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Article ; Online: Immunoexpression of TS, p53, COX2, EGFR, MSH6 and MLH1 biomarkers and its correlation with degree of differentiation, tumor staging and prognostic factors in colorectal adenocarcinoma: a retrospective longitudinal study.

Batista, Wilson Roberto / Santos, Gianni / Vital, Flávia Maria Ribeiro / Matos, Delcio

Sao Paulo medical journal = Revista paulista de medicina

2019 Volume 137, Issue 1, Page(s) 33–38

Abstract: Background: There are cases of colorectal tumors that, although small, show more aggressive evolution than large tumors. This motivated us to study whether there are any proteins capable of alerting about these changes. The aim here was to correlate the ...

Abstract	Background: There are cases of colorectal tumors that, although small, show more aggressive evolution than large tumors. This motivated us to study whether there are any proteins capable of alerting about these changes. The aim here was to correlate the immunoexpression of the TS, p53, COX2, EGFR, MSH6 and MLH1 biomarkers in tumors in patients with colorectal adenocarcinoma, with the degree of cell differentiation, tumor staging and clinical-pathological prognostic factors. Design and setting: Retrospective observational study at a public tertiary-level hospital. Methods: We analyzed tissue-microarray paraffin blocks of tumor tissues that had been resected from 107 patients. We used Fisher's exact test to study associations between tumor differentiation/staging and the immunoexpression of biomarkers. We also used Kaplan-Meier estimation, the log-rank test and the adjusted Cox regression model to investigate the patients' overall survival (in months) according to biomarkers and disease-free interval. Results: The degree of tumor differentiation and tumor staging were not associated with the biomarkers, except in cases of patients in stages III or IV, in which there was a correlation with MLH1 expression (P=0.021). Patient survival and disease-free interval were not associated with the biomarkers. Conclusion: There were no associations between the degree of tumor differentiation, staging, length of survival or disease-free interval and the immunoexpression of the TS, p53, COX2, EGFR or MSH6 tumor markers. In advanced cases of colorectal adenocarcinoma (stages III and IV), there was a higher percentage of MLH1-negative results.
MeSH term(s)	Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Cyclooxygenase 2/analysis ; DNA-Binding Proteins/analysis ; ErbB Receptors/analysis ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Longitudinal Studies ; Male ; Middle Aged ; MutL Protein Homolog 1/analysis ; Neoplasm Staging ; Proportional Hazards Models ; Reference Values ; Retrospective Studies ; Thymidylate Synthase/analysis ; Tissue Array Analysis ; Tumor Suppressor Protein p53/analysis ; Young Adult
Chemical Substances	Biomarkers, Tumor ; DNA-Binding Proteins ; G-T mismatch-binding protein ; MLH1 protein, human ; Tumor Suppressor Protein p53 ; Cyclooxygenase 2 (EC 1.14.99.1) ; Thymidylate Synthase (EC 2.1.1.45) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; MutL Protein Homolog 1 (EC 3.6.1.3)
Language	English
Publishing date	2019-05-21
Publishing country	Brazil
Document type	Journal Article ; Observational Study
ZDB-ID	1203171-9
ISSN	1806-9460 ; 1516-3180 ; 0035-0362
ISSN (online)	1806-9460
ISSN	1516-3180 ; 0035-0362
DOI	10.1590/1516-3180.2018.0270071218
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Article ; Online: INTERVENTIONS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME: A REVIEW OF COCHRANE SYSTEMATIC REVIEWS.

Scaciota, Ana Carolina Lemes / Matos, Delcio / Rosa, Manuelle Mastrorocco Brand / Colovati, Mileny Esbravatti Stephano / Bellotto, Elisa Fatima Benavent Caldas / Martimbianco, Ana Luiza Cabrera

Arquivos de gastroenterologia

2021 Volume 58, Issue 1, Page(s) 120–126

Abstract: Background: Irritable bowel syndrome (IBS) is a complex gastrointestinal disorder, whose understanding is relatively uncertain, and the treatment guidance decision still represents a challenge.: Objective: To identify and critically appraise ... ...

