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Article ; Online: Risk factors and outcomes of abnormal bleeding after external cephalic version.

Matsui, Hitoshi / Ogawa, Kohei / Okamoto, Aikou / Sago, Haruhiko

2021 Volume 49, Issue 6, Page(s) 733–739

Abstract: Objectives: To present the consequences of and risk factors for abnormal bleeding after ECV (external cephalic version).: Methods: We conducted a retrospective chart review at a single center in Japan. Abnormal bleeding was defined as vaginal ... ...

Abstract	Objectives: To present the consequences of and risk factors for abnormal bleeding after ECV (external cephalic version). Methods: We conducted a retrospective chart review at a single center in Japan. Abnormal bleeding was defined as vaginal bleeding and/or intrauterine hemorrhage. We descriptively assessed birth outcomes among women with abnormal bleeding, and investigated the risk factors using a logistic regression analysis. Results: Of 477 women who received ECV, 39 (8.2%) showed abnormal bleeding, including 16 (3.4%) with intrauterine hemorrhage. Of the 16 women with intrauterine hemorrhage, 14 required emergency cesarean section; none experienced placental abruption, a low Apgar score at 5 min (<7), or low umbilical cord artery pH (<7.1). Among 23 women who had vaginal bleeding without intrauterine hemorrhage, four cases underwent emergency cesarean section and one case of vaginal delivery involved placental abruption. The risk of abnormal bleeding was higher in women with a maximum vertical pocket (MVP) of <40 mm in comparison to those with an MVP of >50 mm (adjusted odds ratio [OR]: 3.48, 95% confidence interval [CI]: 1.23-9.90), as was higher in women with unsuccessful ECV than in those with successful ECV (aOR: 4.54, 95% CI: 1.95-10.6). Conclusions: A certain number of women who underwent ECV had abnormal bleeding, including vaginal bleeding and/or intrauterine hemorrhage, many of them resulted in emergency cesarean section. Although all of cases with abnormal bleeding had good birth outcomes, one case of vaginal bleeding was accompanied by placental abruption. Small amniotic fluid volume and unsuccessful ECV are risk factors for abnormal bleeding.
MeSH term(s)	Abruptio Placentae/epidemiology ; Abruptio Placentae/etiology ; Abruptio Placentae/therapy ; Adult ; Apgar Score ; Cesarean Section/methods ; Emergency Medical Services/methods ; Emergency Medical Services/statistics & numerical data ; Female ; Humans ; Japan ; Oligohydramnios/diagnosis ; Oligohydramnios/epidemiology ; Pregnancy ; Pregnancy Outcome/epidemiology ; Risk Assessment/methods ; Risk Factors ; Uterine Hemorrhage/diagnosis ; Uterine Hemorrhage/epidemiology ; Uterine Hemorrhage/etiology ; Uterine Hemorrhage/therapy ; Version, Fetal/adverse effects ; Version, Fetal/methods ; Version, Fetal/statistics & numerical data
Language	English
Publishing date	2021-03-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123512-6
ISSN	1619-3997 ; 0300-5577 ; 0936-174X
ISSN (online)	1619-3997
ISSN	0300-5577 ; 0936-174X
DOI	10.1515/jpm-2020-0453
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Article ; Online: Enhanced atmospheric oxidation toward carbon neutrality reduces methane's climate forcing.

Liu, Mingxu / Song, Yu / Matsui, Hitoshi / Shang, Fang / Kang, Ling / Cai, Xuhui / Zhang, Hongsheng / Zhu, Tong

Nature communications

2024 Volume 15, Issue 1, Page(s) 3148

Abstract: The hydroxyl radical (OH), as the central atmospheric oxidant, controls the removal rates of methane, a powerful greenhouse gas. It is being suggested that OH levels would decrease with reductions of nitrogen oxides and ozone levels by climate polices, ... ...

