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  1. Book ; Online: Advances in Primary Progressive Aphasia

    Matias-Guiu, Jordi A. / Laforce, Robert Jr / Utianski, Rene L.

    2022  

    Keywords Research & information: general ; Biology, life sciences ; primary progressive aphasia ; informativeness ; speech production ; assessment ; diagnosis ; cognitive approach ; dementia ; frontotemporal dementia ; Alzheimer's disease ; neuropsychology ; span ; sentence repetition ; working memory ; phonological ; visuospatial ; natural history ; mortality ; survival ; memory clinic ; graphical markers ; graphical parameters ; writing pressure ; differential diagnosis ; longitudinal assessment ; cognitive changes ; behavioural and psychological symptoms of dementia ; level of functioning ; electroencephalography ; resting-state ; biomarkers machine learning ; K-Nearest Neighbors ; graph theory ; treatment ; speech and language therapy ; intervention ; cognitive rehabilitation ; bilingualism ; semantic dementia ; semantic variant primary progressive aphasia ; word finding ; language therapy ; behavioural therapy ; electroencephalography (EEG) ; network analysis ; progressive apraxia of speech ; n/a
    Language 0|e
    Size 1 electronic resource (206 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021617973
    ISBN 9783036544076 ; 3036544070
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Are there cognitive and neuroimaging signatures in long COVID?

    Matias-Guiu, Jordi A / Díez-Cirarda, María

    Brain communications

    2023  Volume 5, Issue 4, Page(s) fcad189

    Abstract: This scientific commentary refers to 'Markers of limbic system damage following SARS-CoV-2 infection', by ... ...

    Abstract This scientific commentary refers to 'Markers of limbic system damage following SARS-CoV-2 infection', by Thomasson
    Language English
    Publishing date 2023-06-28
    Publishing country England
    Document type Journal Article
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcad189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Primary progressive aphasia: in search of brief cognitive assessments.

    Matias-Guiu, Jordi A / Grasso, Stephanie M

    Brain communications

    2022  Volume 4, Issue 5, Page(s) fcac227

    Abstract: This scientific commentary refers to 'Utility of the Addenbrooke's Cognitive Examination III online calculator to differentiate the primary progressive aphasia variants' by ... ...

    Abstract This scientific commentary refers to 'Utility of the Addenbrooke's Cognitive Examination III online calculator to differentiate the primary progressive aphasia variants' by Foxe
    Language English
    Publishing date 2022-09-06
    Publishing country England
    Document type Journal Article
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcac227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Novel cognitive screening tests to address new clinical priorities and cultural diversity.

    Matias-Guiu, Jordi A / Delgado-Álvarez, Alfonso

    European journal of neurology

    2022  Volume 30, Issue 4, Page(s) 799–801

    MeSH term(s) Humans ; Cognition ; Cultural Diversity
    Language English
    Publishing date 2022-12-08
    Publishing country England
    Document type Editorial
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.15653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4738: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 592: Show issues

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  5. Article: Advances in Primary Progressive Aphasia.

    Matias-Guiu, Jordi A / Laforce, Robert / Lavoie, Monica / Utianski, Rene L

    Brain sciences

    2022  Volume 12, Issue 5

    Abstract: Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by progressive and predominant language impairment [ ... ]. ...

    Abstract Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by progressive and predominant language impairment [...].
    Language English
    Publishing date 2022-05-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci12050636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A review of novel Cognitive Challenge Tests for the assessment of preclinical Alzheimer's disease.

    Curiel Cid, Rosie E / Matias-Guiu, Jordi A / Loewenstein, David A

    Neuropsychology

    2022  Volume 37, Issue 6, Page(s) 661–672

    Abstract: Objectives: There is currently a lack of consensus among neuropsychologists about which cognitive assessment paradigms hold the most promise in identifying subtle cognitive deficits in preclinical Alzheimer's Disease (AD) and which are most useful for ... ...

    Abstract Objectives: There is currently a lack of consensus among neuropsychologists about which cognitive assessment paradigms hold the most promise in identifying subtle cognitive deficits in preclinical Alzheimer's Disease (AD) and which are most useful for monitoring risk of cognitive deterioration. Many widely used instruments are older versions of tests originally developed for the assessment of dementia or traumatic brain injury. Current efforts to digitize these measures provides more uniform and remote assessment, which is an advancement, but does not reflect significant changes in paradigmatic underpinnings or recent advances in cognitive neuroscience.
    Method: This work provides an overview of novel Cognitive Challenge Tests (CCTs) that employ semantic interference paradigms that uniquely measure the failure to recover from proactive semantic interference (frPSI). Other salient methods to measure meaningful cognitive change in early stage AD are also presented, as well as how they compare with traditional neuropsychological assessments. Finally, future directions for the development of more effective assessment paradigms are discussed.
    Results: frPSI is a cognitive marker which measures the persistent inability to learn new semantically competing stimuli despite multiple opportunities to do so. frPSI and deficits in semantic inhibitory control have repeatedly shown utility for the early detection of AD during its preclinical stages. These novel cognitive markers have been related to various biomarkers of AD and neurodegeneration among culturally diverse older adults.
    Conclusions: To meet the critical needs of a rapidly evolving field, cognitive assessment instruments must show sufficient scientific rigor including robust sensitivity, specificity, and predictive utility among culturally and linguistically diverse populations and importantly, be correlated to AD biomarkers. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
    MeSH term(s) Humans ; Aged ; Alzheimer Disease/diagnosis ; Alzheimer Disease/psychology ; Cognitive Dysfunction ; Learning ; Neuropsychological Tests ; Cognition ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-12-08
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1042412-x
    ISSN 1931-1559 ; 0894-4105
    ISSN (online) 1931-1559
    ISSN 0894-4105
    DOI 10.1037/neu0000883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3002: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Cognitive dysfunction in patients with primary adrenal insufficiency: A systematic review.

