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Article: [THE RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND GUT MICROBIOTA].

Matsubara, Atsushi / Nomura, Ayami / Yamaguchi, Time

2022 Volume 71, Issue 3, Page(s) 191–194

MeSH term(s)	Gastrointestinal Microbiome ; Humans ; Rhinitis, Allergic
Language	Japanese
Publishing date	2022-05-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	974201-3
ISSN	0021-4884
ISSN	0021-4884
DOI	10.15036/arerugi.71.191
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Article ; Online: Effect of gut microbial composition and diversity on major inhaled allergen sensitization and onset of allergic rhinitis.

Yamaguchi, Taimu / Nomura, Ayami / Matsubara, Atsushi / Hisada, Takayoshi / Tamada, Yoshinori / Mikami, Tatsuya / Ishida, Mizuri

Allergology international : official journal of the Japanese Society of Allergology

2022 Volume 72, Issue 1, Page(s) 135–142

Abstract: Background: Decreased gut microbiota diversity is associated with gut dysbiosis and causes various diseases, including allergic diseases. We investigated the relationship between gut microbial diversity and sensitization to major inhaled allergens. ... ...

Abstract	Background: Decreased gut microbiota diversity is associated with gut dysbiosis and causes various diseases, including allergic diseases. We investigated the relationship between gut microbial diversity and sensitization to major inhaled allergens. Furthermore, the relationship of allergic symptom onset with bacterial composition in sensitized individuals was investigated. Methods: This study included 1092 local residents who had participated in the Iwaki Health Promotion Project in 2016. Blood samples were analyzed to ascertain specific IgE levels against major inhaled allergens (JCP, HD1, Grass-mix, Weed-mix). Nasal symptoms were estimated by questionnaires. Fecal samples were analyzed for bacterial 16S rRNA using next generation sequencing. The diversity index (α-diversity, β-diversity) and the composition of gut microbes in phylum/order levels were compared between patients sensitized or unsensitized to allergen, and symptomatic and asymptomatic groups. Results: Some α-diversity metrics were significantly decreased in patients who were sensitized to any/all four allergens compared with the unsensitized group. β-diversity differed significantly between those unsensitized and sensitized to all allergens (aged 20-49 years), and between those unsensitized and sensitized to any/all four allergens (aged ≥50 years). The relative abundance of Bacteroidales was significantly lower in the unsensitized than in the sensitized group. The composition and diversity of gut microbiota were similar between the symptomatic and asymptomatic groups. Conclusions: Our results suggest that lack of diversity in gut microbiota has an effect on sensitization to allergens. Bacteroidales in order level may affect sensitization; however, the onset of allergy symptoms was not significantly associated with bacterial composition and diversity.
MeSH term(s)	Humans ; Allergens ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S/genetics ; Rhinitis, Allergic/epidemiology
Chemical Substances	Allergens ; RNA, Ribosomal, 16S
Language	English
Publishing date	2022-07-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1336498-4
ISSN	1440-1592 ; 1323-8930
ISSN (online)	1440-1592
ISSN	1323-8930
DOI	10.1016/j.alit.2022.06.005
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Article: Major basic protein deposited at intra mucosal epithelium with probable eosinophilic chronic rhinosinusitis.

Suzuki, Satoshi / Kudo, Naomi / Matsushita, Daisuke / Hara, Ryutaro / Miura, Tomoya / Matsubara, Atsushi

Asia Pacific allergy

2022 Volume 12, Issue 3, Page(s) e28

Abstract: Background: Eosinophilic chronic rhinosinusitis (ECRS) is diagnosed by Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) scoring system and histopathological eosinophil counts of dissected nasal polyps. Patients ... ...

