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  1. Article ; Online: A Cross-sectional Study to Assess the Need for Standardisation of the Modified Mallampati and Friedman’s Scoring System

    Jithin Mathew Abraham / Leno Ninan Jacob / Sangeetha Merrin Varghese / Ashu Sara Mathai

    Journal of Clinical and Diagnostic Research, Vol 18, Iss 01, Pp 09-

    2024  Volume 12

    Abstract: Introduction: The Modified Mallampati (MM) grading and Friedman’s Tongue Position (FTP) scores are two major scoring systems used to evaluate the oropharyngeal space. However, the current descriptions of performing these scores do not specify the route ... ...

    Abstract Introduction: The Modified Mallampati (MM) grading and Friedman’s Tongue Position (FTP) scores are two major scoring systems used to evaluate the oropharyngeal space. However, the current descriptions of performing these scores do not specify the route of breathing taken by the patient during the examination. The dynamic changes in the tongue and palate, in relation to the route of breathing, may contribute to the high interobserver variability in MM scoring. Aim: To explore the differences in MM scores and Friedman’s scores obtained during mouth breathing and nose breathing in order to standardise the scoring system. Materials and Methods: A community-based cross-sectional study was conducted at the Departments of Anaesthesiology and Community Medicine at Believers Church Medical College Hospital in Central Kerala, India between April 2022 and October 2022, on 702 adults. MM scores and FTP scores were recorded separately for each person during mouth breathing and nose breathing. Socio-demographic variables such as age, gender, and Body Mass Index (BMI) were also collected. The data was analysed using the Z-test for proportions. Results: The mean age of the study participants was 3.58±16.42 years. The majority of the participants were females (69.2%), and more than half (59%) were above 50 years of age. Out of the 135 participants with an MM Score-1 during mouth breathing, 99 (73.3%) had higher scores during nose breathing. For the 196 individuals with an MM Score-2 during mouth breathing, 87 (44.3%) had higher scores during nose breathing. Similarly, out of the 220 people with an MM score of -3 during mouth breathing, 106 (48.2%) had a Score-4 during nose breathing. A similar pattern was observed for the FTP scores. Conclusion: The present study demonstrates significant variability in MM and FTP scores obtained during oral and nasal breathing, highlighting the need to standardise the route of breathing during examination. The study suggests that advising patients to breathe through the mouth may relax the ...
    Keywords friedman’s tongue position ; mallampati score ; oral breathing ; nasal breathing ; Medicine ; R
    Subject code 796
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Regulation of host gene expression by J paramyxovirus

    Elizabeth R. Wrobel / Jared Jackson / Mathew Abraham / Biao He

    PLoS ONE, Vol 18, Iss

    2023  Volume 11

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Regulation of host gene expression by J paramyxovirus.

    Elizabeth R Wrobel / Jared Jackson / Mathew Abraham / Biao He

    PLoS ONE, Vol 18, Iss 11, p e

    2023  Volume 0294173

    Abstract: Paramyxoviruses are negative-sense, single-stranded RNA viruses that are associated with numerous diseases in humans and animals. J paramyxovirus (JPV) was first isolated from moribund mice (Mus musculus) with hemorrhagic lung lesions in Australia in ... ...

    Abstract Paramyxoviruses are negative-sense, single-stranded RNA viruses that are associated with numerous diseases in humans and animals. J paramyxovirus (JPV) was first isolated from moribund mice (Mus musculus) with hemorrhagic lung lesions in Australia in 1972. In 2016, JPV was classified into the newly established genus Jeilongvirus. Novel jeilongviruses are being discovered worldwide in wildlife populations. However, the effects of jeilongvirus infection on host gene expression remains uncharacterized. To address this, cellular RNA from JPV-infected mouse fibroblasts was collected at 2, 4, 8, 12, 16, 24, and 48 hours post-infection (hpi) and were sequenced using single-end 75 base pairs (SE75) sequencing chemistry on an Illumina NextSeq platform. Differentially expressed genes (DEGs) between the virus-infected replicates and mock replicates at each timepoint were identified using the Tophat2-Cufflinks-Cuffdiff protocol. At 2 hpi, 11 DEGs were identified in JPV-infected cells, while 1,837 DEGs were detected at 48 hpi. A GO analysis determined that the genes at the earlier timepoints were involved in interferon responses, while there was a shift towards genes that are involved in antigen processing and presentation processes at the later timepoints. At 48 hpi, a KEGG analysis revealed that many of the DEGs detected were involved in pathways that are important for immune responses. qRT-PCR verified that Rtp4, Ifit3, Mx2, and Stat2 were all upregulated during JPV infection, while G0s2 was downregulated. After JPV infection, the expression of inflammatory and antiviral factors in mouse fibroblasts changes significantly. This study provides crucial insight into the different arms of host immunity that mediate Jeilongvirus infection. Understanding the pathogenic mechanisms of Jeilongvirus will lead to better strategies for the prevention and control of potential diseases that may arise from this group of viruses.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: D. Narayana and Raman Mahadevan (eds.), Shaping India