Abstract	Background: Irritable bowel syndrome (IBS) is a complex gastrointestinal disorder, whose understanding is relatively uncertain, and the treatment guidance decision still represents a challenge. Objective: To identify and critically appraise systematic reviews (SRs) published in the Cochrane Database of SRs (CDSR) on the effects of interventions (pharmacological and non-pharmacological) for the treatment of IBS. Methods: The search was conducted at the Cochrane Library in May 2020. The methodological quality of the SRs was evaluated by the AMSTAR-2 tool. Results: Eight SRs with moderate to high quality were included, which addressed the treatments: (a) pharmacological: volume agents, antispasmodics, antidepressants and tegaserod; and (b) non-pharmacological: homeopathy, acupuncture, phytotherapy, biofeedback, psychological interventions and hypnotherapy. The results were favorable to antispasmodic drugs and antidepressants regarding the improvement of clinical symptoms. There was no difference between volume agents or tegaserod when compared to placebo. Acupuncture and homeopathy showed a little improvement in symptoms compared to placebo, but the certainty of this evidence was considered low to very low. Psychological interventions seem to improve the overall assessment of the patient and relief symptoms such as abdominal pain. However, there was no long-term follow-up of these patients. The results of the other treatments were considered uncertain due to the high risk of bias. Conclusion: Considering the low quality of the studies included in the SRs, pharmacological treatment with antispasmodics and antidepressants seems to be beneficial for patients with IBS. Among non-pharmacological interventions, psychological interventions seem to be beneficial. However, further clinical trials are recommended with greater methodological rigor to prove these findings.
MeSH term(s)	Abdominal Pain ; Humans ; Irritable Bowel Syndrome/drug therapy ; Phytotherapy
Language	English
Publishing date	2021-04-26
Publishing country	Brazil
Document type	Journal Article ; Systematic Review
ZDB-ID	137743-7
ISSN	1678-4219 ; 0004-2803
ISSN (online)	1678-4219
ISSN	0004-2803
DOI	10.1590/S0004-2803.202100000-20
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Article ; Online: Metalloproteinases and colorectal cancer. Correlation of gene expression and clinical-pathological parameters.

Morini, Sandra Regina / Denadai, Marcos Vinicius / Waisberg, Jaques / Lopes Filho, Gaspar de Jesus / Matos, Delcio / Saad, Sarhan Sydney

Acta cirurgica brasileira

2020 Volume 35, Issue 7, Page(s) e202000707

Abstract: Purpose: To analyze gene and protein expression of metalloproteinases 1, 2, 9, 11 and 16 and their correlation with clinicopathological variables in colorectal adenocarcinoma.: Methods: A retrospective study of 114 patients with colorectal ... ...

Abstract	Purpose: To analyze gene and protein expression of metalloproteinases 1, 2, 9, 11 and 16 and their correlation with clinicopathological variables in colorectal adenocarcinoma. Methods: A retrospective study of 114 patients with colorectal adenocarcinoma treated surgically in the period 2006 to 2008 in Hospital de Câncer de Barretos - Fundação Pio XII. The evaluation of gene expression was performed by RT-PCR, and protein by immunohistochemistry. The analysis of gene expression was classified as overexpressed genes and poorly expressed (fold change of approximately 2, p<0.05). The positivity of the markers in the immunohistochemical study was performed by semi-quantitative analysis. The tissue of TMA (Tissue Microarray) was done by two independent pathologists. Results: The gene expression validated by immuno - histochemical was MMP-1(p= 0.00 and 1.57 fold change) and MMP - 2 (p= 0.01 and - 1.84 to fold change) when correlated with the histological types mucinous and adenocarcinoma NOS, MMP9 (p=0.01 and fold change of 1.13) and MMP-16 (p=0.03 and 1.61 fold change) when compared with the histological types villous and adenocarcinoma NOS, MMP - 11 statistically significant in relation to male (p = 0.04 and 1.65 fold change). Conclusions: The MMPs 1, 2, 9, 11 and 16 gene and protein expression with statistical significance in at least one of the clinicopathological variables studied. Thus, we conclude that these MMPs have potential as a prognostic factor in colorectal adenocarcinoma.
MeSH term(s)	Adenocarcinoma ; Colorectal Neoplasms ; Humans ; Immunohistochemistry ; Male ; Matrix Metalloproteinases ; Prognosis ; Retrospective Studies
Chemical Substances	Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2020-08-14
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2012156-8
ISSN	1678-2674 ; 0102-8650
ISSN (online)	1678-2674
ISSN	0102-8650
DOI	10.1590/s0102-865020200070000007
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Article: Surgical practice - is it evidence-based?

