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Article: Gallbladder Volvulus in an Elderly Patient: A Case Report and Review of Literature.

Matías-García, Belén / Sainz-Azara, Carolina / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / Gutiérrez-Calvo, Alberto

Cureus

2023 Volume 15, Issue 9, Page(s) e45167

Abstract: Gallbladder volvulus is an uncommon cause of acute cholecystitis that results from the rotation of the gallbladder about its mesentery along the axis of the cystic pedicle. We present the case of an 87-year-old woman with acute abdominal pain in the ... ...

Abstract	Gallbladder volvulus is an uncommon cause of acute cholecystitis that results from the rotation of the gallbladder about its mesentery along the axis of the cystic pedicle. We present the case of an 87-year-old woman with acute abdominal pain in the right upper quadrant that began two days prior with no additional symptoms. The physical examination showed a large abdominal eventration on the right side and tenderness. A CT scan showed a distended gallbladder outside its liver bed and with a twist on its cystic pedicle, suggesting a gallbladder volvulus. Abdominal ultrasonography complementary revealed the gallbladder outside its vesicular fossa with incipient changes of acute cholecystitis but without evidence of gallstones. With the diagnosis of acute abdomen secondary to gallbladder volvulus, an emergency cholecystectomy was performed. The exact etiology of the gallbladder volvulus is unknown, although anatomical variants that predispose to its appearance have been described. The clinical presentation is similar to acute cholecystitis, so preoperative diagnosis can be challenging for both surgeons and radiologists and is often misdiagnosed. This is one of the few cases diagnosed with preoperative imaging techniques. Once diagnosed, the appropriate treatment is emergency cholecystectomy. Early diagnosis and surgical treatment are important before it progresses to necrosis, perforation, biliary peritonitis, and hemodynamic instability. Gallbladder volvulus is an uncommon condition. A high index of suspicion is required because the preoperative diagnosis is unusual. Once the diagnosis is established, the treatment is fundamentally surgical.
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.45167
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Malignant Bowel Obstruction Due to Intraluminal Metastasis of Endometrial Adenocarcinoma Located in the Sigmoid Colon After Nine Years of Follow-Up.

Matías-García, Belén / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / D'Angelo, Carolina / Gutiérrez-Calvo, Alberto

Cureus

2023 Volume 15, Issue 10, Page(s) e47937

Abstract: Endometrial adenocarcinoma is currently the most common malignant tumor of the female genital tract. In the early stages, surgical or radiotherapy treatment offers high survival rates and excellent prognosis, although late recurrences have been described. ...

Abstract	Endometrial adenocarcinoma is currently the most common malignant tumor of the female genital tract. In the early stages, surgical or radiotherapy treatment offers high survival rates and excellent prognosis, although late recurrences have been described. Recurrences of endometrial adenocarcinoma are more frequent in the vaginal vault; however, implants are sometimes detected in the serosa of the colon and rectum, resulting in extrinsic compression. Here, we present the case of a 77-year-old patient with a clinical history of hysterectomy, lymphadenectomy, and double adnexectomy for endometrial adenocarcinoma (International Federation of Gynecology and Obstetrics (FIGO) Ia). Nine years after the initial treatment, she presented an endoluminal recurrence in the sigmoid colon, which is exceptional. The patient underwent surgery by performing an oncological sigmoidectomy. The immunohistochemical study revealed the tumor origin as metastasis of endometrial adenocarcinoma. The patient had a favorable postoperative period, subsequently receiving adjuvant therapy and being disease-free after 18 months of follow-up.
Language	English
Publishing date	2023-10-29
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.47937
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Single metachronous bone metastasis following rectal adenocarcinoma: A case report.

Matías-García, Belén / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / Ovejero-Merino, Enrique / Vera-Mansilla, Cristina / Blázquez-Martín, Alma / Quiroga-Valcárcel, Ana / Jiménez-Martín, Rubén / D'amico, Rebeca / Lasa-Unzúe, Inmaculada / Gutiérrez-Calvo, Alberto

Medicine international

2024 Volume 4, Issue 1, Page(s) 6

Abstract: Colorectal cancer (CRC) ranks as the third leading cause of cancer-related mortality in developed countries. While its incidence in early stages has increased due to screening programs, a significant number of patients experience the development of ... ...

