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  1. Article ; Online: Frequency and determinants of serum calcium monitoring during eldecalcitol therapy in patients with osteoporosis.

    Ri, Kairi / Fukasawa, Toshiki / Masuda, Soichiro / Tanaka, Shiro / Takeuchi, Masato / Yoshida, Satomi / Kawakami, Koji

    Journal of bone and mineral metabolism

    2023  Volume 41, Issue 6, Page(s) 890–900

    Abstract: Introduction: Eldecalcitol (ELD) is an active vitamin D: Materials and methods: This was a descriptive cohort study using a Japanese electronic medical records database. We identified osteoporosis patients who initiated treatment with ELD or other ... ...

    Abstract Introduction: Eldecalcitol (ELD) is an active vitamin D
    Materials and methods: This was a descriptive cohort study using a Japanese electronic medical records database. We identified osteoporosis patients who initiated treatment with ELD or other AVDs (alfacalcidol and calcitriol) between April 1, 2011 and September 10, 2021. The index date for cohort entry was the first prescription date of ELD or other AVDs. The frequency of serum calcium monitoring was evaluated every 6 months. Determinants of serum calcium monitoring were identified using multivariable logistic regression models. We also calculated the incidence of hypercalcemia and the frequency of serum calcium monitoring within 6 months before hypercalcemia.
    Results: We identified 12,671 ELD users and 7867 other AVD users. Within 6 months after cohort entry, 45.9% of ELD users and 58.7% of other AVD users underwent serum calcium monitoring. Female sex, no use of systemic corticosteroids, moderate-to-good renal function, treatment in smaller hospitals, and treatment in orthopedic surgery departments were associated with a lower likelihood of receiving serum calcium monitoring during ELD therapy. The incidence of hypercalcemia among ELD users was 6.36 per 100 person-years, with 20.6% of cases not receiving serum calcium monitoring before hypercalcemia.
    Conclusion: Our findings suggest that serum calcium monitoring is not given adequate attention during ELD therapy in routine clinical practice.
    MeSH term(s) Humans ; Female ; Calcium ; Hypercalcemia/drug therapy ; Hypercalcemia/chemically induced ; Cohort Studies ; Bone Density ; Vitamin D ; Osteoporosis/drug therapy ; Osteoporosis/chemically induced
    Chemical Substances eldecalcitol (I2JP8UE90H) ; Calcium (SY7Q814VUP) ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2023-10-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1295123-7
    ISSN 1435-5604 ; 0914-8779
    ISSN (online) 1435-5604
    ISSN 0914-8779
    DOI 10.1007/s00774-023-01470-7
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    Zs.A 4894: Show issues Location:
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  2. Article ; Online: Minimally invasive LLIF surgery to decrease the occurrence of adjacent-segment disease compared to conventional open TLIF.

    Otsuki, Bungo / Fujibayashi, Shunsuke / Shimizu, Takayoshi / Murata, Koichi / Masuda, Soichiro / Matsuda, Shuichi

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2023  Volume 32, Issue 9, Page(s) 3200–3209

    Abstract: Purpose: Lateral lumbar interbody fusion with percutaneous pedicle screw fixation (Mis-LLIF) can establish indirect decompression by lifting the vertebra with a large intervertebral cage, which causes less damage to the posterior elements. Thus, Mis- ... ...

