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Article ; Online: The Increased Release Kinetics of Quercetin from Superparamagnetic Nanocarriers in Dialysis

Mandić, Lucija / Matković, Marija / Baranović, Goran / Šegota, Suzana

Antioxidants. 2023 Mar. 16, v. 12, no. 3

2023

Abstract: The actual cumulative mass of released quercetin from nanoparticles within the dialysis membrane was determined under the influence of external stationary and alternating magnetic fields. We have shown that the control of the release kinetics of ... ...

Abstract	The actual cumulative mass of released quercetin from nanoparticles within the dialysis membrane was determined under the influence of external stationary and alternating magnetic fields. We have shown that the control of the release kinetics of quercetin from MNPs, i.e., the distribution of quercetin between the nanoparticles and the suspension within the membrane, can be tuned by the simple combination of stationary and alternating magnetic fields. Under non-sink conditions, the proportion of quercetin in the suspension inside the membrane is increased toward the nanoparticles, resulting in the increased release of quercetin. The results obtained could be applied to the release of insoluble flavonoids in aqueous suspensions in general.
Keywords	dialysis ; magnetism ; nanocarriers ; nanoparticles ; quercetin
Language	English
Dates of publication	2023-0316
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12030732
Database	NAL-Catalogue (AGRICOLA)

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Article: The Increased Release Kinetics of Quercetin from Superparamagnetic Nanocarriers in Dialysis.

Mandić, Lucija / Matković, Marija / Baranović, Goran / Šegota, Suzana

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract	The actual cumulative mass of released quercetin from nanoparticles within the dialysis membrane was determined under the influence of external stationary and alternating magnetic fields. We have shown that the control of the release kinetics of quercetin from MNPs, i.e., the distribution of quercetin between the nanoparticles and the suspension within the membrane, can be tuned by the simple combination of stationary and alternating magnetic fields. Under non-sink conditions, the proportion of quercetin in the suspension inside the membrane is increased toward the nanoparticles, resulting in the increased release of quercetin. The results obtained could be applied to the release of insoluble flavonoids in aqueous suspensions in general.
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12030732
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bis-Pyrene Photo-Switch Open- and Closed-Form Differently Bind to ds-DNA, ds-RNA and Serum Albumin and Reveal Light-Induced Bioactivity.

Orehovec, Iva / Matković, Marija / Pehar, Isabela / Majhen, Dragomira / Piantanida, Ivo

International journal of molecular sciences

2021 Volume 22, Issue 9

Abstract: Newly designed and synthesized diarylethene (DAE) derivatives with aliphatic amine sidearms and one with two pyrenes, revealed excellent photo-switching property of central DAE core in MeOH and water. The only exception was bis-pyrene analogue, its DAE ... ...

Abstract	Newly designed and synthesized diarylethene (DAE) derivatives with aliphatic amine sidearms and one with two pyrenes, revealed excellent photo-switching property of central DAE core in MeOH and water. The only exception was bis-pyrene analogue, its DAE core very readily photochemically closed, but reversible opening completely hampered by aromatic stacking interaction of pyrene(s) with cyclic DAE. In this process, pyrene fluorescence showed to be a reliable monitoring method, an open form characterized by strong emission at 480 nm (typical for pyrene-aggregate), while closed form emitted weakly at 400 nm (typical for pyrene-DAE quenching). Only open DAE-bis-pyrene form interacted measurably with ds-DNA/RNA by flexible insertion in polynucleotide grooves, while self-stacked closed form did not bind to DNA/RNA. For the same steric reasons, flexible open DAE-bis-pyrene form was bound to at least three different binding sites at bovine serum albumin (BSA), while rigid, self-stacked closed form interacted dominantly with only one BSA site. Preliminary screening of antiproliferative activity against human lung carcinoma cell line A549 revealed that all DAE-derivatives are non-toxic. However, bis-pyrene analogue efficiently entered cells and located in the cytoplasm, whereby irradiation by light (315-400 nm) resulted in a strong, photo-induced cytotoxic effect, typical for pyrene-related singlet oxygen species production.
MeSH term(s)	A549 Cells ; Animals ; Cattle ; Cell Survival ; DNA/chemistry ; Electrons ; Humans ; Light ; Molecular Conformation ; Nucleic Acid Denaturation/radiation effects ; Photochemical Processes ; Pyrenes/chemistry ; RNA/chemistry ; Serum Albumin, Bovine/chemistry ; Spectrometry, Fluorescence ; Spectrophotometry, Ultraviolet ; Temperature
Chemical Substances	Pyrenes ; Serum Albumin, Bovine (27432CM55Q) ; RNA (63231-63-0) ; DNA (9007-49-2)
Language	English
Publishing date	2021-05-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22094916
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Application of Long-Chained Auxin Conjugates Influenced Auxin Metabolism and Transcriptome Response in

