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  1. Article: One goal: Health for all; Post-COVID public health initiatives.

    Mathew, Thomas

    Indian journal of public health

    2023  Volume 67, Issue 2, Page(s) 189–191

    Abstract: WHO's theme on its ... ...

    Abstract WHO's theme on its 75
    MeSH term(s) Humans ; Public Health ; Pandemics ; COVID-19 ; India/epidemiology
    Language English
    Publishing date 2023-07-17
    Publishing country India
    Document type Journal Article
    ZDB-ID 800737-8
    ISSN 2229-7693 ; 0019-557X
    ISSN (online) 2229-7693
    ISSN 0019-557X
    DOI 10.4103/ijph.ijph_764_23
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    Zs.B 760: Show issues Location:
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  2. Article ; Online: Gemcitabine with cisplatin and nivolumab: Redefining standard of care for first-line metastatic urothelial carcinoma?

    Mathew Thomas, Vinay / Grivas, Petros / Agarwal, Neeraj

    Med (New York, N.Y.)

    2024  Volume 5, Issue 2, Page(s) 109–111

    Abstract: Nivolumab with gemcitabine/cisplatin in the CheckMate 901 trial improved overall and progression-free survival in front-line locally advanced/metastatic urothelial cancer. The EV-302 trial establishes enfortumab-vedotin plus pembrolizumab as the ... ...

    Abstract Nivolumab with gemcitabine/cisplatin in the CheckMate 901 trial improved overall and progression-free survival in front-line locally advanced/metastatic urothelial cancer. The EV-302 trial establishes enfortumab-vedotin plus pembrolizumab as the preferred standard in this setting. Personalized decisions are crucial given patient eligibility and economics. Ongoing trials and predictive biomarkers will further refine treatment strategies.
    MeSH term(s) Humans ; Cisplatin/therapeutic use ; Gemcitabine ; Nivolumab/therapeutic use ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/pathology ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology ; Standard of Care
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Gemcitabine ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2024-02-10
    Publishing country United States
    Document type Journal Article
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2023.12.003
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  3. Article ; Online: Surface Modification of Bi

    Alex, Jogy / Mathew, Thomas V

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 8

    Abstract: Bismuth oxide nanoparticles with appropriate surface chemistry exhibit many interesting properties that can be utilized in a variety of applications. This paper describes a new route to the surface modification of bismuth oxide nanoparticles ( ... ...

    Abstract Bismuth oxide nanoparticles with appropriate surface chemistry exhibit many interesting properties that can be utilized in a variety of applications. This paper describes a new route to the surface modification of bismuth oxide nanoparticles (Bi
    MeSH term(s) Anti-Infective Agents ; Nanoparticles/chemistry ; Bismuth/pharmacology ; beta-Cyclodextrins/chemistry ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction
    Chemical Substances bismuth oxide (A6I4E79QF1) ; Anti-Infective Agents ; Bismuth (U015TT5I8H) ; beta-Cyclodextrins
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28083604
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    Zs.MO 81: Show issues

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  4. Article ; Online: Triad of cluster-like headaches, hypertension and hypercoagulability a pointer to pheochromocytoma.

    Rampuria, Archana / Mathew, Thomas / Honnali Ravindranath, Aditya

    BMJ case reports

    2024  Volume 17, Issue 2

    Abstract: We report the case of a middle-aged hypertensive woman presenting to the neurology department with short-lasting episodic headaches for 4 years. She was initially diagnosed and treated with cluster headaches for one year. Following this, she presented ... ...

    Abstract We report the case of a middle-aged hypertensive woman presenting to the neurology department with short-lasting episodic headaches for 4 years. She was initially diagnosed and treated with cluster headaches for one year. Following this, she presented with right lower limb arterial claudication. Arterial Doppler of lower limbs showed thrombosis of the bilateral common femoral arteries. Further computed tomography (CT) angiogram of the lower limbs confirmed extensive arterial thrombosis in bilateral lower limbs. The CT angiogram incidentally detected a left adrenal lesion. She had elevated urinary vanillylmandelic Acid and 24-hour metanephrines suggesting the presence of a pheochromocytoma. She was initially medically managed and later underwent left open adrenalectomy. Histopathology examination of the sections proved pheochromocytoma. Postsurgery, the patient's symptoms improved remarkably. This case highlights the importance of diagnosing pheochromocytoma when you encounter a patient with refractory short-lasting headaches, hypertension and hypercoagulability.
    MeSH term(s) Middle Aged ; Female ; Humans ; Pheochromocytoma/complications ; Pheochromocytoma/diagnosis ; Pheochromocytoma/surgery ; Hypertension/etiology ; Hypertension/surgery ; Adrenal Gland Neoplasms/complications ; Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/surgery ; Adrenalectomy ; Headache/etiology ; Headache/surgery ; Thrombophilia/complications ; Thrombophilia/diagnosis ; Thrombosis/surgery
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-257899
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  5. Article ; Online: Importance of ipsilateral residual hearing for spatial hearing by bimodal cochlear implant users

    Mathew Thomas / John J. Galvin / Qian-Jie Fu

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 10

    Abstract: Abstract Bimodal cochlear implant (CI) listeners have difficulty utilizing spatial cues to segregate competing speech, possibly due to tonotopic mismatch between the acoustic input frequency and electrode place of stimulation. The present study ... ...

    Abstract Abstract Bimodal cochlear implant (CI) listeners have difficulty utilizing spatial cues to segregate competing speech, possibly due to tonotopic mismatch between the acoustic input frequency and electrode place of stimulation. The present study investigated the effects of tonotopic mismatch in the context of residual acoustic hearing in the non-CI ear or residual hearing in both ears. Speech recognition thresholds (SRTs) were measured with two co-located or spatially separated speech maskers in normal-hearing adults listening to acoustic simulations of CIs; low frequency acoustic information was available in the non-CI ear (bimodal listening) or in both ears. Bimodal SRTs were significantly better with tonotopically matched than mismatched electric hearing for both co-located and spatially separated speech maskers. When there was no tonotopic mismatch, residual acoustic hearing in both ears provided a significant benefit when maskers were spatially separated, but not when co-located. The simulation data suggest that hearing preservation in the implanted ear for bimodal CI listeners may significantly benefit utilization of spatial cues to segregate competing speech, especially when the residual acoustic hearing is comparable across two ears. Also, the benefits of bilateral residual acoustic hearing may be best ascertained for spatially separated maskers.
    Keywords Medicine ; R ; Science ; Q
    Subject code 390
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Low-dose rituximab should be used for treating MS in resource-limited settings: Yes.

    Piehl, Fredrik / Mathew, Thomas

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2022  Volume 28, Issue 7, Page(s) 1028–1029

    MeSH term(s) Humans ; Immunologic Factors/therapeutic use ; Multiple Sclerosis/drug therapy ; Rituximab/therapeutic use
    Chemical Substances Immunologic Factors ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2022-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585221089890
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4428: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Rectangular tolerance regions and multivariate normal reference regions in laboratory medicine.

    Lucagbo, Michael Daniel / Mathew, Thomas

    Biometrical journal. Biometrische Zeitschrift

    2022  Volume 65, Issue 3, Page(s) e2100180

    Abstract: Reference intervals are widely used in the interpretation of results of biochemical and physiological tests of patients. When there are multiple biochemical analytes measured from each subject, a multivariate reference region is needed. Because of their ... ...

    Abstract Reference intervals are widely used in the interpretation of results of biochemical and physiological tests of patients. When there are multiple biochemical analytes measured from each subject, a multivariate reference region is needed. Because of their greater specificity against false positives, such reference regions are more desirable than separate univariate reference intervals that disregard the cross-correlations between variables. Traditionally, under multivariate normality, reference regions have been constructed as ellipsoidal regions. This approach suffers from a major drawback: it cannot detect component-wise extreme observations. In the present work, procedures are developed to construct rectangular reference regions in the multivariate normal setup. The construction is based on the criteria for tolerance intervals. The problems addressed include the computation of a rectangular tolerance region and simultaneous tolerance intervals. Also addressed is the computation of mixed reference intervals that include both two-sided and one-sided limits, simultaneously. A parametric bootstrap approach is used in the computations, and the accuracy of the proposed methodology is assessed using estimated coverage probabilities. The problem of sample size determination is also addressed, and the results are illustrated using examples that call for the computation of reference regions.
    Language English
    Publishing date 2022-10-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 131640-0
    ISSN 1521-4036 ; 0323-3847 ; 0006-3452
    ISSN (online) 1521-4036
    ISSN 0323-3847 ; 0006-3452
    DOI 10.1002/bimj.202100180
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    Z 1267: Show issues

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  8. Article ; Online: Current and emerging role of sacituzumab govitecan in the management of urothelial carcinoma.

    Mathew Thomas, Vinay / Tripathi, Nishita / Agarwal, Neeraj / Swami, Umang

    Expert review of anticancer therapy

    2022  Volume 22, Issue 4, Page(s) 335–341

    Abstract: Introduction: Despite rapid advances in the treatment landscape of urothelial cancer, there is a substantial unmet need for safe and effective therapies for patients with locally advanced and metastatic urothelial cancer. Sacituzumab govitecan (SG) is ... ...

    Abstract Introduction: Despite rapid advances in the treatment landscape of urothelial cancer, there is a substantial unmet need for safe and effective therapies for patients with locally advanced and metastatic urothelial cancer. Sacituzumab govitecan (SG) is an antibody-drug conjugate, consisting of a Trop-2 directed monoclonal antibody linked to SN-38, the active metabolite of irinotecan. Trop-2 is a glycoprotein overexpressed in various carcinomas, including urothelial carcinomas.
    Areas covered: We review the available data on SG, including mechanism of action, pharmacology, efficacy, safety, and clinical studies regarding locally advanced or metastatic urothelial cancer.
    Expert opinion: SG performed well in the TROPHY-U-01 phase II trial with an objective response rate of 27%. The most common adverse effects were diarrhea, nausea, fatigue, alopecia, and neutropenia, with the most common grade ≥ 3 treatment-related AEs being neutropenia, leukopenia, anemia, diarrhea, and febrile neutropenia. However, these effects were managed effectively with supportive care. SG currently has an accelerated approval for patients with locally advanced or metastatic urothelial cancer who have received platinum-based chemotherapy and either programmed cell death receptor-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitor. Several studies are evaluating SG in urothelial cancers as single-agent or in combination with other agents.
    MeSH term(s) Antibodies, Monoclonal, Humanized/adverse effects ; Camptothecin/adverse effects ; Camptothecin/analogs & derivatives ; Carcinoma, Transitional Cell/drug therapy ; Clinical Trials, Phase II as Topic ; Diarrhea/chemically induced ; Humans ; Immunoconjugates/adverse effects ; Irinotecan ; Neutropenia/chemically induced ; Urinary Bladder Neoplasms/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; Immunoconjugates ; Irinotecan (7673326042) ; sacituzumab govitecan (M9BYU8XDQ6) ; Camptothecin (XT3Z54Z28A)
    Language English
    Publishing date 2022-03-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2022.2049763
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    Zs.A 5907: Show issues Location:
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  9. Article ; Online: Probing the inhibition of MAO-B by chalcones: an integrated approach combining molecular docking, ADME analysis, MD simulation, and MM-PBSA calculations.

    Jose, Jisna / Varughese, Jibin K / Parvez, Mohammad Khalid / Mathew, Thomas V

    Journal of molecular modeling

    2024  Volume 30, Issue 4, Page(s) 103

    Abstract: Context: Monoamine oxidase B (MAO-B), an enzyme of significant relevance in the realm of neurodegenerative disorders, has garnered considerable attention as a potential target for therapeutic intervention. Natural compounds known as chalcones have shown ...

    Abstract Context: Monoamine oxidase B (MAO-B), an enzyme of significant relevance in the realm of neurodegenerative disorders, has garnered considerable attention as a potential target for therapeutic intervention. Natural compounds known as chalcones have shown potential as MAO-B inhibitors. In this particular study, we employed a multimodal computational method to evaluate the inhibitory effects of chalcones on MAO-B.
    Methods: Molecular docking methods were used to study and assess the complicated binding interactions that occur between chalcones and MAO-B. This extensive analysis provided a valuable and deep understanding of possible binding methods as well as the key residues implicated in the inhibition process. Furthermore, the ADME investigation gave valuable insights into the pharmacokinetic properties of chalcones. This allowed them to be assessed in terms of drug-like attributes. The use of MD simulations has benefited in the research of ligand-protein interactions' dynamic behaviour and temporal stability. MM-PBSA calculations were also done to estimate the binding free energies and acquire a better knowledge and understanding of the binding affinity between chalcones and MAO-B. Our thorough method gives a thorough knowledge of chalcones' potential as MAO-B inhibitors, which will be useful for future experimental validation and drug development efforts in the context of neurodegenerative illnesses.
    MeSH term(s) Monoamine Oxidase/chemistry ; Monoamine Oxidase/metabolism ; Molecular Docking Simulation ; Monoamine Oxidase Inhibitors/pharmacology ; Monoamine Oxidase Inhibitors/chemistry ; Chalcones/pharmacology ; Chalcones/chemistry ; Structure-Activity Relationship
    Chemical Substances Monoamine Oxidase (EC 1.4.3.4) ; Monoamine Oxidase Inhibitors ; Chalcones
    Language English
    Publishing date 2024-03-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1284729-X
    ISSN 0948-5023 ; 1610-2940
    ISSN (online) 0948-5023
    ISSN 1610-2940
    DOI 10.1007/s00894-024-05889-1
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  10. Article ; Online: George Andrew Olah (1927-2017).

    Mathew, Thomas

    Nature

    2017  Volume 544, Issue 7649, Page(s) 162

    MeSH term(s) Canada ; Carbon Dioxide/chemistry ; Chemistry, Organic/history ; Evolution, Chemical ; Green Chemistry Technology/history ; History, 20th Century ; Hungary ; Los Angeles ; Methanol/chemical synthesis ; Methanol/chemistry ; Nobel Prize
    Chemical Substances Carbon Dioxide (142M471B3J) ; Methanol (Y4S76JWI15)
    Language English
    Publishing date 2017--12
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/544162a
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    Zs.MO 244: Show issues

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