) Ki67 and other markers, (3) quantification and image analysis, (4) application of cytologic samples, (5) pre-analytical process, and (6) Japan Pathology Quality Assurance System are introduced. Various phases of concepts, guidelines, and methodologies are co-existed in today's clinical practice. It is expected in near future that conventional methods and molecular procedures will be emerged, and Japanese Quality assurance/Quality control (QA/QC) system will work practically. What we have to do in the next generation are to validate novel procedures, to evaluate the relationship between traditional concepts and newly proposed ideas, to establish a well organized QA/QC system, and to standardize pre-analytical process that are the basis of all procedures using pathological tissues.
MeSH term(s)	Biomarkers, Tumor/analysis ; Breast Neoplasms/diagnosis ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Female ; Guidelines as Topic ; Humans ; Immunohistochemistry/methods ; Japan ; Ki-67 Antigen/analysis ; Pathology, Clinical/standards ; Quality Control
Chemical Substances	Biomarkers, Tumor ; Ki-67 Antigen
Language	English
Publishing date	2016-07
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2052429-8
ISSN	1880-4233 ; 1340-6868
ISSN (online)	1880-4233
ISSN	1340-6868
DOI	10.1007/s12282-014-0566-7
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Zs.A 5536: Show issues

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Article: AKR1C3-negative high-risk metastatic castration-sensitive prostate cancer has long-term response to first-line treatment with abiraterone: Four case reports.

Yoshizawa, Tsuyoshi / Nakanishi, Yoko / Obinata, Daisuke / Yamaguchi, Kenya / Masuda, Shinobu / Takahashi, Satoru

Urology case reports

2024 Volume 54, Page(s) 102727

Abstract: We experienced four cases of high-risk metastatic castration-sensitive prostate cancer (mCSPC) in which first-line treatment with abiraterone showed a sustained long-term response of over 5 years. We conducted immunohistochemical staining of aldo-keto ... ...

Abstract	We experienced four cases of high-risk metastatic castration-sensitive prostate cancer (mCSPC) in which first-line treatment with abiraterone showed a sustained long-term response of over 5 years. We conducted immunohistochemical staining of aldo-keto reductase family 1 member C3 (AKR1C3) expression, which associate with poor prognosis of metastatic castration-resistant prostate cancer (mCRPC), and all prostate cancer tissue from four cases showed negative. These results suggested that AKR1C3-negative high-risk mCSPC cases may respond well to first-line treatment with abiraterone. This is the first report describing association of high-risk mCSPC and negative AKR1C3.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2745459-9
ISSN	2214-4420
ISSN	2214-4420
DOI	10.1016/j.eucr.2024.102727
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Article ; Online: A patient with breast fibroadenoma accompanied by carcinoma: early detection by screening.

Enomoto, Katsuhisa / Hara, Yukiko / Dobashi, Kazuyoshi / Masuda, Shinobu / Tada, Keiichiro

Journal of medical ultrasonics (2001)

2022 Volume 50, Issue 1, Page(s) 111–112

MeSH term(s)	Humans ; Female ; Fibroadenoma/diagnostic imaging ; Fibroadenoma/complications ; Breast Neoplasms/diagnostic imaging ; Carcinoma/complications
Language	English
Publishing date	2022-10-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1396630-3
ISSN	1613-2254 ; 0287-0592 ; 1346-4523
ISSN (online)	1613-2254
ISSN	0287-0592 ; 1346-4523
DOI	10.1007/s10396-022-01264-w
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Zs.B 2695 -Engl.Ausg.-: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Correlation between pathology and quantitative ultrasonographic evaluation of pancreatic fat with ultrasonographic classification.

Matsumoto, Naoki / Kumagawa, Mariko / Saito, Kei / Imazu, Hiroo / Ogawa, Masahiro / Kogure, Hirofumi / Okamura, Yukiyasu / Nakanishi, Yoko / Masuda, Shinobu / Sugitani, Masahiko

Journal of medical ultrasonics (2001)

2024

Abstract: Purpose: No studies of the relationship between grayscale sonographic findings and pancreatic fat content have been reported to date. This study aimed to investigate the correlation between echogenicity and fat content of resected specimens using ... ...

