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Article ; Online: Infección por Rothia mucilaginosa. ¿Un patógeno respiratorio?

Ramos, José M / Mateo, Ignacio / Vidal, Inmaculada / Rosillo, Eva M / Merino, Esperanza / Portilla, Joaquín

Enfermedades infecciosas y microbiologia clinica

2014 Volume 32, Issue 5, Page(s) 306–309

Abstract: Introduction: To describe the spectrum of infections caused by Rothia mucilaginosa.: Methods: Retrospective study of 20 cases diagnosed with R. mucilaginosa from 2009 to 2012.: Results: Pulmonary infection was the most frequent clinical ... ...

Title translation	Infection due to Rothia mucilaginosa. A respiratory pathogen?.
Abstract	Introduction: To describe the spectrum of infections caused by Rothia mucilaginosa. Methods: Retrospective study of 20 cases diagnosed with R. mucilaginosa from 2009 to 2012. Results: Pulmonary infection was the most frequent clinical presentation (n=14, 70%): bronchiectasis infected (10), followed by pleural empyema (2), pneumonia (1) and acute bronchitis (1). Two episodes were of gastrointestinal origin: cholangitis secondary to biliary drainage and secondary peritonitis. Two episodes included bacteremia in patients with hematological malignancy. One patient had a surgical wound infection with bacteremia, and another had a bacteremic urinary tract infection in a patient with nephrostomy. Discussion: R. mucilaginosa may be responsible for infections of the lower respiratory tract in predisposed patients.
MeSH term(s)	Actinomycetales Infections/microbiology ; Aged ; Aged, 80 and over ; Female ; Humans ; Infant ; Male ; Micrococcaceae ; Middle Aged ; Respiratory Tract Infections/microbiology ; Retrospective Studies ; Young Adult
Language	Spanish
Publishing date	2014-05
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	1070941-1
ISSN	1578-1852 ; 0213-005X
ISSN (online)	1578-1852
ISSN	0213-005X
DOI	10.1016/j.eimc.2013.12.009
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Article ; Online: Analysis of radio wave propagation for ISM 2.4 GHz Wireless Sensor Networks in inhomogeneous vegetation environments.

Azpilicueta, Leire / López-Iturri, Peio / Aguirre, Erik / Mateo, Ignacio / Astrain, José Javier / Villadangos, Jesús / Falcone, Francisco

Sensors (Basel, Switzerland)

2014 Volume 14, Issue 12, Page(s) 23650–23672

Abstract: The use of wireless networks has experienced exponential growth due to the improvements in terms of battery life and low consumption of the devices. However, it is compulsory to conduct previous radio propagation analysis when deploying a wireless sensor ...

Abstract	The use of wireless networks has experienced exponential growth due to the improvements in terms of battery life and low consumption of the devices. However, it is compulsory to conduct previous radio propagation analysis when deploying a wireless sensor network. These studies are necessary to perform an estimation of the range coverage, in order to optimize the distance between devices in an actual network deployment. In this work, the radio channel characterization for ISM 2.4 GHz Wireless Sensor Networks (WSNs) in an inhomogeneous vegetation environment has been analyzed. This analysis allows designing environment monitoring tools based on ZigBee and WiFi where WSN and smartphones cooperate, providing rich and customized monitoring information to users in a friendly manner. The impact of topology as well as morphology of the environment is assessed by means of an in-house developed 3D Ray Launching code, to emulate the realistic operation in the framework of the scenario. Experimental results gathered from a measurement campaign conducted by deploying a ZigBee Wireless Sensor Network, are analyzed and compared with simulations in this paper. The scenario where this network is intended to operate is a combination of buildings and diverse vegetation species. To gain insight in the effects of radio propagation, a simplified vegetation model has been developed, considering the material parameters and simplified geometry embedded in the simulation scenario. An initial location-based application has been implemented in a real scenario, to test the functionality within a context aware scenario. The use of deterministic tools can aid to know the impact of the topological influence in the deployment of the optimal Wireless Sensor Network in terms of capacity, coverage and energy consumption, making the use of these systems attractive for multiple applications in inhomogeneous vegetation environments.
Language	English
Publishing date	2014-12-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s141223650
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Article ; Online: Detection of early Alzheimer's disease in MCI patients by the combination of MMSE and an episodic memory test

Berciano José / González-Perez Soraya / Sánchez-Juan Pascual / Mateo Ignacio / Vazquez-Higuera José / Rodríguez-Rodríguez Eloy / Pozueta Ana / Combarros Onofre

BMC Neurology, Vol 11, Iss 1, p

2011 Volume 78

Abstract: Abstract Background Mild cognitive impairment (MCI) is a heterogeneous clinical entity that comprises the prodromal phase of Alzheimer's disease (Pr-AD). New biomarkers are useful in detecting Pr-AD, but they are not universally available. We aimed to ... ...