Smolko, Ana / Repar, Jelena / Matković, Marija / Pavlović, Iva / Pěnčík, Aleš / Novák, Ondřej / Ludwig-Müller, Jutta / Salopek-Sondi, Branka

International journal of molecular sciences

2023 Volume 25, Issue 1

Abstract: Auxin amino acid conjugates are considered to be storage forms of auxins. Previous research has shown that indole-3-acetyl-L-alanine (IAA-Ala), indole-3-propionyl-L-alanine (IPA-Ala) and indole-3-butyryl-L-alanine (IBA-Ala) affect the root growth ... ...

Abstract	Auxin amino acid conjugates are considered to be storage forms of auxins. Previous research has shown that indole-3-acetyl-L-alanine (IAA-Ala), indole-3-propionyl-L-alanine (IPA-Ala) and indole-3-butyryl-L-alanine (IBA-Ala) affect the root growth of
MeSH term(s)	Animals ; Indoleacetic Acids/pharmacology ; Brassica rapa/genetics ; Transcriptome ; Indoles ; Alanine ; Gastropoda ; Seedlings/genetics
Chemical Substances	Indoleacetic Acids ; Indoles ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2023-12-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25010447
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Article: Streptomyces coelicolor macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA

Hloušek-Kasun, Andrea / Mikolčević, Petra / Rack, Johannes Gregor Matthias / Tromans-Coia, Callum / Schuller, Marion / Jankevicius, Gytis / Matković, Marija / Bertoša, Branimir / Ahel, Ivan / Mikoč, Andreja

Computational and Structural Biotechnology Journal. 2022, v. 20

2022

Abstract: ADP-ribosylation is an ancient, highly conserved, and reversible covalent modification critical for a variety of endogenous processes in both prokaryotes and eukaryotes. ADP-ribosylation targets proteins, nucleic acids, and small molecules (including ... ...

Abstract	ADP-ribosylation is an ancient, highly conserved, and reversible covalent modification critical for a variety of endogenous processes in both prokaryotes and eukaryotes. ADP-ribosylation targets proteins, nucleic acids, and small molecules (including antibiotics). ADP-ribosylation signalling involves enzymes that add ADP-ribose to the target molecule, the (ADP-ribosyl)transferases; and those that remove it, the (ADP-ribosyl)hydrolases. Recently, the toxin/antitoxin pair DarT/DarG composed of a DNA ADP-ribosylating toxin, DarT, and (ADP-ribosyl)hydrolase antitoxin, DarG, was described. DarT modifies thymidine in single-stranded DNA in a sequence-specific manner while DarG reverses this modification, thereby rescuing cells from DarT toxicity. We studied the DarG homologue SCO6735 which is highly conserved in all Streptomyces species and known to be associated with antibiotic production in the bacterium S. coelicolor. SCO6735 shares a high structural similarity with the bacterial DarG and human TARG1. Like DarG and TARG1, SCO6735 can also readily reverse thymidine-linked ADP-ribosylation catalysed by DarT in vitro and in cells. SCO6735 active site analysis including molecular dynamic simulations of its complex with ADP-ribosylated thymidine suggests a novel catalytic mechanism of DNA-(ADP-ribose) hydrolysis. Moreover, a comparison of SCO6735 structure with ALC1-like homologues revealed an evolutionarily conserved feature characteristic for this subclass of macrodomain hydrolases.
Keywords	Streptomyces coelicolor ; active sites ; antibiotics ; antitoxins ; bacteria ; biotechnology ; eukaryotic cells ; humans ; hydrolases ; hydrolysis ; prokaryotic cells ; single-stranded DNA ; thymidine ; toxicity ; toxins ; transferases
Language	English
Size	p. 4337-4350.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2694435-2
ISSN	2001-0370
ISSN	2001-0370
DOI	10.1016/j.csbj.2022.08.002
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Incorporation of arginine mimetic residue into peptides for recognition of double stranded nucleic acid structure: Binding and aggregation studies.

