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  1. Article: Becoming a brain surgeon.

    Mathew, R K

    British journal of hospital medicine (London, England : 2005)

    2017  Volume 78, Issue 3, Page(s) C45–C48

    MeSH term(s) Biomedical Research ; Career Choice ; Humans ; Internship and Residency ; Interviews as Topic ; Job Application ; Neurosurgery/education ; United Kingdom
    Language English
    Publishing date 2017-03-02
    Publishing country England
    Document type Journal Article
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2017.78.3.C45
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Challenges and opportunities in academic neurosurgery.

    Burger, R / Bolton, W S / Mathew, R K

    British journal of hospital medicine (London, England : 2005)

    2021  Volume 82, Issue 10, Page(s) 1–7

    Abstract: Clinical academia aims to bridge the gap between clinicians and scientists, by combining academic activity with clinical practice. The term 'clinical academics' generally refers to clinicians who have protected time within their job plans for undertaking ...

    Abstract Clinical academia aims to bridge the gap between clinicians and scientists, by combining academic activity with clinical practice. The term 'clinical academics' generally refers to clinicians who have protected time within their job plans for undertaking academic activities. Engagement with academic activity by trainees is not only essential to fulfil necessary curriculum competencies, but also allows them to explore areas of interest outside of clinical practice and develop advanced academic skills. This article provides an overview of different routes into academic neurosurgery, and discusses the advantages and difficulties in pursuing this career path. It also covers the differences between postgraduate research degrees and explores the different job plan models available at consultant level. Academic neurosurgery is a rewarding career and opportunities should be made available to those who wish to explore it further. Developing academic careers may have a positive impact on wider workforce planning strategies and improve the delivery of high-quality evidence-based neurosurgical care.
    MeSH term(s) Career Choice ; Consultants ; Curriculum ; Humans ; Neurosurgery ; Physicians ; Workforce
    Language English
    Publishing date 2021-10-26
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2021.0297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered NK cell phenotype in glioblastoma.

    Close, H J / Stead, L F / Nsengimana, J / Reilly, K A / Droop, A / Wurdak, H / Mathew, R K / Corns, R / Newton-Bishop, J / Melcher, A A / Short, S C / Cook, G P / Wilson, E B

    Clinical and experimental immunology

    2019  Volume 200, Issue 1, Page(s) 33–44

    Abstract: Glioblastoma (GBM) is an aggressive cancer with a very poor prognosis. Generally viewed as weakly immunogenic, GBM responds poorly to current immunotherapies. To understand this problem more clearly we used a combination of natural killer (NK) cell ... ...

    Abstract Glioblastoma (GBM) is an aggressive cancer with a very poor prognosis. Generally viewed as weakly immunogenic, GBM responds poorly to current immunotherapies. To understand this problem more clearly we used a combination of natural killer (NK) cell functional assays together with gene and protein expression profiling to define the NK cell response to GBM and explore immunosuppression in the GBM microenvironment. In addition, we used transcriptome data from patient cohorts to classify GBM according to immunological profiles. We show that glioma stem-like cells, a source of post-treatment tumour recurrence, express multiple immunomodulatory cell surface molecules and are targeted in preference to normal neural progenitor cells by natural killer (NK) cells ex vivo. In contrast, GBM-infiltrating NK cells express reduced levels of activation receptors within the tumour microenvironment, with hallmarks of transforming growth factor (TGF)-β-mediated inhibition. This NK cell inhibition is accompanied by expression of multiple immune checkpoint molecules on T cells. Single-cell transcriptomics demonstrated that both tumour and haematopoietic-derived cells in GBM express multiple, diverse mediators of immune evasion. Despite this, immunome analysis across a patient cohort identifies a spectrum of immunological activity in GBM, with active immunity marked by co-expression of immune effector molecules and feedback inhibitory mechanisms. Our data show that GBM is recognized by the immune system but that anti-tumour immunity is restrained by multiple immunosuppressive pathways, some of which operate in the healthy brain. The presence of immune activity in a subset of patients suggests that these patients will more probably benefit from combination immunotherapies directed against multiple immunosuppressive pathways.
    MeSH term(s) Brain Neoplasms/genetics ; Brain Neoplasms/immunology ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cells, Cultured ; Cohort Studies ; Cytotoxicity, Immunologic/genetics ; Cytotoxicity, Immunologic/immunology ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic/immunology ; Gene Regulatory Networks/immunology ; Glioblastoma/genetics ; Glioblastoma/immunology ; Glioblastoma/pathology ; Humans ; Immune Tolerance/genetics ; Immune Tolerance/immunology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Neoplastic Stem Cells/immunology ; Neoplastic Stem Cells/metabolism ; Phenotype ; Prognosis ; Signal Transduction/genetics ; Signal Transduction/immunology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
    Language English
    Publishing date 2019-12-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1111/cei.13403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 337: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Administration of nitric oxide synthase inhibitors does not alter disease course of amyotrophic lateral sclerosis SOD1 mutant transgenic mice.

    Upton-Rice, M N / Cudkowicz, M E / Mathew, R K / Reif, D / Brown, R H

    Annals of neurology

    1999  Volume 45, Issue 3, Page(s) 413–414

    MeSH term(s) Amyotrophic Lateral Sclerosis/drug therapy ; Animals ; Mice ; Nitric Oxide Synthase/administration & dosage ; Nitric Oxide Synthase/antagonists & inhibitors ; Superoxide Dismutase/genetics ; Superoxide Dismutase-1
    Chemical Substances Nitric Oxide Synthase (EC 1.14.13.39) ; Sod1 protein, mouse (EC 1.15.1.1) ; Superoxide Dismutase (EC 1.15.1.1) ; Superoxide Dismutase-1 (EC 1.15.1.1)
    Language English
    Publishing date 1999-03
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/1531-8249(199903)45:3<413::aid-ana24>3.0.co;2-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1370: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 478: Show issues

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  5. Article: Surat'94: was it melioidosis?--interesting observations from the first case of imported melioidosis in India.

    Murali, R / Ganesh, A / Jesudason, M / Mathew, R K / Date, A

    The Journal of the Association of Physicians of India

    1996  Volume 44, Issue 3, Page(s) 218–219

    MeSH term(s) Brunei ; Diagnosis, Differential ; Disease Outbreaks ; Humans ; India/epidemiology ; Male ; Melioidosis/diagnosis ; Melioidosis/epidemiology ; Middle Aged ; Plague/diagnosis
    Language English
    Publishing date 1996-03
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 313: Show issues Location:
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  6. Article: Basic fibroblast growth factor does not prolong survival in a transgenic model of familial amyotrophic lateral sclerosis.

    Upton-Rice, M N / Cudkowicz, M E / Warren, L / Mathew, R K / Ren, J M / Finklestein, S P / Brown, R H

    Annals of neurology

    1999  Volume 46, Issue 6, Page(s) 934

    MeSH term(s) Animals ; Fibroblast Growth Factor 2/administration & dosage ; Fibroblast Growth Factor 2/therapeutic use ; Humans ; Injections, Intraperitoneal ; Mice ; Mice, Transgenic ; Motor Neuron Disease/drug therapy ; Motor Neuron Disease/genetics ; Motor Neuron Disease/physiopathology ; Superoxide Dismutase/genetics
    Chemical Substances Fibroblast Growth Factor 2 (103107-01-3) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 1999-12
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/1531-8249(199912)46:6<934::aid-ana21>3.0.co;2-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1370: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 478: Show issues

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