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  1. Article ; Online: Beyond ARIA: Will e-diaries replace retrospective questionnaires in measuring the severity of allergic rhinitis in clinical research and daily practice?

    Matricardi, Paolo M / Sousa-Pinto, Bernardo / Dramburg, Stephanie / Bousquet, Jean

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2023  Volume 53, Issue 10, Page(s) 1004–1010

    Abstract: Retrospective questionnaires are used since decades to assess the severity and/or control of allergic diseases. Applications on smartphones have recently facilitated the use of prospective clinical diaries, based on questionnaires filled every day by the ...

    Abstract Retrospective questionnaires are used since decades to assess the severity and/or control of allergic diseases. Applications on smartphones have recently facilitated the use of prospective clinical diaries, based on questionnaires filled every day by the patient. Once limited to clinical trials, these e-diaries, based on validated disease control scores and visual analogue scales, permit a quantitative day-by-day measure free of recall bias. Given the advantages of this procedure, its use could be extended to the daily clinical practice. E-diaries may facilitate (1) a more precise identification of the culprit allergen in the diagnostic work-up of poly-sensitized patients, (2) the stratification of patients for treatment, (3) the follow-up of the patients under treatment for optimized shared decision-making, and (4) a careful assessment of preventive therapies. While a few apps are being used in scientific studies, consensus on their use in daily practice should be reached and guidelines for specialists should be elaborated by scientific associations.
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14372
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  2. Article ; Online: Allergen-specific immunoprophylaxis: toward secondary prevention of allergic rhinitis?

    Matricardi, Paolo M

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2014  Volume 25, Issue 1, Page(s) 15–18

    MeSH term(s) Adolescent ; Allergens/immunology ; Child ; Child, Preschool ; Clinical Trials as Topic ; Desensitization, Immunologic/methods ; Desensitization, Immunologic/trends ; Follow-Up Studies ; Humans ; Immunodominant Epitopes/immunology ; Molecular Targeted Therapy ; Poaceae ; Pollen/immunology ; Rhinitis, Allergic, Seasonal/immunology ; Rhinitis, Allergic, Seasonal/therapy
    Chemical Substances Allergens ; Immunodominant Epitopes
    Language English
    Publishing date 2014-02
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.12200
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  3. Article ; Online: Molecular profile clustering of IgE responses and potential implications for specific immunotherapy.

    Matricardi, Paolo M

    Current opinion in allergy and clinical immunology

    2013  Volume 13, Issue 4, Page(s) 438–445

    Abstract: Purpose of review: To summarize recent data on molecular profiles of IgE sensitization in allergic patients and discuss how they can influence our understanding of allergen specific immunotherapy.: Recent findings: In childhood, Immunoglobulin E (IgE) ...

    Abstract Purpose of review: To summarize recent data on molecular profiles of IgE sensitization in allergic patients and discuss how they can influence our understanding of allergen specific immunotherapy.
    Recent findings: In childhood, Immunoglobulin E (IgE) sensitization to grass pollen starts preclinically as a weak, mono or oligomolecular response and evolves rapidly to become strong, polymolecular and associated with clinical manifestations. This immunological phenomenon has been defined 'molecular spreading' and it makes the IgE sensitization profiles to complex allergenic sources highly heterogeneous in the population.
    Summary: The recent findings raise new questions: do different molecular sensitization profiles (e.g. to grass pollen) underlie different clinical responses to allergen-specific immunotherapy? Should the allergen-specific immunological intervention be anticipated at earlier stages of the IgE sensitization process? Should the regulatory rules for molecularly designed allergen-specific immunotherapy preparations consider the extreme heterogeneity of sensitization profiles in populations?
    MeSH term(s) Allergens/genetics ; Allergens/immunology ; Humans ; Immunoglobulin E ; Immunotherapy ; Poaceae/genetics ; Poaceae/immunology ; Pollen/genetics ; Pollen/immunology ; Rhinitis, Allergic, Seasonal/genetics ; Rhinitis, Allergic, Seasonal/immunology ; Rhinitis, Allergic, Seasonal/prevention & control
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2013-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0b013e3283630ca5
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  4. Article ; Online: Hot topics in allergen immunotherapy, 2023: Current status and future perspective.

    Zemelka-Wiacek, Magdalena / Agache, Ioana / Akdis, Cezmi A / Akdis, Mübeccel / Casale, Thomas B / Dramburg, Stephanie / Jahnz-Różyk, Karina / Kosowska, Anna / Matricardi, Paolo M / Pfaar, Oliver / Shamji, Mohamed H / Jutel, Marek

    Allergy

    2023  Volume 79, Issue 4, Page(s) 823–842

    Abstract: The importance of allergen immunotherapy (AIT) is multifaceted, encompassing both clinical and quality-of-life improvements and cost-effectiveness in the long term. Key mechanisms of allergen tolerance induced by AIT include changes in memory type ... ...

