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Article ; Online: Assessment of neutrophil-lymphocyte and platelet-lymphocyte ratio in patients with hashimoto's thyroiditis

Gašić Sanja / Perić Milica / Matić Tamara / Jorgaćević Teodora / Ilić Slađana

Praxis Medica, Vol 51, Iss 1-2, Pp 15-

2022 Volume 19

Abstract: INTRODUCTION: The ratio of neutrophils-lymphocytes (NLR) and platelet-lymphocytes (PLR) is a new parameter in the assessment of patients with Hashimoto's thyroiditis OBJECTIVE: The aim of this study was to investigate the effect of NLR and PLR in ... ...

Abstract	INTRODUCTION: The ratio of neutrophils-lymphocytes (NLR) and platelet-lymphocytes (PLR) is a new parameter in the assessment of patients with Hashimoto's thyroiditis OBJECTIVE: The aim of this study was to investigate the effect of NLR and PLR in patients with Hashimoto's thyroiditis MATERIALS AND METHODS: In this cross-sectional study, subjects were subjected to tests of thyroid gland function, antithyroid antibodies, as well as laboratory analyzes of blood count with determination of NLR and PLR. The respondents were grouped into two groups. The first group was patients with Hashimoto's thyroiditis (HT), while the second group consisted of healthy individuals who represented the control group. RESULTS: NLR was statistically significantly higher in patients with HT compared to the control group (2.62±0.8 and 2.43±0.8, respectively; p=0.02), while PLR was higher in people with HT compared to the control group, but without statistical significance significance (169±42.5; 159±40.3; p=0.08). Among the examined patients with HT, the group with hypothyroidism showed statistically higher NLR values compared to the group of patients with euthyroid status (2.7±0.9 2.31±0.7 p=0.03). Among the examined patients with HT, the group with hypothyroidism showed statistically higher PLR values compared to the group of patients with euthyroid status, as well as the group with subclinical hypothyroidism (177.8±48.2; 148.3±39.3; 155.5±42.5 p=0.04). NLR and PLR show a statistically significant positive correlation with the level of TSH, Anti TPO and TG At in the group with HT. CONCLUSION: NLR and PLR can serve as practical and valuable markers of the clinical course of the disease, but also markers of autoimmune diseases that progress with chronic inflammation.
Keywords	nlr ; plr ; hashimoto's thyroiditis ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Medicinski fakultet Priština, Društvo lekara Kosova i Metohije Srpskog lekarskog društva
Document type	Article ; Online
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Article ; Online: A step towards tuning the jute fiber structure and properties by employing sodium periodate oxidation and coating with alginate.

Ivanovska, Aleksandra / Milošević, Marija / Lađarević, Jelena / Jankoska, Maja / Matić, Tamara / Svirčev, Zorica / Kostić, Mirjana

International journal of biological macromolecules

2023 Volume 257, Issue Pt 2, Page(s) 128668

Abstract: This paper outlines a novel simple protocol for tuning the structure and properties of jute using sodium periodate ( ... ...

Abstract	This paper outlines a novel simple protocol for tuning the structure and properties of jute using sodium periodate (NaIO
MeSH term(s)	Alginates/chemistry ; Periodic Acid ; Oxidation-Reduction ; Hydrophobic and Hydrophilic Interactions
Chemical Substances	metaperiodate (B45A1BUM4Q) ; Alginates ; Periodic Acid (10450-60-9)
Language	English
Publishing date	2023-12-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.128668
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Article ; Online: Synthesis and characterization of innovative resveratrol nanobelt-like particles and assessment of their bioactivity, antioxidative and antibacterial properties.

Tomić, Nina / Matić, Tamara / Filipović, Nenad / Mitić Ćulafić, Dragana / Boccacccini, Aldo R / Stevanović, Magdalena M

Journal of biomaterials applications

2023 Volume 38, Issue 1, Page(s) 122–133

Abstract: Recently, many studies have shown various beneficial effects of polyphenol resveratrol (Res) on human health. The most important of these effects include cardioprotective, neuroprotective, anti-cancer, anti-inflammatory, osteoinductive, and anti- ... ...

