LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 234

Search options

  1. Article ; Online: Median manubriotomy for ventral access to the caudal cervical and cranial thoracic spine.

    Mateo, Isidro

    Veterinary surgery : VS

    2020  Volume 49, Issue 5, Page(s) 923–929

    Abstract: Objective: To describe median manubriotomy to access the ventral aspect of the caudal cervical and cranial thoracic spine and report the outcomes in dogs with lesions affecting the spinal cord at C6-T2 vertebral bodies. To evaluate possible ... ...

    Abstract Objective: To describe median manubriotomy to access the ventral aspect of the caudal cervical and cranial thoracic spine and report the outcomes in dogs with lesions affecting the spinal cord at C6-T2 vertebral bodies. To evaluate possible complications of this technique and clinical outcomes.
    Study design: Cadaveric study and short case series.
    Study population: Two cadavers and nine dogs with lesions affecting the spinal cord at C6, C7, T1 or T2 vertebral bodies or corresponding intervertebral spaces.
    Methods: Two cadavers were used for demonstration purposes. Medical records (2013-2019) were reviewed for dogs undergoing median manubriotomy to facilitate access to the ventral aspect of C6-T2 vertebral bodies and/or corresponding intervertebral disc spaces. Data on preoperative and postoperative neurological status and diagnostic imaging, surgical technique, and complications were retrieved.
    Results: Indications for surgery included C7-T1 disc extrusions in five dogs, caudal cervical misalignment in three dogs, and C7-T1 and T1-T2 disc protrusions in one dog. The vertebral bodies of C6 to T2 were consistently visualized after median manubriotomy. Preoperative clinical signs resolved in five dogs and improved in two dogs. One dog was euthanized for lack of improvement, and one dog died of pulmonary thromboembolism.
    Conclusion: Median manubriotomy improved the surgical access to the ventral aspect of caudal cervical and cranial thoracic spine without related complications.
    Clinical significance: Median manubriotomy can be considered in dogs undergoing ventral decompression and/or stabilization of C7-T1 and T1-T2 intervertebral disc spaces.
    MeSH term(s) Animals ; Cervical Vertebrae/pathology ; Dog Diseases/surgery ; Dogs ; Female ; Intervertebral Disc Displacement/pathology ; Intervertebral Disc Displacement/veterinary ; Male ; Manubrium/surgery ; Postoperative Complications/veterinary ; Thoracic Vertebrae/pathology
    Language English
    Publishing date 2020-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491071-8
    ISSN 1532-950X ; 0161-3499
    ISSN (online) 1532-950X
    ISSN 0161-3499
    DOI 10.1111/vsu.13412
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Publisher Correction: Directed evolution improves the catalytic efficiency of TEV protease.

    Sanchez, Mateo I / Ting, Alice Y

    Nature methods

    2020  Volume 17, Issue 2, Page(s) 242

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2020-01-06
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2169522-2
    ISSN 1548-7105 ; 1548-7091
    ISSN (online) 1548-7105
    ISSN 1548-7091
    DOI 10.1038/s41592-019-0729-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6022: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Surgical management of a brain abscess due to plant foreign body in a dog.

    Cloquell, Ana / Mateo, Isidro

    Open veterinary journal

    2019  Volume 9, Issue 3, Page(s) 216–221

    Abstract: Background: Intracranial abscesses as a result of grass awn migration have been rarely described in the veterinary literature. The identification of their radiological features is mandatory for proper diagnosis. As occurs with abscesses in other organs, ...