    Mathew Abraham

    The Copenhagen Journal of Asian Studies, Vol 30, Iss

    Economic Change in Historical Perspective

    2014  Volume 2

    Keywords Political institutions and public administration - Asia (Asian studies only) ; JQ1-6651 ; Social sciences and state - Asia (Asian studies only) ; H53
    Language English
    Publishing date 2014-02-01T00:00:00Z
    Publisher CBS Open Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: DIAGNOSTIC IMAGING AND OROTRACHEAL INTUBATION IN CLINICALLY HEALTHY WILD SUNDA PANGOLINS (

    Heng, Yirui / Yeong, Charlene / Yeo, Wenjiin Clara / Mathew, Abraham

    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians

    2023  Volume 54, Issue 3, Page(s) 553–560

    Abstract: Pangolins are amongst the most overexploited species in the world and all eight species of pangolins are threatened with extinction. These animals are rare in zoological collections and often suffer high mortality rates in captivity. Maintaining healthy ... ...

    Abstract Pangolins are amongst the most overexploited species in the world and all eight species of pangolins are threatened with extinction. These animals are rare in zoological collections and often suffer high mortality rates in captivity. Maintaining healthy populations in captivity has become more important with the declining populations in the wild, but knowledge of veterinary care of these animals is limited. Interpreting radiography and ultrasonography images in a patient can be challenging without knowledge of normal findings. The Wildlife Healthcare and Research Center (WHRC) at Mandai Wildlife Reserve (MWR) admits an average of 25 Sunda pangolins (
    MeSH term(s) Animals ; Pangolins ; Singapore ; Retrospective Studies ; Intubation, Intratracheal/veterinary ; Diagnostic Imaging
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2174930-9
    ISSN 1937-2825 ; 1042-7260
    ISSN (online) 1937-2825
    ISSN 1042-7260
    DOI 10.1638/2022-0157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Modified mallampati score – Does it predict more than a difficult airway? A community-based study assessing the association between modified mallampati score and obstructive sleep apnea

    Jithin Mathew Abraham / Sangeetha Merrin Varghese / Gincy Ann Lukachan / Ashu Sara Mathai

    Archives of Medicine and Health Sciences, Vol 11, Iss 2, Pp 172-

    2023  Volume 175

    Abstract: Background and Aim: The suspicion of obstructive sleep apnea (OSA) has serious implications for an anesthesiologist perioperatively. This study examines the association between the modified Mallampati scoring (MMS) and the STOP-BANG score in a community ... ...

    Abstract Background and Aim: The suspicion of obstructive sleep apnea (OSA) has serious implications for an anesthesiologist perioperatively. This study examines the association between the modified Mallampati scoring (MMS) and the STOP-BANG score in a community setting. Materials and Methods: This was a community-based cross-sectional survey among 702 adults in a rural area in South India. Airway assessment using MMS and assessment for OSA using STOP-BANG scoring were made by junior doctors trained in the anesthesia department. The association between the Mallampati score and the STOP-BANG score was tested by the Chi-square test using the SPSS version 21. Results: Among the community-dwelling adults, 19.2% had a score of 1, 27.9% had a score of 2, 31.3% had a score of 3, and 21.5% had a score of 4 on the Mallampati scoring system. Using the STOP-BANG score for risk stratification of OSA, 29.2% had an intermediate risk and 5.8% had a high risk for OSA. Higher Mallampati Grades (3 and 4) were a significant risk factor for OSA (61.8% vs. 38.2%, P = 0.001). Conclusion: A higher Mallampati class (3 or 4) is significantly associated with an intermediate-to high risk for OSA as assessed using STOP-BANG score criteria. Therefore, we suggest using the MMS not only as an airway screening tool but also as a predictor of OSA, in view of the rising obesity rates in India.
    Keywords airway assessment ; community-based study ; modified mallampati score ; obstructive sleep apnea ; stop-bang ; Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: H

    Gupta, Kavya / Mathew, Abraham Binoy / Chakrapani, Harinath / Saini, Deepak Kumar

    Biochimica et biophysica acta. Molecular cell research

    2022  Volume 1870, Issue 2, Page(s) 119388

    Abstract: Aging involves the time-dependent deterioration of physiological functions attributed to various intracellular and extracellular factors. Cellular senescence is akin to aging and involves alteration in redox homeostasis. This is primarily marked by ... ...