Abstract	Recently, many studies have shown various beneficial effects of polyphenol resveratrol (Res) on human health. The most important of these effects include cardioprotective, neuroprotective, anti-cancer, anti-inflammatory, osteoinductive, and anti-microbial effects. Resveratrol has cis and trans isoforms, with the trans isoform being more stable and biologically active. Despite the results of
MeSH term(s)	Humans ; Antioxidants/pharmacology ; Resveratrol/pharmacology ; Nanoparticles/chemistry ; Biocompatible Materials ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Spectroscopy, Fourier Transform Infrared ; Metal Nanoparticles/chemistry ; X-Ray Diffraction
Chemical Substances	Antioxidants ; Resveratrol (Q369O8926L) ; Biocompatible Materials ; Anti-Bacterial Agents
Language	English
Publishing date	2023-06-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639283-0
ISSN	1530-8022 ; 0885-3282
ISSN (online)	1530-8022
ISSN	0885-3282
DOI	10.1177/08853282231183109
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Article ; Online: Relationship between low vitamin D levels with Hashimoto thyroiditis

Gašić Sanja / Smiljić Sonja / Milanović Zvezdan / Gašić Miloš / Ilić Slađana / Bogosavljević Ivan / Dejanović Mirjana / Nestorović Vojkan / Matić Tamara

Srpski Arhiv za Celokupno Lekarstvo, Vol 151, Iss 5-6, Pp 296-

2023 Volume 301

Abstract: Introduction/Objective. Vitamin D not only plays a role in calcium and phosphorus metabolism, but also has antiproliferative, prodifferentiation, anti-inflammatory and immunomodulatory effects. The aim of this study was to investigate the association ... ...

Abstract	Introduction/Objective. Vitamin D not only plays a role in calcium and phosphorus metabolism, but also has antiproliferative, prodifferentiation, anti-inflammatory and immunomodulatory effects. The aim of this study was to investigate the association between vitamin D deficiency in individuals with autoimmune Hashimoto’s thyroiditis. Methods. A total of 156 patients were enrolled and divided into two groups. First group included 108 patients with 25 (OH) D insufficiency, and second included 48 individuals with normal 25 (OH) D levels. All participants underwent a detailed clinical examination, laboratory tests for thyroid function [T3, fT4, TSH, thyroid antibodies (TPO-Ab, and TG-Ab)], as well as ultrasound scanning (thyroid volume and Doppler characteristics). Results. The patients with vitamin D insufficiency (n = 108 (69.2%)) were predominantly female and had a higher body mass index than the patients with normal vitamin D levels. The group with vitamin D insufficiency had statistically significantly higher TSH levels. The prevalence of positive thyroid antibodies was higher in the vitamin D insufficiency group, while thyroid volume, superior thyroid artery, and inferior thyroid arteries resistance index, as well as the prevalence of positive circular dichroism signals, were significantly higher in the vitamin D insufficiency group. Out of the 156 subjects, 44 were diagnosed with thyroiditis (28.2%). The mean serum level of 25 (OH) D was statistically notably lower in patients with thyroiditis (20.23 ± 8.10 ng/mL) than in the group without thyroiditis (25.44 ± 8.38 ng/mL), p < 0.001. Conclusion. There was an association between vitamin D insufficiency and hypothyroidism in subjects with Hashimoto’s thyroiditis.
Keywords	vitamin d ; insufficiency ; hashimoto's thyroiditis ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Serbian Medical Society
Document type	Article ; Online
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Article ; Online: Providing Continuity in Infant Mental Health Services for Medically Fragile Infants and Their Families.

Lakatos, Patricia P / Rodas, Naomi V / Matic, Tamara / Williams, Marian E / Samora, Laura L / Carson, Melissa C

Journal of clinical psychology in medical settings

2023 Volume 31, Issue 1, Page(s) 5–18

Abstract: Having a baby who is prenatally or postnatally diagnosed with a medical condition places considerable stress on the parents, infants, and their developing relationship. Infant mental health (IMH) services offer an opportunity to address the challenges ... ...

Abstract	Having a baby who is prenatally or postnatally diagnosed with a medical condition places considerable stress on the parents, infants, and their developing relationship. Infant mental health (IMH) services offer an opportunity to address the challenges and support the parent-infant relationship. The present study outlined a continuum of care IMH program embedded within various medical settings of a large metropolitan children's hospital. Applications of IMH principles within the fetal care center, neonatal intensive care unit, high risk infant follow-up clinic, and the patient's home are described. Descriptive data about families served across settings and a case study are provided in order to illustrate the implementation of this unique IMH intervention model.
MeSH term(s)	Infant ; Infant, Newborn ; Child ; Humans ; Parents/psychology ; Mental Health Services ; Intensive Care Units, Neonatal
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1235893-9
ISSN	1573-3572 ; 1068-9583
ISSN (online)	1573-3572
ISSN	1068-9583
DOI	10.1007/s10880-023-09957-1
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Article ; Online: Hydroxyapatite-based dental inserts: Microstructure, mechanical properties, bonding efficiency and fracture resistance of molars with occlusal restorations.

