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  1. Article: [Ⅱ. CNS-Associated Macrophages and Immune System in the CNS].

    Masuda, Takahiro

    Gan to kagaku ryoho. Cancer & chemotherapy

    2023  Volume 50, Issue 6, Page(s) 690–693

    MeSH term(s) Humans ; Macrophages ; Central Nervous System/immunology
    Language Japanese
    Publishing date 2023-06-15
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2573: Show issues Location:
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  2. Article: [Preface].

    Masuda, Takahiro

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2023  Volume 158, Issue 4, Page(s) 297

    Language Japanese
    Publishing date 2023-06-27
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.22153
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  3. Article: [Cellular and molecular heterogeneity of CNS macrophages in health and disease].

    Masuda, Takahiro

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2023  Volume 158, Issue 4, Page(s) 308–311

    Abstract: The central nervous system (CNS) is a highly complex collection of various cell-types, such as neurons, glial cells, vascular cells, and immune cells, and their complex and dynamic interactions enable to achieve highly sophisticated functions of the CNS. ...

    Abstract The central nervous system (CNS) is a highly complex collection of various cell-types, such as neurons, glial cells, vascular cells, and immune cells, and their complex and dynamic interactions enable to achieve highly sophisticated functions of the CNS. Among such CNS cells are microglia, which are well-known primary CNS macrophages localized in the CNS parenchyma and play a pivotal role in the maintenance of tissue homeostasis. Besides microglia, there are anatomically distinct macrophage populations at the border of the CNS, such as meninge, and perivascular space, called CNS-associated macrophages (CAMs). Recent studies have given novel insights into the nature of CAMs. In this review, I will discuss our current knowledge of the origins, the cellular properties of CNS macrophages.
    MeSH term(s) Central Nervous System ; Macrophages ; Microglia ; Neurons ; Neuroglia
    Language Japanese
    Publishing date 2023-07-03
    Publishing country Japan
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.22152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recent topics regarding macrophage in the central nervous system.

    Masuda, Takahiro

    Journal of biochemistry

    2022  Volume 173, Issue 3, Page(s) 139–143

    Abstract: The central nervous system (CNS) is a highly complex collection of neurons with a variety of stromal cells, such as glia cells, immune cells, vascular cells and fibroblasts. Microglia are a resident macrophage and a type of glial cells located in the ... ...

    Abstract The central nervous system (CNS) is a highly complex collection of neurons with a variety of stromal cells, such as glia cells, immune cells, vascular cells and fibroblasts. Microglia are a resident macrophage and a type of glial cells located in the parenchyma of the CNS and play a pivotal role in the maintenance of tissue homeostasis. They are early responders to the abnormality of the CNS, leading to the adaptation of their phenotypes by virtue of their plasticity, after which they give an impact on neuronal functions. Besides microglia, there are anatomically and phenotypically distinct macrophage populations at the border of the CNS, such as meninge, perivascular space and choroid plexus, where they show distinct morphology and gene expression profiles when compared with microglia. This review will summarize the recent advance in our knowledge regarding their heterogeneity, plasticity, ontogenetic relationship of these CNS-resident macrophage populations.
    MeSH term(s) Central Nervous System ; Macrophages ; Neuroglia ; Neurons ; Acclimatization
    Language English
    Publishing date 2022-11-08
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 218073-x
    ISSN 1756-2651 ; 0021-924X
    ISSN (online) 1756-2651
    ISSN 0021-924X
    DOI 10.1093/jb/mvac093
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  5. Article ; Online: Is the use of gonad protection protectors necessary during infants chest radiography?

    Masuda, T / Takei, Y / Arao, S

    Radiologia

    2024  Volume 66, Issue 2, Page(s) 107–113

    Abstract: Introduction and objectives: To compare gonad doses with and without a gonad protector and to optimize the use of gonadal protectors in infants thorax radiography.: Materials and methods: Two pediatric anthropomorphic phantoms are used: an X-ray ... ...