Abstract	Purpose: No studies of the relationship between grayscale sonographic findings and pancreatic fat content have been reported to date. This study aimed to investigate the correlation between echogenicity and fat content of resected specimens using quantitative analysis. Methods: Forty-two consecutive patients who underwent pancreatoduodenectomy or distal pancreatectomy for pancreatic tumors were enrolled in this study. Ultrasonographic images were compared with quantitative pathological analysis. Subjective evaluation of echogenicity was classified as hypoechoic, isoechoic, hyperechoic, and super hyperechoic. The total and intralobular fat areas were measured. Results: The mean, median, modal, minimum, and maximum ultrasound gray values correlated with the proportion of total fat area (r = 0.349; 0.357, 0.486, 0.466, and 0.347; p = 0.024, 0.020, 0.014, 0.019, and 0.089, respectively), but did not correlate with the proportion of intralobular fat area. Subjective classification was correlated with median gray value (p < 0.001), intralobular fat area (p = 0.118), and total fat area (p = 0.011). Cases were classified as hypoechoic (n = 3), isoechoic (n = 7), hyperechoic (n = 30), and super hyperechoic (n = 2). The subjective classification was correlated with the median gray value (p < 0.001) and total fat area (p = 0.005), and not correlated with the intralobular fat area (p = 0.118). Hyperechoic or super hyperechoic pancreatic parenchyma contains over 19.7% fat. Computed tomography values correlated with the proportion of intralobular fat area (r = - 0.479, p = 0.004) and total fat area (r = - 0.541, p < 0.001). Conclusion: Echogenicity classified based on subjective evaluation and image analysis were correlated with the proportion of fat in the pancreas.
Language	English
Publishing date	2024-02-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1396630-3
ISSN	1613-2254 ; 0287-0592 ; 1346-4523
ISSN (online)	1613-2254
ISSN	0287-0592 ; 1346-4523
DOI	10.1007/s10396-024-01408-0
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Zs.B 2695: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.B 2695 -Engl.Ausg.-: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Immunohistochemical and molecular profiles of heterogeneous components of metaplastic breast cancer: a squamous cell carcinomatous component was distinct from a spindle cell carcinomatous component.

Suzuki, Takahiro / Nakanishi, Yoko / Tanino, Tomoyuki / Nishimaki-Watanabe, Haruna / Kobayashi, Hiroko / Ohni, Sumie / Tang, Xiaoyan / Hakamada, Kenichi / Masuda, Shinobu

Discover. Oncology

2024 Volume 15, Issue 1, Page(s) 95

Abstract: Metaplastic breast carcinoma (MBC), a category of breast cancer, includes different histological types, which are occasionally mixed and heterogeneous. Considering the heterogeneity of cancer cells in a tumour mass has become highly significant, not only ...

Abstract	Metaplastic breast carcinoma (MBC), a category of breast cancer, includes different histological types, which are occasionally mixed and heterogeneous. Considering the heterogeneity of cancer cells in a tumour mass has become highly significant, not only from a biological aspect but also for clinical management of recurrence. This study aimed to analyse the immunohistochemical and molecular profiles of each MBC component of a tumour mass. Twenty-five MBC tumours were histologically evaluated, and the most frequent MBC component (c) was squamous cell carcinoma (SCC), followed by spindle cell carcinoma (SpCC). A total of 69 components of MBC and non-MBC in formalin-fixed paraffin-embedded sections were examined for 7 markers by immunohistochemistry. SCC(c) were significantly PTEN negative and CK14 positive, and SpCC(c) were significantly E-cadherin negative and vimentin positive. Multivariate analyses revealed that immunohistochemical profiles of normal/intraductal (IC)(c), no special type (NST)(c), and MBC(c) differed; moreover, SCC(c) and SpCC(c) were distinctly grouped. PTEN gene mutation was detected only in SCC(c) (2/7), but not in SpCC(c). Next-generation sequence analyses for 2 cases with tumours containing SCC(c) demonstrated that PTEN gene mutation increased progressively from IC(c) to NST(c) to SCC(c). In conclusion, the immunohistochemical and molecular profiles of the SCC(c) of MBC are distinct from those of the SpCC(c).
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ISSN	2730-6011
ISSN (online)	2730-6011
DOI	10.1007/s12672-024-00950-0
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Article ; Online: Multiple Immunofluorescence Imaging Analysis Reveals Differential Expression of Disialogangliosides GD3 and GD2 in Neuroblastomas.

Nishimaki, Haruna / Nakanishi, Yoko / Yagasaki, Hiroshi / Masuda, Shinobu

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

2021 Volume 25, Issue 2, Page(s) 141–154

Abstract: Background: Peripheral neuroblastic tumors (pNTs) are the most common childhood extracranial solid tumors. There are several therapeutic strategies targeting disialoganglioside GD2. Disialoganglioside GD3 has become a potential target. However, the ... ...

Abstract	Background: Peripheral neuroblastic tumors (pNTs) are the most common childhood extracranial solid tumors. There are several therapeutic strategies targeting disialoganglioside GD2. Disialoganglioside GD3 has become a potential target. However, the mechanism by which pNTs express GD3 and GD2 remains unclear. We investigated the combined expression status of GD3 and GD2 in pNTs and delineated their clinicopathological values. Methods: GD3 and GD2 expression was examined in pNT tissue samples (n = 35) using immunohistochemistry and multiple immunofluorescence imaging. Results: GD3 and GD2 expression was positive in 32/35 and 25/35 samples, respectively. Combinatorial analysis of GD3 and GD2 expression in neuroblastoma showed that both were heterogeneously expressed from cell to cell. There were higher numbers of GD3-positive and GD2-negative cells in the low-risk group than in the intermediate-risk ( Conclusion: We demonstrated that neuroblastomas from low-risk patients included more GD3-positive and GD2-negative cells than those from high-risk patients. Clarifying the heterogeneity of neuroblastoma aids in better understanding the biological characteristics and clinical behavior.
MeSH term(s)	Child ; Fluorescent Antibody Technique ; Gangliosides/metabolism ; Humans ; Immunohistochemistry ; Neuroblastoma/metabolism
Chemical Substances	Gangliosides ; sialogangliosides
Language	English
Publishing date	2021-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463498-3
ISSN	1615-5742 ; 1093-5266
ISSN (online)	1615-5742
ISSN	1093-5266
DOI	10.1177/10935266211048733
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Article ; Online: A comparison of diagnostic utility of new endoscopic scraper combined cell block method and conventional brush catheter for biliary tract cancer.