Abstract	The hydroxyl radical (OH), as the central atmospheric oxidant, controls the removal rates of methane, a powerful greenhouse gas. It is being suggested that OH levels would decrease with reductions of nitrogen oxides and ozone levels by climate polices, but this remains unsettled. Here, we show that driven by the carbon neutrality pledge, the global-mean OH concentration, derived from multiple chemistry-climate model simulations, is projected to be significantly increasing with a trend of 0.071‒0.16% per year during 2015-2100. The leading cause of this OH enhancement is dramatic decreases in carbon monoxide and methane concentrations, which together reduce OH sinks. The OH increase shortens methane's lifetime by 0.19‒1.1 years across models and subsequently diminishes methane's radiative forcing. If following a largely unmitigated scenario, the global OH exhibits a significant decrease that would exacerbate methane's radiative forcing. Thus, we highlight that targeted emission abatement strategies for sustained oxidation capacity can benefit climate change mitigation in the Anthropocene.
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47436-9
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Book ; Online: Morphological features and water solubility of iron in aged fine aerosol particles over the Indian Ocean

Ueda, Sayako / Iwamoto, Yoko / Taketani, Fumikazu / Liu, Mingxu / Matsui, Hitoshi

eISSN:

2023

Abstract: Atmospheric transport of iron (Fe) in fine anthropogenic aerosol particles is an important route of soluble Fe supply from continental areas to remote oceans. To elucidate Fe properties of aerosol particles over remote oceans, we collected atmospheric ... ...

Abstract	Atmospheric transport of iron (Fe) in fine anthropogenic aerosol particles is an important route of soluble Fe supply from continental areas to remote oceans. To elucidate Fe properties of aerosol particles over remote oceans, we collected atmospheric aerosol particles over the Indian Ocean during the RV Hakuho Maru KH-18-6 cruise. After aerosol particles were collected using a cascade impactor, particles of 0.3–0.9 µ m aerodynamic diameter on the sample stage were analyzed using transmission electron microscopy (TEM) with an energy-dispersive X-ray spectrometry analyzer. The particle shape and composition indicated that most particles collected north of the Equator were composed mainly of ammonium sulfate. Regarding the particle number fraction, 0.6 %–3.0 % of particles contained Fe, which mostly co-existed with sulfate. Of those particles, 26 % of Fe occurred as metal spheres, often co-existing with Al or Si, regarded as fly ash; 14 % as mineral dust; and 7 % as iron oxide aggregates. Water dialysis analyses of TEM samples indicated Fe in spherical fly ash as being almost entirely insoluble and Fe in other morphological-type particles as being partly soluble (65 % Fe mass on average). Global model simulations mostly reproduced observed Fe mass concentrations in particulate matter with a diameter of less than 2.5 µm (PM 2.5 ) collected using a high-volume air sampler, including their north–south contrast during the cruise. In contrast, a marked difference was found between the simulated mass fractions of Fe mineral sources and the observed Fe types. For instance, the model underestimated anthropogenic aluminosilicate (illite and kaolinite) Fe contained in matter such as fly ash from coal combustion. Our observations revealed multiple shapes and compositions of Fe minerals in particles over remote ocean areas and further suggested that their solubilities after aging processes differ depending on their morphological and mineral types. Proper consideration of such Fe types at their sources is necessary for ...
Subject code	551
Language	English
Publishing date	2023-09-11
Publishing country	de
Document type	Book ; Online
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Book ; Online: Morphological features and water solubility of iron in aged fine aerosol particles over the Indian Ocean

