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  1. Article: The Aqueous Extract of Polypodium leucotomos (Fernblock®) Regulates Opsin 3 and Prevents Photooxidation of Melanin Precursors on Skin Cells Exposed to Blue Light Emitted from Digital Devices

    Portillo, Mikel / Mataix, Manuel / Alonso-Juarranz, Miguel / Lorrio, Silvia / Villalba, María / Rodríguez-Luna, Azahara / González, Salvador

    Antioxidants. 2021 Mar. 06, v. 10, no. 3

    2021  

    Abstract: The effects of sun exposure on the skin and specifically those related to pigmentation disorders are well known. It has recently been shown that blue light leads to the induction of oxidative stress and long-lasting pigmentation. The protective effect of ...

    Abstract The effects of sun exposure on the skin and specifically those related to pigmentation disorders are well known. It has recently been shown that blue light leads to the induction of oxidative stress and long-lasting pigmentation. The protective effect of an aqueous extract of Polypodium leucotomos (Fernblock®) is known. Our aim was to investigate the action mechanism of Fernblock® against pigmentation induced by blue light from digital devices. Human fibroblasts (HDF) and murine melanocytes (B16-F10) were exposed to artificial blue light (a 400–500 nm LED lamp). Cell viability, mitochondrial morphology, and the expression of the mitogen-activated protein kinase (MAPK) p38, known markers involved in the melanogenesis pathway, were evaluated. The activation of Opsin-3, a membrane protein sensitive to blue light that triggers the activation of the enzyme tyrosinase responsible for melanogenesis in melanocytes, was also analyzed. Our results demonstrated that pretreatment with Fernblock® prevents cell death, alteration of mitochondrial morphology, and phosphorylation of p38 in HDF exposed to blue light. In addition, Fernblock® significantly reduced the activation of Opsin-3 in melanocytes and the photo-oxidation of melanin, preventing its photodegradation. In sum, Fernblock® exerts beneficial effects against the detrimental impact of blue light from digital devices and could prevent early photoaging, while maintaining skin homeostasis.
    Keywords Polypodium ; blue light ; cell death ; cell viability ; fibroblasts ; homeostasis ; humans ; melanin ; melanocytes ; melanogenesis ; membrane proteins ; mice ; mitochondria ; mitogen-activated protein kinase ; opsin ; oxidative stress ; phosphorylation ; photoaging ; photolysis ; photooxidation ; pigmentation ; protective effect
    Language English
    Dates of publication 2021-0306
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10030400
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: The Aqueous Extract of

    Portillo, Mikel / Mataix, Manuel / Alonso-Juarranz, Miguel / Lorrio, Silvia / Villalba, María / Rodríguez-Luna, Azahara / González, Salvador

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 3

    Abstract: The effects of sun exposure on the skin and specifically those related to pigmentation disorders are well known. It has recently been shown that blue light leads to the induction of oxidative stress and long-lasting pigmentation. The protective effect of ...

    Abstract The effects of sun exposure on the skin and specifically those related to pigmentation disorders are well known. It has recently been shown that blue light leads to the induction of oxidative stress and long-lasting pigmentation. The protective effect of an aqueous extract of
    Language English
    Publishing date 2021-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10030400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: FPR2 DNA Aptamers for Targeted Therapy of Wound Repair.

    de Arriba, María Del Carmen / Fernández, Gerónimo / Chacón-Solano, Esteban / Mataix, Manuel / Martínez-Santamaría, Lucía / Illera, Nuria / Carrión-Marchante, Rebeca / Martín, María Elena / Larcher, Fernando / González, Victor M / Del Río, Marcela / Carretero, Marta

    The Journal of investigative dermatology

    2022  Volume 142, Issue 8, Page(s) 2238–2248.e8

    Abstract: Chronic wounds represent a major health problem worldwide. Some of the available therapies based on recombinant proteins usually fail owing to the hostile environment found at the wound bed. Aptamers appear as an attractive alternative to recombinant ... ...