Kuniyoshi, Noriyuki / Yamada, Koji / Osawa, Rota / Nomura, Shuzo / Fujisawa, Mariko / Saito, Kei / Imazu, Hiroo / Masuda, Shinobu / Kogure, Hirofumi

DEN open

2024 Volume 4, Issue 1, Page(s) e331

Abstract: Background/aims: The sensitivities of endoscopic : Methods: We retrospectively reviewed consecutive patients with biliary strictures in whom CBC cytology or Trefle-assisted tissue acquisition under endoscopic retrograde cholangiopancreatography was ... ...

Abstract	Background/aims: The sensitivities of endoscopic Methods: We retrospectively reviewed consecutive patients with biliary strictures in whom CBC cytology or Trefle-assisted tissue acquisition under endoscopic retrograde cholangiopancreatography was performed for suspected BTCs from January 2015 to June 2022 at our institution. Results: 173 patients (CBC group; Conclusions: Compared to CBC cytology, Trefle-assisted tissue acquisition has superior diagnostic performance while maintaining procedural simplicity and is considered useful for diagnosing malignant biliary stricture.
Language	English
Publishing date	2024-01-19
Publishing country	Australia
Document type	Journal Article
ISSN	2692-4609
ISSN (online)	2692-4609
DOI	10.1002/deo2.331
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Article: [Genomic diagnosis in breast cancer practice].

Masuda, Shinobu

Rinsho byori. The Japanese journal of clinical pathology

2012 Volume 60, Issue 10, Page(s) 969–974

Abstract: Significant targeted molecules for breast cancer treatment are hormone receptor and HER2. Since the concept of an "intrinsic subtype" was proposed, breast cancers have been treated according to subtypes including Luminal A, B, HER2 and triple negative. ... ...

Abstract	Significant targeted molecules for breast cancer treatment are hormone receptor and HER2. Since the concept of an "intrinsic subtype" was proposed, breast cancers have been treated according to subtypes including Luminal A, B, HER2 and triple negative. In this article, gene testing useful as a prognostic factor and to predict the chemotherapeutic effect on ER-positive breast cancers will be introduced, although it has not been approved in Japan. Gene testing is useful but expensive so far; therefore, it will be used in parallel to conventional tools, i.e. HE-stained sections and immunohistochemical methods.
MeSH term(s)	Biomarkers, Tumor/genetics ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Female ; Genetic Testing ; Genomics ; Humans ; Japan ; Molecular Targeted Therapy ; Prognosis
Chemical Substances	Biomarkers, Tumor
Language	Japanese
Publishing date	2012-10
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	604196-6
ISSN	0047-1860 ; 0485-1404
ISSN	0047-1860 ; 0485-1404
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Article ; Online: Breast cancer pathology: the impact of molecular taxonomy on morphological taxonomy.

Masuda, Shinobu

Pathology international

2012 Volume 62, Issue 5, Page(s) 295–302

Abstract: The concept of having an 'intrinsic subtype,' or a molecular taxonomy, lets us clearly recognize that breast cancers have characteristically different patterns of gene expression, thus giving newfound significance to morphological taxonomy. In this ... ...

Abstract	The concept of having an 'intrinsic subtype,' or a molecular taxonomy, lets us clearly recognize that breast cancers have characteristically different patterns of gene expression, thus giving newfound significance to morphological taxonomy. In this review, the concept of the 'intrinsic subtype' is discussed, research questions are introduced to refine the significance of morphological taxonomy, and a corresponding example is presented between microarray analysis and 'immunohistochemical subtype,' or histological taxonomy.
MeSH term(s)	Adenocarcinoma/classification ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Apocrine Glands/pathology ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/classification ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Carcinoma/classification ; Carcinoma/genetics ; Carcinoma/pathology ; Carcinoma, Adenoid Cystic/classification ; Carcinoma, Adenoid Cystic/genetics ; Carcinoma, Adenoid Cystic/pathology ; Carcinoma, Ductal, Breast/classification ; Carcinoma, Ductal, Breast/genetics ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Intraductal, Noninfiltrating/classification ; Carcinoma, Intraductal, Noninfiltrating/genetics ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Carcinoma, Lobular/classification ; Carcinoma, Lobular/genetics ; Carcinoma, Lobular/pathology ; Carcinoma, Medullary/classification ; Carcinoma, Medullary/genetics ; Carcinoma, Medullary/pathology ; Cell Line, Tumor ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Oligonucleotide Array Sequence Analysis ; Systems Biology
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2012-05
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1194850-4
ISSN	1440-1827 ; 1320-5463
ISSN (online)	1440-1827
ISSN	1320-5463
DOI	10.1111/j.1440-1827.2012.02790.x
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