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  1. Article ; Online: Reclassifying Papillary, Oncocytic and Chromophobe Renal Tumours Based on the 5 < sup > th < /sup > Who Classification 2022.

    Shaikh, Nilofar / Mathew, Mary

    Turk patoloji dergisi

    2024  Volume 40, Issue 2, Page(s) 122–127

    Abstract: Objective: The classification of renal tumors is expanding with the addition of new molecular entities in the 5th World Health Organization classification. Apart from this, the major updates in the definition of papillary renal cell carcinoma are that ... ...

    Title translation Reclassifying Papillary, Oncocytic and Chromophobe Renal Tumours Based on the 5 < sup > th < /sup > Who Classification 2022.
    Abstract Objective: The classification of renal tumors is expanding with the addition of new molecular entities in the 5th World Health Organization classification. Apart from this, the major updates in the definition of papillary renal cell carcinoma are that these tumors are no longer subtyped into type 1 and type 2. In oncocytic tumors, the new molecularly defined renal tumors, emerging and novel entities need to be considered in the diagnosis of oncocytic and chromophobe renal tumors.
    Material and methods: This is a retrospective study to review and reclassify papillary, oncocytic, and chromophobe renal tumors based on the new WHO classification and correlate with clinical data, gross, microscopic features, and immunohistochemistry markers.
    Results: A total of thirteen cases were reviewed and the tumor grade was changed for three out of four cases of papillary renal cell carcinoma and a single case was recategorized and graded. In nine cases of oncocytic and chromophobe renal tumors, the diagnoses were modified in 3 cases.
    Conclusion: Newly defined molecular renal tumors require advanced immunohistochemistry markers and molecular tests. This poses diagnostic challenges to pathologists practicing in low resource settings where molecular tests are not available.
    MeSH term(s) Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/classification ; Kidney Neoplasms/chemistry ; Retrospective Studies ; Male ; Female ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/classification ; Carcinoma, Renal Cell/chemistry ; Middle Aged ; Aged ; World Health Organization ; Biomarkers, Tumor/analysis ; Adult ; Immunohistochemistry ; Adenoma, Oxyphilic/pathology ; Adenoma, Oxyphilic/classification ; Adenoma, Oxyphilic/chemistry ; Neoplasm Grading
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2024-01-24
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2515899-5
    ISSN 1309-5730 ; 1309-5730
    ISSN (online) 1309-5730
    ISSN 1309-5730
    DOI 10.5146/tjpath.2024.13052
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  2. Article ; Online: Twelve tips for addressing ethical concerns in the implementation of artificial intelligence in medical education.

    Franco D'Souza, Russell / Mathew, Mary / Mishra, Vedprakash / Surapaneni, Krishna Mohan

    Medical education online

    2024  Volume 29, Issue 1, Page(s) 2330250

    Abstract: Artificial Intelligence (AI) holds immense potential for revolutionizing medical education and healthcare. Despite its proven benefits, the full integration of AI faces hurdles, with ethical concerns standing out as a key obstacle. Thus, educators should ...

    Abstract Artificial Intelligence (AI) holds immense potential for revolutionizing medical education and healthcare. Despite its proven benefits, the full integration of AI faces hurdles, with ethical concerns standing out as a key obstacle. Thus, educators should be equipped to address the ethical issues that arise and ensure the seamless integration and sustainability of AI-based interventions. This article presents twelve essential tips for addressing the major ethical concerns in the use of AI in medical education. These include emphasizing transparency, addressing bias, validating content, prioritizing data protection, obtaining informed consent, fostering collaboration, training educators, empowering students, regularly monitoring, establishing accountability, adhering to standard guidelines, and forming an ethics committee to address the issues that arise in the implementation of AI. By adhering to these tips, medical educators and other stakeholders can foster a responsible and ethical integration of AI in medical education, ensuring its long-term success and positive impact.
    MeSH term(s) Humans ; Artificial Intelligence ; Education, Medical ; Social Responsibility ; Students
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2052877-2
    ISSN 1087-2981 ; 1087-2981
    ISSN (online) 1087-2981
    ISSN 1087-2981
    DOI 10.1080/10872981.2024.2330250
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  3. Article ; Online: ChatGPT: A new horizon at the intersect of human and artificial intelligence in academic psychiatry.

    Franco D'Souza, Russell / Amanullah, Shabbir / Mathew, Mary / Tandon, Rajiv / Surapaneni, Krishna Mohan

    Bipolar disorders

    2024  

    Language English
    Publishing date 2024-04-19
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.13441
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  4. Article ; Online: Standardizing Minimally Invasive Tissue Sampling of Postmortem Brain Using Bard Monopty Needle in Newborns with Neurological Injury.

