LIVIVO - Search results -

Search results

Result 1 - 10 of total 6563

Search options

Article ; Online: Recent Progress in Vacuum Engineering of Ionic Liquids.

Matsumoto, Yuji

2023 Volume 28, Issue 4

Abstract: Since the discovery of ionic liquids (ILs) as a new class of liquid that can survive in a vacuum at room temperature, they have been aimed at being characterized with vacuum analysis techniques and used in vacuum processes for the last two decades. In ... ...

Abstract	Since the discovery of ionic liquids (ILs) as a new class of liquid that can survive in a vacuum at room temperature, they have been aimed at being characterized with vacuum analysis techniques and used in vacuum processes for the last two decades. In this review, our state-of-the-art of the vacuum engineering of ILs will be introduced. Beginning with nanoscale vacuum deposition of IL films and their thickness-dependent ionic conductivity, there are presented some new applications of the ellipsometry to in situ monitoring of the thickness of IL films and their glass transitions, and of the surface thermal fluctuation spectroscopy to investigation of the rheological properties of IL films. Furthermore, IL-VLS (vapor-liquid-solid) growth, a vacuum deposition via IL, has been found successful, enhancing the crystallinity of vacuum-deposited crystals and films, and sometimes controlling their surface morphology and polymorphs. Among recent applications of ILs are the use of metal ions-containing IL and thin film nano IL gel. The former is proposed as a low temperature evaporation source of metals, such as Ta, in vacuum deposition, while the latter is demonstrated to work as a gate electrolyte in an electric double layer organic transistor.
MeSH term(s)	Ionic Liquids/chemistry ; Vacuum ; Spectrum Analysis ; Metals ; Gases
Chemical Substances	Ionic Liquids ; Metals ; Gases
Language	English
Publishing date	2023-02-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28041991
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.MO 81: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Development and Evolution of DNA-Dependent Protein Kinase Inhibitors toward Cancer Therapy.

Matsumoto, Yoshihisa

International journal of molecular sciences

2022 Volume 23, Issue 8

Abstract: DNA double-strand break (DSB) is considered the most deleterious type of DNA damage, which is generated by ionizing radiation (IR) and a subset of anticancer drugs. DNA-dependent protein kinase (DNA-PK), which is composed of a DNA-PK catalytic subunit ( ... ...

Abstract	DNA double-strand break (DSB) is considered the most deleterious type of DNA damage, which is generated by ionizing radiation (IR) and a subset of anticancer drugs. DNA-dependent protein kinase (DNA-PK), which is composed of a DNA-PK catalytic subunit (DNA-PKcs) and Ku80-Ku70 heterodimer, acts as the molecular sensor for DSB and plays a pivotal role in DSB repair through non-homologous end joining (NHEJ). Cells deficient for DNA-PKcs show hypersensitivity to IR and several DNA-damaging agents. Cellular sensitivity to IR and DNA-damaging agents can be augmented by the inhibition of DNA-PK. A number of small molecules that inhibit DNA-PK have been developed. Here, the development and evolution of inhibitors targeting DNA-PK for cancer therapy is reviewed. Significant parts of the inhibitors were developed based on the structural similarity of DNA-PK to phosphatidylinositol 3-kinases (PI3Ks) and PI3K-related kinases (PIKKs), including Ataxia-telangiectasia mutated (ATM). Some of DNA-PK inhibitors, e.g., NU7026 and NU7441, have been used extensively in the studies for cellular function of DNA-PK. Recently developed inhibitors, e.g., M3814 and AZD7648, are in clinical trials and on the way to be utilized in cancer therapy in combination with radiotherapy and chemotherapy.
MeSH term(s)	Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; DNA ; DNA Repair ; DNA-Activated Protein Kinase ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Pyridazines ; Quinazolines
Chemical Substances	Pyridazines ; Quinazolines ; DNA (9007-49-2) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; DNA-Activated Protein Kinase (EC 2.7.11.1) ; peposertib (GN429E725A)
Language	English
Publishing date	2022-04-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23084264
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A pictorial essay on radiological changes after stereotactic body radiation therapy for lung tumors.

