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Article ; Online: Crystalline-SiO

Matsui, Yohei / Wakabayashi, Nobuyuki

ACS omega

2022 Volume 7, Issue 23, Page(s) 19591–19599

Abstract: Frequent load changes or daily shut down and restarting have been imposed on thermal power plants in many areas to fill the gap between the demand for electric power and the variable outputs from renewable energy sources. These operations result in ... ...

Abstract	Frequent load changes or daily shut down and restarting have been imposed on thermal power plants in many areas to fill the gap between the demand for electric power and the variable outputs from renewable energy sources. These operations result in temperature changes in boiler furnaces, and the temperature changes may induce cracks in problematic coal ash deposits, which would contribute to their spontaneous shedding from heat-transfer surfaces. In this work, we microscopically investigated the origin of temperature-change-induced cracks in ash deposits. Analyses of the coal ash clinker generated in a utility boiler indicated that many cracks were generated close to the crystalline SiO
Language	English
Publishing date	2022-05-27
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c01296
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Article ; Online: Methylomarinovum tepidoasis

Hirayama, Hisako / Takaki, Yoshihiro / Abe, Mariko / Miyazaki, Masayuki / Uematsu, Katsuyuki / Matsui, Yohei / Takai, Ken

International journal of systematic and evolutionary microbiology

2024 Volume 74, Issue 3

Abstract: A novel aerobic methanotrophic bacterium, designated as strain ... ...

Abstract	A novel aerobic methanotrophic bacterium, designated as strain IN45
MeSH term(s)	Fatty Acids/chemistry ; Nitrates/metabolism ; RNA, Ribosomal, 16S/genetics ; DNA, Bacterial/genetics ; Sequence Analysis, DNA ; Base Composition ; Phylogeny ; Bacterial Typing Techniques ; Phospholipids/chemistry
Chemical Substances	Fatty Acids ; Nitrates ; RNA, Ribosomal, 16S ; DNA, Bacterial ; Phospholipids
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.006288
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Zs.A 409: Show issues

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Article ; Online: Electrochemical cell recharging by solvent separation and transfer processes.

Matsui, Yohei / Kawase, Makoto / Suzuki, Takahiro / Tsushima, Shohji

Scientific reports

2022 Volume 12, Issue 1, Page(s) 3739

Abstract: Electrochemical conversion and storage of unutilized renewable energy will contribute to decarbonization. Here, we create the concept of a liquid electrochemical cell that discharges between the anodic and cathodic sides by reverse reactions of the same ... ...

Abstract	Electrochemical conversion and storage of unutilized renewable energy will contribute to decarbonization. Here, we create the concept of a liquid electrochemical cell that discharges between the anodic and cathodic sides by reverse reactions of the same redox couple in different solvation states, which are created by differences in the mixture ratios of two solvents called the main solvent (MS) and the transferred solvent (TS). The cell can be charged by a transfer of the TS between the discharged anolyte and catholyte. As an example, we demonstrate a cell utilizing a ferro-/ferricyanide redox couple. Stable discharging and charging via the proposed method is achieved by utilizing water (MS) and acetone (TS). Additionally, dominating factors in the design of a high-performance system are discussed, focusing on the electron acceptability of the MS and the TS. The cell voltages are successfully tuned, and a cell voltage of 0.63 V is achieved by the combination of dimethyl sulfoxide (MS) and water (TS). Moreover, the cell can be customized by various electrochemical reaction systems, which can allow multiple options for the charging processes. This concept provides new approaches for the utilization of diverse energy sources as an input for the charging of electrochemical cells.
MeSH term(s)	Dimethyl Sulfoxide ; Electrodes ; Oxidation-Reduction ; Solvents ; Water
Chemical Substances	Solvents ; Water (059QF0KO0R) ; Dimethyl Sulfoxide (YOW8V9698H)
Language	English
Publishing date	2022-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-07573-x
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Article ; Online: Extreme accumulation of ammonia on electroreduced mackinawite: An abiotic ammonia storage mechanism in early ocean hydrothermal systems.

