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  1. Article: Benchmarking critical care processes: Reaching standards of excellence!

    Mathai, Ashu Sara

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2013  Volume 18, Issue 5, Page(s) 265–266

    Language English
    Publishing date 2013-10-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.4103/0972-5229.132462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Assessment of malnutrition and enteral feeding practices in the critically ill: A single-centre observational study.

    Verghese, Prashant P / Mathai, Ashu Sara / Abraham, Valsamma / Kaur, Paramdeep

    Indian journal of anaesthesia

    2018  Volume 62, Issue 1, Page(s) 29–35

    Abstract: Background and aims: Early identification of malnutrition among hospitalised patients is essential to institute appropriate patient-specific nutritional strategies. This study was conducted to evaluate the nutritional status of medical patients at ... ...

    Abstract Background and aims: Early identification of malnutrition among hospitalised patients is essential to institute appropriate patient-specific nutritional strategies. This study was conducted to evaluate the nutritional status of medical patients at admission to the adult intensive care unit (ICU) and to identify factors which prevent attainment of daily feeding goals in them.
    Methods: This was a 1 year prospective, observational study on 200 medical adult ICU patients. The study was carried out based on daily documentation. The primary outcome was the nutritional status of medical Patients at admission to the adult ICU. The tests for statistical analysis used were independent
    Results: Out of the 200 patients in our study, 45%, 48.5% and 9% of patients had mild, moderate and severe malnutrition, respectively, corresponding to subjective global assessment (SGA) rating A,B and C, respectively. The most common reasons for non-attainment of daily feeding goals were delayed feed procurement (17.57%), and feeds being held for procedures (16.36%). The overall mean length of ICU stay was 8.63 ± 7.26 days, and the ICU mortality rate was 47.5% (95/200). Patients with SGA rating B and C at admission had higher risk of mortality in the ICU, with an adjusted odds ratio of 3.54 (95% confidence interval [CI]- 1.71-7.33,
    Conclusion: Malnutrition is commonly present at admission among medical ICU patients, and is associated with higher ICU mortality.
    Language English
    Publishing date 2018-02-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 412570-8
    ISSN 0019-5049
    ISSN 0019-5049
    DOI 10.4103/ija.IJA_513_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Ventilator-associated pneumonia: A persistent healthcare problem in Indian Intensive Care Units!

    Mathai, Ashu Sara / Phillips, Atul / Isaac, Rajesh

    Lung India : official organ of Indian Chest Society

    2016  Volume 33, Issue 5, Page(s) 512–516

    Abstract: Background: Ventilator-associated pneumonia (VAP) is the most common nosocomial infection acquired by patients in the Intensive Care Unit (ICU). However, there are scarce clinical data, particularly from Indian ICUs on the occurrence of this infection.!# ...

    Abstract Background: Ventilator-associated pneumonia (VAP) is the most common nosocomial infection acquired by patients in the Intensive Care Unit (ICU). However, there are scarce clinical data, particularly from Indian ICUs on the occurrence of this infection.
    Aims: To collect data on the incidence, microbiological profile, and outcomes of patients with VAP.
    Settings and design: Tertiary level, medical-surgical ICU; prospective, observational study.
    Subjects and methods: All patients who were mechanically ventilated for >48 h in the ICU during the study were enrolled. VAP was diagnosed according to the Centre for Disease Control (CDC) criteria.
    Results: A total of 95 (38%) patients developed VAP infections, an incidence of 40.1 VAP infections/1000 mechanical ventilation days. These were predominantly caused by Gram-negative organisms, especially the Acinetobacter species (58 isolates, 53.2%). Many of the VAP-causing isolates (27.3%) demonstrated multidrug resistance. Patients with VAP infections experienced a significantly longer ICU stay (13 days [Interquartile Range (IQ) range = 10-21] vs. 6 days [IQ = 4-8], P < 0.0001) and total hospital stay (21 days [IQ = 14-33] vs. 11 days [IQ = 6-18], P < 0.0001). While the overall mortality rates were similar between patients with or without VAP infections, (68.4% vs. 61.3%, P = 0.200), on subgroup analysis, elderly patients (>60 years) and those with higher Acute Physiology and Chronic Health Evaluation II scores at admission had significantly greater mortality rates if they acquired a VAP infection (P = 0.010).
    Conclusions: VAP continues to be a major threat to patients who are admitted for mechanical ventilation into the critical care unit, emphasizing the urgent need for infection control measures.
    Language English
    Publishing date 2016-09-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/0970-2113.188971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Incidence and attributable costs of ventilator-associated pneumonia (VAP) in a tertiary-level intensive care unit (ICU) in northern India.

