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  1. Article ; Online: Neutron dose from a 6-MV X-ray beam in radiotherapy.

    Matsubara, Hiroaki

    Radiological physics and technology

    2023  Volume 16, Issue 2, Page(s) 186–194

    Abstract: Although a 6-MV X-ray beam is employed clinically as a non-neutron-producing beam, no studies have reported how few neutrons are produced from a 6-MV beam. This study aimed to theoretically deduce the neutron dose from a 6-MV beam using Monte Carlo ... ...

    Abstract Although a 6-MV X-ray beam is employed clinically as a non-neutron-producing beam, no studies have reported how few neutrons are produced from a 6-MV beam. This study aimed to theoretically deduce the neutron dose from a 6-MV beam using Monte Carlo simulations for the notification of safety and risk in radiotherapy. Nuclei from a nuclear database with neutron separation energies below 6 MeV were surveyed, suggesting that the certain content of
    MeSH term(s) Humans ; X-Rays ; Radiography ; Radiotherapy, Intensity-Modulated ; Neutrons ; Databases, Factual ; Monte Carlo Method ; Radiotherapy Dosage
    Language English
    Publishing date 2023-02-13
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2433581-2
    ISSN 1865-0341 ; 1865-0333
    ISSN (online) 1865-0341
    ISSN 1865-0333
    DOI 10.1007/s12194-023-00705-6
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  2. Article ; Online: Celebrating 20 years of "Esophagus".

    Matsubara, Hisahiro

    Esophagus : official journal of the Japan Esophageal Society

    2023  Volume 20, Issue 2, Page(s) 183

    Language English
    Publishing date 2023-03-07
    Publishing country Japan
    Document type Editorial
    ZDB-ID 2133367-1
    ISSN 1612-9067 ; 1612-9059
    ISSN (online) 1612-9067
    ISSN 1612-9059
    DOI 10.1007/s10388-023-00990-5
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  3. Article ; Online: Comment on "Particle therapy using protons or carbon ions for cancer patients with cardiac implantable electronic devices (CIED): a retrospective multi-institutional study".

    Matsubara, Hiroaki

    Japanese journal of radiology

    2022  Volume 40, Issue 5, Page(s) 542–543

    MeSH term(s) Carbon/therapeutic use ; Electronics ; Humans ; Neoplasms/radiotherapy ; Protons ; Retrospective Studies
    Chemical Substances Protons ; Carbon (7440-44-0)
    Language English
    Publishing date 2022-01-13
    Publishing country Japan
    Document type Letter ; Multicenter Study ; Comment
    ZDB-ID 2488907-6
    ISSN 1867-108X ; 1867-1071
    ISSN (online) 1867-108X
    ISSN 1867-1071
    DOI 10.1007/s11604-021-01234-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2249: Show issues Location:
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  4. Article ; Online: A message from the new editor-in-chief.

    Matsubara, Hisahiro

    Esophagus : official journal of the Japan Esophageal Society

    2020  Volume 17, Issue 3, Page(s) 215

    MeSH term(s) Esophageal Diseases/epidemiology ; Esophageal Diseases/therapy ; History, 21st Century ; Humans ; Japan ; Journalism, Medical/standards ; Male ; Publishing/standards ; Societies, Scientific/organization & administration
    Language English
    Publishing date 2020-06-16
    Publishing country Japan
    Document type Autobiography ; Editorial ; Historical Article ; Portrait
    ZDB-ID 2133367-1
    ISSN 1612-9067 ; 1612-9059
    ISSN (online) 1612-9067
    ISSN 1612-9059
    DOI 10.1007/s10388-020-00755-4
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  5. Article ; Online: Advances in the surgical treatment of esophageal cancer since 1965.

    Matsubara, Hisahiro

    Annals of gastroenterological surgery

    2020  Volume 4, Issue 3, Page(s) 243–249

    Abstract: In Japan, the treatment of esophageal cancer has undergone significant development since the Japanese Society for Esophageal Diseases was established in 1965 by Doctors Komei Nakayama, Shigetsugu Katsura, and Ichiro Akakura. When the Society was ... ...