Takahagi, Wataru / Okada, Satoshi / Matsui, Yohei / Ono, Shigeaki / Takai, Ken / Takahashi, Yoshio / Kitadai, Norio

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 41, Page(s) e2303302120

Abstract: An increasing amount of evidence suggests that early ocean hydrothermal systems were sustained sources of ammonia, an essential nitrogen species for prebiotic synthesis of life's building blocks. However, it remains a riddle how the abiotically generated ...

Abstract	An increasing amount of evidence suggests that early ocean hydrothermal systems were sustained sources of ammonia, an essential nitrogen species for prebiotic synthesis of life's building blocks. However, it remains a riddle how the abiotically generated ammonia was retained at the vent-ocean interface for the subsequent chemical evolution. Here, we demonstrate that, under simulated geoelectrochemical conditions in early ocean hydrothermal systems ([Formula: see text][Formula: see text] V versus the standard hydrogen electrode), mackinawite gradually reduces to zero-valent iron ([Formula: see text]), generating interlayer [Formula: see text] sites. This reductive conversion leads to an up to 55-fold increase in the solid/liquid partition coefficient for ammonia, enabling over 90% adsorption of 1 mM ammonia in 1 M NaCl at neutral pH. A coordinative binding of ammonia on the interlayer [Formula: see text] sites was computed to be the major mechanism of selective ammonia adsorption. Mackinawite is a ubiquitous sulfide precipitate in submarine hydrothermal systems. Given its reported catalytic function in amination, the extreme accumulation of ammonia on electroreduced mackinawite should have been a crucial initial step for prebiotic nitrogen assimilation, paving the way to the origin of life.
Language	English
Publishing date	2023-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2303302120
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Zs.A 1148: Show issues

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Article: Redox conditions and nitrogen cycling during the Triassic-Jurassic transition: A new perspective from the mid-Panthalassa

Fujisaki, Wataru / Fukami, Yusuke / Matsui, Yohei / Sato, Tomoki / Sawaki, Yusuke / Suzuki, Katsuhiko

Earth-science reviews. 2020 May, v. 204

2020

Abstract: We determined redox-sensitive element concentrations along with δ15NTN values from the Triassic-Jurassic shales interbedded within deep-sea cherts at the Katsuyama section, SW Japan, to clarify the redox and related nitrogen cycle conditions in mid- ... ...

Abstract	We determined redox-sensitive element concentrations along with δ15NTN values from the Triassic-Jurassic shales interbedded within deep-sea cherts at the Katsuyama section, SW Japan, to clarify the redox and related nitrogen cycle conditions in mid-Panthalassa during the TJB biotic crisis, focusing particularly on the linkages with CAMP volcanism. Slight enrichments of Mn and Mo across the TJB suggest a vertically expanded mid-Panthalassic OMZ above a well‐oxygenated deep ocean. Moreover, high-resolution δ15NTN records during the Triassic-Jurassic transition exhibit a negative nitrogen isotope excursion (NNIE) just above the TJB. Relative to the previously reported negative carbon isotope excursion (NCIE) across the TJB, the NNIE can be divided into two intervals: negative interval 1 (NI-1) during the NCIE and NI-2 after the NCIE. The NNIE can be explained as an interval of nitrate-rich conditions, reflecting an oxic Panthalassic Ocean during the Triassic-Jurassic transition. Our geochemical dataset provides new insights into environmental perturbations in mid-Panthalassia during the TJB biotic crisis: (1) a vertically expanded OMZ and decreased primary productivity owing to global warming caused by CAMP volcanism across the TJB resulted in an increased nitrate concentration during the NI-1, and (2) eutrophic, nitrate-rich conditions developed in mid-Panthalassa during the NI-2 due to the enhanced continental weathering and deep-water upwelling. Significantly, our results are the first to demonstrate that the OMZs were expanded not only in the shallow-marine regions, but also in pelagic sites across the TJB, suggesting that the globally expanded OMZs can be regarded as a crucial driver for the TJB biotic crisis.
Keywords	carbon ; data collection ; eutrophication ; global warming ; isotopes ; manganese ; molybdenum ; nitrates ; nitrogen ; nitrogen cycle ; primary productivity ; volcanic activity ; weathering ; Japan
Language	English
Dates of publication	2020-05
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1792-9
ISSN	0012-8252
ISSN	0012-8252
DOI	10.1016/j.earscirev.2020.103173
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Article: Advanced G-CSF-producing non-small cell lung cancer-not otherwise specified, with favourable response to pembrolizumab monotherapy.