    Mathai, Ashu Sara / Phillips, Atul / Kaur, Paramdeep / Isaac, Rajesh

    Journal of infection and public health

    2015  Volume 8, Issue 2, Page(s) 127–135

    Abstract: Background: Ventilator-associated pneumonia (VAP) is the most common nosocomial infection acquired by patients in the intensive care unit (ICU). However, the economic effects of such infections remain unclear particularly in developing countries.: ... ...

    Abstract Background: Ventilator-associated pneumonia (VAP) is the most common nosocomial infection acquired by patients in the intensive care unit (ICU). However, the economic effects of such infections remain unclear particularly in developing countries.
    Methods: Patients who were mechanically ventilated for more than 48 h in the ICU were studied for the occurrence of VAP. Total drug costs and hospital costs were noted, and attributable costs were calculated after adjusting for potential confounders.
    Results: Ninety-five (38%) patients who were ventilated for more than 48 h developed VAP, which resulted in an incidence of 40.1 VAP infections/1000 mechanical ventilation days. The patients with VAP experienced significantly longer hospital stay [21 (IQ = 14-33) days versus 11 (IQ = 6-18) days, P < 0.0001)] and incurred greater hospital costs [USD $6250.92 (IQ = 3525.39-9667.57) versus $2598.84 (IQ = 1644.33-4477.65), P < 0.0001]. Multiple regression analysis revealed that the cost-driving factors in our study population were the occurrence of VAP infections (P < 0.0001) and the duration of hospital stay (P < 0.0001). The attributable cost of VAP infection was calculated to be USD $5200 (95% CI = 3245-7152).
    Conclusion: We conclude that VAP significantly increases the costs of treatment in low-income developing countries. This study highlights the need to implement urgent measures to reduce the incidence of this disease in ICUs.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Health Care Costs ; Humans ; Incidence ; India/epidemiology ; Intensive Care Units ; Length of Stay ; Male ; Middle Aged ; Pneumonia, Ventilator-Associated/economics ; Pneumonia, Ventilator-Associated/epidemiology ; Prospective Studies
    Language English
    Publishing date 2015-03
    Publishing country England
    Document type Journal Article ; Observational Study
    ISSN 1876-035X
    ISSN (online) 1876-035X
    DOI 10.1016/j.jiph.2014.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Acute Poisonings Admitted to a Tertiary Level Intensive Care Unit in Northern India: Patient Profile and Outcomes.

    Ahuja, Hemani / Mathai, Ashu Sara / Pannu, Aman / Arora, Rohit

    Journal of clinical and diagnostic research : JCDR

    2015  Volume 9, Issue 10, Page(s) UC01–4

    Abstract: Background: Poisoning is becoming a real health care burden for developing countries like India. An improved knowledge of the patterns of poisonings, as well as the clinical course and outcomes of these cases can help to formulate better preventive and ... ...

    Abstract Background: Poisoning is becoming a real health care burden for developing countries like India. An improved knowledge of the patterns of poisonings, as well as the clinical course and outcomes of these cases can help to formulate better preventive and management strategies.
    Aim: To study the demographic and clinical profiles of patients admitted to the ICU with acute poisoning and to study the factors that predict their mortality.
    Materials and methods: Retrospective two years (September 1, 2010 to August 31, 2012) study of all consecutive patients admitted to the Intensive Care Unit (ICU) with acute poisoning at a tertiary care hospital in Northern India.
    Results: Out of the 67 patients admitted to the ICU during the study period, the majority were young (median age 29 years) males (69%) who had consumed poison intentionally. Pesticides were the most commonly employed poison, notably organophosphorus compounds (22 patients, 32.8%) and aluminium phosphide (14 patients, 20.9%). While the overall mortality from all poisonings was low (18%), aluminium phosphide was highly toxic, with a mortality rate of 35%. The factors at ICU admission that were found to be associated with a significant risk of death were, high APACHE II and SOFA scores (p =0.0001 and p=0.006, respectively), as well as the need for mechanical ventilation and drugs for vasoactive support (p=0.012 and p= 0.0001, respectively).
    Conclusion: Use of pesticides for intentional poisoning continues to be rampant in Northern India, with many patients presenting in a critical condition to tertiary level hospitals. Pesticide regulations laws, educational awareness, counseling and poison information centers will help to curtail this public health problem.
    Language English
    Publishing date 2015-10-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 2775283-5
    ISSN 0973-709X ; 2249-782X
    ISSN (online) 0973-709X
    ISSN 2249-782X
    DOI 10.7860/JCDR/2015/16008.6632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mechanical and infectious complications of central venous catheterizations in a tertiary-level intensive care unit in northern India.