    Abstract In Japan, the treatment of esophageal cancer has undergone significant development since the Japanese Society for Esophageal Diseases was established in 1965 by Doctors Komei Nakayama, Shigetsugu Katsura, and Ichiro Akakura. When the Society was established, surgery was the first-line treatment for esophageal cancer. Since then, the Society has been led by three successive chairpersons-Doctors Katsura, Nakayama, and Satoh. Over this time, surgery-related mortalities declined to 5%-6% because of the rapid improvements in surgical technique. Beginning in 1980, the bilateral cervical lymph node dissection technique gained attention, and favorable long-term outcomes were gradually reported. A nationwide questionnaire survey, conducted by the Society in 1990, showed that more favorable long-term outcomes were achieved by following the three-field lymph node dissection technique than by following the two-field lymph node dissection technique. Since then, the three-field lymph node dissection technique has been recognized and widely used as the standard surgical procedure for treating esophageal cancer. After clinical studies examined the utility of various pre- and postoperative adjunctive therapies in outcome improvements, preoperative chemotherapy was recognized as the standard treatment in the therapy guidelines. Additionally, less invasive surgical methods have been developed, including endoscopic and robot-assisted surgeries, which are applied in general practice now. However, unresectable and recurrent esophageal cancers remain difficult to treat, and additional treatments should be developed.
    Language English
    Publishing date 2020-04-14
    Publishing country Japan
    Document type Journal Article ; Review
    ISSN 2475-0328
    ISSN (online) 2475-0328
    DOI 10.1002/ags3.12332
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  6. Article ; Online: Effect of the Interfacial Tension on the Stability of Silica Stabilized Pickering Emulsions near the Lower Critical Solution Temperature of 2,6-Lutidine - Water Mixtures.

    Matsubara, Hiroki / Doi, Junya

    Journal of oleo science

    2023  Volume 72, Issue 12, Page(s) 1091–1095

    Abstract: In this paper, the kinetic stability of Pickering emulsions stabilized by spherical silica particles (100 nm in diameter) was examined in the water - 2,6-lutidine mixture. In the close vicinity of the lower critical solution temperature, Pickering ... ...

    Abstract In this paper, the kinetic stability of Pickering emulsions stabilized by spherical silica particles (100 nm in diameter) was examined in the water - 2,6-lutidine mixture. In the close vicinity of the lower critical solution temperature, Pickering emulsions were unstable due to the ultra-low liquid-liquid interfacial tension but increased their stability with increasing the temperature. In this system, the interfacial tension obeys universal scale law and can be tuned by temperature without adding any surface-active agents. Owing to this unique feature, we elucidated the relation between the interfacial tension and the stability of Pickering emulsions.
    MeSH term(s) Emulsions ; Surface Tension ; Temperature ; Water ; Silicon Dioxide ; Particle Size
    Chemical Substances Emulsions ; Water (059QF0KO0R) ; Silicon Dioxide (7631-86-9) ; 2,6-lutidine (15FQ5D0T3P)
    Language English
    Publishing date 2023-11-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2218264-0
    ISSN 1347-3352 ; 1345-8957
    ISSN (online) 1347-3352
    ISSN 1345-8957
    DOI 10.5650/jos.ess23119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Demulsification of Silica Stabilized Pickering Emulsions Using Surface Freezing Transition of CTAC Adsorbed Films at the Tetradecane-Water Interface.

    Shishida, Kazuki / Matsubara, Hiroki

    Journal of oleo science

    2023  Volume 72, Issue 12, Page(s) 1083–1089

    Abstract: The adsorbed film of cetyltrimethylammonium chloride (CTAC) at the tetradecane (C14) - water interface undergoes a first-order surface transition from two-dimensional liquid to solid states upon cooling. In this paper, we utilized this surface freezing ... ...