Matos, Delcio / Lustosa, Suzana Angelica Silva

Acta cirurgica brasileira

2008 Volume 23, Issue 2, Page(s) 115–117

MeSH term(s)	Digestive System Surgical Procedures/standards ; Evidence-Based Medicine ; Humans ; Perioperative Care/standards ; Preoperative Care/standards
Language	English
Publishing date	2008-01-31
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2012156-8
ISSN	1678-2674 ; 0102-8650
ISSN (online)	1678-2674
ISSN	0102-8650
DOI	10.1590/s0102-86502008000200001
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Article: Prevalence of cubital tunnel syndrome among dock workers, Saint Sebastian, São Paulo, Brazil.

Saito, Regina Yumi / Yano, Marcos Yoshio / Angelini, Luiz Carlos / Matos, Delcio / Guimarães, André Vicente

Revista brasileira de medicina do trabalho : publicacao oficial da Associacao Nacional de Medicina do Trabalho-ANAMT

2018 Volume 16, Issue 3, Page(s) 270–276

Abstract: Background: Ports play a substantial role in the Brazilian economy.Despite the large number of port workers, few studies report that the most common musculoskeletal disorders among them involve the upper limbs, including carpal tunnel syndrome, rotator ... ...

Abstract	Background: Ports play a substantial role in the Brazilian economy.Despite the large number of port workers, few studies report that the most common musculoskeletal disorders among them involve the upper limbs, including carpal tunnel syndrome, rotator cuff syndrome, cervicalgia and cubital tunnel syndrome.The latter is a neuritis caused by compression of the ulnar nerve at the cubital tunnel (CuTS) on the elbow. Objective: To estimate the prevalence of a suggestive diagnosis of CuTS among port workers. Method: Seventy-two independent port workers registered with the Labor Management Organ (Órgão Gestor de Mão de Obra - OGMO), Port of Saint Sebastian, were evaluated based on a semi-structured questionnaire and clinical examination, including investigation of pain on palpation of the middle area of the elbow and two maneuvers specific for CuTS, namely, the pressure provocation and maximal flexion tests. Results: The average age of the participants was 48.49 years old, and their average length in the job 23.13 years.Suggestive diagnosis of CuTS was established for five participants.In only two cases elbow pain had begun before, and in three after starting work at the port. Conclusion: The prevalence of a suggestive diagnosis of CuTS was 6.9%, and was higher among the participants with longer length in the job (over one year).
Language	English
Publishing date	2018-09-01
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2735204-3
ISSN	1679-4435
ISSN	1679-4435
DOI	10.5327/Z1679443520180265
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Article ; Online: Mechanical bowel preparation for elective colorectal surgery.

Güenaga, Katia F / Matos, Delcio / Wille-Jørgensen, Peer

The Cochrane database of systematic reviews

2011 , Issue 9, Page(s) CD001544

Abstract: Background: The presence of bowel contents during colorectal surgery has been related to anastomotic leakage, but the belief that mechanical bowel preparation (MBP) is an efficient agent against leakage and infectious complications is based on ... ...