Abstract	Abstract Background Mild cognitive impairment (MCI) is a heterogeneous clinical entity that comprises the prodromal phase of Alzheimer's disease (Pr-AD). New biomarkers are useful in detecting Pr-AD, but they are not universally available. We aimed to investigate baseline clinical and neuropsychological variables that might predict progression from MCI to AD dementia. Methods All patients underwent a complete clinical and neuropsychological evaluation at baseline and every 6 months during a two-year follow-up period, with 54 out of 109 MCI patients progressing to dementia (50 of them progressed to AD dementia), and 55 remaining as stable MCI (S-MCI). Results A combination of MMSE and California Verbal Learning Test Long Delayed Total Recall (CVLT-LDTR) constituted the best predictive model: subjects scoring above 26/30 on MMSE and 4/16 on CVLT-LDTR had a negative predictive value of 93.93% at 2 years, whereas those subjects scoring below both of these cut-off scores had a positive predictive value of 80.95%. Conclusions Pr-AD might be distinguished from S-MCI at baseline using the combination of MMSE and CVLT-LDTR. These two neuropsychological predictors are relatively brief and may be readily completed in non-specialist clinical settings.
Keywords	Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2011-06-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
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Article: Laterality does not influence early mortality in MCA ischemic stroke.

Mateo, Ignacio / Pinedo, Ana / Escalza, Ines / Garcia-Monco, Juan Carlos

Clinical neurology and neurosurgery

2006 Volume 108, Issue 7, Page(s) 628–631

Abstract: Objectives: There is clinical and experimental evidence involving the insula in the control of the autonomic system and cardiac function, with differential participation of right and left brain hemispheres, and these differences could influence ... ...

Abstract	Objectives: There is clinical and experimental evidence involving the insula in the control of the autonomic system and cardiac function, with differential participation of right and left brain hemispheres, and these differences could influence mortality in the acute phase of brain hemisphere ischemic infarcts. Methods: We have analyzed retrospectively the mortality during initial hospitalization in a series of 504 consecutive, unselected patients with middle cerebral artery (MCA) ischemic infarcts to detect potential differences between right (220 patients) and left (284 patients) lesions. Results: Factors associated with a higher mortality were the infarct size, the occurrence of nosocomial respiratory infection, age and a history of diabetes mellitus or chronic obstructive pulmonary disease. Conclusions: The laterality of the infarct did not have a significant influence on stroke mortality during the admission period for the acute stage.
MeSH term(s)	Aged ; Aged, 80 and over ; Autonomic Nervous System/blood supply ; Autonomic Nervous System/pathology ; Autonomic Nervous System/physiopathology ; Autonomic Nervous System Diseases/etiology ; Autonomic Nervous System Diseases/mortality ; Autonomic Nervous System Diseases/physiopathology ; Brain Ischemia/diagnosis ; Brain Ischemia/mortality ; Brain Ischemia/physiopathology ; Cerebral Cortex/blood supply ; Cerebral Cortex/pathology ; Cerebral Cortex/physiopathology ; Cross Infection/complications ; Cross Infection/physiopathology ; Diabetes Complications/physiopathology ; Disease Progression ; Female ; Functional Laterality/physiology ; Humans ; Infarction, Middle Cerebral Artery/diagnosis ; Infarction, Middle Cerebral Artery/mortality ; Infarction, Middle Cerebral Artery/physiopathology ; Magnetic Resonance Imaging ; Male ; Predictive Value of Tests ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Respiratory Tract Infections/complications ; Respiratory Tract Infections/etiology ; Respiratory Tract Infections/physiopathology ; Retrospective Studies ; Survival Rate/trends
Language	English
Publishing date	2006-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2005.10.002
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Article ; Online: When should we start enzyme replacement therapy for infantile Pompe disease with severe cardiomyopathy?