    Abstract Purpose: Lateral lumbar interbody fusion with percutaneous pedicle screw fixation (Mis-LLIF) can establish indirect decompression by lifting the vertebra with a large intervertebral cage, which causes less damage to the posterior elements. Thus, Mis-LLIF is expected to reduce the incidence of adjacent segment disease (ASD). The aim of the study was to compare the occurrence of ASD between Mis-LLIF and conventional open transforaminal interbody fusion (TLIF).
    Methods: A total of 156 patients (TLIF group = 88, Mis-LLIF group = 68) who underwent single-level lumbar interbody fusion (L2/3, L3/4, or L4/5) at a single institution between 2003 and 2018 with minimum 2-year follow-up were retrospectively reviewed. The incidence of symptomatic ASD requiring reoperation (S-ASD) and radiological adjacent segment degeneration (R-ASD) 2 years postoperatively were investigated between 51 paired patients from both groups who were propensity score (PS) matched by demographic and baseline clinical data. The effect of characteristics arising from differences in surgical methods between Mis-LLIF and TLIF, such as the amount of distraction of the index fused level (∆H), on S-ASD and R-ASD was also examined.
    Results: There were no significant differences in the incidence of S-ASD between the Mis-LLIF and TLIF groups (adjusted OR 1.3; 95% CI 0.41-3.9). There was no significant difference in the incidence of R-ASD between the Mis-LLIF and TLIF groups both at the cranial (adjusted OR 1.0; 95% CI 0.22-4.5) and caudal level (adjusted OR 1.5; 95% CI 0.44-5.3). On the other hand, ∆H was significantly higher in the Mis-LLIF group than in the TLIF group (3.6 mm vs. 1.7 mm, respectively, P < 0.0001), and was extracted as a significant independent risk factor for S-ASD (adjusted HR 2.7; 95% CI 1.1-6.3) and R-ASD at the cranial side (adjusted HR 6.4; 95% CI 1.7-24) in multivariable analysis with PS adjustment.
    Conclusions: The incidence of R-ASD or S-ASD was not significantly reduced in the Mis-LLIF group compared to the TLIF group, with greater ∆H potentially being a contributing factor. Using a thin cage in both TLIF and Mis-LLIF may decrease the occurrence of ASD.
    MeSH term(s) Humans ; Retrospective Studies ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Spinal Fusion/adverse effects ; Spinal Fusion/methods ; Minimally Invasive Surgical Procedures/adverse effects ; Minimally Invasive Surgical Procedures/methods ; Lumbosacral Region/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-06-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-023-07806-1
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    Zs.A 3437: Show issues Location:
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  3. Article ; Online: Association between dental procedures and periprosthetic joint infection: A case-crossover study.

    Masuda, Soichiro / Fukasawa, Toshiki / Takeuchi, Masato / Arai, Korenori / Matsuda, Shuichi / Kawakami, Koji

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

    2023  

    Abstract: Background: Although the risk of dental procedures as a cause of bacteremia has been recognized, evidence regarding the association between dental procedures and late periprosthetic joint infection (LPJI) is scarce. We sought to determine whether dental ...

    Abstract Background: Although the risk of dental procedures as a cause of bacteremia has been recognized, evidence regarding the association between dental procedures and late periprosthetic joint infection (LPJI) is scarce. We sought to determine whether dental procedures are associated with an increased risk of LPJI.
    Methods: The study was conducted under a case-crossover design using a large claims database in Japan. We identified adult patients who had undergone dental procedures and were hospitalized for LPJI between April 2014 and September 2021. Exposure to dental procedures was assessed during a case period of 1-4 weeks, with two control periods of 9-12 weeks and 17-20 weeks, preceding LPJI hospital admission. Conditional logistic regression models were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of LPJI associated with dental procedures in the case period compared with the two control periods.
    Results: In total, 241 patients with LPJI were included in the case-crossover study. At least one dental procedure was performed in 46 patients (19.1%) in the hazard period and in 75 patients (31.1%) in the control periods. The OR for LPJI with dental procedures was 0.96 (95% CI, 0.61-1.53; p = 0.88). Findings were robust in several sensitivity analyses, including stratification by whether the dental procedure included antibiotic prophylaxis.
    Conclusions: This study suggests that dental procedures are not associated with increased risk of LPJI, and will raise questions about the recommendation for antibiotic prophylaxis before dental procedures.
    Language English
    Publishing date 2023-08-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1314243-4
    ISSN 1436-2023 ; 0949-2658
    ISSN (online) 1436-2023
    ISSN 0949-2658
    DOI 10.1016/j.jos.2023.07.017
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    Zs.A 4484: Show issues Location:
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  4. Article ; Online: Erratum to: Reoperation Rates of Microendoscopic Discectomy Compared With Conventional Open Lumbar Discectomy: A Large-database Study.

