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  1. Article: Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers.

    Rodrigues, Fernanda Guedes / Ormanji, Milene Subtil / Pietrobom, Igor Gouveia / Matos, Ana Cristina Carvalho de / De Borst, Martin H / Heilberg, Ita Pfeferman

    Journal of clinical medicine

    2023  Volume 12, Issue 15

    Abstract: Background: Sclerostin plays an important role in bone metabolism and adipose tissue. Animal studies suggest that sclerostin influences urinary calcium (UCa), but this relationship has not been evaluated in stone formers (SFs). We aimed to investigate ... ...

    Abstract Background: Sclerostin plays an important role in bone metabolism and adipose tissue. Animal studies suggest that sclerostin influences urinary calcium (UCa), but this relationship has not been evaluated in stone formers (SFs). We aimed to investigate the association of UCa with serum sclerostin, bone mineral density (BMD), and body composition among SFs.
    Methods: Clinical and laboratorial data were retrieved from medical records. Determinants of UCa were studied using linear regression.
    Results: A total of 107 SFs (35.8 ± 9.3 years, 54% male) with eGFR 99.8 ± 14.5 mL/min/1.73 were studied. Subjects were split by sex and grouped into tertiles of UCa levels. Men in the highest UCa tertile had higher body mass index (BMI) and serum sclerostin, lower lean mass, and a trend towards higher fat mass. Women in the highest tertile had higher BMI and a trend towards higher serum sclerostin. Hypertension and metabolic syndrome, but not lower BMD, were more prevalent in the highest UCa tertile for both sexes. Sclerostin was positively correlated with fat mass and inversely correlated with lean mass among men, but not among women. BMD corrected for BMI at lumbar spine was inversely associated with UCa in a univariate analysis, but only serum sclerostin, hypertension, and NaCl intake were independent determinants of UCa in the multivariate model.
    Conclusion: The present findings disclose that in addition to hypertension and salt intake, serum sclerostin is associated with urinary calcium in stone formers, suggesting that in addition to the hormones traditionally thought to alter calcium reabsorption in the kidney, sclerostin may play a significant additional role, warranting further investigation.
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12155027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ischemia and reperfusion injury in renal transplantation: hemodynamic and immunological paradigms.

    Requião-Moura, Lúcio Roberto / Durão Junior, Marcelino de Souza / Matos, Ana Cristina Carvalho de / Pacheco-Silva, Alvaro

    Einstein (Sao Paulo, Brazil)

    2015  Volume 13, Issue 1, Page(s) 129–135

    Abstract: Ischemia and reperfusion injury is an inevitable event in renal transplantation. The most important consequences are delayed graft function, longer length of stay, higher hospital costs, high risk of acute rejection, and negative impact of long-term ... ...

    Abstract Ischemia and reperfusion injury is an inevitable event in renal transplantation. The most important consequences are delayed graft function, longer length of stay, higher hospital costs, high risk of acute rejection, and negative impact of long-term follow-up. Currently, many factors are involved in their pathophysiology and could be classified into two different paradigms for education purposes: hemodynamic and immune. The hemodynamic paradigm is described as the reduction of oxygen delivery due to blood flow interruption, involving many hormone systems, and oxygen-free radicals produced after reperfusion. The immune paradigm has been recently described and involves immune system cells, especially T cells, with a central role in this injury. According to these concepts, new strategies to prevent ischemia and reperfusion injury have been studied, particularly the more physiological forms of storing the kidney, such as the pump machine and the use of antilymphocyte antibody therapy before reperfusion. Pump machine perfusion reduces delayed graft function prevalence and length of stay at hospital, and increases long-term graft survival. The use of antilymphocyte antibody therapy before reperfusion, such as Thymoglobulin™, can reduce the prevalence of delayed graft function and chronic graft dysfunction.
    MeSH term(s) Delayed Graft Function/physiopathology ; Graft Rejection/physiopathology ; Hemodynamics/physiology ; Humans ; Ischemia/immunology ; Ischemia/physiopathology ; Ischemia/prevention & control ; Kidney/blood supply ; Kidney Transplantation/adverse effects ; Reperfusion Injury/immunology ; Reperfusion Injury/physiopathology ; Reperfusion Injury/prevention & control ; Risk Factors ; Time Factors
    Language Portuguese
    Publishing date 2015-01
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2418293-X
    ISSN 2317-6385 ; 1679-4508
    ISSN (online) 2317-6385
    ISSN 1679-4508
    DOI 10.1590/S1679-45082015RW3161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Expanding the pool of kidney donors: use of kidneys with acute renal dysfunction.

    Matos, Ana Cristina Carvalho de / Requião-Moura, Lúcio Roberto / Clarizia, Gabriela / Durão Junior, Marcelino de Souza / Tonato, Eduardo José / Chinen, Rogério / Arruda, Érika Ferraz de / Filiponi, Thiago Corsi / Pires, Luciana Mello de Mello Barros / Bertocchi, Ana Paula Fernandes / Pacheco-Silva, Alvaro

    Einstein (Sao Paulo, Brazil)

    2015  Volume 13, Issue 2, Page(s) 319–325

    Abstract: Given the shortage of organs transplantation, some strategies have been adopted by the transplant community to increase the supply of organs. One strategy is the use of expanded criteria for donors, that is, donors aged >60 years or 50 and 59 years, and ... ...

    Abstract Given the shortage of organs transplantation, some strategies have been adopted by the transplant community to increase the supply of organs. One strategy is the use of expanded criteria for donors, that is, donors aged >60 years or 50 and 59 years, and meeting two or more of the following criteria: history of hypertension, terminal serum creatinine >1.5mg/dL, and stroke as the donor´s cause of death. In this review, emphasis was placed on the use of donors with acute renal failure, a condition considered by many as a contraindication for organ acceptance and therefore one of the main causes for kidney discard. Since these are well-selected donors and with no chronic diseases, such as hypertension, renal disease, or diabetes, many studies showed that the use of donors with acute renal failure should be encouraged, because, in general, acute renal dysfunction is reversible. Although most studies demonstrated these grafts have more delayed function, the results of graft and patient survival after transplant are very similar to those with the use of standard donors. Clinical and morphological findings of donors, the use of machine perfusion, and analysis of its parameters, especially intrarenal resistance, are important tools to support decision-making when considering the supply of organs with renal dysfunction.
    MeSH term(s) Acute Kidney Injury/surgery ; Age Factors ; Aged ; Creatinine/blood ; Delayed Graft Function/mortality ; Donor Selection/organization & administration ; Graft Survival/physiology ; Humans ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/methods ; Kidney Transplantation/mortality ; Length of Stay/statistics & numerical data ; Middle Aged ; Patient Selection ; Survival Rate ; Tissue Donors/supply & distribution
    Chemical Substances Creatinine (AYI8EX34EU)
    Language Portuguese
    Publishing date 2015-04
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2418293-X
    ISSN 2317-6385 ; 1679-4508
    ISSN (online) 2317-6385
    ISSN 1679-4508
    DOI 10.1590/S1679-45082015RW3147
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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