Abstract	Background: Eosinophilic chronic rhinosinusitis (ECRS) is diagnosed by Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) scoring system and histopathological eosinophil counts of dissected nasal polyps. Patients with low JESREC score and small number of tissue eosinophils are diagnosed with non-ECRS (NECRS). Due to the 2 parameters of this diagnostic system, chronic rhinosinusitis is to be divided to 4 groups and some patients fall into the 2 groups other than ECRS and NECRS: probable ECRS (pECRS) and probable non-ECRS (pNECRS). We attempted to clarify clinical and histopathological similarities and differences, especially concerning major basic protein (MBP), among those groups. Methods: One hundred twenty-eight patients treated by endoscopic sinus surgery was included. Clinical characteristics were compared among each group, and immunohistological analysis for MBP was performed to 35 randomly selected patients. MBP deposition at intra mucosal epithelium was evaluated by semiquantificational approach. Results: ECRS patients showed significantly higher comorbidity rate with allergic rhinitis (36 patients, 78.3%), asthma (36 patients, 78.3%) compared with other groups. Also, percentage of the patients complaining olfactory dysfunction (42 patients, 91.3%) was significantly higher ( Conclusion: pECRS might share some characteristics with ECRS although tissue eosinophil count was significantly smaller compared with ECRS. The results of this study have shown that MBP score in pECRS nasal polyps was significantly higher than NECRS patients and close to ECRS. That might suggest that eosinophils have existed in the nasal polyps of pPECRS patients at some point before surgery.
Language	English
Publishing date	2022-07-18
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2614800-6
ISSN	2233-8268 ; 2233-8276
ISSN (online)	2233-8268
ISSN	2233-8276
DOI	10.5415/apallergy.2022.12.e28
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Article: [Topical treatment for eosinophilic otitis media].

Matsubara, Atsushi

Arerugi = [Allergy

2010 Volume 59, Issue 11, Page(s) 1519–1524

MeSH term(s)	Eosinophilia/drug therapy ; Heparin/therapeutic use ; Humans ; Otitis Media/drug therapy ; Steroids/therapeutic use
Chemical Substances	Steroids ; Heparin (9005-49-6)
Language	Japanese
Publishing date	2010-11
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	974201-3
ISSN	0021-4884
ISSN	0021-4884
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Article ; Online: Clostridium paraputrificum Bacteremia in a Patient with Rectal Cancer after Receiving Antibiotic Therapy for Acute Pharyngolaryngitis.

Maeda, Yasunori / Miura, Ryo / Echizenya, Takuma / Hoshi, Kentaro / Kubo, Norihito / Nakai, Hajime / Matsumoto, Kazuhito / Ikejima, Shin / Kudo, Naomi / Matsubara, Atsushi

Internal medicine (Tokyo, Japan)

2023

Abstract: Clostridium paraputrificum bacteremia is very rare, and its clinical importance is poorly understood. An 86-year-old man was receiving lascufloxacin therapy for acute pharyngolaryngitis before presenting to our emergency department with a recurrent fever. ...

Abstract	Clostridium paraputrificum bacteremia is very rare, and its clinical importance is poorly understood. An 86-year-old man was receiving lascufloxacin therapy for acute pharyngolaryngitis before presenting to our emergency department with a recurrent fever. Two sets of blood cultures on admission revealed C. paraputrificum. A stool culture showed a reduced presence of intestinal commensal bacteria. After admission, the patient's fever resolved without antibiotics. Colonoscopy revealed a rectal tumor. Rectal tumor and microbial substitutions caused by antibiotics may have led to bacteremia. When treating C. paraputrificum bacteremia, physicians should be mindful of coexisting gastrointestinal disorders and a history of antibiotic administration.
Language	English
Publishing date	2023-10-27
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2192-23
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Article ; Online: Prevalence of perilymphatic fistula in patients with sudden-onset sensorineural hearing loss as diagnosed by Cochlin-tomoprotein (CTP) biomarker detection: its association with age, hearing severity, and treatment outcomes.

Sasaki, Akira / Ikezono, Tetsuo / Matsuda, Han / Araki, Ryuichiro / Matsumura, Tomohiro / Saitoh, Shiho / Wasano, Koichiro / Matsubara, Atsushi

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2023 Volume 281, Issue 5, Page(s) 2373–2381

Abstract: Purpose: To determine the prevalence of perilymphatic fistula (PLF) in sudden-onset sensorineural hearing loss (SSNHL) patients by employing the Cochlin-tomoprotein (CTP) detection test, a specific diagnostic marker for perilymph. We also analyzed the ... ...