    Masuda, Soichiro / Fukasawa, Toshiki / Takeuchi, Masato / Fujibayashi, Shunsuke / Otsuki, Bungo / Murata, Koichi / Shimizu, Takayoshi / Matsuda, Shuichi / Kawakami, Koji

    Clinical orthopaedics and related research

    2024  Volume 482, Issue 3, Page(s) 569

    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000002982
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    Uk I Zs.188: Show issues Location:
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  5. Article ; Online: Residual anterior cord compression after laminoplasty for cervical spondylotic myelopathy: evaluation of risk factors according to the most severely stenotic vertebral segment.

    Shimizu, Takayoshi / Fujibayashi, Shunsuke / Otsuki, Bungo / Murata, Koichi / Masuda, Soichiro / Matsuda, Shuichi

    Journal of neurosurgery. Spine

    2022  Volume 37, Issue 6, Page(s) 794–801

    Abstract: Objective: Residual anterior spinal cord compression (RASCC) after cervical laminoplasty, which has been confirmed on postoperative MRI, is reportedly associated with poor clinical outcomes. To date, only a few studies have described the risk factors ... ...

    Abstract Objective: Residual anterior spinal cord compression (RASCC) after cervical laminoplasty, which has been confirmed on postoperative MRI, is reportedly associated with poor clinical outcomes. To date, only a few studies have described the risk factors associated with RASCC. The aim of this study was to identify the factors that can predict the occurrence of RASCC after laminoplasty for cervical spondylotic myelopathy (CSM), focusing on the location of the most stenotic segment.
    Methods: In this retrospective, single-center study, 120 patients who underwent C3-7 laminoplasty for multilevel CSM were included. Different techniques were used for C3 decompression, i.e., partial (dome-laminotomy) or complete (laminoplasty/laminectomy) decompression. RASCC was diagnosed using MRI conducted 3 weeks postoperatively. The patients were divided into two groups according to the segment with the most severe stenosis (Seg-MSS; C3-4 vs C4-7). Demographics, radiological data, and C3 decompression technique were compared between the two groups. Furthermore, intergroup comparisons were performed based on Seg-MSS. A logistic regression model was constructed to identify the factors predicting RASCC after patient stratification according to Seg-MSS.
    Results: Forty patients (33.3%) had RASCC. The patients with Seg-MSS at C3-4 (51.3%) had a significantly higher incidence of RASCC (p = 0.003) than those with Seg-MSS at C4-7 (24.7%). Logistic regression analysis showed that in patients with Seg-MSS at C3-4, C3 partial decompression demonstrated a greater association with RASCC as opposed to complete decompression. Conversely, in patients with Seg-MSS at C4-7, kyphotic segmental lordotic angle was associated with an increased risk of RASCC.
    Conclusions: The risk factors for RASCC differed depending on the location of the most stenotic segment (C3-4 vs C4-7). If there is segmental kyphosis at the most stenotic segment at C4-7, anterior decompression and fusion should be considered. If C3-4 is the most stenotic segment, anterior surgery is also recommended, but alternatively, one can choose laminoplasty with complete C3 laminectomy and resection of the C2-3 ligamentum flavum.
    MeSH term(s) Humans ; Laminoplasty/adverse effects ; Laminoplasty/methods ; Spinal Cord Compression/diagnostic imaging ; Spinal Cord Compression/etiology ; Spinal Cord Compression/surgery ; Spondylosis/diagnostic imaging ; Spondylosis/surgery ; Spondylosis/complications ; Retrospective Studies ; Constriction, Pathologic/surgery ; Treatment Outcome ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Spinal Cord Diseases/surgery ; Spinal Osteophytosis/surgery ; Laminectomy/adverse effects ; Laminectomy/methods ; Risk Factors
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2158643-3
    ISSN 1547-5646 ; 1547-5654
    ISSN (online) 1547-5646
    ISSN 1547-5654
    DOI 10.3171/2022.5.SPINE22168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.135 -Spine-: Show issues Location:
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  6. Article ; Online: Predictors of the Need for Surgery in Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Cohort Longitudinal Study Using a Claims-based Database.

