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Article ; Online: Mechanisms Underlying Anti-Inflammatory and Anti-Cancer Properties of Stretching—A Review

Małgorzata Król / Patrycja Kupnicka / Mateusz Bosiacki / Dariusz Chlubek

International Journal of Molecular Sciences, Vol 23, Iss 10127, p

2022 Volume 10127

Abstract: Stretching is one of the popular elements in physiotherapy and rehabilitation. When correctly guided, it can help minimize or slow down the disabling effects of chronic health conditions. Most likely, the benefits are associated with reducing ... ...

Abstract	Stretching is one of the popular elements in physiotherapy and rehabilitation. When correctly guided, it can help minimize or slow down the disabling effects of chronic health conditions. Most likely, the benefits are associated with reducing inflammation; recent studies demonstrate that this effect from stretching is not just systemic but also local. In this review, we present the current body of knowledge on the anti-inflammatory properties of stretching at a molecular level. A total of 22 papers, focusing on anti-inflammatory and anti-cancer properties of stretching, have been selected and reviewed. We show the regulation of oxidative stress, the expression of pro- and anti-inflammatory genes and mediators, and remodeling of the extracellular matrix, expressed by changes in collagen and matrix metalloproteinases levels, in tissues subjected to stretching. We point out that a better understanding of the anti-inflammatory properties of stretching may result in increasing its importance in treatment and recovery from diseases such as osteoarthritis, systemic sclerosis, and cancer.
Keywords	stretching ; inflammation ; collagen ; cytokines ; cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Potential Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Cardiovascular System, Respiratory System and Skin

Jan Korbecki / Agnieszka Maruszewska / Mateusz Bosiacki / Dariusz Chlubek / Irena Baranowska-Bosiacka

International Journal of Molecular Sciences, Vol 24, Iss 1, p

2022 Volume 205

Abstract: In this paper, we present a literature review of the role of CXC motif chemokine ligand 1 (CXCL1) in physiology, and in selected major non-cancer diseases of the cardiovascular system, respiratory system and skin. CXCL1, a cytokine belonging to the CXC ... ...

Abstract	In this paper, we present a literature review of the role of CXC motif chemokine ligand 1 (CXCL1) in physiology, and in selected major non-cancer diseases of the cardiovascular system, respiratory system and skin. CXCL1, a cytokine belonging to the CXC sub-family of chemokines with CXC motif chemokine receptor 2 (CXCR2) as its main receptor, causes the migration and infiltration of neutrophils to the sites of high expression. This implicates CXCL1 in many adverse conditions associated with inflammation and the accumulation of neutrophils. The aim of this study was to describe the significance of CXCL1 in selected diseases of the cardiovascular system (atherosclerosis, atrial fibrillation, chronic ischemic heart disease, hypertension, sepsis including sepsis-associated encephalopathy and sepsis-associated acute kidney injury), the respiratory system (asthma, chronic obstructive pulmonary disease (COPD), chronic rhinosinusitis, coronavirus disease 2019 (COVID-19), influenza, lung transplantation and ischemic-reperfusion injury and tuberculosis) and the skin (wound healing, psoriasis, sunburn and xeroderma pigmentosum ). Additionally, the significance of CXCL1 is described in vascular physiology, such as the effects of CXCL1 on angiogenesis and arteriogenesis.
Keywords	CXCL1 ; CXCR2 ; heart ; liver ; chemokine ; cytokine ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CCL5’s Role in Periodontal Disease

Katarzyna Barczak / Agnieszka Droździk / Mateusz Bosiacki / Ryta Łagocka / Diana Cenariu / Willi Andrei Uriciuc / Irena Baranowska-Bosiacka

International Journal of Molecular Sciences, Vol 24, Iss 24, p

A Narrative Review

2023 Volume 17332

Abstract: Persistent host inflammatory and immune responses to biofilm play a critical role in the mechanisms that govern soft and hard tissue destruction in periodontal disease. Among the less explored facets of these mechanisms are chemokines, including CCL5 (C- ... ...