Li, Mao / Matković, Marija / Piantanida, Ivo / Schmuck, Carsten

Bioorganic & medicinal chemistry

2017 Volume 25, Issue 6, Page(s) 1875–1880

Abstract: An arginine mimetic, featuring a guanidiniocarbonypyrrol as artificial anion binding site (GCP), was introduced into short peptides to study their binding and aggregation with double stranded DNA and RNA. While the incorporation of this GCP modification ... ...

Abstract	An arginine mimetic, featuring a guanidiniocarbonypyrrol as artificial anion binding site (GCP), was introduced into short peptides to study their binding and aggregation with double stranded DNA and RNA. While the incorporation of this GCP modification did not significantly change the overall binding affinity for DNA/RNA, their interactions were more sensitive with respect to the type of polynucleotides. Peptide 4, with four GCP modifications, exhibited amazing fluorescent selectivity for AU- and (to a lesser extent) AT- sequences. GC-containing DNA showed much lower response. Additionally, exclusively tri-GCP modified peptide 3 showed intriguing exciton-coupled bisignate ICD bands for all studied DNA/RNA which suggested that a well-defined GCP-dimer bound into DNA/RNA groove..
MeSH term(s)	Arginine/chemistry ; Chromatography, High Pressure Liquid ; DNA/chemistry ; Molecular Mimicry ; Nucleic Acid Denaturation ; Peptides/chemistry ; RNA, Double-Stranded/chemistry ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Spectrum Analysis/methods
Chemical Substances	Peptides ; RNA, Double-Stranded ; DNA (9007-49-2) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2017-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2017.02.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Tryptophan 'Gate' in the CRISPR-Cas3 Nuclease Controls ssDNA Entry into the Nuclease Site, That When Removed Results in Nuclease Hyperactivity.

He, Liu / Matošević, Zoe Jelić / Mitić, Damjan / Markulin, Dora / Killelea, Tom / Matković, Marija / Bertoša, Branimir / Ivančić-Baće, Ivana / Bolt, Edward L

International journal of molecular sciences

2021 Volume 22, Issue 6

Abstract: Cas3 is a ssDNA-targeting nuclease-helicase essential for class 1 prokaryotic CRISPR immunity systems, which has been utilized for genome editing in human cells. Cas3-DNA crystal structures show that ssDNA follows a pathway from helicase domains into a ... ...

Abstract	Cas3 is a ssDNA-targeting nuclease-helicase essential for class 1 prokaryotic CRISPR immunity systems, which has been utilized for genome editing in human cells. Cas3-DNA crystal structures show that ssDNA follows a pathway from helicase domains into a HD-nuclease active site, requiring protein conformational flexibility during DNA translocation. In genetic studies, we had noted that the efficacy of Cas3 in CRISPR immunity was drastically reduced when temperature was increased from 30 °C to 37 °C, caused by an unknown mechanism. Here, using
MeSH term(s)	Adenosine Triphosphate/chemistry ; Adenosine Triphosphate/genetics ; Adenosine Triphosphate/metabolism ; Alanine/chemistry ; Alanine/genetics ; Alanine/metabolism ; Amino Acid Sequence ; CRISPR-Associated Proteins/chemistry ; CRISPR-Associated Proteins/genetics ; CRISPR-Associated Proteins/metabolism ; CRISPR-Cas Systems ; Catalytic Domain/genetics ; Circular Dichroism ; DNA/chemistry ; DNA/genetics ; DNA/metabolism ; DNA Helicases/chemistry ; DNA Helicases/genetics ; DNA Helicases/metabolism ; DNA, Single-Stranded/chemistry ; DNA, Single-Stranded/genetics ; DNA, Single-Stranded/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Gene Editing/methods ; Humans ; Mutation, Missense ; Protein Conformation ; Sequence Homology, Amino Acid ; Temperature ; Tryptophan/chemistry ; Tryptophan/genetics ; Tryptophan/metabolism
Chemical Substances	CRISPR-Associated Proteins ; DNA, Single-Stranded ; Escherichia coli Proteins ; Tryptophan (8DUH1N11BX) ; Adenosine Triphosphate (8L70Q75FXE) ; DNA (9007-49-2) ; DNA Helicases (EC 3.6.4.-) ; ygcB protein, E coli (EC 3.6.4.12) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2021-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22062848
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Article ; Online: Photochemical Reactivity of Naphthol-Naphthalimide Conjugates and Their Biological Activity.