Abstract	Colorectal cancer (CRC) ranks as the third leading cause of cancer-related mortality in developed countries. While its incidence in early stages has increased due to screening programs, a significant number of patients experience the development of metastases either at the time of diagnosis or during follow-ups. Unlike certain other types of cancer, such as breast, prostate, or lung cancer, where bone tissue is a common site for secondary dissemination, CRC primarily spreads to the lymph nodes, liver and lungs. The occurrence of bone metastases from CRC is rare and usually coincides with tumor involvement in other locations. Risk factors for bone metastases include the location of the primary tumor, the age of the patients, KRAS mutations and the degree of tumor differentiation. Unlike metastases to the liver and lungs, bone metastases tend to be symptomatic, affecting the patient's quality of life and resulting in a poorer prognosis with shorter survival rates. The approach to patient management needs to be personalized. The present study describes the of a patient who underwent surgery for stage IV rectal adenocarcinoma and later developed a metastasis in the costal wall 79 months post-intervention, with no evidence of recurrence at other sites.
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Case Reports
ISSN	2754-1304
ISSN (online)	2754-1304
DOI	10.3892/mi.2024.130
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A retrospective analysis and literature review of neoplastic appendiceal mucinous lesions.

Matias-García, Belén / Mendoza-Moreno, Fernando / Blasco-Martínez, Ana / Busteros-Moraza, José Ignacio / Diez-Alonso, Manuel / Garcia-Moreno Nisa, Francisca

BMC surgery

2021 Volume 21, Issue 1, Page(s) 79

Abstract: Background: At present, the term mucocele is outdated, and mucinous appendiceal neoplasm is preferred. Mucinous appendiceal neoplasm is an uncommon pathology that occurs predominantly in middle-aged women. Its classification and management have been the ...

Abstract	Background: At present, the term mucocele is outdated, and mucinous appendiceal neoplasm is preferred. Mucinous appendiceal neoplasm is an uncommon pathology that occurs predominantly in middle-aged women. Its classification and management have been the subject of debate in recent decades. The aim of this study was to analyse the incidence, clinical management and survival of these tumours diagnosed in our centre in the last 10 years. Methods: This was a retrospective observational study of patients with a diagnosis of appendiceal neoplasms between 2009 and 2018 in our centre. Variables such as sex, age, tumour type, clinical status, diagnosis, treatment and survival were collected. All data were analysed using the statistical program IBM SPSS Statistic® version 25. Results: Twenty-nine patients with a diagnosis of appendiceal neoplasm were identified, and 24 corresponded to neoplastic appendiceal mucinous lesions (85.7%). The average age was 59.7 ± 17.6 years. Most patients were women (15 cases; 62.5%). Most of them presented with chronic abdominal pain (37.5%), and the diagnosis was performed by computed tomography (CT) (50%). The treatment was surgical in all cases. The surgical technique depended on the findings and histology of the tumour. Conclusion: Mucinous appendiceal neoplasms are an uncommon entity, and their pathological classification and management have recently changed.
Language	English
Publishing date	2021-02-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-021-01091-9
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Article: Jejunal diverticulitis as an unusual cause of pylephlebitis.

Sánchez Gollarte, Ana / Matías García, Belén / Minguez García, Javier / Lasa Unzue, Inmaculada / Gutiérrez Calvo, Alberto José

Gastroenterologia y hepatologia

2021 Volume 45 Suppl 1, Page(s) 22–23

MeSH term(s)	Diverticulitis/complications ; Diverticulitis/diagnostic imaging ; Humans ; Jejunal Diseases/complications ; Jejunal Diseases/etiology ; Jejunum ; Phlebitis
Language	Spanish
Publishing date	2021-03-17
Publishing country	Spain
Document type	Letter ; Comment
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2021.02.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Spontaneous cervical hematoma caused by giant parathyroid adenoma in an elderly patient: A case report.

Matías-García, Belén / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / Ovejero-Merino, Enrique / Vera-Mansilla, Cristina / Blázquez-Martín, Alma / Quiroga-Valcárcel, Ana / Jiménez-Martín, Rubén / D'Amico, Rebeca / Lasa-Unzúe, Inmaculada / Gutiérrez-Calvo, Alberto

Medicine international

2023 Volume 4, Issue 1, Page(s) 1

Abstract: Spontaneous cervical hematoma usually occurs as a consequence of extracapsular bleeding from a parathyroid gland, generally due to the presence of an adenoma (giant adenoma), glandular hyperplasia, cystic component, or, less frequently, due to the ... ...

Abstract	Spontaneous cervical hematoma usually occurs as a consequence of extracapsular bleeding from a parathyroid gland, generally due to the presence of an adenoma (giant adenoma), glandular hyperplasia, cystic component, or, less frequently, due to the existence of a carcinoma. The hematoma can be confined to the cervical compartment or extend to the mediastinum, potentially causing airway compression. Despite this, the recommended management in hemodynamically stable patients consists of surveillance and hospital monitoring with delayed surgery after a few weeks. On the other hand, in those patients with airway compromise and instability, emergency surgery, consisting of cervicotomy and drainage, is mandatory. The present study describes the case of a 78-year-old patient with a medical history of high blood pressure, non-insulin-dependent diabetes mellitus, dyslipidemia, moderate aortic stenosis, chronic kidney disease and sarcoidosis under pharmacological treatment who attended the emergency department due to symptoms of neck pain, an increase in soft tissue, and dyspnea on moderate exertion with an evolution leading to respiratory failure. This was secondary to a diagnosis of spontaneous cervical hematoma that required urgent surgical intervention. The results of histopathological analysis revealed that a giant parathyroid adenoma was responsible for the bleeding. The patient had a complicated post-operative period with a prolonged admission to the intensive care unit.
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Case Reports
ISSN	2754-1304
ISSN (online)	2754-1304
DOI	10.3892/mi.2023.125
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Malignant adipocytic tumours: A 20‑year single‑centre retrospective study.