Abstract	Persistent host inflammatory and immune responses to biofilm play a critical role in the mechanisms that govern soft and hard tissue destruction in periodontal disease. Among the less explored facets of these mechanisms are chemokines, including CCL5 (C-C motif chemokine ligand 5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), a proinflammatory CC subfamily chemokine synthesized by T lymphocytes. Despite its importance, there is currently no comprehensive review of the role of CCL5 in periodontitis in the literature. Therefore, this paper aims to fill this gap by summarizing the existing knowledge on the involvement of CCL5 in the onset and progression of periodontitis. In addition, we aim to stimulate interest in this relatively overlooked factor among periodontitis researchers, potentially accelerating the development of drugs targeting CCL5 or its receptors. The review examines the association of CCL5 with periodontitis risk factors, including aging, cigarette smoking, diabetes, and obesity. It discusses the involvement of CCL5 in pathological processes during periodontitis, such as connective tissue and bone destruction. The data show that CCL5 expression is observed in affected gums and gingival crevicular fluid of periodontitis patients, with bacterial activity contributing significantly to this increase, but the reviewed studies of the association between CCL5 expression and periodontal disease have yielded inconclusive results. Although CCL5 has been implicated in the pathomechanism of periodontitis, a comprehensive understanding of its molecular mechanisms and significance remains elusive, hindering the development of drugs targeting this chemokine or its receptors.
Keywords	chemokine CCL5 ; periodontal diseases ; gingival crevicular fluid ; periodontitis ; gingivitis ; inflammation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Micro and Macroelements in Honey and Atmospheric Pollution (NW and Central Poland)

Małgorzata Gałczyńska / Renata Gamrat / Mateusz Bosiacki / Zofia Sotek / Małgorzata Stasińska / Ireneusz Ochmian

Resources, Vol 10, Iss 86, p

2021 Volume 86

Abstract: Urban vegetation is generally exposed to high levels of air pollution in airborne particles, with the greatest exposure in the EU being seen in Poland. With the continuing growth of urban populations, there is a need to confirm whether honey produced ... ...

Abstract	Urban vegetation is generally exposed to high levels of air pollution in airborne particles, with the greatest exposure in the EU being seen in Poland. With the continuing growth of urban populations, there is a need to confirm whether honey produced from urban areas is of similar high quality to that from rural areas. A total of 27 honey samples were collected from urban and rural apiaries and tested for the concentrations of 19 elements by ICP-OES. The results were compared with data on honey produced in old and new EU countries (metadata). Our evaluation used a novel approach to determine threshold values in the identification of the bioproduct contamination index. The analysed urban honey samples demonstrated higher concentrations of K, Sr, Ba, Ni, and Co, and lower levels of Mn and B than rural honey samples. Contamination by PM10 particles and the toxic elements contained in them proved to be a poor predictor of the content of these elements in honey, in contrast to the effect of atmospheric pollution measured during firework shows, which demonstrated higher concentrations of Ba, Pb, Ca, Cu, and Mg. The non-carcinogenic risk assessment indicated that the analysed honey samples are of good quality and are comparable or of even better quality than honey products from other EU countries.
Keywords	natural resources ; food quality ; PM10 ; heavy metals ; micro- and macroelement ; toxic element ; Science ; Q
Subject code	910
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mineral Composition and Antioxidant Potential in the Common Poppy (Papaver rhoeas L.) Petal Infusions.

Katarzyna, Janda / Karolina, Jakubczyk / Patrycja, Kupnicka / Mateusz, Bosiacki / Izabela, Gutowska

Biological trace element research

2020 Volume 199, Issue 1, Page(s) 371–381

Abstract: The flowers of the common poppy are used for medicinal purposes, both internally and externally. They are reported to have antispasmodic and antitussive properties, to alleviate inflammatory conditions and soothe anxiety-related digestive problems. The ... ...