    Masuda, Soichiro / Fukasawa, Toshiki / Takeuchi, Masato / Fujibayashi, Shunsuke / Otsuki, Bungo / Murata, Koichi / Shimizu, Takayoshi / Matsuda, Shuichi / Kawakami, Koji

    Clinical spine surgery

    2023  Volume 36, Issue 6, Page(s) E271–E276

    Abstract: Study design: Retrospective cohort study.: Objective: The aim of this study was to determine predictors associated with the needfor cervical ossification of the posterior longitudinal ligament (cOPLL) surgery amongindividuals with cOPLL.: Summary ... ...

    Abstract Study design: Retrospective cohort study.
    Objective: The aim of this study was to determine predictors associated with the needfor cervical ossification of the posterior longitudinal ligament (cOPLL) surgery amongindividuals with cOPLL.
    Summary of background data: cOPLL is a spinal disorder caused by ectopic ossification of the posterior longitudinal ligament. However, factors associated with a higher rate of surgery to treat the neurological symptoms of cOPLL are poorly understood.
    Materials and methods: This retrospective population-based cohort study using a commercial administrative claims database from JMDC Inc. (Tokyo, Japan) enrolled patients newly diagnosed with cOPLL from April 2005 to October 2020 and followed to April 2021. A total of 1506 cOPLL patients aged 18 years or older with no history of cervical spine surgery and with a record of metabolic profiles obtained at general health checkups were included. Cox proportional hazards regression models identified patient characteristics and comorbidities associated with cOPLL surgery.
    Results: Of 1506 patients with cOPLL with a median of 1.8 years of follow-up after initial cOPLL diagnosis, 439 (29.2%) received cOPLL surgery. The 1-year cumulative incidence (95% CI) was 26.0% (23.7-28.2). In multivariable Cox proportional regression analysis, male (hazard ratio: 1.68; 95% CI: 1.26-2.24; P < 0.001) and obesity (body mass index: ≥25) (hazard ratio: 1.45; 95% CI: 1.10-1.89; P = 0.007) were associated with an increased risk of cOPLL surgery.
    Conclusions: In this large claims-based study of adults newly diagnosed with cOPLL, males and obesity were associated with a higher risk of cOPLL surgery. These findings may help clinicians to predict the future course of cOPLL in patients, although further research is needed to elucidate the biological role of these progression-associated factors.
    MeSH term(s) Adult ; Humans ; Male ; Longitudinal Ligaments/surgery ; Retrospective Studies ; Cohort Studies ; Osteogenesis ; Longitudinal Studies ; Cervical Vertebrae/surgery ; Ossification of Posterior Longitudinal Ligament/surgery ; Ossification of Posterior Longitudinal Ligament/complications ; Obesity/complications ; Treatment Outcome
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2849646-2
    ISSN 2380-0194 ; 2380-0186
    ISSN (online) 2380-0194
    ISSN 2380-0186
    DOI 10.1097/BSD.0000000000001448
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    Zs.A 2427: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: CT-based analysis of sagittal and coronal lumbar endplate morphology: multivariate analysis of factors associated with endplate depth.