Bonilla-Palomas, Juan L / Gámez-López, Antonio L / Tejero-Hernández, María A / Tejero-Mateo, Ignacio / López-López, Juana

Revista espanola de cardiologia (English ed.)

2012 Volume 65, Issue 1, Page(s) 100–102

MeSH term(s)	Cardiomyopathies/drug therapy ; Cardiomyopathies/etiology ; Echocardiography ; Electrocardiography ; Enzyme Replacement Therapy/methods ; Female ; Glycogen Storage Disease Type II/complications ; Glycogen Storage Disease Type II/diagnostic imaging ; Glycogen Storage Disease Type II/drug therapy ; Humans ; Infant ; Infant, Newborn ; Male ; Prognosis ; Radiography ; alpha-Glucosidases/therapeutic use
Chemical Substances	alpha-Glucosidases (EC 3.2.1.20)
Language	Spanish
Publishing date	2012-01
Publishing country	Spain
Document type	Letter
ISSN	1885-5857
ISSN (online)	1885-5857
DOI	10.1016/j.recesp.2011.03.025
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Article ; Online: No association of CDK5 genetic variants with Alzheimer's disease risk

Combarros Onofre / Berciano José / Infante Jon / Rodríguez-Rodríguez Eloy / Sánchez-Juan Pascual / Mateo Ignacio / Vázquez-Higuera José

BMC Medical Genetics, Vol 10, Iss 1, p

2009 Volume 68

Abstract: Abstract Background As cyclin-dependent kinase 5 (CDK5) has been implicated in the abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) brain, and the development of neurofibrillary tangles, we examined the contribution of this gene to the ... ...

Abstract	Abstract Background As cyclin-dependent kinase 5 (CDK5) has been implicated in the abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) brain, and the development of neurofibrillary tangles, we examined the contribution of this gene to the susceptibility for AD. Methods We examined genetic variations of CDK5 by genotyping haplotype tagging SNPs (htSNPs) (rs9278, rs2069459, rs891507, rs2069454, rs1549759 and rs2069442) in a group of 408 Spanish AD cases and 444 controls. Results There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by APOE ε4 allele. Conclusion Our negative findings in the Spanish population argue against the hypothesis that CDK5 genetic variations are causally related to AD risk. Still, additional studies using different sets of patients and control subjects deserve further attention, since supporting evidence for association between CDK5 gene and AD risk in the Dutch population exists.
Keywords	Internal medicine ; RC31-1245 ; Genetics ; QH426-470
Subject code	610
Language	English
Publishing date	2009-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk.

Combarros, Onofre / Rodríguez-Rodríguez, Eloy / Mateo, Ignacio / Vázquez-Higuera, José Luis / Infante, Jon / Berciano, José / Sánchez-Juan, Pascual

Neurobiology of aging

2011 Volume 32, Issue 3, Page(s) 547.e1–6

Abstract: The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-inducible transcription factor that suppresses microglial inflammatory responses and inhibits amyloid beta (Aβ) production through promoting cholesterol efflux from glial cells. PPAR-γ ...

Abstract	The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-inducible transcription factor that suppresses microglial inflammatory responses and inhibits amyloid beta (Aβ) production through promoting cholesterol efflux from glial cells. PPAR-γ agonists have been advanced as a new disease altering approach to Alzheimer's disease (AD), with rosiglitazone therapy having improved cognition in those AD patients that did not possess an Apolipoprotein E (APOE) ε4 allele. The current study was designed to explore the effect of interactions between PPAR-γ and APOE gene polymorphisms on the AD risk. We examined genetic variations of PPAR-γ by genotyping 7 haplotype tagging SNPs (htSNPs) (rs10510412, rs17793951, rs1801282, rs4135263, rs1151999, rs709149, and rs709154) in a group of 352 Spanish late-onset AD cases and 438 controls. The PPAR-γ TCCA haplotype derived from SNPs in introns 4 (rs4135263), 5 (rs1151999), and 6 (rs709149 and rs709154) showed a strong protective effect against AD in APOE ε4 allele noncarriers (p=0.001, permutation p=0.006, Bonferroni corrected p=0.021), with a frequency of 39% in cases and 50% in controls. Our data suggest that PPAR-γ genetic variants may modify the risk of AD in an APOE ε4 allele-dependent fashion.
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Apolipoprotein E4/genetics ; Chi-Square Distribution ; Female ; Gene Frequency/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Humans ; Male ; PPAR gamma/genetics ; Polymorphism, Genetic/genetics
Chemical Substances	Apolipoprotein E4 ; PPAR gamma
Language	English
Publishing date	2011-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2009.07.004
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Article ; Online: Gene-gene interaction between heme oxygenase-1 and liver X receptor-beta and Alzheimer's disease risk.