    Abstract Background: Intracranial abscesses as a result of grass awn migration have been rarely described in the veterinary literature. The identification of their radiological features is mandatory for proper diagnosis. As occurs with abscesses in other organs, surgical drainage and directed antibiotic therapy should be considered the treatment of choice.
    Case description: A clinical case of a Great Dane dog with forebrain signs and magnetic resonance imaging and computed tomography findings compatible with intracranial abscess associated with inflammatory changes in orbital musculature is described. An exploratory rostro-tentorial craniotomy with durotomy was performed, allowing the drainage of purulent content and the extraction of a plant foreign body from the cerebral parenchyma. Antibiotic treatment was instituted and the patient was discharged without recurrence of neurological deficits other than quarterly seizures. Six months later, revision magnetic resonance was performed, revealing the resolution of the intracranial lesion and the normalization of the extracranial tissues.
    Conclusion: This is the first case in veterinary literature in which a grass awn has been surgically extracted from the brain of a dog with long-term outcome described. Observed changes in the extracranial musculature were fundamental to establish the pre-surgical diagnosis of a migratory foreign body.
    MeSH term(s) Animals ; Brain Abscess/surgery ; Brain Abscess/veterinary ; Craniotomy/veterinary ; Dog Diseases/surgery ; Dogs ; Female ; Foreign Bodies/complications ; Foreign Bodies/surgery ; Foreign Bodies/veterinary ; Magnetic Resonance Imaging/veterinary ; Poaceae ; Tomography, X-Ray Computed/veterinary ; Treatment Outcome
    Language English
    Publishing date 2019-08-03
    Publishing country Libya
    Document type Case Reports
    ZDB-ID 2651664-0
    ISSN 2218-6050 ; 2226-4485
    ISSN (online) 2218-6050
    ISSN 2226-4485
    DOI 10.4314/ovj.v9i3.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Directed evolution improves the catalytic efficiency of TEV protease.

    Sanchez, Mateo I / Ting, Alice Y

    Nature methods

    2019  Volume 17, Issue 2, Page(s) 167–174

    Abstract: Tobacco etch virus protease (TEV) is one of the most widely used proteases in biotechnology because of its exquisite sequence specificity. A limitation, however, is its slow catalytic rate. We developed a generalizable yeast-based platform for directed ... ...

    Abstract Tobacco etch virus protease (TEV) is one of the most widely used proteases in biotechnology because of its exquisite sequence specificity. A limitation, however, is its slow catalytic rate. We developed a generalizable yeast-based platform for directed evolution of protease catalytic properties. Protease activity is read out via proteolytic release of a membrane-anchored transcription factor, and we temporally regulate access to TEV's cleavage substrate using a photosensory LOV domain. By gradually decreasing light exposure time, we enriched faster variants of TEV over multiple rounds of selection. Our TEV-S153N mutant (uTEV1Δ), when incorporated into the calcium integrator FLARE, improved the signal/background ratio by 27-fold, and enabled recording of neuronal activity in culture with 60-s temporal resolution. Given the widespread use of TEV in biotechnology, both our evolved TEV mutants and the directed-evolution platform used to generate them could be beneficial across a wide range of applications.
    MeSH term(s) Catalysis ; Directed Molecular Evolution ; Endopeptidases/genetics ; Endopeptidases/metabolism ; HEK293 Cells ; Humans ; Saccharomyces cerevisiae/genetics
    Chemical Substances Endopeptidases (EC 3.4.-) ; TEV protease (EC 3.4.-)
    Language English
    Publishing date 2019-12-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2169522-2
    ISSN 1548-7105 ; 1548-7091
    ISSN (online) 1548-7105
    ISSN 1548-7091
    DOI 10.1038/s41592-019-0665-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6022: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Comparison of maternal, fetal, obstetric and neonatal outcomes for 234 triplet pregnancies conceived in vivo versus IVF and ICSI conceptions.

    Pena-Burgos, E M / Duyos-Mateo, I / Pozo-Kreilinger, J J / Regojo-Zapata, R M / Quirós-González, V / De La Calle, M

    Reproductive biomedicine online

    2023  Volume 48, Issue 2, Page(s) 103419

    Abstract: Research question: Is there a difference in maternal, fetal, obstetric and neonatal outcomes for triplet pregnancies when comparing in vivo conceptions with those conceived by assisted reproductive technology (ART)?: Design: This single-centre, ... ...