    Abstract The importance of allergen immunotherapy (AIT) is multifaceted, encompassing both clinical and quality-of-life improvements and cost-effectiveness in the long term. Key mechanisms of allergen tolerance induced by AIT include changes in memory type allergen-specific T- and B-cell responses towards a regulatory phenotype with decreased Type 2 responses, suppression of allergen-specific IgE and increased IgG
    MeSH term(s) Humans ; Artificial Intelligence ; Desensitization, Immunologic ; Hypersensitivity/diagnosis ; Hypersensitivity/therapy ; Allergens ; Biomarkers ; Immunoglobulin G
    Chemical Substances Allergens ; Biomarkers ; Immunoglobulin G
    Language English
    Publishing date 2023-11-20
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15945
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  5. Article ; Online: Collection of nasal secretions and tears and their use in allergology.

    Castelli, Sveva / Arasi, Stefania / Pawankar, Ruby / Matricardi, Paolo M

    Current opinion in allergy and clinical immunology

    2018  Volume 18, Issue 1, Page(s) 1–9

    Abstract: Purpose of review: The identification of immunological markers in nasal secretions and tears is becoming essential in the study of allergic diseases. The collection procedure of nasal and ocular secretions directly influences the results, thus it is of ... ...

    Abstract Purpose of review: The identification of immunological markers in nasal secretions and tears is becoming essential in the study of allergic diseases. The collection procedure of nasal and ocular secretions directly influences the results, thus it is of paramount importance to validate and standardize the sampling process.
    Recent findings: Current techniques for nasal secretions sampling are mainly based on three principles: collection of spontaneous secretions, nasal washings, and absorption. Collection of spontaneous secretions is appropriate in subjects with nasal hypersecretion, whereas in healthy individuals the collected volume is frequently insufficient. Nasal washings are associated with an unpredictable, high dilution and concentrations of markers often fall below detection limits of immunological assays. Absorption seem to provide the best compromise between sufficient sample amounts and detectability of inflammatory mediators and immunoglobulin E. Tear samples can be obtained by glass capillary tubes, filter paper strips and ophthalmic sponges. Volumes are however small or highly diluted through reflex tearing.
    Summary: Secretions reflect the local inflammatory activity and provide valuable information about the immunological reaction to allergens at the target organ. There is increasing evidence of the potential clinical role of their analysis, for diagnosis, and monitoring of allergic rhino-conjunctivitis. Appropriate collection and processing is very important and requires special attention.
    MeSH term(s) Allergy and Immunology ; Biomarkers/metabolism ; Bodily Secretions/chemistry ; Bodily Secretions/metabolism ; Conjunctivitis, Allergic/diagnosis ; Humans ; Immunoglobulin E/metabolism ; Nasal Mucosa/metabolism ; Rhinitis, Allergic/diagnosis ; Specimen Handling/methods ; Tears/chemistry ; Tears/metabolism
    Chemical Substances Biomarkers ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2018-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000412
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  6. Article ; Online: Molecular allergology and its impact in specific allergy diagnosis and therapy.

    Barber, Domingo / Diaz-Perales, Araceli / Escribese, Maria M / Kleine-Tebbe, Jörg / Matricardi, Paolo M / Ollert, Markus / Santos, Alexandra F / Sastre, Joaquin

    Allergy

    2021  Volume 76, Issue 12, Page(s) 3642–3658

    Abstract: Progressive knowledge of allergenic structures resulted in a broad availability of allergenic molecules for diagnosis. Component-resolved diagnosis allowed a better understanding of patient sensitization patterns, facilitating allergen immunotherapy ... ...

    Abstract Progressive knowledge of allergenic structures resulted in a broad availability of allergenic molecules for diagnosis. Component-resolved diagnosis allowed a better understanding of patient sensitization patterns, facilitating allergen immunotherapy decisions. In parallel to the discovery of allergenic molecules, there was a progressive development of a regulation framework that affected both in vitro diagnostics and Allergen Immunotherapy products. With a progressive understanding of underlying mechanisms associated to Allergen immunotherapy and an increasing experience of application of molecular diagnosis in daily life, we focus in analyzing the evidences of the value provided by molecular allergology in daily clinical practice, with a focus on Allergen Immunotherapy decisions.
    MeSH term(s) Allergens ; Desensitization, Immunologic/methods ; Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/therapy ; Immunoglobulin E
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2021-06-22
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14969
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  7. Article ; Online: Allergy Work-Up Including Component-Resolved Diagnosis: How to Make Allergen-Specific Immunotherapy More Specific.

    Kleine-Tebbe, Jörg / Matricardi, Paolo M / Hamilton, Robert G

    Immunology and allergy clinics of North America

    2016  Volume 36, Issue 1, Page(s) 191–203

    Abstract: Symptoms are recorded by obtaining a clinical history. Allergen sensitization is demonstrated by skin prick test or allergen-specific IgE serology. IgE sensitizations to allergen sources can be identified knowing the relationship between major ... ...