Mendoza-Moreno, Fernando / Matías-García, Belén / Quiroga-Valcárcel, Ana / García-Moreno Nisa, Francisca / Díez-Corral, Cristina / Blázquez-Martín, Alma / Vera-Mansilla, Cristina / Ovejero-Merino, Enrique / Díez-Alonso, Manuel / Diego-García, Lucía / Alvarez-Mon, Melchor / Ortega, Miguel A / Gutiérrez-Calvo, Alberto

Oncology letters

2023 Volume 25, Issue 6, Page(s) 247

Abstract: Adipocytic tumours are the most common soft tissue neoplasms. Among them, liposarcoma is the most frequent malignant neoplasm. However, to the best of our knowledge, no previously published study has assessed the evolution and oncological prognosis of ... ...

Abstract	Adipocytic tumours are the most common soft tissue neoplasms. Among them, liposarcoma is the most frequent malignant neoplasm. However, to the best of our knowledge, no previously published study has assessed the evolution and oncological prognosis of the different subtypes of liposarcoma at the retroperitoneal level compared with at other locations. The present study is a retrospective observational study in which all patients were operated on between October 2000 and January 2020 with a histological diagnosis of liposarcoma. Variables, such as age, sex, location, histological type, recurrence, type of treatment and mortality, among others, were analysed. The patients were divided into two groups: Group A (retroperitoneal location) and group B (non-retroperitoneal location). A total of 52 patients with a diagnosis of liposarcoma (17 women and 35 men) and a mean age of 57.2±15.9 years were assessed. A total of 16 patients were classified into group A and 36 into group B. The OR of recurrence was 1.5 (P=0.02) for R1 vs. R0 resection in group A. The OR of recurrence in group B for R1 vs. R0 resection was 1.8 (P=0.77), whereas for R2 vs. R0 resection, the OR was 69 (P=0.011). In conclusion, 52 cases of malignant adipocytic tumours collected during 2000-2020 were analysed with the new World Health Organization classification (updated 2020). Although its recurrence potential and capacity for distant metastasis depended on each histological type, surgical treatment with unaffected margins was the main prognostic factor for survival. The present study identified differences in relation to the survival of each histological subtype and its location, finding greater survival in dedifferentiated liposarcoma, myxoid liposarcoma and pleomorphic liposarcoma located at the extraperitoneal level than in the retroperitoneal location. Resectability was not influenced by liposarcoma location.
Language	English
Publishing date	2023-04-21
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2023.13833
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Upper Gastrointestinal Bleeding as a Debut Form of Groove Pancreatitis: A Diagnostic Challenge.

Matías-García, Belén / Castellón-Pavón, Camilo José / Díaz-García, Gustavo / Manso-Abajo, Belén / Hernández-Aceituno, Daniel / Hermosín-Peña, Antonio / Mejías-Sosa, Luis / Durán-Poveda, Manuel

Case reports in surgery

2022 Volume 2022, Page(s) 5562778

Abstract: Introduction: Groove pancreatitis (GP) is an unusual subtype of chronic pancreatitis that affects the groove area. Differential diagnosis between groove pancreatitis and pancreatic carcinoma (PC) can be challenging, both clinically and radiologically. ... ...

Abstract	Introduction: Groove pancreatitis (GP) is an unusual subtype of chronic pancreatitis that affects the groove area. Differential diagnosis between groove pancreatitis and pancreatic carcinoma (PC) can be challenging, both clinically and radiologically. Our aim is to report the first case of GP debut with upper gastrointestinal bleeding (UGB). Conclusion: GP is an uncommon type of focal pancreatitis that should be considered as a differential diagnosis of PC. We report the first clinical case of GP whose debut with UGB presented a greater diagnostic and therapeutic challenge.
Language	English
Publishing date	2022-03-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2657697-1
ISSN	2090-6919 ; 2090-6900
ISSN (online)	2090-6919
ISSN	2090-6900
DOI	10.1155/2022/5562778
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prognostic Factors of Survival in Patients with Peritoneal Metastasis from Colorectal Cancer.