Matic, Tamara / Zebic, Maja Lezaja / Miletic, Vesna / Trajkovic, Isaak / Milosevic, Milos / Racic, Aleksandar / Veljovic, Djordje

Journal of biomedical materials research. Part B, Applied biomaterials

2023 Volume 112, Issue 1, Page(s) e35331

Abstract: This study aimed to (1) comparatively analyze properties of Sr- and Mg-substituted hydroxyapatite (HAP)-based dental inserts; (2) evaluate insert bonding to restorative materials, and (3) evaluate the effect of doped HAP inserts on fracture resistance ( ... ...

Abstract	This study aimed to (1) comparatively analyze properties of Sr- and Mg-substituted hydroxyapatite (HAP)-based dental inserts; (2) evaluate insert bonding to restorative materials, and (3) evaluate the effect of doped HAP inserts on fracture resistance (FR) of human molars with large occlusal restorations. By ion-doping with Sr or Mg, 3 insert types were obtained and characterized using XRD, SEM, Vickers hardness and fracture toughness. Shear bond strength (SBS) was determined between acid etched or unetched inserts and following materials: Maxcem cement (Kerr); Filtek Z250 (3M) bonded with Single Bond Universal (SBU; 3M) or Clearfil Universal (Cf; Kuraray). Modified Class I cavities were prepared in 16 intact molars and restored using insert + composite or composite only (control) (n = 8/group). FR of restored molars was determined by static load until fracture upon thermal cycling. Fracture toughness was similar between Sr/Mg-doped inserts (0.94-1.04 MPam
MeSH term(s)	Humans ; Durapatite ; Dentin-Bonding Agents/chemistry ; Composite Resins/chemistry ; Molar ; Fractures, Bone ; Resin Cements/chemistry ; Glass Ionomer Cements/chemistry ; Dental Bonding ; Materials Testing ; Dental Stress Analysis
Chemical Substances	Durapatite (91D9GV0Z28) ; Dentin-Bonding Agents ; Composite Resins ; Resin Cements ; Glass Ionomer Cements
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.35331
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Article ; Online: Child-Parent Psychotherapy with Infants Hospitalized in the Neonatal Intensive Care Unit.

Lakatos, Patricia P / Matic, Tamara / Carson, Melissa / Williams, Marian E

Journal of clinical psychology in medical settings

2019 Volume 26, Issue 4, Page(s) 584–596

Abstract: Hospitalization in the Neonatal Intensive Care Unit (NICU) is a stressful and potentially traumatic experience for infants as well as their parents. The highly specialized medical environment can threaten the development of a nurturing and secure ... ...

Abstract	Hospitalization in the Neonatal Intensive Care Unit (NICU) is a stressful and potentially traumatic experience for infants as well as their parents. The highly specialized medical environment can threaten the development of a nurturing and secure caregiving relationship and potentially derail an infant's development. Well-timed, dose-specific interventions that include an infant mental health approach can buffer the impact of medical traumatic stress and separations and support the attachment relationship. Many psychological interventions in the NICU setting focus on either the parent's mental health or the infant's neurodevelopmental functioning. An alternative approach is to implement a relationship-based, dyadic intervention model that focuses on the developing parent-infant relationship. Child-parent psychotherapy (CPP) is an evidence-based trauma-informed dyadic intervention model for infants and young children who have experienced a traumatic event. This article describes the adaptation of CPP for the NICU environment.
MeSH term(s)	Adult ; Critical Care/psychology ; Female ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units, Neonatal ; Male ; Parents/psychology ; Psychotherapy/methods ; Stress, Psychological/psychology ; Stress, Psychological/therapy
Language	English
Publishing date	2019-04-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1235893-9
ISSN	1573-3572 ; 1068-9583
ISSN (online)	1573-3572
ISSN	1068-9583
DOI	10.1007/s10880-019-09614-6
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Article ; Online: Infant-Family Mental Health in the NICU: A Mixed-Methods Study Exploring Referral Pathways and Family Engagement.