Matsui, Yohei / Yamada, Tadaaki / Masuzawa, Naoko / Hamada, Shinshichi / Takayama, Koichi / Hiranuma, Osamu

Respirology case reports

2020 Volume 8, Issue 7, Page(s) e00625

Abstract: Advanced granulocyte colony-stimulating factor (G-CSF)-producing lung tumours are generally refractory to platinum-based chemotherapy and are associated with poor prognosis. However, therapeutic strategies for these tumours remain unknown. A 74-year-old ... ...

Abstract	Advanced granulocyte colony-stimulating factor (G-CSF)-producing lung tumours are generally refractory to platinum-based chemotherapy and are associated with poor prognosis. However, therapeutic strategies for these tumours remain unknown. A 74-year-old man was diagnosed with non-small cell lung cancer-not otherwise specified (NSCLC-NOS); the clinical stage was T4N0M1c stage IVb. Blood testing showed leucocytosis and aberrant G-CSF expression. We chose single-agent pembrolizumab as the initial treatment because PD-L1 was highly expressed in the tumours. A clinically favourable response was achieved from seven courses of pembrolizumab with a total disease-free survival of 10 months. During this period, the blood leucocyte count was concordant with the disease condition. These observations showed that pembrolizumab monotherapy may be an effective treatment for patients with advanced G-CSF-producing NSCLC-NOS and that the monitoring of leucocyte count may be a useful biomarker for predicting the efficacy of pembrolizumab monotherapy.
Language	English
Publishing date	2020-07-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2750180-2
ISSN	2051-3380
ISSN	2051-3380
DOI	10.1002/rcr2.625
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Article ; Online: Significance of localized expression of full-length growth differentiation factor-15 in cachexia of advanced non-small cell lung cancer.

Morita-Tanaka, Satomi / Miyagawa-Hayashino, Aya / Yamada, Tadaaki / Matsui, Yohei / Morimoto, Kenji / Hiranuma, Osamu / Masuzawa, Naoko / Yoshimura, Akihiro / Iwasaku, Masahiro / Tokuda, Shinsaku / Kaneko, Yoshiko / Kim, Young Hak / Konishi, Eiichi / Takayama, Koichi

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2023 Volume 31, Issue 5, Page(s) 308

Abstract: Purpose: Growth differentiation factor-15 (GDF-15) is one of the key cachexia-inducing factors. Clinical trials on therapies targeting GDF-15 for cancer and cancer cachexia are underway. While the role of circulating GDF-15 in cachexia has been ... ...

Abstract	Purpose: Growth differentiation factor-15 (GDF-15) is one of the key cachexia-inducing factors. Clinical trials on therapies targeting GDF-15 for cancer and cancer cachexia are underway. While the role of circulating GDF-15 in cachexia has been clarified, the effects of GDF-15 expression within cancer cells remain to be fully elucidated. Hence, the objective of this study was to investigate the expression of GDF-15 in advanced lung cancer tissues and to understand its role in cachexia. Methods: We retrospectively examined the expression level of full-length GDF-15 in advanced non-small cell lung cancer tissues and analyzed the relationship between the staining intensity and clinical data in 53 samples. Results: We found that 52.8% of the total samples were GDF-15 positive, and GDF-15 expression significantly correlated with improved C-reactive protein/albumin ratio (p = 0.008). It did not correlate with the existence of cancer cachexia and overall survival (p = 0.43). Conclusion: Our findings show that GDF-15 expression significantly correlated with improved C-reactive protein/albumin ratio, but not the existence of cancer cachexia in advanced NSCLC patients.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/complications ; Lung Neoplasms/complications ; Cachexia/etiology ; Growth Differentiation Factor 15 ; C-Reactive Protein/metabolism ; Retrospective Studies
Chemical Substances	Growth Differentiation Factor 15 ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2023-04-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-023-07771-x
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Zs.A 3697: Show issues

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Article ; Online: Effects of Combined Therapeutic Targeting of AXL and ATR on Pleural Mesothelioma Cells.

