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  1. Book ; Thesis: Quantification of Cerebrospinal Fluid Dynamics using Phase-Contrast Magnetic Resonance Imaging

    Sonnabend, Kristina / Maintz, David / Tittgemeyer, Marc / Wahrmann, Mathis Alexander

    2021  

    Author's details vorgelegt von Kristina Sonnabend ; Betreuer: Prof. Dr. David Maintz, Gutachter: Dr. Marc Tittgemeyer Prof. Dr. Mathias Hoehn
    Subject code 610
    Language English
    Size 118 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    HBZ-ID HT020806072
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2021 D 117 order for loan Magazin

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  2. Article ; Online: Sense the moist and feel the heat: mosquito host and oviposition site detection.

    Verhulst, Niels O / Mathis, Alexander

    Trends in parasitology

    2023  Volume 39, Issue 5, Page(s) 323–324

    Abstract: Laursen et al. identified coreceptor Ir93a that is required for humidity and thermal sensing in the mosquito species Anopheles gambiae and Aedes aegypti. Behavioural studies with mutant mosquitoes with disrupted Ir93a revealed that they were less ... ...

    Abstract Laursen et al. identified coreceptor Ir93a that is required for humidity and thermal sensing in the mosquito species Anopheles gambiae and Aedes aegypti. Behavioural studies with mutant mosquitoes with disrupted Ir93a revealed that they were less attracted to a blood meal source and oviposition site at close distance.
    MeSH term(s) Animals ; Female ; Oviposition ; Anopheles ; Aedes ; Mosquito Vectors
    Language English
    Publishing date 2023-03-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2898: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 16: Show issues
    Zs.MO 251: Show issues

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  3. Article: Thermal preference of Culicoides biting midges in laboratory and semi-field settings.

    Hochstrasser, Alec L / Mathis, Alexander / Verhulst, Niels O

    Journal of thermal biology

    2024  Volume 119, Page(s) 103783

    Abstract: Biting midges of the genus Culicoides (Diptera: Ceratopogonidae) are hematophagous insects, and some species can transmit a plethora of pathogens, e.g., bluetongue virus and African horse sickness virus, that mainly affect animals. The transmission of ... ...

    Abstract Biting midges of the genus Culicoides (Diptera: Ceratopogonidae) are hematophagous insects, and some species can transmit a plethora of pathogens, e.g., bluetongue virus and African horse sickness virus, that mainly affect animals. The transmission of vector-borne pathogens is strongly temperature dependent, and recent studies pointed to the importance of including microclimatic data when modelling disease spread. However, little is known about the preferred temperature of biting midges. The present study addressed the thermal selection of field-caught Culicoides with two experiments. In a laboratory setup, sugar-fed or blood-fed midges were video tracked for 15 min while moving inside a 60 × 30 × 4 cm setup with a 15-25 °C temperature gradient. Culicoides spent over double the time in the coldest zone of the setup compared to the warmest one. This cold selection was significantly stronger for sugar-fed individuals. Calculated preferred temperatures were 18.3 °C and 18.9 °C for sugar-fed and blood-fed Culicoides, respectively. The effect of temperature on walking speed was significant but weak, indicating that their skewed distribution results from preference and not cold trapping. A second experiment consisted of a two-way-choice-setup, performed in a 90 × 45 × 45 cm net cage, placed outdoors in a sheltered environment. Two UV LED CDC traps were placed inside the setup, and a mean temperature difference of 2.2 °C was created between the two traps. Hundred-fifty Culicoides were released per experiment. Recapture rates were negatively correlated with ambient temperature and were on average three times higher in the cooled trap. The higher prevalence of biting midges in cooler environments influences fitness and ability to transmit pathogens and should be considered in models that predict Culicoides disease transmission.
    MeSH term(s) Humans ; Animals ; Ceratopogonidae ; Insect Vectors ; African Horse Sickness Virus ; Environment ; Sugars
    Chemical Substances Sugars
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1498364-3
    ISSN 1879-0992 ; 0306-4565
    ISSN (online) 1879-0992
    ISSN 0306-4565
    DOI 10.1016/j.jtherbio.2024.103783
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  4. Book ; Thesis: Vasopressinspiegel bei Patienten mit schwerer Sepsis

    Wahrmann, Mathis Alexander

    2009  

    Author's details vorgelegt von Mathis Alexander Wahrmann, geb. Höhn
    Language German
    Size 98 S., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2009
    HBZ-ID HT016280211
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 D 237 order for loan Magazin

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  5. Book: Parasitology in veterinary medicine