Ueda, Sayako / Iwamoto, Yoko / Taketani, Fumikazu / Liu, Mingxu / Matsui, Hitoshi

eISSN: 1680-7324

2023

Abstract	Atmospheric transport of iron (Fe) in fine anthropogenic aerosol particles is an important route of soluble Fe supply from continental areas to remote oceans. To elucidate Fe properties of aerosol particles over remote oceans, we collected atmospheric aerosol particles over the Indian Ocean during the RV Hakuho Maru KH-18-6 cruise. After aerosol particles were collected using a cascade impactor, particles of 0.3–0.9 µ m aerodynamic diameter on the sample stage were analyzed using transmission electron microscopy (TEM) with an energy-dispersive X-ray spectrometry analyzer. The particle shape and composition indicated that most particles collected north of the Equator were composed mainly of ammonium sulfate. Regarding the particle number fraction, 0.6 %–3.0 % of particles contained Fe, which mostly co-existed with sulfate. Of those particles, 26 % of Fe occurred as metal spheres, often co-existing with Al or Si, regarded as fly ash; 14 % as mineral dust; and 7 % as iron oxide aggregates. Water dialysis analyses of TEM samples indicated Fe in spherical fly ash as being almost entirely insoluble and Fe in other morphological-type particles as being partly soluble (65 % Fe mass on average). Global model simulations mostly reproduced observed Fe mass concentrations in particulate matter with a diameter of less than 2.5 µm (PM 2.5 ) collected using a high-volume air sampler, including their north–south contrast during the cruise. In contrast, a marked difference was found between the simulated mass fractions of Fe mineral sources and the observed Fe types. For instance, the model underestimated anthropogenic aluminosilicate (illite and kaolinite) Fe contained in matter such as fly ash from coal combustion. Our observations revealed multiple shapes and compositions of Fe minerals in particles over remote ocean areas and further suggested that their solubilities after aging processes differ depending on their morphological and mineral types. Proper consideration of such Fe types at their sources is necessary for ...
Subject code	551
Language	English
Publishing date	2023-09-11
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: The positive radiative forcing by the substantial SO2 emission reductions is counteracted by decreased BC concentrations in China over the recent decade

Liu, Mingxu / Matsui, Hitoshi

eISSN: 1680-7324

2020

Abstract: Anthropogenic emissions in China play an important role in altering global radiation budget. Over the recent decade, the clean-air options in China result in substantial reductions in anthropogenic emissions, especially sulfur dioxide (SO 2 ), and ... ...

Abstract	Anthropogenic emissions in China play an important role in altering global radiation budget. Over the recent decade, the clean-air options in China result in substantial reductions in anthropogenic emissions, especially sulfur dioxide (SO 2 ), and improved air quality. However, the associated changes in aerosol climate effects are poorly understood. In this study, we use an advanced global climate model integrated with latest anthropogenic emission inventory to estimate the changes in the aerosol radiative forcings by the emission variation in China between 2008 and 2016. First, our simulations exhibit decreases of 46 % and 25 % for the annual mean surface-level sulfate and black carbon (BC) mass concentrations in East China, respectively, which is the key region subject to stringent emission control options. The decreasing tendency of aerosol optical depth and aerosol absorption optical depth retrieved by satellites is also captured by the model for the period. We find that the resultant net radiative forcing by the changes in the BC and SO 2 emissions is −0.04 W m −2 in East China. The substantial reductions in SO 2 emissions diminish the scattering effects of sulfate and lead to an overall change of +0.17 W m −2 for the annual mean all-sky shortwave aerosol direct radiative forcing at the top of the atmosphere and +0.13 W m −2 for aerosol-induced cloud radiative forcing. In the meantime, the reduction in BC emissions induces a negative BC radiative forcing of −0.34 W m −2 . By accounting for the joint effect of BC and SO 2 emissions, our results demonstrate that the positive radiative forcing by the SO 2 emission reductions is counteracted by the decrease of BC in China over the recent decade. While the local radiative forcing is small due to the counteracted effects of SO 2 and BC emissions, it is relatively larger (+0.16 W m −2 ) over the north Pacific remote regions for this period, primarily contributed by the reductions in sulfate particles and their effects on cloud properties. With a comprehensive future emission scenario for 2030 and 2050 developed by the recent study, we predict that the strictest environmental policies will induce the change of aerosol radiative forcings of +0.55 and +1.23 W m −2 over East China between 2016–2030 and 2016–2050, respectively. Targeted emission control policies are desirable to improve air quality and mitigate climate change in the future.
Subject code	333
Language	English
Publishing date	2020-07-13
Publishing country	de
Document type	Book ; Online
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Article ; Online: Black carbon radiative effects highly sensitive to emitted particle size when resolving mixing-state diversity.