Hirai, Soichi / Yamada, Tadaaki / Katayama, Yuki / Ishida, Masaki / Kawachi, Hayato / Matsui, Yohei / Nakamura, Ryota / Morimoto, Kenji / Horinaka, Mano / Sakai, Toshiyuki / Sekido, Yoshitaka / Tokuda, Shinsaku / Takayama, Koichi

Molecular cancer therapeutics

2023 Volume 23, Issue 2, Page(s) 212–222

Abstract: Few treatment options exist for pleural mesothelioma (PM), which is a progressive malignant tumor. However, the efficacy of molecular-targeted monotherapy is limited, and further therapeutic strategies are warranted to treat PM. Recently, the cancer cell- ...

Abstract	Few treatment options exist for pleural mesothelioma (PM), which is a progressive malignant tumor. However, the efficacy of molecular-targeted monotherapy is limited, and further therapeutic strategies are warranted to treat PM. Recently, the cancer cell-cycle checkpoint inhibitors have attracted attention because they disrupt cell-cycle regulation. Here, we aimed to establish a novel combinational therapeutic strategy to inhibit the cell-cycle checkpoint kinase, ATR in PM cells. The siRNA screening assay showed that anexelekto (AXL) knockdown enhanced cell growth inhibition when exposed to ATR inhibitors, demonstrating the synergistic effects of the ATR and AXL combination in some PM cells. The AXL and ATR inhibitor combination increased cell apoptosis via the Bim protein and suppressed cell migration when compared with each monotherapy. The combined therapeutic targeting of AXL and ATR significantly delayed regrowth compared with monotherapy. Thus, optimal AXL and ATR inhibition may potentially improve the PM outcome.
MeSH term(s)	Humans ; Receptor Protein-Tyrosine Kinases ; Mesothelioma, Malignant ; Mesothelioma/drug therapy ; Mesothelioma/genetics ; Mesothelioma/metabolism ; Cell Proliferation ; Pleural Neoplasms/drug therapy ; Pleural Neoplasms/pathology ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Cell Line, Tumor ; Ataxia Telangiectasia Mutated Proteins/metabolism
Chemical Substances	Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Protein Kinase Inhibitors ; ATR protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1)
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2063563-1
ISSN	1538-8514 ; 1535-7163
ISSN (online)	1538-8514
ISSN	1535-7163
DOI	10.1158/1535-7163.MCT-23-0138
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Zs.A 5750: Show issues

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Article ; Online: Late-onset Pleural and Pericardial Effusion as Immune-related Adverse Events after 94 Cycles of Nivolumab.

Sawada, Ryo / Matsui, Yohei / Uchino, Junji / Okura, Naoko / Morimoto, Yoshie / Iwasaku, Masahiro / Kaneko, Yoshiko / Yamada, Tadaaki / Takayama, Koichi

Internal medicine (Tokyo, Japan)

2021 Volume 60, Issue 22, Page(s) 3585–3588

Abstract: A 67-year-old man with primary lung adenocarcinoma was hospitalized due to massive bilateral pleural effusion and pericardial effusion after 94 cycles of nivolumab therapy. We were unable to identify the cause of these effusions using blood tests, ... ...