Abstract	Background: The presence of bowel contents during colorectal surgery has been related to anastomotic leakage, but the belief that mechanical bowel preparation (MBP) is an efficient agent against leakage and infectious complications is based on observational data and expert opinions only.An enema before the rectal surgery to clean the rectum and facilitate the manipulation for the mechanical anastomosis is used for many surgeons. This is analysed separately Objectives: To determine the security and effectiveness of MBP on morbidity and mortality in colorectal surgery. Search strategy: Publications describing trials of MBP before elective colorectal surgery were sought through searches of MEDLINE, EMBASE, LILACS, IBECS and The Cochrane Library; by handsearching relevant medical journals and conference proceedings, and through personal communication with colleagues.Searches were performed December 1, 2010. Selection criteria: Randomised controlled trials (RCTs) including participants submitted for elective colorectal surgery. Eligible interventions included any type of MBP compared with no MBP. Primary outcomes included anastomosis leakage - both rectal and colonic - and combined figures. Secondary outcomes included mortality, peritonitis, reoperation, wound infection, extra-abdominal complications, and overall surgical site infections. Data collection and analysis: Data were independently extracted and checked. The methodological quality of each trial was assessed. Details of randomisation, blinding, type of analysis, and number lost to follow up were recorded. For analysis, the Peto-Odds Ratio (OR) was used as the default (no statistical heterogeneity was observed). Main results: At this update six trials and a new comparison (Mechanical bowel preparation versus enema) were added. Altogether eighteen trials were analysed, with 5805 participants; 2906 allocated to MBP (Group A), and 2899 to no preparation (Group B), before elective colorectal surgery.For the comparison Mechanical Bowel Preparation Versus No Mechanical Bowel Preparation results were:1. Anastomotic leakage for low anterior resection: 8.8% (38/431) of Group A, compared with 10.3% (43/415) of Group B; Peto OR 0.88 [0.55, 1.40].2. Anastomotic leakage for colonic surgery: 3.0% (47/1559) of Group A, compared with 3.5% (56/1588) of Group B; Peto OR 0.85 [0.58, 1.26].3. Overall anastomotic leakage: 4.4% (101/2275) of Group A, compared with 4.5% (103/2258) of Group B; Peto OR 0.99 [0.74, 1.31].4. Wound infection: 9.6% (223/2305) of Group A, compared with 8.5% (196/2290) of Group B; Peto OR 1.16 [0.95, 1.42].Sensitivity analyses did not produce any differences in overall results.For the comparison Mechanical Bowel Preparation (A) Versus Rectal Enema (B) results were:1. Anastomotic leakage after rectal surgery: 7.4% (8/107) of Group A, compared with 7.9% (7/88) of Group B; Peto OR 0.93 [0.34, 2.52].2. Anastomotic leakage after colonic surgery: 4.0% (11/269) of Group A, compared with 2.0% (6/299) of Group B; Peto OR 2.15 [0.79, 5.84].3. Overall anastomotic leakage: 4.4% (27/601) of Group A, compared with 3.4% (21/609) of Group B; Peto OR 1.32 [0.74, 2.36].4. Wound infection: 9.9% (60/601) of Group A, compared with 8.0% (49/609) of Group B; Peto OR 1.26 [0.85, 1.88]. Authors' conclusions: Despite the inclusion of more studies with a total of 5805 participants, there is no statistically significant evidence that patients benefit from mechanical bowel preparation, nor the use of rectal enemas. In colonic surgery the bowel cleansing can be safely omitted and induces no lower complication rate. The few studies focused in rectal surgery suggested that mechanical bowel preparation could be used selectively, even though no significant effect was found. Further research on patients submitted for elective rectal surgery, below the peritoneal verge, in whom bowel continuity is restored, and studies with patients submitted to laparoscopic surgeries are still warranted.
MeSH term(s)	Digestive System Surgical Procedures/adverse effects ; Elective Surgical Procedures/adverse effects ; Enema/methods ; Fecal Incontinence/etiology ; Fecal Incontinence/prevention & control ; Gastrointestinal Contents ; Humans ; Laxatives/administration & dosage ; Preoperative Care/methods ; Randomized Controlled Trials as Topic ; Surgical Wound Dehiscence/epidemiology ; Surgical Wound Dehiscence/prevention & control ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/prevention & control
Chemical Substances	Laxatives
Language	English
Publishing date	2011-09-07
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ISSN	1469-493X
ISSN (online)	1469-493X
DOI	10.1002/14651858.CD001544.pub4
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Article ; Online: Combination chemotherapy versus single-agent chemotherapy during preoperative chemoradiation for resectable rectal cancer.