Matsui, Hitoshi / Hamilton, Douglas S / Mahowald, Natalie M

Nature communications

2018 Volume 9, Issue 1, Page(s) 3446

Abstract: Post-industrial increases in atmospheric black carbon (BC) have a large but uncertain warming contribution to Earth's climate. Particle size and mixing state determine the solar absorption efficiency of BC and also strongly influence how effectively BC ... ...

Abstract	Post-industrial increases in atmospheric black carbon (BC) have a large but uncertain warming contribution to Earth's climate. Particle size and mixing state determine the solar absorption efficiency of BC and also strongly influence how effectively BC is removed, but they have large uncertainties. Here we use a multiple-mixing-state global aerosol microphysics model and show that the sensitivity (range) of present-day BC direct radiative effect, due to current uncertainties in emission size distributions, is amplified 5-7 times (0.18-0.42 W m
Language	English
Publishing date	2018-08-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-018-05635-1
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Article ; Online: A pregnant woman with thymoma-associated pure red cell aplasia.

Shibata, Megumi / Kaneko, Kayoko / Umehara, Nagayoshi / Matsui, Hitoshi / Kawai, Toshinao / Nakadate, Hisaya / Murashimia, Atsuko / Sago, Haruhiko

BMC pregnancy and childbirth

2022 Volume 22, Issue 1, Page(s) 795

Abstract: Background: Pure red cell aplasia (PRCA) is a hematological disorder characterized by anemia with severe reticulocytopenia caused by a marked reduction in erythroid precursors in the bone marrow. PRCA is known to be associated with pregnancy, but ... ...

Abstract	Background: Pure red cell aplasia (PRCA) is a hematological disorder characterized by anemia with severe reticulocytopenia caused by a marked reduction in erythroid precursors in the bone marrow. PRCA is known to be associated with pregnancy, but thymoma-associated PRCA during pregnancy is very rare, and its successful management has not been reported. Case presentation: A 37-year-old primiparous woman with severe anemia was referred to our center at 27 weeks' gestation. She was diagnosed with PRCA based on bone aspiration findings at 33 weeks' gestation. Magnetic resonance imaging (MRI) revealed an anterior mediastinal mass 4 cm in size suspected of being thymoma. She was therefore diagnosed with thymoma-associated PRCA during pregnancy. Surgery for thymoma was planned after delivery, since the imaging findings were suggestive of early-stage thymoma (Masaoka stage I or II). With transfusion of a total 3,360 ml of red blood cells (RBCs) during pregnancy, the patient gave birth to a baby girl weighing 2,548 g at 40 weeks' gestation. The baby showed transient congenital cutaneous candidiasis. The placental pathology revealed subamniotic inflammation with a fungal structure. Treatment with topical anti-fungal cream immediately ameliorated the baby's skin lesion. Maternal anemia did not improve after delivery; however, the thymoma did not increase in size. At five months after delivery, the mother underwent thymectomy with oral cyclosporine A. A pathological examination revealed Masaoka stage II-a thymoma. She completely had recovered from anemia at six months after surgery. Cyclosporine A treatment was discontinued three years after surgery. Remission has been sustained for four years since surgery. Conclusions: A very rare case of thymoma-associated PRCA during pregnancy was diagnosed without any subjective symptoms and was expectantly managed, resulting in a good prognosis. Although bone marrow aspiration during pregnancy is an invasive test, it is important to confirm the diagnosis. Conservative management with blood transfusion was possible for early-stage thymoma-associated PRCA during pregnancy. Active surveys, including MRI, for PRCA during pregnancy led to the detection of thymoma at an early stage and the achievement of a preferable pregnancy outcome.
MeSH term(s)	Female ; Humans ; Pregnancy ; Infant, Newborn ; Adult ; Thymoma/complications ; Thymoma/diagnostic imaging ; Thymoma/surgery ; Cyclosporine ; Pregnant Women ; Placenta/pathology ; Thymus Neoplasms/complications ; Thymus Neoplasms/diagnosis ; Thymus Neoplasms/surgery ; Red-Cell Aplasia, Pure/complications ; Red-Cell Aplasia, Pure/pathology
Chemical Substances	Cyclosporine (83HN0GTJ6D)
Language	English
Publishing date	2022-10-27
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-022-05145-5
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Article ; Online: Constraining the atmospheric limb of the plastic cycle.