    Abstract Research question: Is there a difference in maternal, fetal, obstetric and neonatal outcomes for triplet pregnancies when comparing in vivo conceptions with those conceived by assisted reproductive technology (ART)?
    Design: This single-centre, retrospective cohort study included all triplet pregnancies followed up at La Paz University Hospital, Madrid between 2000 and 2022. The characteristics of the pregnant women, and maternal, fetal, obstetric and perinatal outcomes were examined. Univariate and multivariate statistical analyses were performed.
    Results: In total, 234 triplet pregnancies were analysed: 92 in the natural and assisted insemination conception group (in-vivo conception) and 142 in the in vitro fertilization and intracytoplasmic sperm injection conception group (ART conception). ART triplet pregnancies were more common between 2000 and 2010 (P = 0.003). The percentage of monochorionic triamniotic pregnancies was significantly higher (P = 0.02) in the in-vivo conception group, and the percentage of dichorionic triamniotic pregnancies was significantly higher (P = 0.003) in the ART conception group. After adjusting for confounders, intrauterine growth restriction (IUGR) remained significantly more common in the ART conception group (adjusted odds ratio 8.65, 95% CI 1.66-45.03; P = 0.01). Differences in maternal age (P = 0.61), threatened preterm labour (P = 0.10), Apgar score ≤5 at 5 min (P = 0.99), umbilical cord pH <7.20 (P = 0.99) and fetal death (P = 0.99) disappeared after adjustment for confounders.
    Conclusion: ART triplet pregnancies had a higher rate of IUGR than in vivo triplet pregnancies. This could be related to higher maternal age, and higher rates of Apgar score ≤5 at 5 min and umbilical cord pH <7.20 in these pregnancies. In these cases, placental examination could provide valuable information.
    MeSH term(s) Infant, Newborn ; Pregnancy ; Female ; Male ; Humans ; Sperm Injections, Intracytoplasmic ; Pregnancy, Triplet ; Retrospective Studies ; Placenta ; Semen ; Reproductive Techniques, Assisted ; Fertilization in Vitro ; Pregnancy Outcome/epidemiology
    Language English
    Publishing date 2023-09-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2113823-0
    ISSN 1472-6491 ; 1472-6483
    ISSN (online) 1472-6491
    ISSN 1472-6483
    DOI 10.1016/j.rbmo.2023.103419
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5792: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Diverticulum of the third ventricle and absence of the interthalamic adhesion in a dog.

    Mateo, Isidro

    The Canadian veterinary journal = La revue veterinaire canadienne

    2012  Volume 53, Issue 5, Page(s) 539–542

    Abstract: A 10-month-old male Pomeranian dog was examined for neurological abnormalities consistent with diffuse forebrain and cerebellar disease. Based on ultrasound and magnetic resonance imaging (MRI) a diagnosis of diverticulum of the third ventricle, partial ... ...

    Abstract A 10-month-old male Pomeranian dog was examined for neurological abnormalities consistent with diffuse forebrain and cerebellar disease. Based on ultrasound and magnetic resonance imaging (MRI) a diagnosis of diverticulum of the third ventricle, partial agenesis of the corpus callosum, and absence of the interthalamic adhesion was made. As conservative treatment was unsuccessful, a ventriculoperitoneal shunt was placed.
    MeSH term(s) Agenesis of Corpus Callosum/diagnosis ; Agenesis of Corpus Callosum/surgery ; Agenesis of Corpus Callosum/veterinary ; Animals ; Diverticulum/diagnosis ; Diverticulum/surgery ; Diverticulum/veterinary ; Dog Diseases/diagnosis ; Dog Diseases/surgery ; Dogs ; Magnetic Resonance Spectroscopy ; Male ; Thalamus/abnormalities ; Treatment Outcome ; Ultrasonography/veterinary ; Ventriculoperitoneal Shunt/veterinary
    Language English
    Publishing date 2012-10-31
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 41603-4
    ISSN 0008-5286
    ISSN 0008-5286
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Palliative ventriculoperitoneal shunting in dogs with obstructive hydrocephalus caused by tumors affecting the third ventricle.