Resende, Heloisa M / Jacob, Luiz Felipe Pitzer / Quinellato, Luciano Vasconcellos / Matos, Delcio / da Silva, Edina Mk

The Cochrane database of systematic reviews

2015 Volume 10, Page(s) CD008531

Abstract: Background: Colorectal cancer represents 10% of all cancers and is the third most common cause of death in women and men. Almost two-thirds of all bowel cancers are cancers of the colon and over one-third (34%) are cancers of the rectum, including the ... ...

Abstract	Background: Colorectal cancer represents 10% of all cancers and is the third most common cause of death in women and men. Almost two-thirds of all bowel cancers are cancers of the colon and over one-third (34%) are cancers of the rectum, including the anus. Surgery is the cornerstone for curative treatment of rectal cancer. Mesorectal excision decreases the rate of local recurrences; however, it does not improve the overall survival of people with locally advanced rectal cancer. There have been significant research efforts since the mid-1990s to optimise the treatment of rectal cancer. Based on the findings of clinical trials, people with T3/T4 or N+ rectal tumours are now being treated preoperatively with radiation and chemotherapy, mainly fluoropyrimidine. However, the incidence of distant metastases remains as high as 30%. Combination chemotherapy regimens, similar to those used in metastatic disease with the addition of oxaliplatin and irinotecan, have been tested to improve the prognosis of people with rectal cancer. Objectives: To compare outcomes (including overall survival, disease-free survival and toxicity) between two 5-fluorouracil-containing chemotherapy regimens in people with stage II and III rectal cancer who are receiving preoperative chemoradiation. Search methods: We searched the Cochrane Colorectal Cancer Group Specialised Register (January 2015), the Cochrane Central Register of Controlled Trials (2015, Issue 1), Ovid MEDLINE (1950 to January 2015), Ovid EMBASE (1974 to January 2015) and LILACS (1982 to January 2015). We reviewed the reference lists of included studies, checked clinical trials registers and handsearched relevant journal proceedings. We applied no language or publication restrictions. Selection criteria: Randomised controlled trials (RCTs) comparing single-agent chemotherapy (fluoropyrimidine) versus combination chemotherapy (fluoropyrimidine plus another agent including, but not limited to, oxaliplatin) during preoperative radiochemotherapy in people with resectable rectal cancer. Data collection and analysis: Two review authors (HMR, EMKS) independently extracted data and assessed trial quality. When necessary, we requested additional information and clarification of published data from the authors of individual trials. Main results: We included four RCTs involving 3875 people with resectable rectal cancer. In the preoperative period, the participants of these studies were randomised to receive chemoradiation either with a single fluoropyrimidine agent (capecitabine or 5-fluorouracil) or with a combination of drugs (fluoropyrimidine plus oxaliplatin). The only study that reported overall survival and disease-free survival found no significant differences between the intervention and control groups; we considered this evidence very low quality. For pathological complete response after preoperative treatment (ypCR) there was high quality evidence favouring the intervention group (odds ratio (OR) 1.23, 95% confidence interval (CI) 1.04 to 1.46), but there was also moderate quality evidence suggesting a higher risk for early toxicity in the intervention group (OR 2.07, 95% CI 1.31 to 3.27). Moderate to high quality evidence suggested that the control group had better compliance to radiotherapy (OR 0.32, 95% CI 0.14 to 0.75). There were no significant differences between groups in postoperative mortality within 60 days, postoperative morbidity, resection margins, abdominoperineal resection and Hartmann procedures. Authors' conclusions: There was very low quality evidence that people with resectable rectal cancer who receive combination preoperative chemotherapy have no improvements in overall survival or disease-free survival. There was high quality evidence that suggested that combination chemotherapy with oxaliplatin may improve local tumour control in people with resectable rectal cancer, but this regimen also caused more toxicity. The review included four RCTs but only one reported survival; therefore, we cannot make robust conclusions or useful clinical recommendations. The publication of more survival data from these studies will contribute to future analyses.
Language	English
Publishing date	2015-10-21
Publishing country	England
Document type	Journal Article ; Review
ISSN	1469-493X
ISSN (online)	1469-493X
DOI	10.1002/14651858.CD008531.pub2
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Article ; Online: HNF4A expression as a potential diagnostic tool to discriminate primary gastric cancer from breast cancer metastasis in a Brazilian cohort.