Brahney, Janice / Mahowald, Natalie / Prank, Marje / Cornwell, Gavin / Klimont, Zbigniew / Matsui, Hitoshi / Prather, Kimberly Ann

Proceedings of the National Academy of Sciences of the United States of America

2021 Volume 118, Issue 16

Abstract: Plastic pollution is one of the most pressing environmental and social issues of the 21st century. Recent work has highlighted the atmosphere's role in transporting microplastics to remote locations [S. Allen et al., ...

Abstract	Plastic pollution is one of the most pressing environmental and social issues of the 21st century. Recent work has highlighted the atmosphere's role in transporting microplastics to remote locations [S. Allen et al.,
MeSH term(s)	Atmosphere/analysis ; Atmosphere/chemistry ; Dust ; Environmental Monitoring/methods ; Environmental Pollution/analysis ; Microplastics/adverse effects ; Microplastics/chemistry ; Particulate Matter/analysis ; Plastics/analysis ; Plastics/chemistry ; Polymers ; Soil
Chemical Substances	Dust ; Microplastics ; Particulate Matter ; Plastics ; Polymers ; Soil
Language	English
Publishing date	2021-03-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2020719118
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Zs.A 1148: Show issues

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Article ; Online: Allergen Stability and Immunological Reactivity during Co-dissolution and Incubation of House Dust Mite and Japanese Cedar Pollen SLIT-Tablets.

Watanabe, Akiko / Yamamoto, Takashi / Matsuhara, Hiroki / Matsui, Hitoshi / Nakazawa, Hiroshi / Lund, Kaare / Ohashi-Doi, Katsuyo

Biological & pharmaceutical bulletin

2020 Volume 43, Issue 10, Page(s) 1448–1450

Abstract: Japanese allergic subjects are commonly sensitized to both house dust mite (HDM) and Japanese cedar pollen (JCP) and combined treatment with sublingual immunotherapy (SLIT) tablets is desirable. However, mixing extracts of two non-homologous allergens ... ...