    Orlandi, Rocio / Vasilache, Cornel G / Mateo, Isidro

    Journal of veterinary internal medicine

    2020  Volume 34, Issue 4, Page(s) 1556–1562

    Abstract: Background: Hypertensive or obstructive hydrocephalus is a common complication in dogs with tumors affecting the third ventricle for which few therapeutic options are available.: Objectives: To describe signalment, neurological status, and pre- and ... ...

    Abstract Background: Hypertensive or obstructive hydrocephalus is a common complication in dogs with tumors affecting the third ventricle for which few therapeutic options are available.
    Objectives: To describe signalment, neurological status, and pre- and postsurgical findings, complications and survival time in 4 dogs with obstructive hydrocephalus caused by third ventricle tumors that were palliatively treated using ventriculoperitoneal shunting (VPS).
    Animals: Four client-owned dogs with obstructive hydrocephalus caused by tumors affecting the third ventricle.
    Methods: Medical records were reviewed for dogs diagnosed with third ventricular tumors. Inclusion criteria were complete medical record, advanced diagnostic imaging for review, and VPS as sole surgical treatment.
    Results: At the time of diagnosis, all patients displayed acute onset and rapidly progressive diffuse intracranial clinical signs. On advanced imaging, all dogs had a homogeneously enhancing mass occupying or collapsing the third ventricle as well as obstructive hydrocephalus. All of the dogs underwent VPS of the most dilated lateral ventricle. In 2 of the patients, intracranial hypertension followed by normotension after VPS placement was confirmed intraoperatively by means of direct intracranial pressure monitoring. Excellent clinical improvement was observed in all dogs immediately after surgery. Three patients required a second VPS in the contralateral lateral ventricle 3, 7 and 11 months after the first surgery, all of them with renewed improvement in clinical signs.
    Conclusion and clinical importance: Ventriculoperitoneal shunting is a rapid and effective treatment for patients with obstructive (hypertensive) hydrocephalus caused by tumors located within the third ventricle.
    MeSH term(s) Animals ; Brain Neoplasms/complications ; Brain Neoplasms/surgery ; Brain Neoplasms/veterinary ; Dog Diseases/surgery ; Dogs ; Female ; Hydrocephalus/surgery ; Hydrocephalus/veterinary ; Male ; Palliative Care ; Third Ventricle/surgery ; Ventriculoperitoneal Shunt/methods ; Ventriculoperitoneal Shunt/veterinary
    Language English
    Publishing date 2020-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.15818
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4095: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Dorsal Atlantoaxial Ligament Hypertrophy as a Cause for Clinical Signs in Dogs with Dens Abnormalities.

    Cloquell, Ana / Orlandi, Rocio / Vázquez, Fernando / Mateo, Isidro

    Journal of the American Animal Hospital Association

    2020  Volume 57, Issue 1, Page(s) 26–31

    Abstract: The objective of this study is to suggest clinical and subclinical atlantoaxial (AA) instability as a cause for dorsal AA ligament hypertrophy responsible for clinical signs in dogs with dens abnormalities. Clinical information from five dogs with ... ...

    Abstract The objective of this study is to suggest clinical and subclinical atlantoaxial (AA) instability as a cause for dorsal AA ligament hypertrophy responsible for clinical signs in dogs with dens abnormalities. Clinical information from five dogs with malformed dens and dorsal spinal cord compression at the AA junction was collected. All dogs had neck pain, associated with tetraparesis in three cases. Radiological examination revealed hypoplastic dens in two dogs and a defect in its ossification in the other three. Stress views were able to demonstrate obvious AA instability only in two cases, but it was suspected in the other owing to response to surgical fixation of the joint and the presence of a dorsal compressive band, which was considered an enlarged dorsal AA ligament. Surgical and histopathological examination of compressive tissue confirmed hypertrophy of the ligament. Long-term prognosis in the four operated cases, either by dorsal decompression and ventral fixation or by ventral fixation alone, was excellent. A malformed dens can cause subclinical instability, unnoted in dynamic studies. As instability may lead to hypertrophy of joint ligaments, soft tissue changes (specifically dorsal AA ligament hypertrophy) points out this instability and the need for joint fixation if surgical management is required.
    MeSH term(s) Animals ; Atlanto-Axial Joint/pathology ; Dog Diseases/pathology ; Dogs ; Female ; Hypertrophy/pathology ; Hypertrophy/veterinary ; Joint Instability/pathology ; Joint Instability/veterinary ; Ligaments, Articular/pathology ; Male ; Odontoid Process/abnormalities ; Odontoid Process/pathology
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410383-x
    ISSN 1547-3317 ; 1062-8266 ; 0587-2871
    ISSN (online) 1547-3317
    ISSN 1062-8266 ; 0587-2871
    DOI 10.5326/JAAHA-MS-7013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4255: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: What makes one feel eustress or distress in quarantine? An analysis from conservation of resources (COR) theory.