Jucá, Patrícia Chaves de Freitas Campos / Corrêa, Stephany / Vignal, Giselle Maria / Accioly, Maria Theresa de Souza / Lustosa, Suzana Angélica Silva / Abdelhay, Eliana / Matos, Delcio

Diagnostic pathology

2017 Volume 12, Issue 1, Page(s) 43

Abstract: Background: Among the many challenges in cancer diagnosis is the early distinction between metastatic cancer and a secondary tumor. This difficulty stems from the lack of markers that offer high sensitivity and specificity and can be easily applied in ... ...

Abstract	Background: Among the many challenges in cancer diagnosis is the early distinction between metastatic cancer and a secondary tumor. This difficulty stems from the lack of markers that offer high sensitivity and specificity and can be easily applied in routine laboratory work. An example of this challenge is distinguishing gastric metastases originating from breast cancer from a gastric primary tumor. Hepatocyte nuclear factor 4 alpha (HNF4A) has been suggested as a potential marker in these cases. The aim of this study was to analyze the expression of HNF4A, estrogen receptor (ER), progesterone receptor (PR) and gross cystic disease fluid protein 15 (GCDFP-15) in a Brazilian cohort. Methods: We performed immunohistochemistry analysis of HNF4A, ER, PR and GCDFP-15 in 126 patients divided into three cohorts: primary breast cancer, primary gastric cancer and both types of tumors. Results: Our data confirmed the sensitivity and specificity of the HNF4A marker compared to other currently used clinical markers. Conclusion: HNF4A alone could be a gold standard marker for distinguishing primary gastric cancer from breast metastasis, thus validating its potential clinical use, especially in populations with high genetic diversity.
Language	English
Publishing date	2017-06-05
Publishing country	England
Document type	Journal Article
ISSN	1746-1596
ISSN (online)	1746-1596
DOI	10.1186/s13000-017-0635-2
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Article ; Online: Effects of preoperative irradiation using fractioned electron beam on the healing process of colocolonic anastomosis in rats undergoing early and late surgical intervention.

Simões Neto, Joaquim / Reis Neto, José Alfredo dos / Matos, Delcio

Acta cirurgica brasileira

2012 Volume 28, Issue 1, Page(s) 72–77

Abstract: Purpose: To investigate the effects of preoperative fractioned irradiation using an electron beam on the healing process of colocolonic anastomoses in rats that underwent early and late surgical intervention.: Methods: Thirty Wistar rats, distributed ...