    Shima, Koichiro / Fujibayashi, Shunsuke / Takemoto, Mitsuru / Shimizu, Takayoshi / Masuda, Soichiro / Shimizu, Yu / Otsuki, Bungo / Murata, Koichi / Matsuda, Shuichi

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2023  Volume 32, Issue 5, Page(s) 1546–1552

    Abstract: Purpose: Lumbar endplate morphology varies in individuals; thus, custom-made implants are sometimes more useful than standardized implants. This study aimed to analyze endplate morphology and factors associated with endplate depth using computed ... ...

    Abstract Purpose: Lumbar endplate morphology varies in individuals; thus, custom-made implants are sometimes more useful than standardized implants. This study aimed to analyze endplate morphology and factors associated with endplate depth using computed tomography (CT) in a non-symptomatic population.
    Methods: In total, 118 lumbar CT images of non-symptomatic individuals without severe degenerative change (aged 20-79 years) were retrospectively reviewed. The following radiographic parameters were measured in each lumbar vertebral segment (T12-S1) to determine endplate depth: superior/inferior endplate depth in the midsagittal and midcoronal planes, disk angle, and height. The relationship between baseline demographics (age, sex, body mass index [BMI], Hounsfield unit of the L1 vertebral body, and pelvic incidence [PI]) and endplate depth was analyzed.
    Results: Toward the caudal level, the superior endplate depth increased, sagittal inferior depth decreased, and coronal inferior depth increased. Multivariate analysis revealed that endplate depth was significantly associated with age (p < 0.001), while inferior endplate depth was associated with PI (p = 0.01). Superior endplate depth was associated with female sex (sagittal: p = 0.005, coronal: p = 0.002). Endplate depth, except for the inferior coronal region, was associated with low BMI (sagittal superior: p = 0.005; coronal superior and sagittal inferior: p = 0.02).
    Conclusion: Endplate depths tend to be larger toward the caudal level, particularly in the superior endplate. Surgeons should thoroughly evaluate the preoperative CT image because various endplate morphologies require attention to cage shape when performing lumbar interbody fusion, especially in patients who are older, are female, have low BMI, and have large PI.
    Level of evidence i: Diagnostic: individual cross-sectional studies with consistently applied reference standard and blinding.
    MeSH term(s) Humans ; Female ; Male ; Retrospective Studies ; Cross-Sectional Studies ; Lumbosacral Region/surgery ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Tomography, X-Ray Computed ; Spinal Fusion/methods ; Multivariate Analysis
    Language English
    Publishing date 2023-03-15
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-023-07642-3
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    Zs.A 3437: Show issues Location:
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  8. Article ; Online: Incidence of Surgical Site Infection Following Lateral Lumbar Interbody Fusion Compared With Posterior/Transforaminal Lumbar Interbody Fusion: A Propensity Score-Weighted Study.

    Masuda, Soichiro / Fukasawa, Toshiki / Takeuchi, Masato / Fujibayashi, Shunsuke / Otsuki, Bungo / Murata, Koichi / Shimizu, Takayoshi / Matsuda, Shuichi / Kawakami, Koji

    Spine

    2023  Volume 48, Issue 13, Page(s) 901–907

    Abstract: Study design: Retrospective cohort study.: Objective: The objective of this study was to compare the incidence of surgical site infection (SSI) after lateral lumbar interbody fusion (LLIF) and posterior/transforaminal lumbar interbody fusion ( P / ... ...