Matsumoto, Yasuo

Japanese journal of radiology

2022 Volume 40, Issue 7, Page(s) 647–663

Abstract: Stereotactic body radiation therapy (SBRT) is a frequently used modality for the treatment of early stage non-small cell lung cancer and oligometastatic disease of the lung. The radiological changes observed in the lung after SBRT are likely to differ ... ...

Abstract	Stereotactic body radiation therapy (SBRT) is a frequently used modality for the treatment of early stage non-small cell lung cancer and oligometastatic disease of the lung. The radiological changes observed in the lung after SBRT are likely to differ from those observed after conventional thoracic radiation therapy, primarily due to the small size of the target volume and highly conformal dose distributions with steep dose gradients from the target to surrounding normal lung tissues used in SBRT. Knowledge of the radiological changes that can occur after SBRT is required to correctly diagnose local failure. Herein, I report several radiological changes specific to SBRT that have been observed.
MeSH term(s)	Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Lung Neoplasms/radiotherapy ; Radiosurgery
Language	English
Publishing date	2022-02-20
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2488907-6
ISSN	1867-108X ; 1867-1071
ISSN (online)	1867-108X
ISSN	1867-1071
DOI	10.1007/s11604-022-01252-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2249: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Direct visualization and measurement of the plantar aponeurosis behavior in foot arch deformation via the windlass mechanism.

Matsumoto, Yuka / Ogihara, Naomichi

Clinical anatomy (New York, N.Y.)

2024

Abstract: The plantar aponeurosis (PA) is an elastic longitudinal band that contributes to the generation of a propulsive force in the push-off phase during walking and running through the windlass mechanism. However, the dynamic behavior of the PA remains unclear ...

Abstract	The plantar aponeurosis (PA) is an elastic longitudinal band that contributes to the generation of a propulsive force in the push-off phase during walking and running through the windlass mechanism. However, the dynamic behavior of the PA remains unclear owing to the lack of direct measurement of the strain it generates. Therefore, this study aimed to visualize and quantify the PA behavior during two distinct foot postures: (i) neutral posture and (ii) windlass posture with midtarsal joint plantarflexion and metatarsophalangeal joint dorsiflexion, using computed tomography scans. Six healthy adult males participated in the experiment, and three-dimensional reconstruction of the PA was conducted to calculate its path length, width, thickness, and cross-sectional area. This study successfully visualized and quantified the morphological changes in the PA induced by the windlass mechanism, providing a precise reference for biomechanical modeling. This study also highlighted the interindividual variability in the PA morphology and stretching patterns. Although the windlass posture was not identical to that observed in the push-off phase during walking, the observed PA behavior provides valuable insights into its mechanics and potential implications for foot disorders.
Language	English
Publishing date	2024-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025505-9
ISSN	1098-2353 ; 0897-3806
ISSN (online)	1098-2353
ISSN	0897-3806
DOI	10.1002/ca.24171
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2592: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Learning and memory in the cricket Gryllus bimaculatus

Matsumoto, Yukihisa

Physiological entomology. 2022 Sept., v. 47, no. 3

2022

Abstract: For insects living in an environment where food supplies constantly change, the ability to learn and to memorize the association of a specific cue with food is indispensable. The advantages of using insects for studies on learning and memory have been of ...