Driver, Myisha / Mikhail, Sandra / Carson, Melissa C / Lakatos, Patricia P / Matic, Tamara / Chin, Steven / Williams, Marian E

The Journal of perinatal & neonatal nursing

2021 Volume 35, Issue 1, Page(s) 68–78

Abstract: Parents and infants in the neonatal intensive care unit (NICU) are exposed to considerable stress, and infant-family mental health (IFMH) services foster emotional well-being in the context of the parent-infant relationship. This mixed-methods study ... ...

Abstract	Parents and infants in the neonatal intensive care unit (NICU) are exposed to considerable stress, and infant-family mental health (IFMH) services foster emotional well-being in the context of the parent-infant relationship. This mixed-methods study examined the role of an IFMH program introduced in a level 4 NICU. The study included (1) retrospective medical record review of NICU patients who were referred to the IFMH program and (2) qualitative interviews with NICU nurse managers, neonatologists, and medical social workers to explore their understanding of the IFMH program, explore the referral pathways and factors that supported family engagement, and identify specific recommendations for program improvement. Of the 311 infant-parent dyads referred to the IFMH program, 62% had at least one session and Spanish-speaking families were more likely to engage. Of those families receiving services, about one-third had brief intervention, one-third had 4 to 10 sessions, and one-third had long-term services, including in-home after-discharge services. Qualitative interviews with health providers identified unique qualities of the IFMH program and why families were and were not referred to the program. Recommendations centered on adding a full-time IFMH mental health provider to the NICU and increasing communication and integration between the IFMH program and the medical team.
MeSH term(s)	Female ; Humans ; Infant Health ; Infant, Newborn ; Infant, Premature/psychology ; Intensive Care Units, Neonatal ; Intensive Care, Neonatal/psychology ; Kangaroo-Mother Care Method/psychology ; Male ; Mental Health/statistics & numerical data ; Parents/psychology ; Patient Discharge ; Social Support
Language	English
Publishing date	2021-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036365-8
ISSN	1550-5073 ; 0893-2190
ISSN (online)	1550-5073
ISSN	0893-2190
DOI	10.1097/JPN.0000000000000545
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Article ; Online: Examination of myeloperoxidase activity, as an indicator of inflammation in obese participants with metabolic syndrome

Matić Tamara / Puhalo-Sladoje Dragana / Kisić Bojana / Trajković Goran / Dragojević Ilija / Mirić Dijana

Praxis Medica, Vol 45, Iss 3-4, Pp 15-

2016 Volume 21

Abstract: Introduction. Obesity is a complex metabolic disorder and one of the most common modern health problems. Numerous studies indicate association between chronic low-grade inflammatory state and obesity. Myeloperoxidase (MPO) and its reactive oxidants ... ...

Abstract	Introduction. Obesity is a complex metabolic disorder and one of the most common modern health problems. Numerous studies indicate association between chronic low-grade inflammatory state and obesity. Myeloperoxidase (MPO) and its reactive oxidants participate in tissue damage in the course of inflammatory processes. The aim of this study was to examine MPO activity in the serum of obese participants with metabolic syndrome and its relationship with other indicators of inflammation. Material and Methods: Participants were divided into three groups according to the anthropometric parameters and biochemical indicators: normally fed ones (n=30), participants with abdominal obesity (n = 30) and participants with metabolic syndrome (n = 30). In the serum of patients was being determined chlorination activity of MPO by spectrophotometry. Results: Significant differences were found in MPO activity in all three groups of participants such as: the maximum activity was measured in patients with metabolic syndrome (p <0.001). There was a positive correlation between MPO activity and atherogenic index, as well as between the MPO and the concentration of LDL-cholesterol, while the negative correlation was found between MPO and the concentration of HDL-cholesterol. Conclusion: The examination has shown that the activity of MPO progressively increases with obesity and metabolic syndrome. The obtained results suggest that MPO can be of great importance for the pathophysiological mechanisms leading to the development of complications of obesity and metabolic syndrome.
Keywords	myeloperoxidase ; metabolic syndrome ; inflammation ; obesity ; dyslipidemia ; Medicine ; R
Subject code	796
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Medicinski fakultet Priština, Društvo lekara Kosova i Metohije Srpskog lekarskog društva
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