Abstract	Purpose: To determine the prevalence of perilymphatic fistula (PLF) in sudden-onset sensorineural hearing loss (SSNHL) patients by employing the Cochlin-tomoprotein (CTP) detection test, a specific diagnostic marker for perilymph. We also analyzed the clinical characteristics associated with hearing outcomes in this cohort. Methods: A total of 74 eligible patients were prospectively enrolled. Following myringotomy, middle ear lavage (MEL) samples underwent the CTP test to identify perilymph leakage. Intratympanic dexamethasone (IT-DEX) therapy was administered, and hearing outcomes were assessed. Control groups comprised patients with chronic otitis media (n = 40) and non-inflammatory middle ears (n = 51) with concurrent MEL sample collection. Results: CTP was positive in 16 (22%) patients. No control samples showed positive results. Multiple regression analysis indicated that age and pre-treatment hearing levels significantly contributed to the CTP value. We found a positive correlation between CTP values, age, and pre-treatment pure-tone averages. Notably, CTP values in SSNHL cases aged 60 and above were significantly higher than in those below 60 years. Patients with positive CTP had significantly worse recovery rates after IT-DEX treatment. Conclusion: This study is the first prospective investigation demonstrating a positive relationship between CTP values, age, and hearing severity in SSNHL, indicating that PLF might be the essential cause of SSNHL, particularly in the elderly. Our findings suggest that IT-DEX may be less effective for PLF-associated SSNHL. Future research could reveal that PLF repair surgery is a viable treatment strategy for SSNHL. This study was registered under the UMIN Clinical Trials Registry (UMIN000010837) on 30/May/2013.
MeSH term(s)	Aged ; Humans ; Prevalence ; Prospective Studies ; Vestibular Diseases/diagnosis ; Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sensorineural/epidemiology ; Hearing Loss, Sensorineural/etiology ; Hearing Loss, Sudden/diagnosis ; Hearing Loss, Sudden/epidemiology ; Hearing Loss, Sudden/etiology ; Treatment Outcome ; Hearing ; Fistula/surgery ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-12-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-023-08368-0
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Article: CD11c(+) dendritic cells coexpressing thymic stromal lymphopoietin receptor in animal model of eosinophilic otitis media.

Hara, Ryutaro / Kudo, Naomi / Suzuki, Satoshi / Miura, Tomoya / Matsubara, Atsushi

Asia Pacific allergy

2020 Volume 10, Issue 4, Page(s) e41

Abstract: Background: Eosinophilic otitis media (EOM) is an intractable middle ear disease often associated with eosinophilic inflammatory airway conditions. Recently, dendritic cells (DCs) have been indicated as an essential component of Th2 allergic ... ...

Abstract	Background: Eosinophilic otitis media (EOM) is an intractable middle ear disease often associated with eosinophilic inflammatory airway conditions. Recently, dendritic cells (DCs) have been indicated as an essential component of Th2 allergic inflammation, such as bronchial asthma. DCs are activated by thymic stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine. However, the relationship between TSLP and DCs in EOM remains unknown. Objective: This study aimed to investigate the relationship between DCs and TSLP and to determine the involvement of DCs in EOM in an animal model. Methods: Hartley guinea pigs were used as the animal model. Daily ovalbumin (OVA) stimulation of the middle ear was performed for 7 or 14 days. The temporal bone was dissected on the last day of stimulation, and paraffin-embedded sections were prepared. Immunostaining and immunofluorostaining for TSLP receptor (TSLPR) and CD11c, a surface marker of DCs, were performed. Results: We found CD11c-immunopositive cells in the submucosal area of the middle ear epithelium, particularly around the eustachian tube. TSLPR-immunopositive cells exhibited a similar distribution as CD11c-positive cells. Conclusion: CD11c positive DCs coexpressing TSLPR were recruited after OVA challenge which might activate Th2 allergic reaction.
Language	English
Publishing date	2020-10-26
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2614800-6
ISSN	2233-8268 ; 2233-8276
ISSN (online)	2233-8268
ISSN	2233-8276
DOI	10.5415/apallergy.2020.10.e41
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Article ; Online: Survey of nebulizer therapy for nasal inflammatory diseases in Japan before and during the COVID-19 pandemic.

Hyo, Yukiyoshi / Fujieda, Shigeharu / Matsubara, Atsushi / Takeuchi, Kazuhiko / Ohki, Motofumi / Shimizu, Takeshi / Kurono, Yuichi

Auris, nasus, larynx

2021 Volume 49, Issue 3, Page(s) 504–510

Abstract: Objective: Nebulizer therapy is an effective and safe topical treatment for rhinosinusitis and is frequently used by otolaryngologists in Japan. However, treatment methods used vary among regions and according to doctors' preferences. In this study, we ... ...