Abstract	The flowers of the common poppy are used for medicinal purposes, both internally and externally. They are reported to have antispasmodic and antitussive properties, to alleviate inflammatory conditions and soothe anxiety-related digestive problems. The aim of the study was to determine the antioxidant potential and the content of vitamin C, polyphenols, and minerals in infusions made from the petals of the common poppy at different temperatures. The infusions were made at various temperatures (25 °C, 70 °C, 80 °C, and 90 °C). The antioxidant potential and the content of polyphenols and vitamin C were determined by spectrophotometric methods. The mineral content was determined using the ICP-OES method. The total polyphenol content ranged from 135.2 to 137.24 ppm and that of vitamin C-from 15.47 to 15.78 mg/100 mL. The temperature of the water used to make the infusions did not appear to have a significant effect on these parameters. The temperature did, however, significantly affect the antioxidant potential of the infusions-the highest antioxidant activity (71.21% DPPH inhibition) was observed in the infusion prepared using water at 80 °C. The infusions included in the study contained a number of minerals. No significant effect of temperature was found for the content of K, Zn, Cu, Fe, and Ni in the infusions. On the other hand, the content of Ca in the infusions was significantly correlated with the increasing temperature of the water. It was concluded that poppy petal infusions may serve as a valuable dietary supplement, providing antioxidants and minerals required by the human body to function properly.
MeSH term(s)	Antioxidants ; Ascorbic Acid ; Humans ; Minerals ; Papaver ; Plant Extracts/pharmacology
Chemical Substances	Antioxidants ; Minerals ; Plant Extracts ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2020-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-020-02134-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Level of Disability after Total Hip Replacement in Patients with Some COMT Gene Polymorphism

Alina Jurewicz / Violetta Dziedziejko / Monika Rać / Marta Białecka / Krzysztof Safranow / Mateusz Kurzawski / Damian Malinowski / Mateusz Bosiacki / Katarzyna Leźnicka / Andrzej Bohatyrewicz / Monika Białecka / Marek Droździk / Anna Machoy-Mokrzyńska

Journal of Clinical Medicine, Vol 12, Iss 24, p

2023 Volume 7652

Abstract: Background: The COMT gene encodes the enzyme catechol-O-methyltransferase, which is a key modulator of dopaminergic and adrenergic neurotransmission. Hip osteoarthritis is accompanied by reduced mobility and some level of disability. In our study, we ... ...

Abstract	Background: The COMT gene encodes the enzyme catechol-O-methyltransferase, which is a key modulator of dopaminergic and adrenergic neurotransmission. Hip osteoarthritis is accompanied by reduced mobility and some level of disability. In our study, we analyzed the association between some COMT gene polymorphisms and reduced mobility in patients after total hip replacement (THR). Methods: The operative procedures were performed on 195 patients with symptomatic and radiologically advanced hip osteoarthritis. In the postoperative follow-up, we assessed hip function with the Harris Hip Score (HHS) and the degree of disability with the Oswestry Disability Index (ODI). These procedures were repeated three times at defined intervals (one week, six weeks, and six months) after the total hip replacement. Genomic DNA was extracted from peripheral blood. SNPs in the COMT genes rs4680:A>G , rs6269: A>G , rs4633: C>T , and rs4818: C>G were genotyped. Results: Our findings suggest an association between COMT gene variability and the level of disability measured by the Oswestry Disability Index (ODI) in patients after total hip replacement (THR). Conclusions: A higher number of COMT G alleles (rs4818) is an independent factor in a significant reduction in disability degree at both one week and six months after total hip replacement (THR), regardless of age or gender.
Keywords	total hip replacement ; disability ; COMT gene polymorphism ; Medicine ; R
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Are cadmium and lead levels linked to the development of anxiety and depression? - A systematic review of observational studies

Anna Maria Cybulska / Szymon Grochans / Magdalena Sylwia Kamińska / Mateusz Bosiacki / Karolina Skonieczna-Żydecka / Elżbieta Grochans

Ecotoxicology and Environmental Safety, Vol 216, Iss , Pp 112211- (2021)

2021

Abstract: The aim of this systematic review was to assess if cadmium and lead levels are linked to anxiety and depression. A systematic literature search was conducted to identify observational trials evaluating the impact of cadmium and lead on the incidence and ... ...

Abstract	The aim of this systematic review was to assess if cadmium and lead levels are linked to anxiety and depression. A systematic literature search was conducted to identify observational trials evaluating the impact of cadmium and lead on the incidence and phenotype of depression and anxiety. The search identified 1059 records. Overall eighteen studies comprising 28,304 participants with a female predominance (n = 19,483; 69%) were included. Cadmium and lead levels were analyzed in eight and thirteen studies, respectively. Five studies found an association between blood cadmium levels and depression, among them three trials which reported that individuals in the highest quartile of blood cadmium had higher odds of showing depressive symptoms. Sex and smoking status were found to be potential confounders of cadmium impact on the depressive phenotype. None of the studies found association between the level of anxiety and blood cadmium levels. Nine studies demonstrated association between depressive symptoms and blood lead concentration. High lead levels may be associated with anxiety and neurobehavioral deficits. There are many factors that influence both the levels of cadmium and lead, and the severity of depression and anxiety in the respondents. There is no clear evidence for the impact of cadmium and lead levels on the development of depressive symptoms but a lot of indirect evidence points to this.
Keywords	Cadmium ; Lead ; Anxiety ; Depression ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	500
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Perineuronal Nets and Their Role in Synaptic Homeostasis