    Abstract Study design: Retrospective cohort study.
    Objective: The objective of this study was to compare the incidence of surgical site infection (SSI) after lateral lumbar interbody fusion (LLIF) and posterior/transforaminal lumbar interbody fusion ( P /TLIF).
    Summary of background data: Previous studies have shown that LLIF can improve neurological symptoms to a comparable degree to P /TLIF. However, data on the risk of SSI after LLIF is lacking compared with P /TLIF.
    Materials and methods: The study was conducted under a retrospective cohort design in patients undergoing LLIF or P /TLIF for lumbar degenerative diseases between 2013 and 2020 using a hospital administrative database. We used propensity score overlap weighting to adjust for confounding factors including age, sex, body mass index, comorbidities, number of fusion levels, hospital size, and surgery year. We estimated weighted odds ratios (ORs) and 95% CIs for SSI within 30 days postoperatively.
    Results: We compared the risk of SSI between 2874 patients who underwent LLIF and 24,245 patients who received P/TLIF Patients who had received LLIF were at significantly less risk of experiencing an SSI compared with those receiving P/TLIF (0.7% vs. 1.2%; weighted OR: 0.57; 95% CI: 0.36 -0.92; P=0.02). As a secondary outcome, patients who had received LLIF had less risk of transfusion (7.8% vs. 11.8%; weighted OR: 0.63; 95% CI:0.54 -0.73; P <0.001).
    Conclusions: In this large retrospective cohort study of adults undergoing lumbar interbody fusion, LLIF was associated with a significantly lower risk of SSI than P /TLIF. The small, but significantly, decreased risk of SSI associated with LLIF may inform decisions regarding the technical approach for lumbar interbody fusion.
    MeSH term(s) Adult ; Humans ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; Retrospective Studies ; Incidence ; Lumbar Vertebrae/surgery ; Propensity Score ; Spinal Fusion/adverse effects
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752024-4
    ISSN 1528-1159 ; 0362-2436
    ISSN (online) 1528-1159
    ISSN 0362-2436
    DOI 10.1097/BRS.0000000000004587
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    Zs.A 1305: Show issues Location:
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  9. Article ; Online: Are Dental Procedures Associated With Pyogenic Vertebral Osteomyelitis?

    Masuda, Soichiro / Fukasawa, Toshiki / Takeuchi, Masato / Arai, Korenori / Fujibayashi, Shunsuke / Otsuki, Bungo / Murata, Koichi / Shimizu, Takayoshi / Matsuda, Shuichi / Kawakami, Koji

    Clinical orthopaedics and related research

    2023  Volume 482, Issue 4, Page(s) 716–723

    Abstract: Background: Dental procedures can lead to bacteremia and have been considered a potential risk factor for pyogenic vertebral osteomyelitis (PVO). However, data on the association between dental procedures and PVO are limited.: Questions/purposes: (1) ...

    Abstract Background: Dental procedures can lead to bacteremia and have been considered a potential risk factor for pyogenic vertebral osteomyelitis (PVO). However, data on the association between dental procedures and PVO are limited.
    Questions/purposes: (1) After controlling for relevant confounding variables, are dental procedures associated with an increased risk of PVO? (2) Does antibiotic prophylaxis before dental procedures effectively decrease the risk of PVO?
    Methods: A case-crossover study was conducted to investigate the association between dental procedures and PVO using a Japanese claims database. The advantage of this study design is that confounding factors that do not vary over time are automatically adjusted for, because cases act as their own controls. From April 2014 to September 2021, the database included 8414 patients who were hospitalized for PVO. Of these, 50% (4182 of 8414) were excluded because they had not undergone any dental procedures before the index date, a further 0.1% (10 of 8414) were excluded because they were younger than 18 years at the index date, and a further 7% (623 of 8414) were excluded because they did not have at least 20 weeks of continuous enrollment before the index date, leaving 43% (3599 of 8414) eligible for analysis here. The mean age was 77 ± 11 years, and 55% (1985 of 3599) were men. Sixty-five percent (2356 of 3599) of patients had a diagnosis of diabetes mellitus, and 42% (1519 of 3599) of patients had a diagnosis of osteoporosis. We compared the frequency of dental procedures between a 4-week hazard period before the admission date for PVO and two control periods, 9 to 12 weeks and 17 to 20 weeks before the admission date for PVO, within individuals. We calculated odds ratios and 95% confidence intervals using conditional logistic regression analysis.
    Results: Comparing the hazard and matched control periods within individuals demonstrated that dental procedures were not associated with an increased risk of PVO (OR 0.81 [95% CI 0.72 to 0.92]; p < 0.001). Additional analysis stratified by antibiotic prophylaxis use showed that antibiotic prophylaxis was not associated with a lower OR of developing PVO after dental procedures (with antibiotic prophylaxis: OR 1.11 [95% CI 0.93 to 1.32]; p < 0.26, without antibiotic prophylaxis: OR 0.72 [95% CI 0.63 to 0.83]; p < 0.001). Our sensitivity analyses, in which the exposure assessment interval was extended from 4 to 8 or 12 weeks and exposure was stratified by whether the dental procedure was invasive, demonstrated results that were consistent with our main analysis.
    Conclusion: Dental procedures were not associated with an increased risk of subsequent PVO in this case-crossover study. The effectiveness of antibiotic prophylaxis was not demonstrated in the additional analysis that categorized exposure according to the use of antibiotic prophylaxis. Our results suggest that the association between dental procedures and PVO may have been overestimated. Maintaining good oral hygiene may be important in preventing the development of PVO. The indications for antibiotic prophylaxis before dental procedures should be reconsidered in view of the potential risk of adverse drug reactions to antibiotic prophylaxis and the emergence of drug-resistant pathogens. Larger randomized controlled trials are needed to confirm these findings and assess the role of antibiotic prophylaxis.
    Level of evidence: Level III, therapeutic study.
    MeSH term(s) Male ; Humans ; Aged ; Aged, 80 and over ; Female ; Cross-Over Studies ; Osteoporosis/complications ; Anti-Bacterial Agents/adverse effects ; Antibiotic Prophylaxis ; Osteomyelitis/drug therapy ; Dentistry
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000002871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Strontium-loaded 3D intramedullary nail titanium implant for critical-sized femoral defect in rabbits.