    Abstract The adsorbed film of cetyltrimethylammonium chloride (CTAC) at the tetradecane (C14) - water interface undergoes a first-order surface transition from two-dimensional liquid to solid states upon cooling. In this paper, we utilized this surface freezing transition to realize a spontaneous demulsification of Pickering emulsions stabilized by silica particles. In the temperature range above the surface freezing transition, the interfacial tension of silica laden oil-water interface was lower than CTAC adsorbed film, hence, stable Pickering emulsion was obtained by vortex mixing. However, the interfacial tension of CTAC adsorbed film decreased rapidly below the surface freezing temperature and became lower than the silica laden interface. The reversal of the interfacial tensions between silica laden and CTAC adsorbed films gave rise to Pickering emulsion demulsification by the desorption of silica particles from the oil-water interface. The exchange of silica particles and CTAC at the surface of emulsion droplets was also confirmed experimentally by using phase modulation ellipsometry at the oil-water interface.
    MeSH term(s) Emulsions ; Silicon Dioxide ; Cetrimonium ; Water ; Freezing
    Chemical Substances Emulsions ; Silicon Dioxide (7631-86-9) ; n-tetradecane (03LY784Y58) ; Cetrimonium (Z7FF1XKL7A) ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-11-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2218264-0
    ISSN 1347-3352 ; 1345-8957
    ISSN (online) 1347-3352
    ISSN 1345-8957
    DOI 10.5650/jos.ess23102
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  8. Article ; Online: Intersubunit communication in glycogen phosphorylase influences substrate recognition at the catalytic sites.

    Kamada, Nahori / Ikeda, Ayato / Makino, Yasushi / Matsubara, Hiroshi

    Amino acids

    2024  Volume 56, Issue 1, Page(s) 14

    Abstract: Glycogen phosphorylase (GP) is biologically active as a dimer of identical subunits, each activated by phosphorylation of the serine-14 residue. GP exists in three interconvertible forms, namely GPa (di-phosphorylated form), GPab (mono-phosphorylated ... ...

    Abstract Glycogen phosphorylase (GP) is biologically active as a dimer of identical subunits, each activated by phosphorylation of the serine-14 residue. GP exists in three interconvertible forms, namely GPa (di-phosphorylated form), GPab (mono-phosphorylated form), and GPb (non-phosphorylated form); however, information on GPab remains scarce. Given the prevailing view that the two GP subunits collaboratively determine their catalytic characteristics, it is essential to conduct GPab characterization to gain a comprehensive understanding of glycogenolysis regulation. Thus, in the present study, we prepared rabbit muscle GPab from GPb, using phosphorylase kinase as the catalyst, and identified it using a nonradioactive phosphate-affinity gel electrophoresis method. Compared with the half-half GPa/GPb mixture, the as-prepared GPab showed a unique AMP-binding affinity. To further investigate the intersubunit communication in GP, its catalytic site was probed using pyridylaminated-maltohexaose (a maltooligosaccharide-based substrate comprising the essential dextrin structure for GP; abbreviated as PA-0) and a series of specifically modified PA-0 derivatives (substrate analogs lacking part of the essential dextrin structure). By comparing the initial reaction rates toward the PA-0 derivative (V
    MeSH term(s) Animals ; Rabbits ; Catalytic Domain ; Dextrins ; Glycogen Phosphorylase/metabolism ; Muscles/metabolism ; Communication
    Chemical Substances Dextrins ; Glycogen Phosphorylase (EC 2.4.1.-)
    Language English
    Publishing date 2024-02-10
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 1121341-3
    ISSN 1438-2199 ; 0939-4451
    ISSN (online) 1438-2199
    ISSN 0939-4451
    DOI 10.1007/s00726-023-03362-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3490: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Essential dextrin structure as donor substrate for 4-α-glucanotransferase in glycogen debranching enzyme.

    Uno, Rentaro / Makino, Yasushi / Matsubara, Hiroshi

    Journal of biochemistry

    2024  

    Abstract: Glycogen debranching enzyme is a single polypeptide with distinct catalytic sites for 4-α-glucanotransferase and amylo-α-1,6-glucosidase. To allow phosphorylase to degrade the inner tiers of highly branched glycogen, 4-α-glucanotransferase converts the ... ...