Abstract	Purpose: To investigate the effects of preoperative fractioned irradiation using an electron beam on the healing process of colocolonic anastomoses in rats that underwent early and late surgical intervention. Methods: Thirty Wistar rats, distributed as follows: group A (surgery only), group B (fractionated irradiation for 30 days (if), surgery seven days after the end of it), group C (if for 30 days, and surgery after 30 days of termination). On the seventh postoperative day the anastomotic segment analysis was taken, using tension tests, histology and collagen deposition evaluation by computerized analysis. Results: Regarding the tension resistance of the anastomosis, there were no statistical differences (p=0.42). However, a significant increase in cells number in the inflammatory infiltrate in the group with a longer interval between surgery and pre op radiation (p<0.05). The collagen concentration had no significant variance. Conclusion: The irradiation in divided doses increased local inflammatory cellularity when the surgery was performed later. This result did not affect the increase of complications, nor on the local concentration of collagen, achieving similar clinical outcomes.
MeSH term(s)	Anastomosis, Surgical ; Animals ; Collagen/analysis ; Colon/surgery ; Dose Fractionation, Radiation ; Preoperative Care ; Random Allocation ; Rats ; Rats, Wistar ; Reproducibility of Results ; Time Factors ; Treatment Outcome ; Wound Healing/radiation effects
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2012-09-01
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2012156-8
ISSN	1678-2674 ; 0102-8650
ISSN (online)	1678-2674
ISSN	0102-8650
DOI	10.1590/s0102-86502013000100012
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Article ; Online: Relationship between the preoperative body mass index and the resolution of metabolic syndrome following Roux-en-Y gastric bypass.

Saboya, Carlos / Arasaki, Carlos Haruo / Matos, Delcio / Lopes-Filho, Gaspar Jesus

Metabolic syndrome and related disorders

2012 Volume 10, Issue 4, Page(s) 292–296

Abstract: Background: The increased prevalence of overweight and obesity has reached alarming proportions worldwide and has serious health implications, including an association with an increase in metabolic syndrome. Among the methods to control metabolic ... ...

Abstract	Background: The increased prevalence of overweight and obesity has reached alarming proportions worldwide and has serious health implications, including an association with an increase in metabolic syndrome. Among the methods to control metabolic syndrome, bariatric surgery plays an important role and can provide a significant improvement in the components of metabolic syndrome. Objective: The aim of this study was to determine the relationship between the preoperative body mass index (BMI) and the postoperative resolution of metabolic syndrome [using the National Cholesterol Education Program (NCEP ATP III criteria)] in patients undergoing Roux-en-Y gastric bypass (RYGB). Methods: Retrospective analysis of a consecutive series of cases, stratified by BMI into three groups (group 1, BMI <40 kg/m(2), group 2, BMI 40-49.9 kg/m(2), and group 3, BMI 50 ≥ kg/m(2)) consisting of both sexes between 20 and 60 years of age. The cohort consisted of 149 patients undergoing RYGB. Anthropometric, biochemical, and clinical evaluations were performed preoperatively and then at 30 and 180 days postoperatively. Results: The average age was 40 years, and the patients were predominately female (72%). At the end of the study period, all groups showed a significant reduction in metabolic syndrome compared with preoperative levels. Logistic regression showed a higher percentage of metabolic syndrome in patients in group 3 after 180 days. Conclusion: There was significant resolution of metabolic syndrome in all groups, independently of the preoperative BMI. However, in group 3 (BMI ≥ 50 kg/m(2)), 22% of individuals still presented with metabolic syndrome at 180 days postoperatively (P=0.03).
MeSH term(s)	Adult ; Blood Glucose/metabolism ; Body Mass Index ; Body Weight ; Cohort Studies ; Female ; Gastric Bypass/methods ; Humans ; Insulin Resistance ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/surgery ; Middle Aged ; Obesity/complications ; Obesity/surgery ; Retrospective Studies ; Time Factors ; Weight Loss
Chemical Substances	Blood Glucose
Language	English
Publishing date	2012-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2151220-6
ISSN	1557-8518 ; 1540-4196
ISSN (online)	1557-8518
ISSN	1540-4196
DOI	10.1089/met.2012.0014
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