    Abstract Introduction and objectives: To compare gonad doses with and without a gonad protector and to optimize the use of gonadal protectors in infants thorax radiography.
    Materials and methods: Two pediatric anthropomorphic phantoms are used: an X-ray system for KXO-50SS/DRX-3724HD, and a digital radiography system for CALNEO Smart C12, with and without a gonad protector during infants thorax radiography. A real time skin dosimeter is placed on the X-ray system, and a real time skin dosimeter is inserted on the front side of the mammary gland, the front and back sides of the true pelvis level, and on the ovaries and testes. The X-ray system is irradiated 15 times using phantoms with and without a gonad protector. The measured entrance patient doses values of for the real time skin dosimeter are compared for each phantom, with and without the gonad protector.
    Results: The medium of measured entrance patient doses values for front side dose of the true pelvis level with and without the protector are 10.00 and 5.00 μGy at newborn, and 10.00 and 0.00μGy at one year, respectively. The medium of measured entrance patient doses values for the back side dose of the true pelvis level with and without the protector are 0.00 and 0.00 μGy at both newborn one year, respectively. The measured entrance patient doses cannot be detected in the ovaries and testes with or without the protector. No significant differences are observed in the measured entrance patient doses values for the front and back side doses of the pelvis, ovaries, and testes at newborn and one year, with and without the protector (p>0.05).
    Conclusions: No significant difference was observed in gonad dose measurements with and without the gonad protector during infants chest radiography. We believe that gonadal protector wearing is not necessary.
    MeSH term(s) Infant ; Infant, Newborn ; Humans ; Child ; Gonads ; Radiography
    Language English
    Publishing date 2024-03-06
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5107
    ISSN (online) 2173-5107
    DOI 10.1016/j.rxeng.2022.08.003
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  6. Article ; Online: Effects of cellular radioresponse on therapeutic helium-, carbon-, oxygen-, and neon-ion beams: a simulation study.

    Masuda, Takamitsu / Inaniwa, Taku

    Physics in medicine and biology

    2024  Volume 69, Issue 4

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Humans ; Neon/therapeutic use ; Carbon/therapeutic use ; Helium/therapeutic use ; Oxygen/therapeutic use ; Ions ; Relative Biological Effectiveness
    Chemical Substances Neon (4VB4Y46AHD) ; Carbon (7440-44-0) ; Helium (206GF3GB41) ; Oxygen (S88TT14065) ; Ions
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ad1f87
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    Zs.A 199: Show issues Location:
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  7. Article ; Online: [7. Statistical Analysis in Clinical Research].

    Masuda, Takanori

    Nihon Hoshasen Gijutsu Gakkai zasshi

    2021  Volume 77, Issue 7, Page(s) 739–744

    MeSH term(s) Research Design
    Language Japanese
    Publishing date 2021-07-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2269092-X
    ISSN 1881-4883 ; 0369-4305
    ISSN (online) 1881-4883
    ISSN 0369-4305
    DOI 10.6009/jjrt.2021_JSRT_77.7.739
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  8. Article: Lipid in microglial biology - from material to mediator.

    Yamamoto, Shota / Masuda, Takahiro

    Inflammation and regeneration

    2023  Volume 43, Issue 1, Page(s) 38

    Abstract: Microglia are resident macrophages in the central nervous system (CNS) that play various roles during brain development and in the pathogenesis of CNS diseases. Recently, reprogramming of cellular energetic metabolism in microglia has drawn attention as ... ...

    Abstract Microglia are resident macrophages in the central nervous system (CNS) that play various roles during brain development and in the pathogenesis of CNS diseases. Recently, reprogramming of cellular energetic metabolism in microglia has drawn attention as a crucial mechanism for diversification of microglial functionality. Lipids are highly diverse materials and crucial components of cell membranes in every cell. Accumulating evidence has shown that lipid and its metabolism are tightly involved in microglial biology. In this review, we summarize the current knowledge about microglial lipid metabolism in health and disease.
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-023-00289-z
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    Zs.B 2929: Show issues Location:
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  9. Article ; Online: Fluid homeostasis induced by sodium-glucose cotransporter 2 inhibitors: novel insight for better cardio-renal outcomes in chronic kidney disease.