    Abstract Glycogen debranching enzyme is a single polypeptide with distinct catalytic sites for 4-α-glucanotransferase and amylo-α-1,6-glucosidase. To allow phosphorylase to degrade the inner tiers of highly branched glycogen, 4-α-glucanotransferase converts the phosphorylase-limit biantennary branch G-G-G-G-(G-G-G-G↔)G-G- (G: D-glucose, hyphens: α-1,4-linkages; double-headed arrow: α-1,6-linkage) into the G-G-G-G-(G↔)G-G- residue, which is then subjected to amylo-α-1,6-glucosidase to release the remaining G↔ residue. However, while the essential side-chain structure of the 4-α-glucanotransferase donor substrate has been determined to be the G-G-G-G↔ residue (Watanabe, Y., et al. (2008) J. Biochem.  143, 435-440), its essential main-chain structure remains to be investigated. In this study, we probed the 4-α-glucanotransferase donor-binding region using novel fluorogenic dextrins Gm-(G4↔)G-Gn-F (F: 1-deoxy-1-[(2-pyridyl)amino]-D-glucitol) and maltohexaose (G6) as the donor and acceptor substrates, respectively. 4-α-Glucanotransferase exhibited maximum activity toward G4-(G4↔)G-F and G4-(G4↔)G-G-F, indicating that recognition of the G4-(G4↔)G- moiety was essential for full enzyme function. Notably, when the 4-α-glucanotransferase activity toward G4-(G4↔)G-G-F was taken as unity, those toward nonbranching dextrins were <0.001. This indicated that the disproportionation activities toward maltooligosaccharides (Gm) are abnormal behaviors of 4-α-glucanotransferase. Notably, however, these activities have been traditionally measured to identify the 4-α-glucanotransferase mutations causing glycogen storage disease type III. This study provides a basis for more accurate identification.
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 218073-x
    ISSN 1756-2651 ; 0021-924X
    ISSN (online) 1756-2651
    ISSN 0021-924X
    DOI 10.1093/jb/mvae030
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    Uc I Zs.202: Show issues Location:
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  10. Article: Stabilisation of weathered limestone surfaces using microbially enhanced calcium carbonate deposition

    Matsubara, Hitoshi

    Engineering geology. 2021 Apr., v. 284

    2021  

    Abstract: Surface weathering of limestone may result in rock embrittlement via internal or surficial mineral alterations, potentially triggering serious rock falls, slope failure, etc. Traditional stabilisation techniques have relied on physical approaches such as ...

    Abstract Surface weathering of limestone may result in rock embrittlement via internal or surficial mineral alterations, potentially triggering serious rock falls, slope failure, etc. Traditional stabilisation techniques have relied on physical approaches such as anchoring and retaining walls, though these can require maintenance and even restoration as their effects are not permanent, requiring the development of novel ground-restoration techniques with self-organising restoration functions and environmentally-friendly properties. For example, bio-mediated calcium carbonates may be useful as a bio-protection material for weathered rocks. In this study, the author used field observations and laboratory experiments to assess a weathered limestone outcrop near the Giza cliff in Okinawa, Japan, found to be widely covered by such material, and examined the feasibility of bio-protection technology based on photoautotrophic microorganisms. In the presence of water, calcium carbonate grew around biofilms and other fibrous materials and on limestone particles; the relevant microorganisms were more active in terms of their growth in water with ~100 ppm of calcium ion concentration than at higher concentrations. The Giza site had naturally optimal environmental conditions for these processes, suggesting that bio-protection techniques based on photoautotrophic microorganisms would be useful for protecting weathering limestone surfaces where surface and/or spring water is present.
    Keywords Ryukyu Archipelago ; biofilm ; calcium ; calcium carbonate ; limestone
    Language English
    Dates of publication 2021-04
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ISSN 0013-7952
    DOI 10.1016/j.enggeo.2021.106044
    Database NAL-Catalogue (AGRICOLA)

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