    Abstract Symptoms are recorded by obtaining a clinical history. Allergen sensitization is demonstrated by skin prick test or allergen-specific IgE serology. IgE sensitizations to allergen sources can be identified knowing the relationship between major aeroallergens and homologous allergen families. Some develop allergic sensitization to pan-allergens. Allergen extracts do not allow definitive separation of the sources. IgE antibody analysis of the major allergenic molecules facilitates differentiation of sensitizing allergen sources. IgE sensitizations to inhalant allergens are only relevant in the case of corresponding symptoms. In questionable cases, conjunctival or nasal provocation tests help induce confirmatory symptoms and identify relevant allergens for immunotherapy.
    MeSH term(s) Allergens/immunology ; Animals ; Desensitization, Immunologic ; Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/immunology ; Hypersensitivity/therapy ; Immunoglobulin E/metabolism ; Molecular Targeted Therapy ; Pollen/immunology ; Profilins/immunology
    Chemical Substances Allergens ; Profilins ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2015.08.012
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  8. Article ; Online: Toward a definition of asthma phenotypes in childhood: making a long way shorter?

    Wahn, Ulrich / Matricardi, Paolo M

    The Journal of allergy and clinical immunology

    2012  Volume 130, Issue 1, Page(s) 111–112

    MeSH term(s) Asthma/physiopathology ; Female ; Humans ; Hypersensitivity, Immediate/physiopathology ; Male ; Respiratory Sounds/physiopathology ; Severity of Illness Index
    Language English
    Publishing date 2012-07
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2012.05.025
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  9. Article ; Online: Molecular reactivity profiling upon immunotherapy with a 300 IR sublingual house dust mite tablet reveals marked humoral changes towards major allergens.

    Potapova, Ekaterina / Bordas-Le Floch, Véronique / Schlederer, Thomas / Vrtala, Susanne / Huang, Huey-Jy / Canonica, Giorgio W / Valenta, Rudolf / Matricardi, Paolo M / Mascarell, Laurent

    Allergy

    2022  Volume 77, Issue 10, Page(s) 3084–3095

    Abstract: Background: Molecular antibody reactivity profiles have not yet been studied in depth in patients treated by sublingual house dust mite (HDM) tablet immunotherapy. Humoral immune responses to a large panel of HDM mite allergens were studied using ... ...

    Abstract Background: Molecular antibody reactivity profiles have not yet been studied in depth in patients treated by sublingual house dust mite (HDM) tablet immunotherapy. Humoral immune responses to a large panel of HDM mite allergens were studied using allergen microarray technology in a subset of clinically defined high and low responder patients from a double-blind placebo-controlled allergen-specific immunotherapy (AIT) trial using sublingual 300 IR HDM tablets.
    Methods: Serum levels of IgE, IgG and IgG
    Results: Der p 1, Der p 2 and Der p 23 were the most frequently recognized allergens in the study population. Patients with HDM-related asthma had significantly higher allergen-specific IgE levels to Der p 1 and Der p 23. No significant difference in the distribution of allergen sensitization pattern was observed between high and low responders. An increase in serum allergen-specific IgG and IgG
    Conclusions: We confirm for our study population that Der p 1- and Der p 23-specific IgE levels are associated with asthma. IgE reactivity profiles were not predicitive of sublingual AIT outcomes, with 300 IR tablets as efficacious in pauci- and multi-sensitized subjects. Our study is the first to demonstrate the induction of IgG and IgG
    MeSH term(s) Allergens ; Animals ; Antigens, Dermatophagoides ; Asthma/therapy ; Humans ; Immunoglobulin E ; Immunoglobulin G ; Immunologic Factors ; Pyridinolcarbamate ; Pyroglyphidae ; Sublingual Immunotherapy ; Tablets
    Chemical Substances Allergens ; Antigens, Dermatophagoides ; Immunoglobulin G ; Immunologic Factors ; Tablets ; Immunoglobulin E (37341-29-0) ; Pyridinolcarbamate (81R511UV73)
    Language English
    Publishing date 2022-05-09
    Publishing country Denmark
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15327
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  10. Article: The role of early infections, hygiene and intestinal microflora.

    Matricardi, Paolo M

    Pediatric pulmonology. Supplement

    2004  Volume 26, Page(s) 211–212

    MeSH term(s) Asthma/immunology ; Hepatitis A/immunology ; Humans ; Hygiene ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology ; Th1 Cells/immunology ; Th2 Cells/immunology
    Language English
    Publishing date 2004-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645120-2
    ISSN 1054-187X
    ISSN 1054-187X
    DOI 10.1002/ppul.70108
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