    Masuda, Takahiro / Nagata, Daisuke

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 5, Page(s) 1195–1201

    Abstract: Hypertension in chronic kidney disease (CKD) patients is a risk factor for end-stage renal disease, cardiovascular events, and mortality. Thus, the prevention and appropriate management of hypertension in these patients are essential strategies for ... ...

    Abstract Hypertension in chronic kidney disease (CKD) patients is a risk factor for end-stage renal disease, cardiovascular events, and mortality. Thus, the prevention and appropriate management of hypertension in these patients are essential strategies for better cardio-renal outcomes. In this review, we show novel risk factors for hypertension with CKD, several promising prognostic markers and treatment for cardio-renal outcomes. Of note, the clinical use of sodium-glucose cotransporter 2 (SGLT2) inhibitors has recently expanded to non-diabetic patients with CKD and heart failure as well as diabetic patients. SGLT2 inhibitors have an antihypertensive effect, but are also associated with a low risk of hypotension. This unique mechanism of blood pressure regulation by SGLT2 inhibitors may partially depend on body fluid homeostasis, which is mediated by the autoregulation property between "accelerator" (diuretic action) and "brake" (increase in anti-diuretic hormone vasopressin and fluid intake). Mineralocorticoid receptor (MR) blockers are used in the treatment of essential hypertension and hyperaldosteronism. Recently, a new MR blocker, finerenone, has been launched as a treatment for CKD with type 2 diabetes. These advances in relation to hypertension in CKD may contribute to the reduction of renal and cardiovascular events.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Hypertension/drug therapy ; Glucose/therapeutic use ; Sodium
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01220-2
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    Zs.A 3898: Show issues Location:
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  10. Article: Update on the source of phenoloxidase activity in the hemolymph of kuruma prawn Marsupenaeus japonicus

    Masuda, Taro

    Fisheries science. 2021 Nov., v. 87, no. 6

    2021  

    Abstract: Crustacean phenoloxidase (PO) and hemocyanin (Hc) are classified as type 3 copper proteins. PO catalyzes the oxidation of mono- and di-phenol compounds, which is the rate-limiting step of melanization, while Hc generally functions as a dioxygen- ... ...

    Abstract Crustacean phenoloxidase (PO) and hemocyanin (Hc) are classified as type 3 copper proteins. PO catalyzes the oxidation of mono- and di-phenol compounds, which is the rate-limiting step of melanization, while Hc generally functions as a dioxygen-transporting protein in the hemolymph of arthropods. To date, many studies have shown PO activity in Hc, which is inspired by their structural similarity. Here, the source of PO activity in crustaceans was re-examined by purifying Hc and PO exclusively from the hemolymph of kuruma prawn. The conventional procedure for the preparation of arthropod Hc, which includes precipitation of Hc by ultracentrifugation and subsequent purification by size exclusion chromatography, was not able to completely remove hemolymph-type PO from Hc. In contrast, fractionation with 50% saturation of ammonium sulfate and subsequent hydrophobic chromatography yielded sufficiently pure Hc, which contained no detectable PO protein and virtually no PO enzymatic activity. These results indicate that the main source of PO activity in the hemolymph of kuruma prawn is hemolymph-type PO and that the improved purification method of Hc is preferable for evaluating the PO activity of Hc.
    Keywords Marsupenaeus japonicus ; ammonium sulfate ; arthropods ; enzyme activity ; fractionation ; gel chromatography ; hemocyanin ; hemolymph ; hydrophobicity ; melanization ; monophenol monooxygenase ; oxidation ; purification methods ; reaction kinetics ; ultracentrifugation
    Language English
    Dates of publication 2021-11
    Size p. 861-869.
    Publishing place Springer Japan
    Document type Article
    ZDB-ID 1192654-5
    ISSN 1444-2906 ; 0919-9268
    ISSN (online) 1444-2906
    ISSN 0919-9268
    DOI 10.1007/s12562-021-01558-x
    Database NAL-Catalogue (AGRICOLA)

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