    Kaur, Randeep / Mathai, Ashu Sara / Abraham, John

    Indian journal of anaesthesia

    2012  Volume 56, Issue 4, Page(s) 376–381

    Abstract: Background: Central venous catheters (CVC) are associated with mechanical, infectious and thrombotic complications.: Aims: To study (a) the incidence of mechanical and infectious complications of CVC insertions and to compare, (b) the rates of these ... ...

    Abstract Background: Central venous catheters (CVC) are associated with mechanical, infectious and thrombotic complications.
    Aims: To study (a) the incidence of mechanical and infectious complications of CVC insertions and to compare, (b) the rates of these complications between the internal jugular venous (IJV) and the subclavian venous (SCV) accesses.
    Settings and design: An adult intensive care unit of a tertiary care hospital. Prospective, observational study.
    Methods: All landmark-based CVC insertions performed between 1(st) October 2008 and 30(th) September 2009 were prospectively studied for mechanical and infectious complications.
    Statistical analysis: SPSS software for Windows, Version SPSS 16.0, and Epi Info (3.5.1) software.
    Results: Four hundred and eighty central venous catheterizations were studied (IJV route, 241 and SCV route, 239). Mechanical complications occurred in 86 patients (17.9%, bleeding complications-48, catheter-related complications-27 and pneumothorax-11). The IJV route was associated with a significantly higher incidence of bleeding complications (P=0.009). Forty-seven patients had infectious complications (9.79%), like exit site infections (n=17), catheter tip infections (n=22) and catheter-related bloodstream infections (CRBSIs) (n=8). The risks of infectious complications increased significantly if the CVC was in situ for longer than 7 days (P=0.009), especially with IJV cannulae. The incidence density of CVC tip infections was 7.67 per 1000 catheter days and of CRBSIs was 2.79 per 1000 catheter days.
    Conclusions: Bleeding complications occurred more frequently with IJV insertions and infectious complications occurred more commonly in cannulae that were left in situ for longer than 7 days.
    Language English
    Publishing date 2012-08-14
    Publishing country India
    Document type Journal Article
    ZDB-ID 412570-8
    ISSN 0976-2817 ; 0019-5049
    ISSN (online) 0976-2817
    ISSN 0019-5049
    DOI 10.4103/0019-5049.100823
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  7. Article ; Online: Acinetobacter infections in a tertiary level intensive care unit in northern India: epidemiology, clinical profiles and outcomes.

    Mathai, Ashu Sara / Oberoi, Aroma / Madhavan, Sheeba / Kaur, Parmdeep

    Journal of infection and public health

    2012  Volume 5, Issue 2, Page(s) 145–152

    Abstract: Background: Nosocomial Acinetobacter infections are an increasing concern in intensive care units (ICU).: Objectives: To study the demographic and clinical characteristics and the outcomes of ICU patients with Acinetobacter infections.: Methods: A ...

    Abstract Background: Nosocomial Acinetobacter infections are an increasing concern in intensive care units (ICU).
    Objectives: To study the demographic and clinical characteristics and the outcomes of ICU patients with Acinetobacter infections.
    Methods: A retrospective, 1-year audit of all Acinetobacter infections diagnosed in ICU patients between January 1 and December 31, 2009.
    Results: Acinetobacter infection occurred in 94 patients (108 episodes). The most common site of infection was the respiratory tract (83 patients, 76.85%), with medical patients being more susceptible than surgical patients to Acinetobacter lung infections (P=0.04), particularly late-onset ventilator-associated pneumonia (VAP) (P=0.04). The majority (63.8%) of infections were acquired in the ICU, and patients with ICU acquired infections were intubated significantly longer than the other patients (P=0.02). Seventy percent of the infections were caused by multidrug-resistant (MDR) strains, and the overall crude mortality rate was over 70%. The most important factors affecting mortality were the duration of intubation (P=0.001) and the inappropriate use of antibiotics (P=0.021) after diagnosis of the infection.
    Conclusions: Acinetobacter infections are highly prevalent in the ICU, with medical patients being more susceptible to lung infections, particularly late-onset VAP. The early and appropriate selection of antibiotics is the most important determinant of survival among these patients.
    MeSH term(s) Acinetobacter Infections/drug therapy ; Acinetobacter Infections/epidemiology ; Acinetobacter Infections/mortality ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Cross Infection/mortality ; Female ; Humans ; India/epidemiology ; Intensive Care Units ; Male ; Middle Aged ; Retrospective Studies ; Survival Analysis ; Treatment Outcome ; Young Adult
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2012-04
    Publishing country England
    Document type Journal Article
    ISSN 1876-035X
    ISSN (online) 1876-035X
    DOI 10.1016/j.jiph.2011.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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