    Merino, M Dolores / Vallellano, M Dolores / Oliver, Coral / Mateo, Inmaculada

    British journal of health psychology

    2021  Volume 26, Issue 2, Page(s) 606–623

    Abstract: Objective: Health quarantines produce serious deterioration in psychological health, which becomes more affected the longer the quarantine lasts. According to the Conservation of Resources theory from Hobfoll (1989, American Psychologist, 44, 513), ... ...

    Abstract Objective: Health quarantines produce serious deterioration in psychological health, which becomes more affected the longer the quarantine lasts. According to the Conservation of Resources theory from Hobfoll (1989, American Psychologist, 44, 513), those people who have a good supply of resources will be able to cope better with the adversities and will show less distress. The objective of this research is to identify what are the resources that, in a situation of confinement under the threat of COVID-19, predict eustress or well-being, and the loss or lack of which resources predict distress or discomfort.
    Design and method: A total of 839 people complete an online questionnaire during the first week of COVID-19 confinement in Spain. The sample is weighted to obtain a distribution that is similar to the Spanish population. Using multiple linear regression analysis, factors are identified that are associated with eustress and distress based on the Conservation of Resources theory.
    Results: A model is identified that explains 55% of the variance of eustress consisting mostly of personal resources, with vitality as the recourse having the most weight. The factors that explain distress (18.9% of the variance) are those related to work (employment situation, work satisfaction, and time devoted to work) and conditions in the home (space).
    Conclusions: The models that predict eustress and distress are completely different. Based on these results, a series of recommendations are proposed aimed at increasing eustress and reducing distress in a situation of confinement. Additionally, proposals are offered for future research.
    MeSH term(s) COVID-19 ; Humans ; Quarantine ; SARS-CoV-2 ; Spain ; Stress, Psychological
    Language English
    Publishing date 2021-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2026500-1
    ISSN 2044-8287 ; 1359-107X
    ISSN (online) 2044-8287
    ISSN 1359-107X
    DOI 10.1111/bjhp.12501
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy.

    Jamiolkowski, Ryan M / Nguyen, Quynh-Anh / Farrell, Jordan S / McGinn, Ryan J / Hartmann, David A / Nirschl, Jeff J / Sanchez, Mateo I / Buch, Vivek P / Soltesz, Ivan

    Nature medicine

    2024  

    Abstract: Targeted tissue ablation involving the anterior hippocampus is the standard of care for patients with drug-resistant mesial temporal lobe epilepsy. However, a substantial proportion continues to suffer from seizures even after surgery. We identified the ... ...

    Abstract Targeted tissue ablation involving the anterior hippocampus is the standard of care for patients with drug-resistant mesial temporal lobe epilepsy. However, a substantial proportion continues to suffer from seizures even after surgery. We identified the fasciola cinereum (FC) neurons of the posterior hippocampal tail as an important seizure node in both mice and humans with epilepsy. Genetically defined FC neurons were highly active during spontaneous seizures in epileptic mice, and closed-loop optogenetic inhibition of these neurons potently reduced seizure duration. Furthermore, we specifically targeted and found the prominent involvement of FC during seizures in a cohort of six patients with epilepsy. In particular, targeted lesioning of the FC in a patient reduced the seizure burden present after ablation of anterior mesial temporal structures. Thus, the FC may be a promising interventional target in epilepsy.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-024-02924-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 39: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top