    Honda, Shintaro / Fujibayashi, Shunsuke / Shimizu, Takayoshi / Yamaguchi, Seiji / Okuzu, Yaichiro / Takaoka, Yusuke / Masuda, Soichiro / Takemoto, Mitsuru / Kawai, Toshiyuki / Otsuki, Bungo / Goto, Koji / Matsuda, Shuichi

    Journal of biomedical materials research. Part B, Applied biomaterials

    2024  Volume 112, Issue 3, Page(s) e35393

    Abstract: The treatment of critical-sized bone defects has long been a major problem for surgeons. In this study, an intramedullary nail shaped three-dimensional (3D)-printed porous titanium implant that is capable of releasing strontium ions was developed through ...

    Abstract The treatment of critical-sized bone defects has long been a major problem for surgeons. In this study, an intramedullary nail shaped three-dimensional (3D)-printed porous titanium implant that is capable of releasing strontium ions was developed through a simple and cost-effective surface modification technique. The feasibility of this implant as a stand-alone solution was evaluated using a rabbit's segmental diaphyseal as a defect model. The strontium-loaded implant exhibited a favorable environment for cell adhesion, and mechanical properties that were commensurate with those of a rabbit's cortical bone. Radiographic, biomechanical, and histological analyses revealed a significantly higher amount of bone ingrowth and superior bone-bonding strength in the strontium-loaded implant when compared to an untreated porous titanium implant. Furthermore, one-year histological observations revealed that the strontium-loaded implant preserved the native-like diaphyseal bone structure without failure. These findings suggest that strontium-releasing 3D-printed titanium implants have the clinical potential to induce the early and efficient repair of critical-sized, load-bearing bone defects.
    MeSH term(s) Animals ; Rabbits ; Titanium/pharmacology ; Internal Fixators ; Prostheses and Implants ; Cell Adhesion ; Strontium/pharmacology
    Chemical Substances Titanium (D1JT611TNE) ; Strontium (YZS2RPE8LE)
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2099992-6
    ISSN 1552-4981 ; 1552-4973 ; 0021-9304
    ISSN (online) 1552-4981
    ISSN 1552-4973 ; 0021-9304
    DOI 10.1002/jbm.b.35393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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