    Sreenivas, Athira / Lewis, Leslie / Purkayastha, Jayashree / Lakshmi R, Vani / Mathew, Mary

    Fetal and pediatric pathology

    2024  Volume 43, Issue 2, Page(s) 94–110

    Abstract: Introduction: Minimally invasive tissue sampling of the brain in newborns using the Bard Monopty needle helps to diagnose various neurological conditions by obtaining relevant brain cores. We designed a modified procedure to provide maximum diagnostic ... ...

    Abstract Introduction: Minimally invasive tissue sampling of the brain in newborns using the Bard Monopty needle helps to diagnose various neurological conditions by obtaining relevant brain cores. We designed a modified procedure to provide maximum diagnostic utility in brain tissue biopsies.
    Method: Twenty newborns underwent postmortem minimally invasive tissue sampling of the brain through the anterior fontanelle and posterior approach, using the engraved lines on the needle labeled from mark 0 to 13. The cores were correlated with conventional autopsy findings.
    Results: Meninges were best obtained at marks 0 and 1 from the anterior fontanelle and mark 1 from posterior fontenelle in 85% of cases. Periventricular brain parenchyma was best obtained from mark 3 and mark 1 from anterior and posterior fontanel, respectively in 90% cases. The sampling success in obtaining brain cores was 100%.
    Discussion: This modified technique increases the yield of meninges and brain tissue in newborns and aids in diagnosis.
    MeSH term(s) Humans ; Infant, Newborn ; Needles ; Biopsy ; Autopsy/methods ; Brain
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2165508-X
    ISSN 1551-3823 ; 1551-3815 ; 1522-7952
    ISSN (online) 1551-3823
    ISSN 1551-3815 ; 1522-7952
    DOI 10.1080/15513815.2023.2301448
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  5. Article ; Online: Community perceptions of postmortem examination and minimally invasive tissue sampling in neonates:a qualitative study in South India.

    Sreenivas, Athira / Jaihind Jothikaran, Teddy Andrews / Lewis, Leslie / Mathew, Mary

    BMC pregnancy and childbirth

    2023  Volume 23, Issue 1, Page(s) 804

    Abstract: Background: Postmortem examination is the gold standard for establishing the cause of death. Minimally Invasive Tissue Sampling (MITS) of organs is a novel approach that can be used as an alternative to postmortem examination. In this study, the ... ...

    Abstract Background: Postmortem examination is the gold standard for establishing the cause of death. Minimally Invasive Tissue Sampling (MITS) of organs is a novel approach that can be used as an alternative to postmortem examination. In this study, the community perceptions in two states in South India towards neonatal postmortem and the acceptance towards the MITS technique is studied.
    Methods: In-depth interviews were conducted among the participants from Kerala and Karnataka to understand the perception towards postmortem and the acceptance of the novel MITS technique. The interviews were audio recorded, and a thematic analysis was done to identify the overarching themes and codes.
    Results: The knowledge and attitude of participants on conventional and MITS postmortem techniques, reasons for refusal, and the need for raising awareness were identified in the study. Participants favored the MITS techniques as it was less disfiguring and less time-consuming. The major concerns for refusal of conventional postmortem were that the procedure was disfiguring, time-consuming, and caused emotional stress to the parents.
    Conclusions: Participants favored the MITS approach over conventional postmortem as it caused less disfigurement and was conducive to the religious practice of burial of the body.
    MeSH term(s) Humans ; Infant, Newborn ; Autopsy ; Cause of Death ; India ; Parents ; Qualitative Research ; Perception
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-023-06123-1
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  6. Article ; Online: Towards understanding accountability for physicians practice in India.

    Mathew, Mary / Klabbers, Gonnie / de Wert, Guido / Krumeich, Anja

    Asian journal of psychiatry

    2023  Volume 82, Page(s) 103505

    Abstract: The lack of accountability is considered to be a major cause of the crisis in health care in India. Physicians as key stakeholders in the health care delivery system have traditionally been accountable for health concerns at the doctor-patient interface. ...