Abstract	For insects living in an environment where food supplies constantly change, the ability to learn and to memorize the association of a specific cue with food is indispensable. The advantages of using insects for studies on learning and memory have been of great help to uncover a reliable capability of associative learning in various insect species. However, regarding neuronal and molecular mechanisms underlying learning and memory, reports are largely confined to a few insect species: the fruit fly, honey bee, and field cricket. In this review, I will introduce summarized results obtained from our studies on learning and memory in crickets. First, associative conditioning paradigms, which have been our main experimental procedures, will be described. Second, I will introduce the roles of octopamine and dopamine in conveying signals about appetitive stimuli and aversive stimuli, respectively, in learning and in memory retrieval. Third, short‐term memory and long‐term memory, two distinct memory phases of associative memory in crickets, will be introduced with details of signalling pathways involved in long‐term memory formation. Fourth, the high capability of learning and memory and characteristics of complex memory will be described. Lastly, I will summarize the results of studies on age‐related memory impairment in crickets. Crickets have the potential to be suitable model insects for studying neuromolecular mechanisms underlying learning and memory, following fruit flies and honey bees. Extensive studies on learning and memory in crickets will contribute to the elucidation of diversities in the neuromolecular mechanisms of learning and memory acquired through evolution in insects.
Keywords	Gryllus bimaculatus ; dopamine ; entomology ; evolution ; fruit flies ; fruits ; honey ; honey bees ; memory ; memory disorders ; neurons ; octopamine
Language	English
Dates of publication	2022-09
Size	p. 147-161.
Publishing place	The Royal Entomological Society
Document type	Article
Note	REVIEW
ZDB-ID	194751-5
ISSN	0307-6962
ISSN	0307-6962
DOI	10.1111/phen.12387
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 78/730: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Effects of mucus trail following on the distance between individuals of opposite sex and its influence on the evolution of the trait in the Ezo abalone

Matsumoto, Yukio

PeerJ

2020 Volume 8, Page(s) e8710

Abstract: Background: Aggregation affects the fertilization rate of species that utilize external fertilization. However, the process of aggregation has not been studied in detail, using either theoretical models or real world observations. We used the Ezo ... ...

Abstract	Background: Aggregation affects the fertilization rate of species that utilize external fertilization. However, the process of aggregation has not been studied in detail, using either theoretical models or real world observations. We used the Ezo abalone Methods: We used a y-maze to test whether Results: Haliotis discus hannai Conclusions: These results suggest that observed MTF behavior might have evolved as a mechanism to increase the fertilization rates although other factors could also be involved.
Language	English
Publishing date	2020-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.8710
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Facilitating Drug Discovery in Human Disease Models Using Insects.

Matsumoto, Yasuhiko

Biological & pharmaceutical bulletin

2020 Volume 43, Issue 2, Page(s) 216–220

Abstract: Drugs are developed through basic studies and clinical trials. In basic studies, researchers seek drug candidates using in vitro evaluation systems and subsequently examine their effectiveness in animal experiments as in vivo evaluations. Drug candidates ...

Abstract	Drugs are developed through basic studies and clinical trials. In basic studies, researchers seek drug candidates using in vitro evaluation systems and subsequently examine their effectiveness in animal experiments as in vivo evaluations. Drug candidates identified in basic studies are tested to determine whether they are effective against human diseases in clinical trials. However, most drug candidates identified in in vitro evaluation systems do not show therapeutic effects in animal experiments due to pharmacokinetics and toxicity problems in the in vivo evaluations. This review outlines drug discovery using insect disease models that allow us to perform in vivo screening. Since insects have various advantages as experimental animals such as low cost for rearing and few ethical concerns, researchers can perform large-scale in vivo screening to find drug candidates. Silkworms are insects frequently used for studies of drug efficacy, pharmacokinetics, and toxicity. Based on silkworm research, I describe the benefits of using insect disease models for drug discovery. The use of insect disease models for in vivo screening is expected to facilitate drug discovery.
MeSH term(s)	Animals ; Bombyx ; Disease Models, Animal ; Drug Discovery/methods ; Drug Evaluation, Preclinical/methods ; Insecta
Language	English
Publishing date	2020-01-27
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b19-00834
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1474: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Analysis for the diagnostic accuracy of PCR detection of

Kanno, Shoko / Matsumoto, Yusuke

Open veterinary journal

2023 Volume 13, Issue 12, Page(s) 1769–1775

Abstract: Background: Macrorhabdus ornithogaster: Case description: Ninety fecal samples collected from companion birds that visited or were admitted to a hospital, regardless of their stage of : Conclusion: The findings suggest that the PCR ... ...