Mateusz Bosiacki / Magdalena Gąssowska-Dobrowolska / Klaudyna Kojder / Marta Fabiańska / Dariusz Jeżewski / Izabela Gutowska / Anna Lubkowska

International Journal of Molecular Sciences, Vol 20, Iss 17, p

2019 Volume 4108

Abstract: Extracellular matrix (ECM) molecules that are released by neurons and glial cells form perineuronal nets (PNNs) and modulate many neuronal and glial functions. PNNs, whose structure is still not known in detail, surround cell bodies and dendrites, which ... ...

Abstract	Extracellular matrix (ECM) molecules that are released by neurons and glial cells form perineuronal nets (PNNs) and modulate many neuronal and glial functions. PNNs, whose structure is still not known in detail, surround cell bodies and dendrites, which leaves free space for synapses to come into contact. A reduction in the expression of many neuronal ECM components adversely affects processes that are associated with synaptic plasticity, learning, and memory. At the same time, increased ECM activity, e.g., as a result of astrogliosis following brain damage or in neuroinflammation, can also have harmful consequences. The therapeutic use of enzymes to attenuate elevated neuronal ECM expression after injury or in Alzheimer’s disease has proven to be beneficial by promoting axon growth and increasing synaptic plasticity. Yet, severe impairment of ECM function can also lead to neurodegeneration. Thus, it appears that to ensure healthy neuronal function a delicate balance of ECM components must be maintained. In this paper we review the structure of PNNs and their components, such as hyaluronan, proteoglycans, core proteins, chondroitin sulphate proteoglycans, tenascins, and Hapln proteins. We also characterize the role of ECM in the functioning of the blood-brain barrier, neuronal communication, as well as the participation of PNNs in synaptic plasticity and some clinical aspects of perineuronal net impairment. Furthermore, we discuss the participation of PNNs in brain signaling. Understanding the molecular foundations of the ways that PNNs participate in brain signaling and synaptic plasticity, as well as how they change in physiological and pathological conditions, may help in the development of new therapies for many degenerative and inflammatory diseases of the brain.
Keywords	perineuronal nets (PNNs) ; extracellular matrix (ECM) ; synaptogenesis ; neuronal communication ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	612
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phosphorus Concentration in Knee Joint Structures of Patients Following Replacement Surgery.

Żaneta, Ciosek / Danuta, Kosik-Bogacka / Natalia, Łanocha-Arendarczyk / Karolina, Kot / Maciej, Karaczun / Paweł, Ziętek / Patrycja, Kupnicka / Aleksandra, Szylińska / Mateusz, Bosiacki / Iwona, Rotter

International journal of environmental research and public health

2019 Volume 16, Issue 4

Abstract: The aim of the study was to assess phosphorus (P) concentration in structures of the knee joint-including the tibial spongy bone, articular cartilage, meniscus, anterior cruciate ligament, and infrapatellar fat pad (Hoffa's fat pad)-of patients following ...

Abstract	The aim of the study was to assess phosphorus (P) concentration in structures of the knee joint-including the tibial spongy bone, articular cartilage, meniscus, anterior cruciate ligament, and infrapatellar fat pad (Hoffa's fat pad)-of patients following knee joint replacement. The study also aimed to assess the influence of selected biological and environmental factors on P concentration in studied parts of the knee joint. Phosphorus concentration was determined using inductively coupled plasma-atomic emission spectrometry (ICP-AES). Statistically significant differences in P concentration were found between different elements of the knee joint. The highest P concentration was measured in the spongy bone (72,746.68 mg kg
MeSH term(s)	Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Knee ; Female ; Humans ; Knee Joint/anatomy & histology ; Knee Joint/chemistry ; Male ; Middle Aged ; Phosphorus/analysis
Chemical Substances	Phosphorus (27YLU75U4W)
Language	English
Publishing date	2019-02-13
Publishing country	Switzerland
Document type	Journal Article
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph16040525
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