    Abstract The lack of accountability is considered to be a major cause of the crisis in health care in India. Physicians as key stakeholders in the health care delivery system have traditionally been accountable for health concerns at the doctor-patient interface. Following social and organizational dynamics, the interpretations of accountability have broadened and shifted in the recent literature, expanding accountability to the community, national and global levels and to social domains. The objective of this study is to provide a comprehensive framework of accountability in medical practice that can be used as a vehicle for further contextualized research and policy input. Through literature review, this paper is presented in two parts. First, a description of accountability of a physician inclusive of the social domains is extracted by posing three pertinent questions: who is accountable? accountability to whom? and accountability for what? which addresses the roles, relationships with other stakeholders and domains of accountability. Second, a framework of accountability of a physician is designed and presented to illustrate the professional and social domains. This study revealed a shift from individual physician's accountability to collective accountability involving multiple stakeholders through complex reciprocal and multi-layered mechanisms inclusive of the social dimensions. We propose a comprehensive framework of accountability of the physician to include the social domains that its multidimensional and integrative of all stakeholders. Furthermore, we discuss the utility of the framework in the Indian health care system and how this can facilitate further research in understanding the social dimensions of all stakeholders.
    MeSH term(s) Humans ; India ; Physician-Patient Relations ; Physicians ; Social Responsibility
    Language English
    Publishing date 2023-02-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2023.103505
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  7. Article ; Online: Appraising the performance of ChatGPT in psychiatry using 100 clinical case vignettes.

    Franco D'Souza, Russell / Amanullah, Shabbir / Mathew, Mary / Surapaneni, Krishna Mohan

    Asian journal of psychiatry

    2023  Volume 89, Page(s) 103770

    Abstract: Background: ChatGPT has emerged as the most advanced and rapidly developing large language chatbot system. With its immense potential ranging from answering a simple query to cracking highly competitive medical exams, ChatGPT continues to impress the ... ...

    Abstract Background: ChatGPT has emerged as the most advanced and rapidly developing large language chatbot system. With its immense potential ranging from answering a simple query to cracking highly competitive medical exams, ChatGPT continues to impress the scientists and researchers worldwide giving room for more discussions regarding its utility in various fields. One such field of attention is Psychiatry. With suboptimal diagnosis and treatment, assuring mental health and well-being is a challenge in many countries, particularly developing nations. To this regard, we conducted an evaluation to assess the performance of ChatGPT 3.5 in Psychiatry using clinical cases to provide evidence-based information regarding the implication of ChatGPT 3.5 in enhancing mental health and well-being.
    Methods: ChatGPT 3.5 was used in this experimental study to initiate the conversations and collect responses to clinical vignettes in Psychiatry. Using 100 clinical case vignettes, the replies were assessed by expert faculties from the Department of Psychiatry. There were 100 different psychiatric illnesses represented in the cases. We recorded and assessed the initial ChatGPT 3.5 responses. The evaluation was conducted using the objective of questions that were put forth at the conclusion of the case, and the aim of the questions was divided into 10 categories. The grading was completed by taking the mean value of the scores provided by the evaluators. Graphs and tables were used to represent the grades.
    Results: The evaluation report suggests that ChatGPT 3.5 fared extremely well in Psychiatry by receiving "Grade A" ratings in 61 out of 100 cases, "Grade B" ratings in 31, and "Grade C" ratings in 8. Majority of the queries were concerned with the management strategies, which were followed by diagnosis, differential diagnosis, assessment, investigation, counselling, clinical reasoning, ethical reasoning, prognosis, and request acceptance. ChatGPT 3.5 performed extremely well, especially in generating management strategies followed by diagnoses for different psychiatric conditions. There were no responses which were graded "D" indicating that there were no errors in the diagnosis or response for clinical care. Only a few discrepancies and additional details were missed in a few responses that received a "Grade C" CONCLUSION: It is evident from our study that ChatGPT 3.5 has appreciable knowledge and interpretation skills in Psychiatry. Thus, ChatGPT 3.5 undoubtedly has the potential to transform the field of Medicine and we emphasize its utility in Psychiatry through the finding of our study. However, for any AI model to be successful, assuring the reliability, validation of information, proper guidelines and implementation framework are necessary.
    MeSH term(s) Humans ; Reproducibility of Results ; Psychiatry ; Diagnosis, Differential ; Mental Disorders/diagnosis ; Mental Disorders/drug therapy ; Communication
    Language English
    Publishing date 2023-09-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2023.103770
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  8. Article ; Online: Cause of Death in Neonates With Neurological Insults in the Neonatal Intensive Care Unit: Insights From A MITS Pilot Study.

    Mathew, Mary / Lewis, Leslie / Sreenivas, Athira / Purkayastha, Jayashree

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue Suppl_5, Page(s) S408–S414

    Abstract: Background: Minimally invasive tissue sampling (MITS) of organs has been used as an alternative to complete diagnostic autopsy in countries where refusal for autopsy in newborns is common for sociocultural reasons. There is a paucity of literature ... ...