Mendoza-Moreno, Fernando / Diez-Alonso, Manuel / Matías-García, Belén / Ovejero-Merino, Enrique / Gómez-Sanz, Remedios / Blázquez-Martín, Alma / Quiroga-Valcárcel, Ana / Vera-Mansilla, Cristina / Molina, Raquel / San-Juan, Alberto / Barrena-Blázquez, Silvestra / Ortega, Miguel A / Alvarez-Mon, Melchor / Gutiérrez-Calvo, Alberto

Journal of clinical medicine

2022 Volume 11, Issue 16

Abstract: Objectives: The aim of this study was to analyze the prognostic factors of survival in patients with peritoneal metastasis (PM) from colorectal cancer (CRC). The type of relationship between survival and the PM time of detection was used to determine ... ...

Abstract	Objectives: The aim of this study was to analyze the prognostic factors of survival in patients with peritoneal metastasis (PM) from colorectal cancer (CRC). The type of relationship between survival and the PM time of detection was used to determine whether it was synchronous with the primary tumor or metachronous. Patients and Methods: Retrospective observational study. It included patients treated for colorectal adenocarcinoma diagnosed between January 2005 and December 2019 who presented PM at the time of diagnosis or during follow-up. Variables, such as sex, age, differentiation grade, positive adenopathy (pN+), tumor size (pT), tumor location, mucinous component, peritoneal carcinomatosis index (PCI), and KRAS mutational status, were analyzed. Results: During the study period, 1882 patients were surgically treated for CRC in our hospital. Of these, 240 patients (12.8%) were included in the study after evidence of PM. The mean age was 67 ± 12 years (range: 32−92 years), and 114 patients were female (47.5%). The mean follow-up was 20 ± 13 months (median 12 months). The Kaplan−Meier survival at 36 months was higher in patients with metachronous PM (24% vs. 8%; p = 0.002), WT-KRAS tumors (31% vs. 15%; p < 0.001), N0 stage (30% vs. 19%; p < 0.001), T3 stage tumors (18% vs. 19% in T4A and 3% in T4B; p > 0.001), and tumors with classic adenocarcinoma histology (18% vs. 8%; p = 0.011). Patients with a PCI of 1−10 showed a likelihood of survival at 36 months of 56%, which was longer than that found in patients with a PCI of 11−20 (8%) or a PCI of >20 (0%) (p < 0.001). In the multiple regression analysis, the factors with an independent prognostic value were: poor grade of differentiation (HR 1.995; 95% CI: 1.294−3.077), KRAS mutation (HR 1.751; 95% CI: 1.188−2.581), PCI 11−20 (HR: 9.935; 95% CI: 5.204−18.966) and PCI > 20 (HR: 4.011; 95% CI: 2.291−7.023). Conclusions: PCI should continue as the as the most useful prognostic indicator in order to assess prognostic estimations as well as therapeutic and surgical decisions, but tumor grade and KRAS mutational status may help in the treatment decision process by providing complementary information. The time of PM detection did not achieve statistical significance in the multiple regression analysis.
Language	English
Publishing date	2022-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11164922
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Article: Unusual Case of Gallbladder Adenocarcinoma Metastasis to the Abdominal Wall 11 Years Later: Synchronous Presentation with Two Malignant Colon Tumors, Coincidence or Not?

Matías-García, Belén / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / Quiroga-Valcárcel, Ana / Aguirregoicoa-García, Elena / Vera-Mansilla, Cristina / Ovejero-Merino, Enrique / Mínguez-García, Javier / Córdova-García, Diego / Gutiérrez-Calvo, Alberto

Case reports in surgery

2021 Volume 2021, Page(s) 6662275

Abstract: Introduction: Abdominal wall masses are a common finding in clinical practice. A high percentage of these masses are malignant. We present the case of a patient operated for a gallbladder adenocarcinoma, who consulted eleven years later for a malignant ... ...

Abstract	Introduction: Abdominal wall masses are a common finding in clinical practice. A high percentage of these masses are malignant. We present the case of a patient operated for a gallbladder adenocarcinoma, who consulted eleven years later for a malignant mass of the abdominal wall in synchrony with two adenocarcinomas of the left colon and sigmoid. Conclusion: Abdominal wall metastasis from gallbladder carcinoma is rare, and its synchronous presentation with a malignant neoplasm of the colon is exceptional. This is the first report of a patient with abdominal wall metastasis from a gallbladder adenocarcinoma operated eleven years ago that debuted synchronously with two adenocarcinomas of the left colon and sigma.
Language	English
Publishing date	2021-02-26
Publishing country	United States
Document type	Case Reports
ZDB-ID	2657697-1
ISSN	2090-6919 ; 2090-6900
ISSN (online)	2090-6919
ISSN	2090-6900
DOI	10.1155/2021/6662275
Database	MEDical Literature Analysis and Retrieval System OnLINE

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