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  1. Article ; Online: Bothrops venom-induced hemostasis disorders in the rat: Between Scylla and Charybdis.

    Larréché, Sébastien / Chevillard, Lucie / Jourdi, Georges / Mathé, Simon / Servonnet, Aurélie / Joly, Bérangère S / Siguret, Virginie / Chippaux, Jean-Philippe / Mégarbane, Bruno

    PLoS neglected tropical diseases

    2023  Volume 17, Issue 11, Page(s) e0011786

    Abstract: Hemostasis impairment represents the most threatening consequence of Viperidae envenoming, notably with Bothrops genus. In the French departments of America, B. atrox envenomation in French Guiana may lead to bleeding while B. lanceolatus envenomation in ...

    Abstract Hemostasis impairment represents the most threatening consequence of Viperidae envenoming, notably with Bothrops genus. In the French departments of America, B. atrox envenomation in French Guiana may lead to bleeding while B. lanceolatus envenomation in Martinique to thrombosis. Bleeding related to B. atrox envenomation is attributed to vascular damage mediated by venom metalloproteinases and blood uncoagulable state resulting from thrombocytopenia and consumptive coagulopathy. Thrombosis related to B. lanceolatus envenomation are poorly understood. We aimed to compare the effects of B. atrox and B. lanceolatus venoms in the rat to identify the determinants of the hemorrhagic versus thrombotic complications. Viscoelastometry (ROTEM), platelet count, plasma fibrinogen, thrombin generation assay, fibrinography, endothelial (von Willebrand factor, ADAMTS13 activity, ICAM-1, and soluble E-selectin), and inflammatory biomarkers (IL-1β, IL-6, TNF-α, MCP-1, and PAI-1) were determined in blood samples obtained at H3, H6, and H24 after the subcutaneous venom versus saline injection. In comparison to the control, initial fibrinogen consumption was observed with the two venoms while thrombocytopenia and reduction in the clot amplitude only with B. atrox venom. Moreover, we showed an increase in thrombin generation at H3 with the two venoms, an increase in fibrin generation accompanied with hyperfibrinogenemia at H24 and an increase in inflammatory biomarkers with B. lanceolatus venom. No endothelial damage was found with the two venoms. To conclude, our data support two-sided hemostasis complications in Bothrops envenoming with an initial risk of hemorrhage related to platelet consumption and hypocoagulability followed by an increased risk of thrombosis promoted by the activated inflammatory response and rapid-onset fibrinogen restoration.
    MeSH term(s) Rats ; Animals ; Thrombin/adverse effects ; Crotalid Venoms/toxicity ; Hemostasis ; Hemorrhage ; Blood Coagulation Disorders ; Fibrinogen ; Thrombocytopenia ; Thrombosis/chemically induced ; Biomarkers ; Bothrops/physiology ; Snake Bites/complications
    Chemical Substances Thrombin (EC 3.4.21.5) ; Crotalid Venoms ; Fibrinogen (9001-32-5) ; Biomarkers
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bleeding and Thrombosis: Insights into Pathophysiology of

    Larréché, Sébastien / Chippaux, Jean-Philippe / Chevillard, Lucie / Mathé, Simon / Résière, Dabor / Siguret, Virginie / Mégarbane, Bruno

    International journal of molecular sciences

    2021  Volume 22, Issue 17

    Abstract: ... Toxins ... ...

    Abstract Toxins from
    MeSH term(s) Animals ; Antivenins/therapeutic use ; Blood Coagulation/drug effects ; Blood Coagulation/physiology ; Blood Coagulation Disorders/drug therapy ; Blood Coagulation Disorders/physiopathology ; Blood Platelets/drug effects ; Blood Platelets/physiology ; Crotalid Venoms/antagonists & inhibitors ; Crotalid Venoms/metabolism ; Hemorrhage/physiopathology ; Hemostasis/physiology ; Humans ; Thrombosis/physiopathology
    Chemical Substances Antivenins ; Crotalid Venoms
    Language English
    Publishing date 2021-09-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22179643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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