Infante, Jon / Rodríguez-Rodríguez, Eloy / Mateo, Ignacio / Llorca, Javier / Vázquez-Higuera, José Luis / Berciano, José / Combarros, Onofre

Neurobiology of aging

2010 Volume 31, Issue 4, Page(s) 710–714

Abstract: Increasing cellular cholesterol levels results in high amyloid beta (Abeta) synthesis, which is central to the pathogenesis of Alzheimer's disease (AD). Heme oxygenase-1 (HO-1) stimulates oxidation of glial cholesterol to oxysterols, and increased ... ...

Abstract	Increasing cellular cholesterol levels results in high amyloid beta (Abeta) synthesis, which is central to the pathogenesis of Alzheimer's disease (AD). Heme oxygenase-1 (HO-1) stimulates oxidation of glial cholesterol to oxysterols, and increased oxysterol concentrations may protect neural tissues by activation of liver X receptor-beta (LXR-beta), which induces transcription of genes associated with reduction of cellular cholesterol concentrations and decrease of Abeta formation. Underexpression of HO-1 in concert with underexpression of LXR-beta would result in increased cholesterol accumulation, induction of Abeta production, and increased AD risk. We examined a functional polymorphism in the HO-1 promoter region (-413, rs2071746), and three LXR-beta polymorphisms in introns 2 (rs2695121), 5 (rs1052533), and 7 (rs1405655), in a group of 414 Spanish AD cases and 442 controls. Subjects carrying both the HO-1 (-413) TT genotype and the LXR-beta (intron 2) TT genotype (OR=2.63), LXR-beta (intron 5) AA genotype (OR=1.90), or LXR-beta (intron 7) TT genotype (OR=1.75) had a higher risk of developing AD than subjects without these risk genotypes. Considering synergistic effects between polymorphisms in cellular cholesterol efflux-related genes may help in determining the risk profile for AD.
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/physiopathology ; Cholesterol/metabolism ; DNA Mutational Analysis ; Epistasis, Genetic/genetics ; Female ; Gene Expression Regulation/physiology ; Genetic Markers/genetics ; Genetic Predisposition to Disease/genetics ; Genetic Testing ; Genotype ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Humans ; Introns/genetics ; Liver X Receptors ; Male ; Middle Aged ; Orphan Nuclear Receptors/genetics ; Polymorphism, Genetic/genetics ; Promoter Regions, Genetic/genetics
Chemical Substances	Genetic Markers ; Liver X Receptors ; Orphan Nuclear Receptors ; Cholesterol (97C5T2UQ7J) ; Heme Oxygenase-1 (EC 1.14.14.18)
Language	English
Publishing date	2010-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2008.05.025
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Article: Association between glycogen synthase kinase-3beta genetic polymorphism and late-onset Alzheimer's disease.

Mateo, Ignacio / Infante, Jon / Llorca, Javier / Rodríguez, Eloy / Berciano, José / Combarros, Onofre

Dementia and geriatric cognitive disorders

2006 Volume 21, Issue 4, Page(s) 228–232

Abstract: Aberrant phosphorylated tau is the major component of the neurofibrillary tangles in Alzheimer's disease (AD) brains. Glycogen synthase kinase-3beta (GSK-3beta) phosphorylates tau protein, and increased GSK-3beta expression has been associated with ... ...