    Abstract Background: Minimally invasive tissue sampling (MITS) of organs has been used as an alternative to complete diagnostic autopsy in countries where refusal for autopsy in newborns is common for sociocultural reasons. There is a paucity of literature regarding the diagnostic utility of MITS of the brain after death in neonates with neurological insults, especially in India.
    Methods: This was a prospective, preliminary single-center tertiary care hospital study in India, focused specifically on MITS of the brain after neonatal death as a diagnostic tool to identify the various neurological insults. All neonatal deaths with neurological symptoms occurring within the first 30 days of life were enrolled, irrespective of the suspected clinical diagnosis.
    Results: Sixteen neonates were enrolled after death for MITS of the brain, performed for diagnostic purposes, during the study period from February 2020 to March 2021. Their gestational ages ranged from 26 to 38 weeks. All neonates had either a history of seizures and/or respiratory distress or clinical evidence of sepsis and were on ventilator support. Histopathology in all 16 neonates showed evidence of anoxia, with or without reactive astrogliosis or microgliosis. In 5 neonates with cranial ultrasound evidence of brain hemorrhage, MITS of the brain showed intraventricular hemorrhage, subdural hemorrhage, or intraparenchymal white matter microhemorrhages. Premortem blood culture-proven sepsis was seen in 9 neonates. In all cases (100%), MITS had a good diagnostic yield and was useful to establish the neurological insult in the brain.
    Conclusions: MITS of the brain provides an accurate and adequate diagnosis and can be an alternative to complete diagnostic autopsy for establishing the cause of death due to neurological insults, especially in low-resource settings where obtaining consent for more invasive procedure is often challenging.
    MeSH term(s) Autopsy/methods ; Cause of Death ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units, Neonatal ; Pilot Projects ; Prospective Studies
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab857
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    Zs.A 1505: Show issues Location:
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  9. Article ; Online: Anticipated and Experienced Barriers to Telehealth in Congregate Care Facilities Across Virginia.

    Mathew, Mary / Flickinger, Tabor / Nappi, Anthony / Gordon, David / Ryall, Amy / Wibberly, Katharine / Collins, Samuel / Archbald-Pannone, Laurie

    Journal of the American Medical Directors Association

    2024  Volume 25, Issue 6, Page(s) 104974

    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Letter
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2024.02.012
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    Zs.A 5971: Show issues Location:
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  10. Article ; Online: Identification of micropollutants from graywater of different complexity and remediation using multilayered membranes

    Athullya, Manappillil K. / Dineep, Devadasan / Mathew, Mary L. / Aravindakumar, Charuvila T. / Aravind, Usha K.

    Environ Sci Pollut Res. 2022 Jan., v. 29, no. 3 p.4206-4218

    2022  

    Abstract: Graywater reuse is one of the important concepts in attaining water sustainability. A major challenge in this area is to realize various components present in graywater. The present study involves the identification of the chemical components of ... ...

    Abstract Graywater reuse is one of the important concepts in attaining water sustainability. A major challenge in this area is to realize various components present in graywater. The present study involves the identification of the chemical components of graywater collected from three different environments and to investigate the efficiency of removal of some of these chemical components using ultrafiltration membranes (polyelectrolyte multilayer (PEM) membranes). The chemical components were analyzed using liquid chromatography connected with quadrupole time-of-flight (UPLC-Q-ToF-MS). A number of micropollutants including surfactants and certain contaminants of emerging concern (CECs) were identified from these samples. Out of 16 compounds identified, 13 were surfactants and the remaining were caffeine, oxybenzone, and benzophenone. These surfactants are mostly the ingredients of various detergents. Low-pressure filtration studies of the collected samples were carried out utilizing chitosan/polyacrylic acid (CHI/PAA) multilayer membranes. A 5.5 bilayer membrane showed more than 95% rejection of the identified compounds in the selected samples and significant improvement in the water quality parameters. This demonstrates that the membrane used in this work is effective in the removal of various chemicals from graywater as well as enhancing the water quality.
    Keywords benzophenones ; caffeine ; chitosan ; electrolytes ; greywater ; liquid chromatography ; pollutants ; polyacrylic acid ; remediation ; ultrafiltration ; water quality
    Language English
    Dates of publication 2022-01
    Size p. 4206-4218.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-15516-8
    Database NAL-Catalogue (AGRICOLA)

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