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  1. Article ; Online: Nutraceutical and therapeutic potential of Phycocyanobilin for treating Alzheimer's disease.

    Matamoros, Beatriz Piniella- / Prida, Javier Marin- / Rol, Giselle Penton-

    Journal of biosciences

    2021  Volume 46

    Abstract: Alzheimer's disease (AD) is a devastating neurodegenerative condition provoking the loss of cognitive and memory performances. Despite huge efforts to develop effective AD therapies, there is still no cure for this neurological condition. Here, we review ...

    Abstract Alzheimer's disease (AD) is a devastating neurodegenerative condition provoking the loss of cognitive and memory performances. Despite huge efforts to develop effective AD therapies, there is still no cure for this neurological condition. Here, we review the main biological properties of Phycocyanobilin (PCB), accounting for its potential uses against AD. PCB, given individually or released in vivo from C-Phycocyanin (C-PC), acts as a bioactive-molecule-mediating antioxidant, is anti-inflammatory and has immunomodulatory activities. PCB/C-PC are able to scavenge reactive oxygen and nitrogen species, to counteract lipid peroxidation and to inhibit enzymes such as NADPH oxidase and COX-2. In animal models of multiple sclerosis and ischemic stroke, these compounds induce remyelination as demonstrated by electron microscopy and the expression of genes such as
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Dietary Supplements/analysis ; Disease Models, Animal ; Gene Expression Regulation/drug effects ; Humans ; Immunologic Factors/pharmacology ; Microglia/drug effects ; Microglia/metabolism ; Microglia/pathology ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Oxidative Stress/drug effects ; Phycobilins/pharmacology ; Phycocyanin/pharmacology ; Rats ; Reactive Nitrogen Species ; Reactive Oxygen Species ; Remyelination/drug effects
    Chemical Substances Anti-Inflammatory Agents ; Antioxidants ; Immunologic Factors ; Nerve Tissue Proteins ; Phycobilins ; Reactive Nitrogen Species ; Reactive Oxygen Species ; Phycocyanin (11016-15-2) ; phycocyanobilin (36NUT04V2K)
    Language English
    Publishing date 2021-12-01
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 756157-x
    ISSN 0973-7138 ; 0250-5991
    ISSN (online) 0973-7138
    ISSN 0250-5991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Positive effects of Phycocyanobilin on gene expression in glutamate-induced excitotoxicity in SH-SY5Y cells and animal models of multiple sclerosis and cerebral ischemia.

    Gardón, Daniel Palenzuela / Cervantes-Llanos, Majel / Matamoros, Beatriz Piniella / Rodríguez, Hanlet Camacho / Tan, Chan-Yuan / Marín-Prida, Javier / Falcón-Cama, Viviana / Pavón-Fuentes, Nancy / Lemus, Jessica Gómez / Ruiz, Laura de la Caridad Bakos / Argudin, Tamara Díaz / Donato, Gillian Martínez / Perera, Yasser / Yang, Ke / Pentón-Rol, Giselle

    Heliyon

    2022  Volume 8, Issue 6, Page(s) e09769

    Abstract: Background: Oxidative stress has a predominant role in the pathogenesis of neurodegenerative diseases and therefore the modulation of genes and the identification of biological pathways associated with antioxidant therapies, have an impact on its ... ...

    Abstract Background: Oxidative stress has a predominant role in the pathogenesis of neurodegenerative diseases and therefore the modulation of genes and the identification of biological pathways associated with antioxidant therapies, have an impact on its treatment.
    Objective: The objective of this study was the comparison of 2 methods for the analysis of real-time PCR (qPCR) data, through the use of the evaluation of genes that mediate the effect of Phycocyanobilin (PCB) and its validation in animal models.
    Methods: We evaluated the effect of PCB:" in vitro" on gene modulation through qPCR analyzed by parametric ANOVA and multivariate principal component analysis (PCA) in a model of glutamate-induced excitotoxicity in the SH-SY5Y cell line and" in vivo"; in animal models of multiple sclerosis (MS) and cerebral ischemia (CI).
    Results: The results showed that PCA is a robust and powerful method that allows the assessment of gene expression profiles. We detected the significant down-regulation of the
    Conclusion: We concluded that the mechanisms by which PCB protected cells included the reduction of oxidative stress damage, which could contribute to its clinical efficacy for the treatment of neurodegenerative diseases.
    Language English
    Publishing date 2022-06-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e09769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Positive effects of Phycocyanobilin on gene expression in glutamate-induced excitotoxicity in SH-SY5Y cells and animal models of multiple sclerosis and cerebral ischemia

    Gardon, Daniel Palenzuela / Cervantes-Llanos, Majel / Matamoros, Beatriz Piniella / Rodríguez, Hanlet Camacho / Tan, Chan-yuan / Marín –Prida, Javier / Falcón-Cama, Viviana / Pavón-Fuentes, Nancy / Lemus, Jessica Gómez / Ruiz, Laura de la Caridad Bakos / Argudin, Tamara Díaz / Donato, Gillian Martínez / Perera, Yasser / Yang, Ke / Pentón-Rol, Giselle

    Heliyon. 2022 June 16,

    2022  

    Abstract: Oxidative stress has a predominant role in the pathogenesis of neurodegenerative diseases and therefore the modulation of genes and the identification of biological pathways associated with antioxidant therapies, have an impact on its treatment. The ... ...

    Abstract Oxidative stress has a predominant role in the pathogenesis of neurodegenerative diseases and therefore the modulation of genes and the identification of biological pathways associated with antioxidant therapies, have an impact on its treatment. The objective of this study was the comparison of 2 methods for the analysis of real-time PCR (qPCR) data, through the use of the evaluation of genes that mediate the effect of Phycocyanobilin (PCB) and its validation in animal models. We evaluated the effect of PCB:” in vitro” on gene modulation through qPCR analyzed by parametric ANOVA and multivariate principal component analysis (PCA) in a model of glutamate-induced excitotoxicity in the SH-SY5Y cell line and” in vivo”; in animal models of multiple sclerosis (MS) and cerebral ischemia (CI). The results showed that PCA is a robust and powerful method that allows the assessment of gene expression profiles. We detected the significant down-regulation of the CYBB (NOX2), and HMOX1 by the action of PCB in SH-5YSH cell line insulted with Glutamate. The decrease in pro-inflammatory cytokines and markers related to apoptosis and innate immune response, mediated the effect of PCB in the animal models of MS and CI, respectively. We concluded that the mechanisms by which PCB protected cells included the reduction of oxidative stress damage, which could contribute to its clinical efficacy for the treatment of neurodegenerative diseases.
    Keywords animals ; antioxidants ; apoptosis ; cell lines ; cytokines ; gene expression ; genes ; glutamic acid ; innate immunity ; ischemia ; oxidative stress ; pathogenesis ; principal component analysis ; quantitative polymerase chain reaction ; sclerosis
    Language English
    Dates of publication 2022-0616
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e09769
    Database NAL-Catalogue (AGRICOLA)

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