Sambol, Matija / Benčić, Patricia / Erben, Antonija / Matković, Marija / Mihaljević, Branka / Piantanida, Ivo / Kralj, Marijeta / Basarić, Nikola

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 11

Abstract: Quinone methide ... ...

Abstract	Quinone methide precursors
Language	English
Publishing date	2021-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26113355
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Article: Streptomyces coelicolor

Computational and structural biotechnology journal

2022 Volume 20, Page(s) 4337–4350

Abstract	ADP-ribosylation is an ancient, highly conserved, and reversible covalent modification critical for a variety of endogenous processes in both prokaryotes and eukaryotes. ADP-ribosylation targets proteins, nucleic acids, and small molecules (including antibiotics). ADP-ribosylation signalling involves enzymes that add ADP-ribose to the target molecule, the (ADP-ribosyl)transferases; and those that remove it, the (ADP-ribosyl)hydrolases. Recently, the toxin/antitoxin pair DarT/DarG composed of a DNA ADP-ribosylating toxin, DarT, and (ADP-ribosyl)hydrolase antitoxin, DarG, was described. DarT modifies thymidine in single-stranded DNA in a sequence-specific manner while DarG reverses this modification, thereby rescuing cells from DarT toxicity. We studied the DarG homologue SCO6735 which is highly conserved in all
Language	English
Publishing date	2022-08-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2694435-2
ISSN	2001-0370
ISSN	2001-0370
DOI	10.1016/j.csbj.2022.08.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Photoelimination of nitrogen from adamantane and pentacycloundecane (PCU) diazirines: a spectroscopic study and supramolecular control.

Šumanovac, Tatjana / Alešković, Marija / Šekutor, Marina / Matković, Marija / Baron, Thibaut / Mlinarić-Majerski, Kata / Bohne, Cornelia / Basarić, Nikola

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

2019 Volume 18, Issue 7, Page(s) 1806–1822

Abstract: Photochemical reactivity of pentacycloundecane (PCU) and adamantane diazirines was investigated by preparative irradiation in different solvents, laser flash photolysis (LFP) and quantum chemical computations. In addition, formation of inclusion ... ...

Abstract	Photochemical reactivity of pentacycloundecane (PCU) and adamantane diazirines was investigated by preparative irradiation in different solvents, laser flash photolysis (LFP) and quantum chemical computations. In addition, formation of inclusion complexes for diazirines with cucurbit[7]uril, β- and γ-cyclodextrin (β- and γ-CD) was investigated by 1H NMR spectroscopy, isothermal microcalorimetry and circular dichroism spectroscopy, followed by the investigation of photochemical reactivity of the formed complexes. Diazirines undergo efficient photochemical elimination of nitrogen (ΦR > 0.5) and deliver the corresponding singlet carbenes. Singlet carbenes react in intra- and intermolecular reactions and we found a rare singlet carbene pathway in CH3OH involving protonation and formation of a carbocation, detected due to the specific rearrangement of the pentacycloundecane skeleton. Singlet diazirines undergo intersystem crossing and deliver triplet carbenes that react with oxygen to form ketones which were isolated after irradiation. Our main finding is that the formation of diazirine inclusion complexes with β-CD and γ-CD changes the relative ratio of singlet vs. triplet pathways, with singlet carbene products being dominant from the chemistry of the irradiated complexes. Our combined theoretical and experimental studies provide new insights into the supramolecular control of carbene reactivity which has possible applications for the control of product distribution by solvent effects and the choice of constrained media.
Language	English
Publishing date	2019-06-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2072584-X
ISSN	1474-9092 ; 1474-905X
ISSN (online)	1474-9092
ISSN	1474-905X
DOI	10.1039/c9pp00124g
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