    Abstract Chronic wounds represent a major health problem worldwide. Some of the available therapies based on recombinant proteins usually fail owing to the hostile environment found at the wound bed. Aptamers appear as an attractive alternative to recombinant factors owing in part to their stability, sensitivity, specificity, and low-cost production. In this study, the Cell-Systematic Evolution of Ligands by EXponential Enrichment technology was employed to generate aptamers that specifically recognize and modulate the function of the FPR2, a receptor expressed in a variety of cells involved in wound repair. Three aptamers were obtained that specifically bound to FPR2 stable transfectants generated in HaCaT cells. The targeted aptamers were shown to act as FPR2 agonists in different in vitro functional assays, including wound healing assays, and elicited a similar pattern of response to that obtained with other known FPR2 peptide agonists, such as the human LL37 cathelicidin. We have also obtained in vivo evidence for the prohealing activities of one of these FPR2 aptamers in a skin-humanized mouse model developed by us, previously shown to accurately recreate the main phases of physiological human wound repair process. In conclusion, we provide evidence of the potential therapeutic value of FPR2 aptamers for cutaneous repair.
    MeSH term(s) Animals ; Aptamers, Nucleotide ; Humans ; Ligands ; Mice ; Receptors, Formyl Peptide/agonists ; Receptors, Formyl Peptide/genetics ; Receptors, Formyl Peptide/metabolism ; Receptors, Lipoxin/agonists ; Receptors, Lipoxin/genetics ; Receptors, Lipoxin/metabolism ; Wound Healing
    Chemical Substances Aptamers, Nucleotide ; FPR2 protein, human ; Ligands ; Receptors, Formyl Peptide ; Receptors, Lipoxin
    Language English
    Publishing date 2022-01-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2021.12.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Extract of

    Zamarrón, Alicia / Morel, Esther / Lucena, Silvia Rocío / Mataix, Manuel / Pérez-Davó, Azahara / Parrado, Concepción / González, Salvador

    International journal of molecular sciences

    2019  Volume 20, Issue 6

    Abstract: Exposure to natural and artificial light and environmental pollutants are the main factors that challenge skin homeostasis, promoting aging or even different forms of skin cancer through a variety of mechanisms that include accumulation of reactive ... ...

    Abstract Exposure to natural and artificial light and environmental pollutants are the main factors that challenge skin homeostasis, promoting aging or even different forms of skin cancer through a variety of mechanisms that include accumulation of reactive oxygen species (ROS), engagement of DNA damage responses, and extracellular matrix (ECM) remodeling upon release of metalloproteases (MMPs). Ultraviolet A radiation is the predominant component of sunlight causative of photoaging, while ultraviolet B light is considered a potentiator of photoaging. In addition, different chemicals contribute to skin aging upon penetration through skin barrier disruption or hair follicles, aryl hydrocarbon receptors (AhR) being a major effector mechanism through which toxicity is exerted.
    MeSH term(s) Caspase 3/metabolism ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Cell Nucleus/radiation effects ; Cell Shape/drug effects ; Cell Shape/radiation effects ; DNA Damage ; Dermis/pathology ; Dermis/radiation effects ; Fibroblasts/drug effects ; Fibroblasts/pathology ; Fibroblasts/radiation effects ; Histones/metabolism ; Humans ; Keratinocytes/drug effects ; Keratinocytes/pathology ; Keratinocytes/radiation effects ; Matrix Metalloproteinase 1/metabolism ; Membrane Proteins/metabolism ; Microtubule-Associated Proteins/metabolism ; Plant Extracts/pharmacology ; Poaceae/chemistry ; Poly(ADP-ribose) Polymerases/metabolism ; Polychlorinated Dibenzodioxins/toxicity ; Receptors, Aryl Hydrocarbon/metabolism ; Signal Transduction ; Stress, Physiological/drug effects ; Stress, Physiological/radiation effects ; Ultraviolet Rays
    Chemical Substances H2AX protein, human ; Histones ; MAP1LC3A protein, human ; Membrane Proteins ; Microtubule-Associated Proteins ; Plant Extracts ; Polychlorinated Dibenzodioxins ; Receptors, Aryl Hydrocarbon ; loricrin ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; Caspase 3 (EC 3.4.22.-) ; Matrix Metalloproteinase 1 (EC 3.4.24.7)
    Language English
    Publishing date 2019-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20061356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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