    Abstract Aging involves the time-dependent deterioration of physiological functions attributed to various intracellular and extracellular factors. Cellular senescence is akin to aging and involves alteration in redox homeostasis. This is primarily marked by increased reactive oxygen/nitrogen species (ROS/RNS), inflammatory gene expression, and senescence-associated beta-galactosidase activity, all hallmarks of aging. It is proposed that gasotransmitters which include hydrogen sulfide (H
    MeSH term(s) Humans ; Cellular Senescence ; Hydrogen Sulfide/pharmacology ; Hydrogen Sulfide/metabolism ; Inflammation/genetics ; NF-kappa B/metabolism ; Nitric Oxide ; Nitrosative Stress ; Reactive Oxygen Species ; Cystathionine gamma-Lyase/metabolism
    Chemical Substances Hydrogen Sulfide (YY9FVM7NSN) ; NF-kappa B ; Nitric Oxide (31C4KY9ESH) ; Reactive Oxygen Species ; Cystathionine gamma-Lyase (EC 4.4.1.1)
    Language English
    Publishing date 2022-11-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamcr.2022.119388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: MANAGEMENT OF

    Heng, Yirui / Hsu, Chia-Da / Mathew, Abraham / Oh, Pei Yee / Li, Wen-Ta / Xie, Shangzhe

    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians

    2023  Volume 54, Issue 2, Page(s) 272–281

    Abstract: Amebiasis caused ... ...

    Abstract Amebiasis caused by
    MeSH term(s) Animals ; Entamoeba ; Metronidazole ; Singapore/epidemiology ; Amebiasis/veterinary ; Reptiles/parasitology ; Enteritis/veterinary
    Chemical Substances Metronidazole (140QMO216E)
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2174930-9
    ISSN 1937-2825 ; 1042-7260
    ISSN (online) 1937-2825
    ISSN 1042-7260
    DOI 10.1638/2022-0068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Acetylcholine Structure-Based Small Activatable Fluorogenic Probe for Specific Detection of Acetylcholinesterase.

    Sidhu, Jagpreet S / Rajendran, Kalpana / Mathew, Abraham B / Iqbal, Tabish / Saini, Deepak K / Das, Debasis

    Analytical chemistry

    2023  Volume 95, Issue 19, Page(s) 7594–7602

    Abstract: Early detection of Alzheimer's disease (AD) is important for taking proper measures against AD pathogenesis. Acetylcholinesterase (AChE) is widely reported to be associated with the pathogenicity of AD. Here, employing the "acetylcholine-mimic" approach, ...

    Abstract Early detection of Alzheimer's disease (AD) is important for taking proper measures against AD pathogenesis. Acetylcholinesterase (AChE) is widely reported to be associated with the pathogenicity of AD. Here, employing the "acetylcholine-mimic" approach, we designed and synthesized a new class of naphthalimide (Naph)-based fluorogenic probes for specific detection of AChE and avoiding interference of butyrylcholinesterase (BuChE), the pseudocholinesterase. We investigated the action of the probes on
    MeSH term(s) Humans ; Acetylcholinesterase/metabolism ; Butyrylcholinesterase/metabolism ; Acetylcholine ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Alzheimer Disease
    Chemical Substances Acetylcholinesterase (EC 3.1.1.7) ; Butyrylcholinesterase (EC 3.1.1.8) ; Acetylcholine (N9YNS0M02X) ; Cholinesterase Inhibitors
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c00099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Acetylcholine Structure-Based Small Activatable Fluorogenic Probe for Specific Detection of Acetylcholinesterase

    Sidhu, Jagpreet S. / Rajendran, Kalpana / Mathew, Abraham B. / Iqbal, Tabish / Saini, Deepak K. / Das, Debasis

    Analytical Chemistry. 2023 May 03, v. 95, no. 19 p.7594-7602

    2023  

    Abstract: Early detection of Alzheimer’s disease (AD) is important for taking proper measures against AD pathogenesis. Acetylcholinesterase (AChE) is widely reported to be associated with the pathogenicity of AD. Here, employing the “acetylcholine-mimic” approach, ...

    Abstract Early detection of Alzheimer’s disease (AD) is important for taking proper measures against AD pathogenesis. Acetylcholinesterase (AChE) is widely reported to be associated with the pathogenicity of AD. Here, employing the “acetylcholine-mimic” approach, we designed and synthesized a new class of naphthalimide (Naph)-based fluorogenic probes for specific detection of AChE and avoiding interference of butyrylcholinesterase (BuChE), the pseudocholinesterase. We investigated the action of the probes on Electrophorus electricus AChE, and the native human brain AChE that we expressed in Escherichia coli and purified in the active form for the first time. The probe Naph-3 exhibited a substantial fluorescence enhancement with AChE and majorly avoided BuChE. Naph-3 successfully crossed the cell membrane of the Neuro-2a cells and fluoresced upon reaction with endogenous AChE. We further established that the probe could be effectively used for screening AChE inhibitors. Our study provides a new avenue for the specific detection of AChE, which can be extended to the diagnosis of AChE-related complications.
    Keywords Electrophorus electricus ; Escherichia coli ; acetylcholine ; acetylcholinesterase ; analytical chemistry ; brain ; cell membranes ; cholinesterase ; fluorescence ; fluorescent dyes ; humans ; pathogenesis ; pathogenicity
    Language English
    Dates of publication 2023-0503
    Size p. 7594-7602.
    Publishing place American Chemical Society
    Document type Article ; Online
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c00099
    Database NAL-Catalogue (AGRICOLA)

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