Abstract	Japanese allergic subjects are commonly sensitized to both house dust mite (HDM) and Japanese cedar pollen (JCP) and combined treatment with sublingual immunotherapy (SLIT) tablets is desirable. However, mixing extracts of two non-homologous allergens may compromise allergen stability and affect the clinical outcome. Therefore, we investigated the stability of major allergens and total allergenic reactivity of HDM and JCP SLIT-tablets following dissolution in human saliva or artificial gastric juice. Two fast-dissolving freeze-dried SLIT-tablets were completely dissolved and incubated at 37 °C. Major allergen concentrations and total allergenic reactivity were measured. After mixing and co-incubation of HDM and JCP SLIT tablets in human saliva for 10 min at 37°C, there were no statistically significant changes in major allergen concentrations. In addition, no loss of allergenic reactivity of the mixed two SLIT-tablet solutions was seen. In contrast, complete loss of allergenic reactivity and detectable major allergen concentrations occurred when the two SLIT-tablets were dissolved and incubated in artificial gastric juice. These results demonstrate that HDM or JCP major allergens and the total allergenic reactivity of both SLIT-tablets measured here remain intact after dissolution and co-incubation in human saliva, supporting the possibility of a dual HDM and JCP SLIT-tablet administration regimen if clinically indicated. The complete loss of allergenic reactivity after incubation in artificial gastric juice can furthermore be taken to indicate that the immunological activity of the allergen extracts contained in the two SLIT-tablets is likely to be lost or severely compromised upon swallowing.
MeSH term(s)	Administration, Sublingual ; Allergens/administration & dosage ; Allergens/chemistry ; Allergens/pharmacokinetics ; Antigens, Dermatophagoides/administration & dosage ; Antigens, Dermatophagoides/chemistry ; Cryptomeria/immunology ; Drug Compounding/methods ; Drug Liberation ; Drug Stability ; Humans ; Japan ; Mouth Mucosa/chemistry ; Mouth Mucosa/metabolism ; Oral Mucosal Absorption ; Pollen/immunology ; Rhinitis, Allergic/etiology ; Rhinitis, Allergic/therapy ; Saliva/chemistry ; Sublingual Immunotherapy/methods ; Tablets ; Treatment Outcome
Chemical Substances	Allergens ; Antigens, Dermatophagoides ; Tablets
Language	English
Publishing date	2020-08-04
Publishing country	Japan
Document type	Letter
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b20-00330
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Zs.A 1474: Show issues

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Article ; Online: Co-localization of TRPV2 and insulin-like growth factor-I receptor in olfactory neurons in adult and fetal mouse.

Matsui, Hitoshi / Noguchi, Tomohiro / Takakusaki, Kaoru / Kashiwayanagi, Makoto

Biological & pharmaceutical bulletin

2014 Volume 37, Issue 12, Page(s) 1907–1912

Abstract: TRPV2, a member of the transient receptor potential family, has been isolated as a capsaicin-receptor homolog and is thought to respond to noxious heat. Here we show that TRPV2 mRNA is predominantly expressed in the subpopulation of olfactory sensory ... ...

Abstract	TRPV2, a member of the transient receptor potential family, has been isolated as a capsaicin-receptor homolog and is thought to respond to noxious heat. Here we show that TRPV2 mRNA is predominantly expressed in the subpopulation of olfactory sensory neurons (OSNs). We carried out histochemical analyses of TRPV2 and insulin-like growth factor-I receptor (IGF-IR) using in situ hybridization and immunofluorescence in the adult olfactory system. In olfactory mucosa, intensive TRPV2 immunostaining was observed at the olfactory axon bundles but not at the soma. TRPV2-positive labeling was preferentially found in the olfactory nerve layer in the olfactory bulb (OB). Furthermore, we demonstrated that a positive signal for IGF-IR mRNA was detected in OSNs expressing TRPV2 mRNA. In embryonic stages, TRPV2 immunoreactivity was observed on axon bundles of developing OSNs in the nasal region starting from 12.5 d of gestation and through fetal development. Observations in this study suggest that TRPV2 coupled with IGF-IR localizes to growing olfactory axons in the OSNs.
MeSH term(s)	Animals ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Fetus/metabolism ; Gene Expression Regulation, Developmental/physiology ; Insulin-Like Growth Factor I/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism ; Olfactory Bulb/cytology ; Protein Transport ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptor, IGF Type 1/genetics ; Receptor, IGF Type 1/metabolism ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism
Chemical Substances	Calcium Channels ; RNA, Messenger ; TRPV Cation Channels ; Trpv2 protein, mouse ; Insulin-Like Growth Factor I (67763-96-6) ; Receptor, IGF Type 1 (EC 2.7.10.1)
Language	English
Publishing date	2014-10-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b14-00413
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