    Ramos-Leví, Ana M / Cañada, Emma / Matias-Guiu, Jordi A

    Applied neuropsychology. Adult

    2022  Volume 30, Issue 6, Page(s) 802–813

    Abstract: Addison's disease (AD) entails a chronic insufficient production of gluco- and mineralocorticoids. Fatigue and decreased quality of life are frequently reported symptoms, but little is known about its effects on cognition. This study aims to explore the ... ...

    Abstract Addison's disease (AD) entails a chronic insufficient production of gluco- and mineralocorticoids. Fatigue and decreased quality of life are frequently reported symptoms, but little is known about its effects on cognition. This study aims to explore the existence of cognitive impairment in patients with AD and the influence of treatment regimens. We conducted a systematic review. Inclusion criteria were met by 10 articles, most of them ranked as intermediate quality. Three studies analyzed the relationship between AD and cognitive impairment; one explored the effect of delaying treatment showing no effect on cognitive performance, and another one studied the effect of fludrocortisone treatment. Episodic memory was the most frequent cognitive domain impaired across studies, in comparison to healthy controls. Two papers investigated the relationship between impaired sleep quality and poor cognitive performance. Two studies related cognitive impairments with hypocortisolism-derived brain neuroglycopenia. Two studies investigated the effect of DHEA substitution. In conclusion, patients exhibit a moderately reduced performance in verbal learning. The pathophysiology of this impairment is likely multifactorial. Future studies should include larger sample sizes, the use of comprehensive and multi-domain neuropsychological and behavioral protocols, and neuroimaging.
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2673736-X
    ISSN 2327-9109 ; 2327-9095
    ISSN (online) 2327-9109
    ISSN 2327-9095
    DOI 10.1080/23279095.2022.2090256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4952: Show issues Location:
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  8. Article ; Online: Genetic-based patient stratification in Alzheimer's disease.

    Hernández-Lorenzo, Laura / García-Gutiérrez, Fernando / Solbas-Casajús, Ana / Corrochano, Silvia / Matías-Guiu, Jordi A / Ayala, Jose L

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9970

    Abstract: Alzheimer's disease (AD) shows a high pathological and symptomatological heterogeneity. To study this heterogeneity, we have developed a patient stratification technique based on one of the most significant risk factors for the development of AD: ... ...

    Abstract Alzheimer's disease (AD) shows a high pathological and symptomatological heterogeneity. To study this heterogeneity, we have developed a patient stratification technique based on one of the most significant risk factors for the development of AD: genetics. We addressed this challenge by including network biology concepts, mapping genetic variants data into a brain-specific protein-protein interaction (PPI) network, and obtaining individualized PPI scores that we then used as input for a clustering technique. We then phenotyped each obtained cluster regarding genetics, sociodemographics, biomarkers, fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging, and neurocognitive assessments. We found three clusters defined mainly by genetic variants found in MAPT, APP, and APOE, considering known variants associated with AD and other neurodegenerative disease genetic architectures. Profiling of these clusters revealed minimal variation in AD symptoms and pathology, suggesting different biological mechanisms may activate the neurodegeneration and pathobiological patterns behind AD and result in similar clinical and pathological presentations, even a shared disease diagnosis. Lastly, our research highlighted MAPT, APP, and APOE as key genes where these genetic distinctions manifest, suggesting them as potential targets for personalized drug development strategies to address each AD subgroup individually.
    MeSH term(s) Alzheimer Disease/genetics ; Alzheimer Disease/diagnostic imaging ; Humans ; tau Proteins/genetics ; Apolipoproteins E/genetics ; Positron-Emission Tomography ; Male ; Female ; Aged ; Genetic Predisposition to Disease ; Amyloid beta-Protein Precursor/genetics ; Protein Interaction Maps/genetics ; Biomarkers ; Brain/diagnostic imaging ; Brain/pathology ; Brain/metabolism
    Chemical Substances tau Proteins ; Apolipoproteins E ; MAPT protein, human ; Amyloid beta-Protein Precursor ; Biomarkers ; ApoE protein, human ; APP protein, human
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-60707-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Predominance of visuoconstructive impairment after mild COVID-19?

    Díez-Cirarda, María / Yus, Miguel / Matías-Guiu, Jorge / Matias-Guiu, Jordi A

    Molecular psychiatry

    2022  Volume 28, Issue 2, Page(s) 536–537

    MeSH term(s) Humans ; COVID-19 ; Memory ; Neuropsychological Tests
    Language English
    Publishing date 2022-09-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-022-01797-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4812: Show issues Location:
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  10. Article ; Online: A taxonomic approach to cognitive diagnostics is viable and achievable in MS.

    Hancock, Laura M / Galioto, Rachel / Samsonov, Alexey / Busch, Robyn M / Hermann, Bruce / Matias-Guiu, Jordi A

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2023  Volume 29, Issue 8, Page(s) 1040–1042

    MeSH term(s) Humans ; Multiple Sclerosis/diagnosis ; Cognition
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585231157011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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