Abstract	Aberrant phosphorylated tau is the major component of the neurofibrillary tangles in Alzheimer's disease (AD) brains. Glycogen synthase kinase-3beta (GSK-3beta) phosphorylates tau protein, and increased GSK-3beta expression has been associated with neurofibrillary tangles. Saitohin (STH) is a recently identified protein that shares tissue expression pattern with tau, and previous evidence in the Spanish population indicated that a polymorphism at codon 7 (Q7R) of the STH gene was associated with late-onset AD. Since both GSK-3beta and STH are related to tau, we examined the association between a polymorphism in the promoter region (-50) of the GSK-3beta gene and AD, either through an independent effect or through interaction with the STH (Q7R) polymorphism, in a well-defined group of 333 sporadic AD patients and 307 control subjects from Spain. The current study reveals that GSK-3beta (-50) TT genotype is associated with an increased risk (OR 1.99, p = 0.003) for late-onset (after the age of 72 years) AD. Our results indicate that both the GSK-3beta (-50) and STH (Q7R) polymorphisms increase the risk of late-onset (subjects >72 years) AD, although they appear to be independent and thus not to interact synergistically.
MeSH term(s)	Age Factors ; Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Apolipoprotein E4 ; Apolipoproteins E/genetics ; Catchment Area (Health) ; Codon/genetics ; Female ; Genotype ; Glycogen Synthase Kinase 3/genetics ; Glycogen Synthase Kinase 3 beta ; Humans ; Male ; Middle Aged ; Phosphorylation ; Polymorphism, Genetic/genetics ; Promoter Regions, Genetic/genetics ; Spain/epidemiology ; tau Proteins/genetics
Chemical Substances	Apolipoprotein E4 ; Apolipoproteins E ; Codon ; STH protein, human ; tau Proteins ; GSK3B protein, human (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 (EC 2.7.11.26)
Language	English
Publishing date	2006
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1026007-9
ISSN	1420-8008 ; 1013-7424
ISSN	1420-8008 ; 1013-7424
DOI	10.1159/000091044
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Article ; Online: Genetic interaction between tau and the apolipoprotein E receptor LRP1 Increases Alzheimer's disease risk.

Vázquez-Higuera, José Luis / Mateo, Ignacio / Sánchez-Juan, Pascual / Rodríguez-Rodríguez, Eloy / Pozueta, Ana / Infante, Jon / Berciano, José / Combarros, Onofre

Dementia and geriatric cognitive disorders

2009 Volume 28, Issue 2, Page(s) 116–120

Abstract: Abnormal tau hyperphosphorylation is one of the central events in the development of neurofibrillary tangles (NFTs) in Alzheimer's disease (AD), and phosphorylation of tau is accelerated by the increase in the level of neuronal cholesterol. ... ...

Abstract	Abnormal tau hyperphosphorylation is one of the central events in the development of neurofibrillary tangles (NFTs) in Alzheimer's disease (AD), and phosphorylation of tau is accelerated by the increase in the level of neuronal cholesterol. Apolipoprotein E (APOE) promotes the neuronal uptake of cholesterol via APOE receptors such as the low-density lipoprotein receptor-related protein 1 (LRP1), and the APOE epsilon4 allele is associated with an increase in NFT burden in AD brain. In a case-control study in 246 AD patients and 237 healthy controls, we examined whether the combined gene effects between tau (intron 9, rs2471738) polymorphism and LRP1 (exon 3, rs1799986) polymorphism might be responsible for susceptibility to AD, independently or in concert with the APOE epsilon4 allele. Subjects carrying both the tau (intron 9, rs2471738) T allele (CT and TT genotypes) and the LRP1 (exon 3, rs1799986) T allele (CT and TT genotypes) had a 6 times higher risk of developing AD than subjects without these risk genotypes (odds ration = 6.20, 95% confidence interval = 1.74-22.05, p = 0.005), and this genetic interaction was observed in either the presence or the absence of the APOE epsilon4 allele. These data suggest that the synergistic effects (epistasis) between tau and LRP1 might modify the risk of AD in an APOE epsilon4 allele-independent fashion.
MeSH term(s)	Aged ; Alleles ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Apolipoprotein E4/genetics ; Apolipoproteins E/genetics ; Female ; Humans ; Low Density Lipoprotein Receptor-Related Protein-1/genetics ; Male ; Middle Aged ; Odds Ratio ; Polymorphism, Genetic ; Risk ; Spain/epidemiology ; tau Proteins/genetics
Chemical Substances	Apolipoprotein E4 ; Apolipoproteins E ; Low Density Lipoprotein Receptor-Related Protein-1 ; tau Proteins
Language	English
Publishing date	2009
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1026007-9
ISSN	1421-9824 ; 1013-7424
ISSN (online)	1421-9824
ISSN	1013-7424
DOI	10.1159/000234913
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