    Deplazes, Peter / Eckert, Johannes / Mathis, Alexander / Samson-Himmelstjerna, Georg von / Zahner, Horst

    2016  

    Title translation Lehrbuch der Parasitologie für die Tiermedizin
    Author's details Peter Deplazes, Johannes Eckert, Alexander Mathis, Georg von Samson-Himmelstjerna, Horst Zahner
    Keywords Tiermedizin ; Parasitäre Krankheit
    Subject Parasitäre Infektion ; Parasitose ; Tierheilkunde ; Veterinärmedizin
    Subject code 636.089696
    Language English
    Size 653 Seiten, Illustrationen, 29 cm
    Edition First published
    Publisher Wageningen Academic Publishers
    Publishing place Wageningen
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT019285337
    ISBN 978-90-8686-274-0 ; 90-8686-274-8
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    174/81 available for loan (reading room) Freihandmagazin (U1)

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  6. Article ; Online: NeuroAI: If grid cells are the answer, is path integration the question?

    Frey, Markus / Mathis, Mackenzie W / Mathis, Alexander

    Current biology : CB

    2023  Volume 33, Issue 5, Page(s) R190–R192

    Abstract: Spatially modulated neurons known as grid cells are thought to play an important role in spatial cognition. A new study has found that units with grid-cell-like properties can emerge within artificial neural networks trained to path integrate, and ... ...

    Abstract Spatially modulated neurons known as grid cells are thought to play an important role in spatial cognition. A new study has found that units with grid-cell-like properties can emerge within artificial neural networks trained to path integrate, and developed a unifying theory explaining the formation of these cells which shows what circuit constraints are necessary and how learned systems carry out path integration.
    MeSH term(s) Entorhinal Cortex/physiology ; Neural Networks, Computer ; Neurons/physiology ; Cognition ; Learning ; Models, Neurological ; Space Perception/physiology ; Action Potentials/physiology
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.01.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3208: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Task-driven neural network models predict neural dynamics of proprioception.

    Marin Vargas, Alessandro / Bisi, Axel / Chiappa, Alberto S / Versteeg, Chris / Miller, Lee E / Mathis, Alexander

    Cell

    2024  Volume 187, Issue 7, Page(s) 1745–1761.e19

    Abstract: Proprioception tells the brain the state of the body based on distributed sensory neurons. Yet, the principles that govern proprioceptive processing are poorly understood. Here, we employ a task-driven modeling approach to investigate the neural code of ... ...

    Abstract Proprioception tells the brain the state of the body based on distributed sensory neurons. Yet, the principles that govern proprioceptive processing are poorly understood. Here, we employ a task-driven modeling approach to investigate the neural code of proprioceptive neurons in cuneate nucleus (CN) and somatosensory cortex area 2 (S1). We simulated muscle spindle signals through musculoskeletal modeling and generated a large-scale movement repertoire to train neural networks based on 16 hypotheses, each representing different computational goals. We found that the emerging, task-optimized internal representations generalize from synthetic data to predict neural dynamics in CN and S1 of primates. Computational tasks that aim to predict the limb position and velocity were the best at predicting the neural activity in both areas. Since task optimization develops representations that better predict neural activity during active than passive movements, we postulate that neural activity in the CN and S1 is top-down modulated during goal-directed movements.
    MeSH term(s) Animals ; Proprioception/physiology ; Neurons/physiology ; Brain/physiology ; Movement/physiology ; Primates ; Neural Networks, Computer
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.02.036
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 58: Show issues

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  8. Article: Temperature preference of sugar- or blood-fed Aedes japonicus mosquitoes under semi-natural conditions.

    Ziegler, Raphaela / Blanckenhorn, Wolf U / Mathis, Alexander / Verhulst, Niels O

    Journal of thermal biology

    2023  Volume 114, Page(s) 103592

    Abstract: Mosquito-borne diseases pose a major burden on humans and animals. Temperature strongly influences the physiology and life cycle of mosquitoes and also the pathogens they transmit. Thermoregulatory behaviour of mosquitoes has been addressed in a few ... ...

    Abstract Mosquito-borne diseases pose a major burden on humans and animals. Temperature strongly influences the physiology and life cycle of mosquitoes and also the pathogens they transmit. Thermoregulatory behaviour of mosquitoes has been addressed in a few laboratory studies. Here, we expand such studies by investigating the thermal preference when resting of Aedes japonicus, an invasive and putative vector species of many pathogens, in a semi-field setup during summers in a temperate climate. Blood-fed or sugar-fed Ae. japonicus females were released in the late afternoon in a large outdoor cage containing three resting boxes. The next morning, temperature treatments were applied to the boxes, creating a "cool" (over all experiments around 18 °C), and a "warm" (around 35 °C) microhabitat in addition to an untreated "ambient" (around 26 °C) one. The mosquitoes resting within the three boxes were counted five times, every 2 h between 9h and 17h. The highest proportions of mosquitoes (e.g. up to 21% of blood-fed ones) were found in the cool box while both blood-fed and sugar-fed mosquitoes avoided the warm box. The mean resting temperatures of Ae. japonicus were below the ambient temperatures measured by a nearby meteorological station, and this was more pronounced at higher outdoor temperatures and in blood-fed as compared to sugar-fed mosquitoes. Thus, over all experiments with blood-fed mosquitoes, the calculated average resting temperature was 4 °C below the outdoor temperature. As mosquitoes prefer cooler resting places than temperatures measured by weather stations in summer, models to predict mosquito-borne disease outbreaks need to account for the thermoregulatory behaviour of mosquitoes, especially in the wake of climate change.
    MeSH term(s) Animals ; Female ; Humans ; Aedes/physiology ; Temperature ; Sugars ; Mosquito Vectors/physiology ; Weather
    Chemical Substances Sugars
    Language English
    Publishing date 2023-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1498364-3
    ISSN 1879-0992 ; 0306-4565
    ISSN (online) 1879-0992
    ISSN 0306-4565
    DOI 10.1016/j.jtherbio.2023.103592
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  9. Article: Spatial repellency and vapour toxicity of transfluthrin against the biting midges Culicoides nubeculosus and C. sonorensis (Ceratopogonidae)

    Verhulst, Niels O. / Cavegn, Jannis Ceril / Mathis, Alexander

    Current research in insect science. 2021, v. 1

    2021  

    Abstract: Biting midges (Diptera; Ceratopogonidae; Culicoides spp.) are biological vectors of disease agents, and they cause nuisance and insect bite hypersensitivity. Currently there are no effective means to control biting midges as screening is impractical and ... ...

    Abstract Biting midges (Diptera; Ceratopogonidae; Culicoides spp.) are biological vectors of disease agents, and they cause nuisance and insect bite hypersensitivity. Currently there are no effective means to control biting midges as screening is impractical and the application of insecticides or repellents is of limited efficacy. Spatial repellents have the advantage over contact repellents that they can create a vector-free environment. Studies have shown the efficacy of spatial repellents to protect humans against mosquitoes, also outdoors, but no data are available for biting midges. We tested the spatial repellency and toxicity (knockdown effect) of the volatile pyrethroid transfluthrin against the laboratory-reared biting midges Culicoides nubeculosus (Meigen) and Culicoides sonorensis (Wirth and Jones) and the mosquito Aedes aegypti (Linnaeus) in a high-throughput tube setup. Observations were made 15, 30 and 60 min. after application of the repellent. In addition to transfluthrin, the non-volatile pyrethroid permethrin and DEET, the gold standard of repellents, were included. Spatial repellency by transfluthrin was observed against both biting midge species and Ae. aegypti, already at the first observation after 15 min. and at much lower concentrations than DEET. Permethrin was spatially repellent only to C. sonorensis at the highest concentration tested (10 μg/cm²). Knockdown of biting midges and mosquitoes by transfluthrin, both by vapour or contact toxicity, was observed even at low concentrations. DEET had little to no effect on the knockdown of the insects, neither by direct contact nor vapour toxicity, while permethrin caused a high proportion of knockdown when direct contact was possible. In case these results can be confirmed in field experiments, spatial repellents could become a novel tool in integrated control programmes to reduce biting by Culicoides spp.
    Keywords Aedes aegypti ; Culicoides nubeculosus ; Culicoides sonorensis ; deet ; direct contact ; hypersensitivity ; laboratory rearing ; midges ; permethrin ; pyrethrins ; research ; toxicity ; vapors
    Language English
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2666-5158
    DOI 10.1016/j.cris.2020.100002
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Morphological description and multilocus genotyping of

    Manzanell, Ralph / Stocker, Anna-Sophia / Deplazes, Peter / Mathis, Alexander

    International journal for parasitology. Parasites and wildlife

    2022  Volume 19, Page(s) 273–284

    Abstract: Onchocercosis is a parasitic disease caused by over ... ...

    Abstract Onchocercosis is a parasitic disease caused by over 30
    Language English
    Publishing date 2022-11-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2715239-X
    ISSN 2213-2244
    ISSN 2213-2244
    DOI 10.1016/j.ijppaw.2022.10.004
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