Abstract	A 67-year-old man with primary lung adenocarcinoma was hospitalized due to massive bilateral pleural effusion and pericardial effusion after 94 cycles of nivolumab therapy. We were unable to identify the cause of these effusions using blood tests, cytology tests, or bacterial culture of pleural effusion and thoracoscopy. Finally, we administrated corticosteroids, which immediately improved the fluid accumulation. This case may support the introduction of corticosteroids for late-onset pleural and pericardial effusion during immune checkpoint inhibitor (ICI) treatment. However, the safety of rechallenge of ICIs after the improvement of fluid accumulation is controversial.
MeSH term(s)	Aged ; Humans ; Lung Neoplasms/drug therapy ; Male ; Nivolumab/adverse effects ; Pericardial Effusion/chemically induced ; Pericardial Effusion/diagnosis ; Pleura ; Pleural Effusion/chemically induced ; Pleural Effusion/diagnosis
Chemical Substances	Nivolumab (31YO63LBSN)
Language	English
Publishing date	2021-06-05
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.7219-21
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Zs.A 240: Show issues

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Article ; Online: Pathogenicity of Mycolicibacterium phlei, a non-pathogenic nontuberculous mycobacterium in an immunocompetent host carrying anti-interferon gamma autoantibodies: a case report.

Tanaka, Satomi / Hoshino, Yoshihiko / Sakagami, Takuro / Fukano, Hanako / Matsui, Yohei / Hiranuma, Osamu

BMC infectious diseases

2019 Volume 19, Issue 1, Page(s) 454

Abstract: Background: Mycolicibacterium phlei (M. phlei) is known to be a non-pathogenic nontuberculous mycobacterium (NTM) which rarely causes diseases in humans. A disseminated NTM infection is mostly caused by the Mycobacterium avium complex (MAC) and is known ...

Abstract	Background: Mycolicibacterium phlei (M. phlei) is known to be a non-pathogenic nontuberculous mycobacterium (NTM) which rarely causes diseases in humans. A disseminated NTM infection is mostly caused by the Mycobacterium avium complex (MAC) and is known to develop in immunocompromised hosts, like those with acquired immune deficiency syndrome (AIDS). Here, we report a case of disseminated M. phlei infection in an immunocompetent host carrying anti-interferon gamma (IFN-γ) autoantibodies. Case presentation: We detected M. phlei in multiple organs of an elderly woman with no significant medical history except positivity for anti-IFN-γ autoantibodies. She tested negative for human immunodeficiency virus (HIV)-1, 2/ Human T-cell leukemia virus type 1 (HTLV-1) antibody. High-resolution computed tomography (HRCT) of the chest demonstrated a nodule in the left S1 + 2 segment, interlobular septal thickening, multi lymphadenopathy, and osteolysis. A maximum intensity projection image following fluorodeoxyglucose-positron emission tomography (FDG-PET) revealed multifocal hypermetabolic lesions in the nodule and all the swollen lymph nodes seen in HRCT. FDG also accumulated in multiple bones. Advanced primary lung cancer was suspected, and biopsies of each lesion were performed. The pathology revealed caseating granuloma, positive for acid-fast bacteria, and DNA sequencing of the acid-fast bacteria confirmed the organism to be M. phlei. The patient also tested positive for anti-IFN-γ autoantibodies. Based on these findings, she was diagnosed with disseminated M. phlei infection, with anti-IFN-γ autoantibodies. Conclusions: Though known to be non-pathogenic, we show that M. phlei can be pathogenic like the MAC in immunocompetent individuals carrying anti-IFN-γ autoantibodies.
MeSH term(s)	Aged ; Anti-Bacterial Agents/therapeutic use ; Autoantibodies ; Bone and Bones/diagnostic imaging ; Bone and Bones/pathology ; Female ; Granuloma/diagnostic imaging ; Granuloma/drug therapy ; Granuloma/microbiology ; Humans ; Immunocompetence ; Interferon-gamma/immunology ; Mycobacterium Infections, Nontuberculous/diagnostic imaging ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/immunology ; Mycobacterium Infections, Nontuberculous/microbiology ; Nontuberculous Mycobacteria/immunology ; Nontuberculous Mycobacteria/pathogenicity ; Positron-Emission Tomography/methods ; Tomography, X-Ray Computed/methods ; Virulence
Chemical Substances	Anti-Bacterial Agents ; Autoantibodies ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2019-05-22
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-019-4050-z
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