Abstract	Objective: Nebulizer therapy is an effective and safe topical treatment for rhinosinusitis and is frequently used by otolaryngologists in Japan. However, treatment methods used vary among regions and according to doctors' preferences. In this study, we aimed to investigate the use of nebulizer therapy for rhinosinusitis. Administration of nebulizer therapy has been affected by the coronavirus disease 2019 (COVID-19) pandemic. Thus, we also investigated the difference in the prevalence of nebulizer use before and during the pandemic. Methods: Between February and September 2016 and in January 2021, we administered questionnaire surveys on nebulizer treatment for rhinosinusitis to otorhinolaryngologists, who were members of the Oto-Rhino-Laryngological Society of Japan, in Aomori, Saitama, Mie, Fukui, Shiga, Okayama, and Kagoshima prefectures. Results: More than 90% of the otorhinolaryngologists performed nebulizer treatment for rhinosinusitis in 2016. In April 2020 (the first wave of the COVID-19 pandemic), the use rate decreased to 20%, but in January 2021, the use rate increased to 60%. Jet nebulizers were the most frequently used type. One-third of the otolaryngologists enlarged the natural opening of the paranasal sinuses in more than half of their patients by using vasoconstrictors. Cefmenoxime and betamethasone were the most commonly used antibiotics and steroids, respectively. Conclusion: Because it is important to perform nasal pretreatment and strict disinfection of nebulizer equipment, it is clear that education of otorhinolaryngologists as well as paramedical personnel is required to ensure safe and effective use of nebulizer therapy in Japan.
MeSH term(s)	COVID-19 ; Humans ; Japan/epidemiology ; Nebulizers and Vaporizers ; Pandemics ; Sinusitis/drug therapy ; Surveys and Questionnaires
Language	English
Publishing date	2021-11-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604552-2
ISSN	1879-1476 ; 0385-8146
ISSN (online)	1879-1476
ISSN	0385-8146
DOI	10.1016/j.anl.2021.11.007
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Article ; Online: Brain Computer Interface Using Modulation of Auditory Steady-State Response with Help of Stochastic Resonance

Nishifuji, Seiji / Nakamura, Hirotaka / Matsubara, Atsushi

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2018 Volume 2018, Page(s) 2028–2031

Abstract: This paper proposes an eye-movement independent brain computer interface based on the modulations of auditory steady-state response (ASSR-BCI) to amplitude-modulated (AM) tones elicited by paying selective attention to one of the two AM tones. Moreover, ... ...

Abstract	This paper proposes an eye-movement independent brain computer interface based on the modulations of auditory steady-state response (ASSR-BCI) to amplitude-modulated (AM) tones elicited by paying selective attention to one of the two AM tones. Moreover, the proposed ASSR-BCI exploits a stochastic resonance effect to improve the signal separation and attained the mean classification accuracy of 77 % across nine normal subjects under a noise-added condition with sound pressures 60 dB for the two tones and 30 dB for the noise added to the two AM tones. Results from information transfer rate and its inter-individual difference suggest that it may be adequate to set an inter-trial interval at 2∽3 s for a trial time length. It is consequently feasible to develop a practical eye-movement-independent BCI available in eyes-closed state by optimizing the parameters such as the trial time length and electrode sites each user.
MeSH term(s)	Acoustic Stimulation ; Adult ; Attention ; Auditory Perception ; Brain-Computer Interfaces ; Electroencephalography ; Evoked Potentials, Auditory ; Humans ; Male ; Sound ; Young Adult
Language	English
Publishing date	2018-09-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2018.8512686
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Article: [Diagnosis of and therapy for eosinophilic otitis media and paranasal sinusitis--preservation therapy for eosinophilic otitis media according to the classification].

Matsubara, Atsushi

Nihon Jibiinkoka Gakkai kaiho

2007 Volume 110, Issue 3, Page(s) 91–94

MeSH term(s)	Administration, Oral ; Anti-Allergic Agents/administration & dosage ; Betamethasone/administration & dosage ; Betamethasone/analogs & derivatives ; Drug Therapy, Combination ; Eosinophilia/classification ; Eosinophilia/drug therapy ; Glucocorticoids/administration & dosage ; Heparin/administration & dosage ; Histamine H1 Antagonists, Non-Sedating/administration & dosage ; Humans ; Injections ; Otitis Media/classification ; Otitis Media/drug therapy ; Triamcinolone/administration & dosage
Chemical Substances	Anti-Allergic Agents ; Glucocorticoids ; Histamine H1 Antagonists, Non-Sedating ; Triamcinolone (1ZK20VI6TY) ; betamethasone sodium phosphate (7BK02SCL3W) ; Heparin (9005-49-6) ; Betamethasone (9842X06Q6M)
Language	Japanese
Publishing date	2007-05-01
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	968067-6
ISSN	0030-6622
ISSN	0030-6622
DOI	10.3950/jibiinkoka.110.91
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