Abstract	Background: Macrorhabdus ornithogaster Case description: Ninety fecal samples collected from companion birds that visited or were admitted to a hospital, regardless of their stage of Conclusion: The findings suggest that the PCR for
MeSH term(s)	Animals ; Bird Diseases/microbiology ; Birds/microbiology ; Feces ; Mycoses/microbiology ; Mycoses/veterinary ; Polymerase Chain Reaction/veterinary
Language	English
Publishing date	2023-12-31
Publishing country	Libya
Document type	Journal Article
ZDB-ID	2651664-0
ISSN	2218-6050 ; 2218-6050
ISSN (online)	2218-6050
ISSN	2218-6050
DOI	10.5455/OVJ.2023.v13.i12.26
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Aberrant Glycosylation as Immune Therapeutic Targets for Solid Tumors.

Matsumoto, Yasuyuki / Ju, Tongzhong

Cancers

2023 Volume 15, Issue 14

Abstract: Glycosylation occurs at all major types of biomolecules, including proteins, lipids, and RNAs to form glycoproteins, glycolipids, and glycoRNAs in mammalian cells, respectively. The carbohydrate moiety, known as glycans on glycoproteins and glycolipids, ... ...

Abstract	Glycosylation occurs at all major types of biomolecules, including proteins, lipids, and RNAs to form glycoproteins, glycolipids, and glycoRNAs in mammalian cells, respectively. The carbohydrate moiety, known as glycans on glycoproteins and glycolipids, is diverse in their compositions and structures. Normal cells have their unique array of glycans or glycome which play pivotal roles in many biological processes. The glycan structures in cancer cells, however, are often altered, some having unique structures which are termed as tumor-associated carbohydrate antigens (TACAs). TACAs as tumor biomarkers are glycan epitopes themselves, or glycoconjugates. Some of those TACAs serve as tumor glyco-biomarkers in clinical practice, while others are the immune therapeutic targets for treatment of cancers. A monoclonal antibody (mAb) to GD2, an intermediate of sialic-acid containing glycosphingolipids, is an example of FDA-approved immune therapy for neuroblastoma indication in young adults and many others. Strategies for targeting the aberrant glycans are currently under development, and some have proceeded to clinical trials. In this review, we summarize the currently established and most promising aberrant glycosylation as therapeutic targets for solid tumors.
Language	English
Publishing date	2023-07-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15143536
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: IR cavity ringdown spectroscopy and density functional theory calculation of pyrrole-diethyl ketone clusters: impacts of carbon-chain flexibility on the diversity of N-H⋯OC hydrogen bonds.

Matsumoto, Yoshiteru / Honma, Kenji

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 29, Page(s) 19633–19647

Abstract: The N-H⋯OC hydrogen bond (H-bond) plays a key role in stabilizing the geometry and energy of biomolecules such as protein folding and DNA double strand. To investigate N-H⋯OC H-bonds in a microscopic view, we apply IR cavity ringdown spectroscopy (IR- ... ...

Abstract	The N-H⋯OC hydrogen bond (H-bond) plays a key role in stabilizing the geometry and energy of biomolecules such as protein folding and DNA double strand. To investigate N-H⋯OC H-bonds in a microscopic view, we apply IR cavity ringdown spectroscopy (IR-CRDS) and density functional theory (DFT) calculation to pyrrole-diethyl ketone (Py-Dek) clusters in the gas phase. Dek exhibits a pentane carbon chain, which provides various conformations such as
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp01466e
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito